N-(2-Guanidinoethyl)-5-isoquinolinesulfonamide (BioDeep_00001876960)

   


代谢物信息卡片


N-(2-Guanidinoethyl)-5-isoquinolinesulfonamide

化学式: C12H15N5O2S (293.094641)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC2=C(C=CN=C2)C(=C1)S(=O)(=O)NCCN=C(N)N
InChI: InChI=1S/C12H15N5O2S/c13-12(14)16-6-7-17-20(18,19)11-3-1-2-9-8-15-5-4-10(9)11/h1-5,8,17H,6-7H2,(H4,13,14,16)

描述信息

D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D004791 - Enzyme Inhibitors > D047428 - Protein Kinase Inhibitors
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators

同义名列表

1 个代谢物同义名

N-(2-Guanidinoethyl)-5-isoquinolinesulfonamide



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Marisa J Wainszelbaum, María L Belaunzarán, Estela M Lammel, Mónica Florin-Christensen, Jorge Florin-Christensen, Elvira L D Isola. Free fatty acids induce cell differentiation to infective forms in Trypanosoma cruzi. The Biochemical journal. 2003 Nov; 375(Pt 3):705-12. doi: 10.1042/bj20021907. [PMID: 12887332]
  • Manuela Cerezo, M Luisa Laorden, M Victoria Milanés. Inhibition of protein kinase C but not protein kinase A attenuates morphine withdrawal excitation of rat hypothalamus-pituitary-adrenal axis. European journal of pharmacology. 2002 Sep; 452(1):57-66. doi: 10.1016/s0014-2999(02)02245-8. [PMID: 12323385]
  • Ye Zhang, Ratha Mahendran, Lai Lai Yap, Kesavan Esuvaranathan, Hoon Eng Khoo. The signalling pathway for BCG-induced interleukin-6 production in human bladder cancer cells. Biochemical pharmacology. 2002 Jan; 63(2):273-82. doi: 10.1016/s0006-2952(01)00831-0. [PMID: 11841803]
  • P Y Chang, S Luo, T Jiang, Y T Lee, S C Lu, P D Henry, C H Chen. Oxidized low-density lipoprotein downregulates endothelial basic fibroblast growth factor through a pertussis toxin-sensitive G-protein pathway: mediator role of platelet-activating factor-like phospholipids. Circulation. 2001 Jul; 104(5):588-93. doi: 10.1161/hc3101.092213. [PMID: 11479258]
  • H Tang, P A Sharp. Transcriptional regulation of the murine 3' IgH enhancer by OCT-2. Immunity. 1999 Nov; 11(5):517-26. doi: 10.1016/s1074-7613(00)80127-2. [PMID: 10591177]
  • X Liu, X Ye, M Yanoff, W Li. Extracellular matrix of retinal pigment epithelium regulates choriocapillaris endothelial survival in vitro. Experimental eye research. 1997 Jul; 65(1):117-26. doi: 10.1006/exer.1997.0317. [PMID: 9237872]
  • C D Albright, C A Carter, D G Kaufman. Tamoxifen alters the localization of F-actin and alpha 5/beta 1-integrin fibronectin receptors in human endometrial stromal cells and carcinoma cells. Pathobiology : journal of immunopathology, molecular and cellular biology. 1997; 65(4):177-83. doi: 10.1159/000164120. [PMID: 9396040]
  • S G Mandla, D M Byers, N D Ridgway, H W Cook. Differential alterations of ethanolamine and choline phosphoglyceride metabolism by clofibrate and retinoic acid in human fibroblasts are not mediated by phorbol ester-sensitive protein kinase C. Lipids. 1996 Jul; 31(7):747-55. doi: 10.1007/bf02522891. [PMID: 8827698]
  • P Wiklund, P A Ekström, M Edbladh, D Tonge, A Edström. Protein kinase C and mouse sciatic nerve regeneration. Brain research. 1996 Apr; 715(1-2):145-54. doi: 10.1016/0006-8993(95)01570-1. [PMID: 8739633]
  • V K Singh, J F Cheng, S J Leu. Effect of substance P and protein kinase inhibitors on beta-amyloid peptide-induced proliferation of cultured brain cells. Brain research. 1994 Oct; 660(2):353-6. doi: 10.1016/0006-8993(94)91313-7. [PMID: 7529654]
