(2R,3S)-3-Hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid (BioDeep_00001877908)
代谢物信息卡片
(2R,3S)-3-Hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid
化学式: C9H15NO3 (185.105188)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1C2CCC1C(C(C2)O)C(=O)O
InChI: InChI=1S/C9H15NO3/c1-10-5-2-3-6(10)8(9(12)13)7(11)4-5/h5-8,11H,2-4H2,1H3,(H,12,13)/t5?,6?,7-,8+/m0/s1
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
同义名列表
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Nicolás Fernández, Laura Marina Cabanillas, Nancy Mónica Olivera, Patricia Noemí Quiroga. Optimization and validation of simultaneous analyses of ecgonine, cocaine, and seven metabolites in human urine by gas chromatography-mass spectrometry using a one-step solid-phase extraction.
Drug testing and analysis.
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Analytical and bioanalytical chemistry.
2013 Dec; 405(30):9805-16. doi:
10.1007/s00216-013-7417-9. [PMID: 24202193] - Michael L Smith, Eric Shimomura, Buddha D Paul, Edward J Cone, W David Darwin, Marilyn A Huestis. Urinary excretion of ecgonine and five other cocaine metabolites following controlled oral, intravenous, intranasal, and smoked administration of cocaine.
Journal of analytical toxicology.
2010 Mar; 34(2):57-63. doi:
10.1093/jat/34.2.57. [PMID: 20223096] - Thomas Visalli, Rita Turkall, Mohamed S Abdel-Rahman. Gender differences in cocaine pharmacokinetics in CF-1 mice.
Toxicology letters.
2005 Jan; 155(1):35-40. doi:
10.1016/j.toxlet.2004.08.008. [PMID: 15585357] - A Queiroz-Neto, G Zamur, J C Lacerda-Neto, T Tobin. Determination of the highest no-effect dose (HNED) and of the elimination pattern for cocaine in horses.
Journal of applied toxicology : JAT.
2002 Mar; 22(2):117-21. doi:
10.1002/jat.836. [PMID: 11920936] - A Klingmann, G Skopp, R Aderjan. Analysis of cocaine, benzoylecgonine, ecogonine methyl ester, and ecgonine by high-pressure liquid chromatography-API mass spectrometry and application to a short-term degradation study of cocaine in plasma.
Journal of analytical toxicology.
2001 Sep; 25(6):425-30. doi:
10.1093/jat/25.6.425. [PMID: 11550815] - R J Briscoe, P M Jeanville, C Cabrera, T J Baird, J H Woods, D W Landry. A catalytic antibody against cocaine attenuates cocaine's cardiovascular effects in mice: a dose and time course analysis.
International immunopharmacology.
2001 Jun; 1(6):1189-98. doi:
10.1016/s1567-5769(01)00054-6. [PMID: 11407313] - G Skopp, A Klingmann, L Pötsch, R Mattern. In vitro stability of cocaine in whole blood and plasma including ecgonine as a target analyte.
Therapeutic drug monitoring.
2001 Apr; 23(2):174-81. doi:
10.1097/00007691-200104000-00014. [PMID: 11294520] - D L Allen, J S Oliver. The application of supercritical fluid extraction to cocaine and its metabolites in blood and urine.
Journal of analytical toxicology.
2000 Apr; 24(3):228-32. doi:
10.1093/jat/24.3.228. [PMID: 10774543] - K L Peterson, B K Logan, G D Christian. Detection of cocaine and its polar transformation products and metabolites in human urine.
Forensic science international.
1995 Jun; 73(3):183-96. doi:
10.1016/0379-0738(95)01749-9. [PMID: 7657184] - C L Hornbeck, K M Barton, R J Czarny. Urine concentrations of ecgonine from specimens with low benzoylecgonine levels using a new ecgonine assay.
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10.1016/0378-4347(94)00209-6. [PMID: 7952133] - M Nishikawa, K Nakajima, M Tatsuno, F Kasuya, K Igarashi, M Fukui, H Tsuchihashi. The analysis of cocaine and its metabolites by liquid chromatography/atmospheric pressure chemical ionization-mass spectrometry (LC/APCI-MS).
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1994 Jun; 66(3):149-58. doi:
10.1016/0379-0738(94)90340-9. [PMID: 7959465] - C Giroud, T Colassis, L Rivier, E Ottinger. [Cocaine and alcohol: an explosive cocktail!].
Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis.
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NULL. [PMID: 8511449] - K Nakashima, M Okamoto, K Yoshida, N Kuroda, S Akiyama, M Yamaguchi. Preparation of a fluorescent derivative of benzoylecgonine, and preliminary studies of its application to the analysis of urine.
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1992 Dec; 584(2):275-9. doi:
10.1016/0378-4347(92)80587-g. [PMID: 1484114] - J de Kanel, L Dunlap, T D Hall. Extending the detection limit of the TDx fluorescence polarization immunoassay for benzoylecgonine in urine.
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10.1093/clinchem/35.10.2110. [PMID: 2791279] - A R Jeffcoat, M Perez-Reyes, J M Hill, B M Sadler, C E Cook. Cocaine disposition in humans after intravenous injection, nasal insufflation (snorting), or smoking.
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1989 Mar; 17(2):153-9. doi:
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1988 Sep; 12(5):242-5. doi:
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