g(m3) Ganglioside (BioDeep_00001877179)
代谢物信息卡片
g(m3) Ganglioside
化学式: C65H118N2O21 (1262.8226658)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCCCC=CC(C(COC1C(C(C(C(O1)CO)OC2C(C(C(C(O2)CO)O)OC3(CC(C(C(O3)C(C(CO)O)O)NC(=O)C)O)C(=O)O)O)O)O)NC(=O)CCCCCCCCCCCCCC=CCCCCCCCC)O
InChI: InChI=1S/C65H118N2O21/c1-4-6-8-10-12-14-16-18-19-20-21-22-23-24-25-27-29-31-33-35-37-39-52(75)67-46(47(72)38-36-34-32-30-28-26-17-15-13-11-9-7-5-2)44-83-62-57(79)56(78)59(51(43-70)85-62)86-63-58(80)61(55(77)50(42-69)84-63)88-65(64(81)82)40-48(73)53(66-45(3)71)60(87-65)54(76)49(74)41-68/h18-19,36,38,46-51,53-63,68-70,72-74,76-80H,4-17,20-35,37,39-44H2,1-3H3,(H,66,71)(H,67,75)(H,81,82)/b19-18-,38-36+/t46-,47+,48-,49+,50+,51+,53+,54+,55-,56+,57+,58+,59+,60+,61-,62+,63-,65-/m0/s1
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yuanqing Gu, Björn M Reinhard. Membrane fluidity properties of lipid-coated polylactic acid nanoparticles.
Nanoscale.
2024 May; 16(17):8533-8545. doi:
10.1039/d3nr06464f. [PMID: 38595322] - Fangni Zhang, Kan Li, Wenhui Zhang, Ziyan Zhao, Fangyuan Chang, Jie Du, Xu Zhang, Kaiwen Bao, Chunyong Zhang, Lei Shi, Zongwei Liu, Xiangchen Dai, Chen Chen, Dao Wen Wang, Zhong Xian, Hongfeng Jiang, Ding Ai. Ganglioside GM3 Protects Against Abdominal Aortic Aneurysm by Suppressing Ferroptosis in Vascular Smooth Muscle Cells.
Circulation.
2023 Nov; ?(?):. doi:
10.1161/circulationaha.123.066110. [PMID: 38018467] - Mariko Komuro, Hinano Mizugaki, Masaki Nagane, Misako Morimoto, Tomoki Fukuyama, Kikumi Ogihara, Yuko Naya, Emi Yokomori, Kimika Kaneshima, Yasushi Kawakami, Junichi Kamiie, Yuki Shibata, Mira Suzuki, Takuto Shimizu, Nagako Kawashima, Mariko Okamoto, Teruo Ikeda, Tadashi Yamashita. Ganglioside GM3 deficiency enhances mast cell sensitivity.
The FEBS journal.
2023 09; 290(17):4268-4280. doi:
10.1111/febs.16806. [PMID: 37098812] - Tanushree Das, Chaitali Mukhopadhyay. Comparison and Possible Binding Orientations of SARS-CoV-2 Spike N-Terminal Domain for Gangliosides GM3 and GM1.
The journal of physical chemistry. B.
2023 08; 127(31):6940-6948. doi:
10.1021/acs.jpcb.3c02286. [PMID: 37523476] - Motohide Murate, Noriko Yokoyama, Nario Tomishige, Ludovic Richert, Nicolas Humbert, Brigitte Pollet, Asami Makino, Nozomu Kono, Laura Mauri, Junken Aoki, Yasushi Sako, Sandro Sonnino, Naoko Komura, Hiromune Ando, Mika K Kaneko, Yukinari Kato, Kei-Ichiro Inamori, Jin-Ichi Inokuchi, Yves Mély, Kazuhisa Iwabuchi, Toshihide Kobayashi. Cell density-dependent membrane distribution of ganglioside GM3 in melanoma cells.
Cellular and molecular life sciences : CMLS.
2023 May; 80(6):167. doi:
10.1007/s00018-023-04813-9. [PMID: 37249637] - Simon Fridolf, Quoc Dat Pham, Jon Pallbo, Katja Bernfur, Sara Linse, Daniel Topgaard, Emma Sparr. Ganglioside GM3 stimulates lipid-protein co-assembly in α-synuclein amyloid formation.
Biophysical chemistry.
