N-(2-(3,4-Dichlorophenyl)ethyl)-N-methyl-2-(dimethylamino)ethylamine (BioDeep_00001876916)
代谢物信息卡片
N-(2-(3,4-Dichlorophenyl)ethyl)-N-methyl-2-(dimethylamino)ethylamine
化学式: C13H20Cl2N2 (274.1003)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)CCN(C)CCC1=CC(=C(C=C1)Cl)Cl
InChI: InChI=1S/C13H20Cl2N2/c1-16(2)8-9-17(3)7-6-11-4-5-12(14)13(15)10-11/h4-5,10H,6-9H2,1-3H3
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Omar Vélez López, Santhi Gorantla, Annabell C Segarra, María C Andino Norat, Manuel Álvarez, Richard L Skolasky, Loyda M Meléndez. Sigma-1 Receptor Antagonist (BD1047) Decreases Cathepsin B Secretion in HIV-Infected Macrophages Exposed to Cocaine.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.
2019 06; 14(2):226-240. doi:
10.1007/s11481-018-9807-4. [PMID: 30306495] - Rika Kasahara, Naoki Yamamoto, Kenji Suzuki, Kazuya Sobue. The σ1 receptor regulates accumulation of GM1 ganglioside-enriched autophagosomes in astrocytes.
Neuroscience.
2017 01; 340(?):176-187. doi:
10.1016/j.neuroscience.2016.10.058. [PMID: 27815022] - Mohan Pabba, Adrian Y C Wong, Nina Ahlskog, Elitza Hristova, Dante Biscaro, Wissam Nassrallah, Johnny K Ngsee, Melissa Snyder, Jean-Claude Beique, Richard Bergeron. NMDA receptors are upregulated and trafficked to the plasma membrane after sigma-1 receptor activation in the rat hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2014 Aug; 34(34):11325-38. doi:
10.1523/jneurosci.0458-14.2014. [PMID: 25143613] - Go Obara, Yumiko Toyohira, Hirohide Inagaki, Keita Takahashi, Takafumi Horishita, Takashi Kawasaki, Susumu Ueno, Masato Tsutsui, Takeyoshi Sata, Nobuyuki Yanagihara. Pentazocine inhibits norepinephrine transporter function by reducing its surface expression in bovine adrenal medullary cells.
Journal of pharmacological sciences.
2013; 121(2):138-47. doi:
10.1254/jphs.12164fp. [PMID: 23370666] - Linda Garcés-Ramírez, Jennifer L Green, Takato Hiranita, Theresa A Kopajtic, Maddalena Mereu, Alexandra M Thomas, Christophe Mesangeau, Sanju Narayanan, Christopher R McCurdy, Jonathan L Katz, Gianluigi Tanda. Sigma receptor agonists: receptor binding and effects on mesolimbic dopamine neurotransmission assessed by microdialysis.
Biological psychiatry.
2011 Feb; 69(3):208-17. doi:
10.1016/j.biopsych.2010.07.026. [PMID: 20950794] - Honghong Yao, Yanjing Yang, Kee Jun Kim, Crystal Bethel-Brown, Nan Gong, Keiko Funa, Howard E Gendelman, Tsung-Ping Su, John Q Wang, Shilpa Buch. Molecular mechanisms involving sigma receptor-mediated induction of MCP-1: implication for increased monocyte transmigration.
Blood.
2010 Jun; 115(23):4951-62. doi:
10.1182/blood-2010-01-266221. [PMID: 20354174] - Felix J Kim, Ivanka Kovalyshyn, Maxim Burgman, Claire Neilan, Chih-Cheng Chien, Gavril W Pasternak. Sigma 1 receptor modulation of G-protein-coupled receptor signaling: potentiation of opioid transduction independent from receptor binding.
Molecular pharmacology.
2010 Apr; 77(4):695-703. doi:
10.1124/mol.109.057083. [PMID: 20089882] - Vanessa Villard, Julie Espallergues, Emeline Keller, Tursun Alkam, Atsumi Nitta, Kiyofumi Yamada, Toshitaka Nabeshima, Alexandre Vamvakides, Tangui Maurice. Antiamnesic and neuroprotective effects of the aminotetrahydrofuran derivative ANAVEX1-41 against amyloid beta(25-35)-induced toxicity in mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2009 May; 34(6):1552-66. doi:
10.1038/npp.2008.212. [PMID: 19052542] - Y-H Wang, Y-C Shen, J-F Liao, C-H Lee, C-H Li, C-Y Chou, K-T Liou, Y-C Chou. Anti-inflammatory effects of dimemorfan on inflammatory cells and LPS-induced endotoxin shock in mice.
British journal of pharmacology.
2008 Jul; 154(6):1327-38. doi:
10.1038/bjp.2008.202. [PMID: 18500357] - Yuh-Chiang Shen, Yea-Hwey Wang, Yueh-Ching Chou, Kuo-Tong Liou, Jiin-Cherng Yen, Wen-Yen Wang, Jyh-Fei Liao. Dimemorfan protects rats against ischemic stroke through activation of sigma-1 receptor-mediated mechanisms by decreasing glutamate accumulation.
Journal of neurochemistry.
2008 Jan; 104(2):558-72. doi:
10.1111/j.1471-4159.2007.05058.x. [PMID: 18173806] - J Meunier, J Ieni, T Maurice. The anti-amnesic and neuroprotective effects of donepezil against amyloid beta25-35 peptide-induced toxicity in mice involve an interaction with the sigma1 receptor.
British journal of pharmacology.
2006 Dec; 149(8):998-1012. doi:
10.1038/sj.bjp.0706927. [PMID: 17057756] - Johann Meunier, Bénédicte Demeilliers, Aurélie Célérier, Tangui Maurice. Compensatory effect by sigma1 (sigma1) receptor stimulation during alcohol withdrawal in mice performing an object recognition task.
Behavioural brain research.
2006 Jan; 166(1):166-76. doi:
10.1016/j.bbr.2005.07.019. [PMID: 16191445] - B R de Costa, L Radesca, L Di Paolo, W D Bowen. Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines: structural requirements and binding affinity at the sigma receptor.
Journal of medicinal chemistry.
1992 Jan; 35(1):38-47. doi:
10.1021/jm00079a004. [PMID: 1310114]
