3,5-Dioxooctanedioic acid (BioDeep_00001876947)
代谢物信息卡片
化学式: C8H10O6 (202.04773600000001)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CC(=O)O)C(=O)CC(=O)CC(=O)O
InChI: InChI=1S/C8H10O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-4H2,(H,11,12)(H,13,14)
描述信息
An alpha,omega-dicarboxylic acid that is suberic acid which oxo groups replace the hydrogens at positions 3 and 5. It is an abnormal metabolite of the tyrosine metabolic pathway and a marker for type 1 tyrosinaemia.
同义名列表
1 个代谢物同义名
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- David Cassiman, Renate Zeevaert, Elisabeth Holme, Eli-Anne Kvittingen, Jaak Jaeken. A novel mutation causing mild, atypical fumarylacetoacetase deficiency (Tyrosinemia type I): a case report.
Orphanet journal of rare diseases.
2009 Dec; 4(?):28. doi:
10.1186/1750-1172-4-28. [PMID: 20003495] - S Lindstedt, E Holme, E A Lock, O Hjalmarson, B Strandvik. Treatment of hereditary tyrosinaemia type I by inhibition of 4-hydroxyphenylpyruvate dioxygenase.
Lancet (London, England).
1992 Oct; 340(8823):813-7. doi:
10.1016/0140-6736(92)92685-9. [PMID: 1383656] - H Schierbeek, R Berger. Determination of succinylacetone and succinylacetoacetate in physiological samples as the common product 5(3)-methyl-3(5)-isoxazole propionic acid using an isotope dilution method and mass spectrometry.
Clinica chimica acta; international journal of clinical chemistry.
1989 Oct; 184(3):243-50. doi:
10.1016/0009-8981(89)90057-0. [PMID: 2611997] - M Tuchman, D K Freese, H L Sharp, M L Ramnaraine, N Ascher, J R Bloomer. Contribution of extrahepatic tissues to biochemical abnormalities in hereditary tyrosinemia type I: study of three patients after liver transplantation.
The Journal of pediatrics.
1987 Mar; 110(3):399-403. doi:
10.1016/s0022-3476(87)80501-2. [PMID: 3546650] - S K Wadman, M Duran, D Ketting, L Bruinvis, F J van Sprang, R Berger, G P Smit, B Steinmann, J V Leonard, P Divry, J P Farriaux, B Cartigny. Urinary excretion of deuterated metabolites in patients with tyrosinemia type I after oral loading with deuterated L-tyrosine.
Clinica chimica acta; international journal of clinical chemistry.
1983 May; 130(2):231-8. doi:
10.1016/0009-8981(83)90120-1. [PMID: 6872257] - B Lindblad, G Steen. Identification of 4,6-dioxoheptanoic acid (succinylacetone), 3,5-dioxooctanedioic acid (succinylacetoacetate) and 4-Oxo-6-hydroxyheptanoic acid in the urine from patients with hereditary tyrosinemia.
Biomedical mass spectrometry.
1982 Oct; 9(10):419-24. doi:
10.1002/bms.1200091003. [PMID: 7171740] - S P Fällström, B Lindblad, G Steen. On the renal tubular damage in hereditary tyrosinemia and on the formation of succinylacetoacetate and succinylacetone.
Acta paediatrica Scandinavica.
1981; 70(3):315-20. doi:
10.1111/j.1651-2227.1981.tb16558.x. [PMID: 7246125]