2023 02; 293(?):106934. doi:
10.1016/j.bpc.2022.106934. [PMID: 36493587] - Giulia Lunghi, Maria Fazzari, Maria Grazia Ciampa, Laura Mauri, Erika Di Biase, Elena Chiricozzi, Sandro Sonnino. Regulation of signal transduction by gangliosides in lipid rafts: focus on GM3-IR and GM1-TrkA interactions.
FEBS letters.
2022 12; 596(24):3124-3132. doi:
10.1002/1873-3468.14532. [PMID: 36331354] - Han Zang, Menna Siddiqui, Suryaram Gummuluru, Wilson W Wong, Björn M Reinhard. Ganglioside-Functionalized Nanoparticles for Chimeric Antigen Receptor T-Cell Activation at the Immunological Synapse.
ACS nano.
2022 11; 16(11):18408-18420. doi:
10.1021/acsnano.2c06516. [PMID: 36282488] - Juntao Wang, Dan Lu, Ran Sun, Shuwen Lei, Shuhua Luo, Xin Dang, Yang Zhang, Chang Yuan, Yong Zhang, Jinhong Wu, Guangyu Yang, Lei Fu, Faqin Jiang. One-Pot Enzymatic Synthesis and Biological Evaluation of Ganglioside GM3 Derivatives as Potential Cancer Immunotherapeutics.
Journal of medicinal chemistry.
2022 02; 65(3):1883-1897. doi:
10.1021/acs.jmedchem.1c01301. [PMID: 35073068] - James C Dodge, Thomas J Tamsett, Christopher M Treleaven, Tatyana V Taksir, Peter Piepenhagen, S Pablo Sardi, Seng H Cheng, Lamya S Shihabuddin. Glucosylceramide synthase inhibition reduces ganglioside GM3 accumulation, alleviates amyloid neuropathology, and stabilizes remote contextual memory in a mouse model of Alzheimer's disease.
Alzheimer's research & therapy.
2022 02; 14(1):19. doi:
10.1186/s13195-022-00966-0. [PMID: 35105352] - Hirotaka Kanoh. [Homeostatic and Pathophysiological Regulation of Toll-like Receptor 4 Signaling by GM3 Ganglioside Molecular Species].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2022; 142(3):195-203. doi:
10.1248/yakushi.21-00193. [PMID: 35228371] - Tong Rong, Bo Wei, Meiying Ao, Haonan Zhao, Yuanfang Li, Yang Zhang, Ying Qin, Jinhua Zhou, Fenfen Zhou, Yong Chen. Enhanced Anti-Atherosclerotic Efficacy of pH-Responsively Releasable Ganglioside GM3 Delivered by Reconstituted High-Density Lipoprotein.
International journal of molecular sciences.
2021 Dec; 22(24):. doi:
10.3390/ijms222413624. [PMID: 34948420] - Mira Suzuki, Masaki Nagane, Kazuhiro Kato, Akinori Yamauchi, Takuto Shimizu, Hiroko Yamashita, Naoyuki Aihara, Junichi Kamiie, Nagako Kawashima, Shokichi Naito, Tadashi Yamashita. Endothelial ganglioside GM3 regulates angiogenesis in solid tumors.
Biochemical and biophysical research communications.
2021 09; 569(?):10-16. doi:
10.1016/j.bbrc.2021.06.063. [PMID: 34216992] - Mikito Nakano, Shinya Hanashima, Toshiaki Hara, Kazuya Kabayama, Yuya Asahina, Hironobu Hojo, Naoko Komura, Hiromune Ando, Thomas K M Nyholm, J Peter Slotte, Michio Murata. FRET detects lateral interaction between transmembrane domain of EGF receptor and ganglioside GM3 in lipid bilayers.
Biochimica et biophysica acta. Biomembranes.
2021 08; 1863(8):183623. doi:
10.1016/j.bbamem.2021.183623. [PMID: 33933428] - Shiomi Koudatsu, Tatsunori Masatani, Rikako Konishi, Masahito Asada, Hassan Hakimi, Yuna Kurokawa, Kanna Tomioku, Osamu Kaneko, Akikazu Fujita. Glycosphingolipid GM3 is localized in both exoplasmic and cytoplasmic leaflets of Plasmodium falciparum malaria parasite plasma membrane.
Scientific reports.
2021 07; 11(1):14890. doi:
10.1038/s41598-021-94037-3. [PMID: 34290278] - Shuqiang Chen, Ming Wang, Li Li, Jun Wang, Xuhui Ma, Hengde Zhang, Yang Cai, Bin Kang, Jianlei Huang, Bo Li. High-coverage targeted lipidomics revealed dramatic lipid compositional changes in asthenozoospermic spermatozoa and inverse correlation of ganglioside GM3 with sperm motility.