  • N Denisenko, P Burighel, S Citi. Different effects of protein kinase inhibitors on the localization of junctional proteins at cell-cell contact sites. Journal of cell science. 1994 Apr; 107 ( Pt 4)(?):969-81. doi: 10.1242/jcs.107.4.969. [PMID: 8056850]
  • O Shinohara, Y Murata, C Kubota, T Shinagawa. Protein kinase C inhibitors enhance differentiation of rat adipocyte precursor cells in serum-free culture. Biochemical medicine and metabolic biology. 1994 Feb; 51(1):85-90. doi: 10.1006/bmmb.1994.1012. [PMID: 8192922]
  • C E Somers, D F Mosher. Protein kinase C modulation of fibronectin matrix assembly. The Journal of biological chemistry. 1993 Oct; 268(30):22277-80. doi: 10.1016/s0021-9258(18)41525-6. [PMID: 8226736]
  • H Harada, H Tai, A Motomura, S Suzuki, Y Suketa. Extracellular ATP-induced regulation of epidermal growth factor signaling in cultured renal LLC-PK1 cells. The American journal of physiology. 1993 Apr; 264(4 Pt 1):C956-60. doi: 10.1152/ajpcell.1993.264.4.c956. [PMID: 8476024]
  • Z L Chang, D H Beezhold, C D Personius, Z L Shen. Fibronectin cell-binding domain triggered transmembrane signal transduction in human monocytes. Journal of leukocyte biology. 1993 Jan; 53(1):79-85. doi: 10.1002/jlb.53.1.79. [PMID: 8426095]
  • A Zheleznyak, E J Brown. Immunoglobulin-mediated phagocytosis by human monocytes requires protein kinase C activation. Evidence for protein kinase C translocation to phagosomes. The Journal of biological chemistry. 1992 Jun; 267(17):12042-8. doi: 10.1016/s0021-9258(19)49803-7. [PMID: 1376316]
  • S Citi. Protein kinase inhibitors prevent junction dissociation induced by low extracellular calcium in MDCK epithelial cells. The Journal of cell biology. 1992 Apr; 117(1):169-78. doi: 10.1083/jcb.117.1.169. [PMID: 1556151]
  • Y P Au, R D Kenagy, A W Clowes. Heparin selectively inhibits the transcription of tissue-type plasminogen activator in primate arterial smooth muscle cells during mitogenesis. The Journal of biological chemistry. 1992 Feb; 267(5):3438-44. doi: 10.1016/s0021-9258(19)50750-5. [PMID: 1310687]
  • J R Bandekar, R Castagna, B M Sultzer. Roles of protein kinase C and G proteins in activation of murine resting B lymphocytes by endotoxin-associated protein. Infection and immunity. 1992 Jan; 60(1):231-6. doi: 10.1128/iai.60.1.231-236.1992. [PMID: 1370274]
  • C A Sei, C E Irons, A B Sprenkle, P M McDonough, J H Brown, C C Glembotski. The alpha-adrenergic stimulation of atrial natriuretic factor expression in cardiac myocytes requires calcium influx, protein kinase C, and calmodulin-regulated pathways. The Journal of biological chemistry. 1991 Aug; 266(24):15910-6. doi: NULL. [PMID: 1714900]
  • K Hirata, K Fujiwara. Possible contribution of protein kinase C activation to priming for DNA synthesis induced by epidermal growth factor with insulin and its inhibition by plasma membrane in primary cultured rat hepatocytes. Biochemical and biophysical research communications. 1990 Sep; 171(3):1093-8. doi: 10.1016/0006-291x(90)90796-p. [PMID: 2222429]
  • M Manganel, R J Turner. Agonist-induced activation of Na+/H+ exchange in rat parotid acinar cells is dependent on calcium but not on protein kinase C. The Journal of biological chemistry. 1990 Mar; 265(8):4284-9. doi: 10.1016/s0021-9258(19)39560-2. [PMID: 2155219]
  • Y Kinoshita, M Fukase, R Hishikawa, T Fujita. Calcitonin-induced increase in phosphate accumulation in LLC-PK1 cells probably through protein kinase C activation. Endocrinologia japonica. 1988 Apr; 35(2):217-23. doi: 10.1507/endocrj1954.35.217. [PMID: 2850157]