SCH79797 (BioDeep_00001876983)
代谢物信息卡片
N3-Cyclopropyl-7-[(4-propan-2-ylphenyl)methyl]pyrrolo[3,2-f]quinazoline-1,3-diamine
化学式: C23H25N5 (371.210985)
中文名称: SCH 79797二盐酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)C1=CC=C(C=C1)CN2C=CC3=C2C=CC4=C3C(=NC(=N4)NC5CC5)N
InChI: InChI=1S/C23H25N5/c1-14(2)16-5-3-15(4-6-16)13-28-12-11-18-20(28)10-9-19-21(18)22(24)27-23(26-19)25-17-7-8-17/h3-6,9-12,14,17H,7-8,13H2,1-2H3,(H3,24,25,26,27)
描述信息
同义名列表
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yoshikazu Yokono, Kenji Hanada, Masato Narita, Yota Tatara, Yousuke Kawamura, Naotake Miura, Kazutaka Kitayama, Masamichi Nakata, Masashi Nozaka, Tomo Kato, Natsumi Kudo, Michiko Tsushima, Yuichi Toyama, Ken Itoh, Hirofumi Tomita. Blockade of PAR-1 Signaling Attenuates Cardiac Hypertrophy and Fibrosis in Renin-Overexpressing Hypertensive Mice.
Journal of the American Heart Association.
2020 06; 9(12):e015616. doi:
10.1161/jaha.119.015616. [PMID: 32495720] - Emily A Andreae, Debra J Warejcka, Sally S Twining. Thrombin alters the synthesis and processing of CYR61/CCN1 in human corneal stromal fibroblasts and myofibroblasts through multiple distinct mechanisms.
Molecular vision.
2020; 26(?):540-562. doi:
. [PMID: 32818017] - NULL. The role of spinal thrombin through protease-activated receptor 1 in hyperalgesia after neural injury.
Journal of neurosurgery. Spine.
2017 Apr; 26(4):532-541. doi:
10.3171/2016.9.spine16501. [PMID: 28059686] - Tomomi Hayama, Naoto Kamio, Tatsu Okabe, Koichiro Muromachi, Kiyoshi Matsushima. Kallikrein Promotes Inflammation in Human Dental Pulp Cells Via Protease-Activated Receptor-1.
Journal of cellular biochemistry.
2016 07; 117(7):1522-8. doi:
10.1002/jcb.25437. [PMID: 26566265] - William H Nugent, Nikita Mishra, Jerome F Strauss, Scott W Walsh. Matrix Metalloproteinase 1 Causes Vasoconstriction and Enhances Vessel Reactivity to Angiotensin II via Protease-Activated Receptor 1.
Reproductive sciences (Thousand Oaks, Calif.).
2016 Apr; 23(4):542-8. doi:
10.1177/1933719115607998. [PMID: 26438597] - Michael Schuliga, Simon G Royce, Shenna Langenbach, Asres Berhan, Trudi Harris, Christine R Keenan, Alastair G Stewart. The Coagulant Factor Xa Induces Protease-Activated Receptor-1 and Annexin A2-Dependent Airway Smooth Muscle Cytokine Production and Cell Proliferation.
American journal of respiratory cell and molecular biology.
2016 Feb; 54(2):200-9. doi:
10.1165/rcmb.2014-0419oc. [PMID: 26120939] - Paula Vélez, Irene Izquierdo, Isaac Rosa, Ángel García. A 2D-DIGE-based proteomic analysis reveals differences in the platelet releasate composition when comparing thrombin and collagen stimulations.
Scientific reports.
2015 Feb; 5(?):8198. doi:
10.1038/srep08198. [PMID: 25645904] - Kyle M Ware, Jay C Vance, Navin Muni, Lee A Hebert, Anjali A Satoskar, Gyongyi Nadasdy, Iouri Ivanov, Tibor Nadasdy, Brad H Rovin, Sergey V Brodsky. Oral warfarin and the thrombin inhibitor dabigatran increase blood pressure in rats: hidden danger of anticoagulants?.
American journal of hypertension.
2015 Feb; 28(2):182-9. doi:
10.1093/ajh/hpu129. [PMID: 25023204] - Michael J V White, Elkin Galvis-Carvajal, Richard H Gomer. A brief exposure to tryptase or thrombin potentiates fibrocyte differentiation in the presence of serum or serum amyloid p.
Journal of immunology (Baltimore, Md. : 1950).
2015 Jan; 194(1):142-50. doi:
10.4049/jimmunol.1401777. [PMID: 25429068] - Kun-Ming Tao, Yong Tao, Cai-Yang Chen, Li-Qun Yang, Zhi-Jie Lu, Yu-Ming Sun, Sheng-Dong Huang, Wei-Feng Yu. Proteinase-activated receptor 1 contributed to up-regulation of enkephalin in keratinocytes of patients with obstructive jaundice.
Anesthesiology.
2014 Jul; 121(1):127-39. doi:
10.1097/aln.0000000000000210. [PMID: 24614324] - Junhao Yan, Anatol Manaenko, Sheng Chen, Damon Klebe, Qingyi Ma, Basak Caner, Mutsumi Fujii, Changman Zhou, John H Zhang. Role of SCH79797 in maintaining vascular integrity in rat model of subarachnoid hemorrhage.
Stroke.
2013 May; 44(5):1410-7. doi:
10.1161/strokeaha.113.678474. [PMID: 23539525] - Eman Abdelazeem El Eter, Abdulmajeed Aldrees. Inhibition of proinflammatory cytokines by SCH79797, a selective protease-activated receptor 1 antagonist, protects rat kidney against ischemia-reperfusion injury.
Shock (Augusta, Ga.).
2012 Jun; 37(6):639-44. doi:
10.1097/shk.0b013e3182507774. [PMID: 22592635] - Klaus Höcherl, Melanie Gerl, Frank Schweda. Proteinase-activated receptors 1 and 2 exert opposite effects on renal renin release.
Hypertension (Dallas, Tex. : 1979).
2011 Oct; 58(4):611-8. doi:
10.1161/hypertensionaha.111.173229. [PMID: 21859963] - Luc De Vries, Christiane Palmier, Frederic Finana, Bruno Le Grand, Michel Perez, Didier Cussac. Pharmacological characterization of protease activated receptor-1 by a serum responsive element-dependent reporter gene assay: major role of calmodulin.
Biochemical pharmacology.
2006 May; 71(10):1449-58. doi:
10.1016/j.bcp.2006.02.001. [PMID: 16524561] - Sebastian Bergmann, Kerstin Junker, Peter Henklein, Morley D Hollenberg, Utz Settmacher, Roland Kaufmann. PAR-type thrombin receptors in renal carcinoma cells: PAR1-mediated EGFR activation promotes cell migration.
Oncology reports.
2006 Apr; 15(4):889-93. doi:
10.3892/or.15.4.889. [PMID: 16525676]