Reproductive biology and endocrinology : RB&E.
2021 Jul; 19(1):105. doi:
10.1186/s12958-021-00792-3. [PMID: 34233713] - Hai Yu, Madhusudhan Reddy Gadi, Yuanyuan Bai, Libo Zhang, Lei Li, Jun Yin, Peng G Wang, Xi Chen. Chemoenzymatic Total Synthesis of GM3 Gangliosides Containing Different Sialic Acid Forms and Various Fatty Acyl Chains.
The Journal of organic chemistry.
2021 07; 86(13):8672-8682. doi:
10.1021/acs.joc.1c00450. [PMID: 34152144] - Rhona McGonigal, Jennifer A Barrie, Denggao Yao, Lauren E Black, Mark McLaughlin, Hugh J Willison. Neuronally expressed a-series gangliosides are sufficient to prevent the lethal age-dependent phenotype in GM3-only expressing mice.
Journal of neurochemistry.
2021 07; 158(2):217-232. doi:
10.1111/jnc.15365. [PMID: 33864399] - Marjorie Damian, Maxime Louet, Antoniel Augusto Severo Gomes, Céline M'Kadmi, Séverine Denoyelle, Sonia Cantel, Sophie Mary, Paulo M Bisch, Jean-Alain Fehrentz, Laurent J Catoire, Nicolas Floquet, Jean-Louis Banères. Allosteric modulation of ghrelin receptor signaling by lipids.
Nature communications.
2021 06; 12(1):3938. doi:
10.1038/s41467-021-23756-y. [PMID: 34168117] - Xu-Guang Yin, Jie Lu, Jian Wang, Ru-Yan Zhang, Xi-Feng Wang, Chun-Miao Liao, Xiao-Peng Liu, Zheng Liu, Jun Guo. Synthesis and Evaluation of Liposomal Anti-GM3 Cancer Vaccine Candidates Covalently and Noncovalently Adjuvanted by αGalCer.
Journal of medicinal chemistry.
2021 02; 64(4):1951-1965. doi:
10.1021/acs.jmedchem.0c01186. [PMID: 33539088] - Takuto Shimizu, Masaki Nagane, Mira Suzuki, Akinori Yamauchi, Kazuhiro Kato, Nagako Kawashima, Yuki Nemoto, Takuya Maruo, Yasushi Kawakami, Tadashi Yamashita. Tumor hypoxia regulates ganglioside GM3 synthase, which contributes to oxidative stress resistance in malignant melanoma.
Biochimica et biophysica acta. General subjects.
2020 12; 1864(12):129723. doi:
10.1016/j.bbagen.2020.129723. [PMID: 32861756] - Jin-Wen Song, Sin Man Lam, Xing Fan, Wen-Jing Cao, Si-Yu Wang, He Tian, Gek Huey Chua, Chao Zhang, Fan-Ping Meng, Zhe Xu, Jun-Liang Fu, Lei Huang, Peng Xia, Tao Yang, Shaohua Zhang, Bowen Li, Tian-Jun Jiang, Raoxu Wang, Zehua Wang, Ming Shi, Ji-Yuan Zhang, Fu-Sheng Wang, Guanghou Shui. Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis.
Cell metabolism.
2020 08; 32(2):188-202.e5. doi:
10.1016/j.cmet.2020.06.016. [PMID: 32610096] - Hirotaka Kanoh, Takahiro Nitta, Shinji Go, Kei-Ichiro Inamori, Lucas Veillon, Wataru Nihei, Mayu Fujii, Kazuya Kabayama, Atsushi Shimoyama, Koichi Fukase, Umeharu Ohto, Toshiyuki Shimizu, Taku Watanabe, Hiroki Shindo, Sorama Aoki, Kenichi Sato, Mika Nagasaki, Yutaka Yatomi, Naoko Komura, Hiromune Ando, Hideharu Ishida, Makoto Kiso, Yoshihiro Natori, Yuichi Yoshimura, Asia Zonca, Anna Cattaneo, Marilena Letizia, Maria Ciampa, Laura Mauri, Alessandro Prinetti, Sandro Sonnino, Akemi Suzuki, Jin-Ichi Inokuchi. Homeostatic and pathogenic roles of GM3 ganglioside molecular species in TLR4 signaling in obesity.
The EMBO journal.
2020 06; 39(12):e101732. doi:
10.15252/embj.2019101732. [PMID: 32378734] - Zhixiong Deng, Xuemei Lu, Cheng Xu, Bing Yuan, Kai Yang. Lipid-specific interactions determine the organization and dynamics of membrane-active peptide melittin.
Soft matter.
2020 Apr; 16(14):3498-3504. doi:
10.1039/d0sm00046a. [PMID: 32215386] - Tamara K Nowling, Jessalyn Rodgers, Thirumagal Thiyagarajan, Bethany Wolf, Evelyn Bruner, Kamala Sundararaj, Ivan Molano, Gary Gilkeson. Targeting glycosphingolipid metabolism as a potential therapeutic approach for treating disease in female MRL/lpr lupus mice.
PloS one.
2020; 15(3):e0230499. doi:
10.1371/journal.pone.0230499. [PMID: 32187230] - Bo Hyun Kim, Won Seok Ju, Ji-Su Kim, Sun-Uk Kim, Soon Ju Park, Sean M Ward, Ju Hyeong Lyu, Young-Kug Choo. Effects of Gangliosides on Spermatozoa, Oocytes, and Preimplantation Embryos.
International journal of molecular sciences.
2019 Dec; 21(1):. doi:
10.3390/ijms21010106. [PMID: 31877897] - Yosuke Takeuchi, Yuichiro Inatomi, Makoto Nakajima, Toshiro Yonehara. [Guillain-Barré syndrome with refractory optic neuropathy].
Rinsho shinkeigaku = Clinical neurology.
2019 Oct; 59(10):652-658. doi:
10.5692/clinicalneurol.cn-001329. [PMID: 31564705] - Carmen Bedia, Miriam Badia, Laia Muixí, Thierry Levade, Romà Tauler, Angels Sierra. GM2-GM3 gangliosides ratio is dependent on GRP94 through down-regulation of GM2-AP cofactor in brain metastasis cells.
Scientific reports.
2019 10; 9(1):14241. doi:
10.1038/s41598-019-50761-5. [PMID: 31578452] - Qinying Li, Mei Sun, Mingsheng Yu, Qianyun Fu, Hao Jiang, Guangli Yu, Guoyun Li. Gangliosides profiling in serum of breast cancer patient: GM3 as a potential diagnostic biomarker.
Glycoconjugate journal.
2019 10; 36(5):419-428. doi:
10.1007/s10719-019-09885-z. [PMID: 31297734] - Meiying Ao, Kun Wang, Xing Zhou, Guo Chen, Yun Zhou, Bo Wei, Wenxiang Shao, Jie Huang, Huanhuan Liao, Zhexuan Wang, Yanan Sun, Sufen Zeng, Yong Chen. Exogenous GM3 ganglioside inhibits atherosclerosis via multiple steps: A potential atheroprotective drug.
Pharmacological research.
2019 10; 148(?):104445. doi:
10.1016/j.phrs.2019.104445. [PMID: 31526872] - Masako Nishikawa, Makoto Kurano, Takahiro Nitta, Hirotaka Kanoh, Jin-Ichi Inokuchi, Yutaka Yatomi. Serum GM3(d18:1-16:0) and GM3(d18:1-24:1) levels may be associated with lymphoma: An exploratory study with haematological diseases.
Scientific reports.
2019 04; 9(1):6308. doi:
10.1038/s41598-019-42817-3. [PMID: 31004109] - Pieter Vrijens, Sam Noppen, Talitha Boogaerts, Els Vanstreels, Roberto Ronca, Paola Chiodelli, Manon Laporte, Evelien Vanderlinden, Sandra Liekens, Annelies Stevaert, Lieve Naesens. Influenza virus entry via the GM3 ganglioside-mediated platelet-derived growth factor receptor β signalling pathway.
The Journal of general virology.
2019 04; 100(4):583-601. doi:
10.1099/jgv.0.001235. [PMID: 30762518] - Christophe Paget, Shenglou Deng, Daphnée Soulard, David A Priestman, Silvia Speca, Johanna von Gerichten, Anneliese O Speak, Ashish Saroha, Yael Pewzner-Jung, Anthony H Futerman, Thierry Mallevaey, Christelle Faveeuw, Xiaobo Gu, Frances M Platt, Roger Sandhoff, François Trottein. TLR9-mediated dendritic cell activation uncovers mammalian ganglioside species with specific ceramide backbones that activate invariant natural killer T cells.
PLoS biology.
2019 03; 17(3):e3000169. doi:
10.1371/journal.pbio.3000169. [PMID: 30822302] - Wataru Nihei, Masakazu Nagafuku, Hirotaka Hayamizu, Yuta Odagiri, Yumi Tamura, Yui Kikuchi, Lucas Veillon, Hirotaka Kanoh, Kei-Ichiro Inamori, Kenta Arai, Kazuya Kabayama, Koichi Fukase, Jin-Ichi Inokuchi. NPC1L1-dependent intestinal cholesterol absorption requires ganglioside GM3 in membrane microdomains.
Journal of lipid research.
2018 11; 59(11):2181-2187. doi:
10.1194/jlr.m089201. [PMID: 30242108] - Fangda Xu, Asanga Bandara, Hisashi Akiyama, Behnaz Eshaghi, David Stelter, Tom Keyes, John E Straub, Suryaram Gummuluru, Björn M Reinhard. Membrane-wrapped nanoparticles probe divergent roles of GM3 and phosphatidylserine in lipid-mediated viral entry pathways.
Proceedings of the National Academy of Sciences of the United States of America.
2018 09; 115(39):E9041-E9050. doi:
10.1073/pnas.1804292115. [PMID: 30190430] - Kei-Ichiro Inamori, Hideki Ito, Yumi Tamura, Takahiro Nitta, Xiaohua Yang, Wataru Nihei, Fumi Shishido, Susumu Imazu, Sohei Tsukita, Tetsuya Yamada, Hideki Katagiri, Jin-Ichi Inokuchi. Deficient ganglioside synthesis restores responsiveness to leptin and melanocortin signaling in obese KKAy mice.
Journal of lipid research.
2018 08; 59(8):1472-1481. doi:
10.1194/jlr.m085753. [PMID: 29880531] - Kaare Bjerregaard-Andersen, Hedda Johannesen, Noha Abdel-Rahman, Julie Elisabeth Heggelund, Helene Mykland Hoås, Fana Abraha, Paula A Bousquet, Lene Støkken Høydahl, Daniel Burschowsky, Gertrudis Rojas, Stefan Oscarson, Geir Åge Løset, Ute Krengel. Crystal structure of an L chain optimised 14F7 anti-ganglioside Fv suggests a unique tumour-specificity through an unusual H-chain CDR3 architecture.
Scientific reports.
2018 Jul; 8(1):10836. doi:
10.1038/s41598-018-28918-5. [PMID: 30022069] - Xueheng Zhao, Marion G Brusadelli, Sharon Sauter, Melinda Butsch Kovacic, Wujuan Zhang, Lindsey E Romick-Rosendale, Paul F Lambert, Kenneth D R Setchell, Susanne I Wells. Lipidomic Profiling Links the Fanconi Anemia Pathway to Glycosphingolipid Metabolism in Head and Neck Cancer Cells.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2018 06; 24(11):2700-2709. doi:
10.1158/1078-0432.ccr-17-3686. [PMID: 29530934] - Josko Bozic, Anita Markotic, Vedrana Cikes-Culic, Anela Novak, Josip A Borovac, Hrvoje Vucemilovic, Gorana Trgo, Tina Ticinovic Kurir. Ganglioside GM3 content in skeletal muscles is increased in type 2 but decreased in type 1 diabetes rat models: Implications of glycosphingolipid metabolism in pathophysiology of diabetes.
Journal of diabetes.
2018 Feb; 10(2):130-139. doi:
10.1111/1753-0407.12569. [PMID: 28544772] - Kenichi G N Suzuki, Hiromune Ando, Naoko Komura, Miku Konishi, Akihiro Imamura, Hideharu Ishida, Makoto Kiso, Takahiro K Fujiwara, Akihiro Kusumi. Revealing the Raft Domain Organization in the Plasma Membrane by Single-Molecule Imaging of Fluorescent Ganglioside Analogs.
Methods in enzymology.
2018; 598(?):267-282. doi:
10.1016/bs.mie.2017.06.038. [PMID: 29306438] - Mayrel Labrada, Denise Dorvignit, Giselle Hevia, Nely Rodríguez-Zhurbenko, Ana M Hernández, Ana M Vázquez, Luis E Fernández. GM3(Neu5Gc) ganglioside: an evolution fixed neoantigen for cancer immunotherapy.
Seminars in oncology.
2018 01; 45(1-2):41-51. doi:
10.1053/j.seminoncol.2018.04.003. [PMID: 30318083] - Fumi Shishido, Satoshi Uemura, Takahiro Nitta, Jin-Ichi Inokuchi. Identification of a new liver-specific c-type mRNA transcriptional variant for mouse ST3GAL5 (GM3/GM4 synthase).
Glycoconjugate journal.
2017 10; 34(5):651-659. doi:
10.1007/s10719-017-9788-1. [PMID: 28808804] - Kenichi G N Suzuki, Hiromune Ando, Naoko Komura, Takahiro K Fujiwara, Makoto Kiso, Akihiro Kusumi. Development of new ganglioside probes and unraveling of raft domain structure by single-molecule imaging.
Biochimica et biophysica acta. General subjects.
2017 Oct; 1861(10):2494-2506. doi:
10.1016/j.bbagen.2017.07.012. [PMID: 28734966] - Hyo-Jin Park, Sung-Kyu Chae, Jin-Woo Kim, Seul-Gi Yang, Jae-Min Jung, Min-Ji Kim, Gabbine Wee, Dong-Seok Lee, Sun-Uk Kim, Deog-Bon Koo. Ganglioside GM3 induces cumulus cell apoptosis through inhibition of epidermal growth factor receptor-mediated PI3K/AKT signaling pathways during in vitro maturation of pig oocytes.
Molecular reproduction and development.
2017 Aug; 84(8):702-711. doi:
10.1002/mrd.22848. [PMID: 28585705] - Hyunju Choi, Un-Ho Jin, Sung-Koo Kang, Fukushi Abekura, Jun-Young Park, Kyung-Min Kwon, Seok-Jong Suh, Seung-Hak Cho, Ki-Tae Ha, Young-Coon Lee, Tae-Wook Chung, Cheorl-Ho Kim. Monosialyl Ganglioside GM3 Decreases Apolipoprotein B-100 Secretion in Liver Cells.
Journal of cellular biochemistry.
2017 08; 118(8):2168-2181. doi:
10.1002/jcb.25860. [PMID: 28019668] - Shinji Go, Shiori Go, Lucas Veillon, Maria Grazia Ciampa, Laura Mauri, Chihiro Sato, Ken Kitajima, Alessandro Prinetti, Sandro Sonnino, Jin-Ichi Inokuchi. Altered expression of ganglioside GM3 molecular species and a potential regulatory role during myoblast differentiation.
The Journal of biological chemistry.
2017 04; 292(17):7040-7051. doi:
10.1074/jbc.m116.771253. [PMID: 28275055] - Martin Dufresne, Daniel Guneysu, Nathan Heath Patterson, Mieczyslaw Martin Marcinkiewicz, Anthony Regina, Michel Demeule, Pierre Chaurand. Multimodal detection of GM2 and GM3 lipid species in the brain of mucopolysaccharidosis type II mouse by serial imaging mass spectrometry and immunohistochemistry.
Analytical and bioanalytical chemistry.
2017 Feb; 409(5):1425-1433. doi:
10.1007/s00216-016-0076-x. [PMID: 27873002] - Duncan Hieu M Dam, Xiao-Qi Wang, Sarah Sheu, Mahima Vijay, Desmond Shipp, Luke Miller, Amy S Paller. Ganglioside GM3 Mediates Glucose-Induced Suppression of IGF-1 Receptor-Rac1 Activation to Inhibit Keratinocyte Motility.
The Journal of investigative dermatology.
2017 02; 137(2):440-448. doi:
10.1016/j.jid.2016.09.028. [PMID: 27729281] - Naoko Komura, Kenichi G N Suzuki, Hiromune Ando, Miku Konishi, Akihiro Imamura, Hideharu Ishida, Akihiro Kusumi, Makoto Kiso. Syntheses of Fluorescent Gangliosides for the Studies of Raft Domains.
Methods in enzymology.
2017; 597(?):239-263. doi:
10.1016/bs.mie.2017.06.004. [PMID: 28935104] - Robin B Chan, Adler J Perotte, Bowen Zhou, Christopher Liong, Evan J Shorr, Karen S Marder, Un J Kang, Cheryl H Waters, Oren A Levy, Yimeng Xu, Hong Bin Shim, Itsik Pe'er, Gilbert Di Paolo, Roy N Alcalay. Elevated GM3 plasma concentration in idiopathic Parkinson's disease: A lipidomic analysis.
PloS one.
2017; 12(2):e0172348. doi:
10.1371/journal.pone.0172348. [PMID: 28212433] - George Hedger, David Shorthouse, Heidi Koldsø, Mark S P Sansom. Free Energy Landscape of Lipid Interactions with Regulatory Binding Sites on the Transmembrane Domain of the EGF Receptor.
The journal of physical chemistry. B.
2016 08; 120(33):8154-63. doi:
10.1021/acs.jpcb.6b01387. [PMID: 27109430] - M Virginia Gentilini, M Eugenia Pérez, Pablo Mariano Fernández, Leonardo Fainboim, Eloísa Arana. The tumor antigen N-glycolyl-GM3 is a human CD1d ligand capable of mediating B cell and natural killer T cell interaction.
Cancer immunology, immunotherapy : CII.
2016 May; 65(5):551-62. doi:
10.1007/s00262-016-1812-y. [PMID: 26969612] - J M Wentworth, G Naselli, K Ngui, G K Smyth, R Liu, P E O'Brien, C Bruce, J Weir, M Cinel, P J Meikle, L C Harrison. GM3 ganglioside and phosphatidylethanolamine-containing lipids are adipose tissue markers of insulin resistance in obese women.
International journal of obesity (2005).
2016 Apr; 40(4):706-13. doi:
10.1038/ijo.2015.223. [PMID: 26499445] - Fangda Xu, Michael Reiser, Xinwei Yu, Suryaram Gummuluru, Lee Wetzler, Björn M Reinhard. Lipid-Mediated Targeting with Membrane-Wrapped Nanoparticles in the Presence of Corona Formation.
ACS nano.
2016 Jan; 10(1):1189-200. doi:
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Biochimie.
2016 Jan; 120(?):105-9. doi:
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The FEBS journal.
2015 Sep; 282(17):3334-47. doi:
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Glycobiology.
2015 Aug; 25(8):855-68. doi:
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Clinical and experimental nephrology.
2015 Jun; 19(3):403-10. doi:
10.1007/s10157-014-1003-0. [PMID: 24985965] - Misato Yoshikawa, Shinji Go, Shun-ichi Suzuki, Akemi Suzuki, Yukio Katori, Thierry Morlet, Steven M Gottlieb, Michihiro Fujiwara, Katsunori Iwasaki, Kevin A Strauss, Jin-ichi Inokuchi. Ganglioside GM3 is essential for the structural integrity and function of cochlear hair cells.
Human molecular genetics.
2015 May; 24(10):2796-807. doi:
10.1093/hmg/ddv041. [PMID: 25652401] - Dayong Xu, Libin Yang, Yunpeng Li, Yongqiang Sun. Clinical study of ganglioside (GM) combined with methylprednisolone (MP) for early acute spinal injury.
Pakistan journal of pharmaceutical sciences.
2015 Mar; 28(2 Suppl):701-4. doi:
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Glycobiology.
2015 Mar; 25(3):303-18. doi:
10.1093/glycob/cwu112. [PMID: 25303960] - Sen-Itiroh Hakomori, Kazuko Handa. GM3 and cancer.
Glycoconjugate journal.
2015 Feb; 32(1-2):1-8. doi:
10.1007/s10719-014-9572-4. [PMID: 25613425] - Nadia Martinez-Martin, Abel Viejo-Borbolla, Rocío Martín, Soledad Blanco, Jeffrey L Benovic, Marcus Thelen, Antonio Alcamí. Herpes simplex virus enhances chemokine function through modulation of receptor trafficking and oligomerization.
Nature communications.
2015 Jan; 6(?):6163. doi:
10.1038/ncomms7163. [PMID: 25625471] - Igor Vukovic, Josko Bozic, Anita Markotic, Srecko Ljubicic, Tina Ticinovic Kurir. The missing link - likely pathogenetic role of GM3 and other gangliosides in the development of diabetic nephropathy.
Kidney & blood pressure research.
2015; 40(3):306-14. doi:
10.1159/000368506. [PMID: 26043887] - Francesca Margheri, Laura Papucci, Nicola Schiavone, Riccardo D'Agostino, Silvana Trigari, Simona Serratì, Anna Laurenzana, Alessio Biagioni, Cristina Luciani, Anastasia Chillà, Elena Andreucci, Tommaso Del Rosso, Giancarlo Margheri, Mario Del Rosso, Gabriella Fibbi. Differential uPAR recruitment in caveolar-lipid rafts by GM1 and GM3 gangliosides regulates endothelial progenitor cells angiogenesis.
Journal of cellular and molecular medicine.
2015 Jan; 19(1):113-23. doi:
10.1111/jcmm.12410. [PMID: 25313007] - Lucas Veillon, Shinji Go, Wakana Matsuyama, Akemi Suzuki, Mika Nagasaki, Yutaka Yatomi, Jin-Ichi Inokuchi. Identification of Ganglioside GM3 Molecular Species in Human Serum Associated with Risk Factors of Metabolic Syndrome.
PloS one.
2015; 10(6):e0129645. doi:
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Methods in molecular biology (Clifton, N.J.).
2015; 1273(?):379-90. doi:
10.1007/978-1-4939-2343-4_23. [PMID: 25753721] - Elena Lukina, Nora Watman, Marta Dragosky, Gregory M Pastores, Elsa Avila Arreguin, Hanna Rosenbaum, Ari Zimran, Jennifer Angell, Leorah Ross, Ana Cristina Puga, Judith M Peterschmitt. Eliglustat, an investigational oral therapy for Gaucher disease type 1: Phase 2 trial results after 4 years of treatment.
Blood cells, molecules & diseases.
2014 Dec; 53(4):274-6. doi:
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Discovery medicine.
2014 Sep; 18(98):113-24. doi:
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Analytical biochemistry.
2014 Jun; 455(?):26-34. doi:
10.1016/j.ab.2014.03.014. [PMID: 24680754] - Xiang Li, Yang Zhang, Min Xia, Erich Gulbins, Krishna M Boini, Pin-Lan Li. Activation of Nlrp3 inflammasomes enhances macrophage lipid-deposition and migration: implication of a novel role of inflammasome in atherogenesis.
PloS one.
2014; 9(1):e87552. doi:
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Cell transplantation.
2014; 23(12):1613-30. doi:
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Journal of physiology and biochemistry.
2013 Dec; 69(4):727-35. doi:
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Biochemical and biophysical research communications.
2013 Jul; 436(3):394-9. doi:
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Lipids.
2013 Jul; 48(7):739-47. doi:
10.1007/s11745-013-3789-z. [PMID: 23591593] - Kirenia Pérez, Marta Osorio, Julio Hernández, Adriana Carr, Luis Enrique Fernández. NGcGM3/VSSP vaccine as treatment for melanoma patients.
Human vaccines & immunotherapeutics.
2013 Jun; 9(6):1237-40. doi:
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Molecular cancer research : MCR.
2013 Jun; 11(6):665-75. doi:
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Advances in experimental medicine and biology.
2013; 991(?):15-26. doi:
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Journal of cellular biochemistry.
2012 Sep; 113(9):2967-78. doi:
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Neurochemical research.
2012 Jun; 37(6):1372-80. doi:
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FEBS letters.
2012 Jan; 586(2):191-5. doi:
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ACS chemical biology.
2012 Jan; 7(1):235-40. doi:
10.1021/cb200358r. [PMID: 22013921] - Satoshi Uemura. [The regulation of ganglioside GM3 synthesis].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2012; 132(8):895-901. doi:
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Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2012; 132(4):417-23. doi:
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Immunobiology.
2011 Dec; 216(12):1239-47. doi:
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Langmuir : the ACS journal of surfaces and colloids.
2011 Nov; 27(22):13675-83. doi:
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The Journal of biological chemistry.
2011 Sep; 286(36):31437-46. doi:
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Glycobiology.
2011 Sep; 21(9):1206-16. doi:
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Cornea.
2011 Jul; 30(7):796-803. doi:
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Immunology letters.
2011 Jun; 137(1-2):38-45. doi:
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Proceedings of the National Academy of Sciences of the United States of America.
2011 May; 108(22):9044-8. doi:
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Molecular immunology.
2011 Apr; 48(8):1059-67. doi:
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Nutrients.
2011 02; 3(2):228-44. doi:
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PloS one.
2010 Nov; 5(11):e14010. doi:
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Glycobiology.
2010 Oct; 20(10):1289-97. doi:
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The Journal of biological chemistry.
2010 Jul; 285(27):20423-7. doi:
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Nature medicine.
2010 Jul; 16(7):788-92. doi:
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Journal of neurology, neurosurgery, and psychiatry.
2010 Jun; 81(6):623-8. doi:
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Cytotherapy.
2010 Apr; 12(2):131-42. doi:
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