Conduritol epoxide (BioDeep_00001876909)

   


代谢物信息卡片


Conduritol epoxide

化学式: C6H10O5 (162.052821)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1(C(C(C2C(C1O)O2)O)O)O
InChI: InChI=1S/C6H10O5/c7-1-2(8)4(10)6-5(11-6)3(1)9/h1-10H

描述信息

D004791 - Enzyme Inhibitors

同义名列表

1 个代谢物同义名

Conduritol epoxide



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Edwin R Burgess, Neil D Sanscrainte, Caitlin E Taylor, Lyle J Buss, Alden S Estep. Expression, activity, and consequences of biochemical inhibition of α- and β-glucosidases in different life stages of Culex quinquefasciatus. PloS one. 2023; 18(8):e0286609. doi: 10.1371/journal.pone.0286609. [PMID: 37643188]
  • Christina M Ridley, Karen E Thur, Jessica Shanahan, Nagendra Babu Thillaiappan, Ann Shen, Karly Uhl, Charlotte M Walden, Ahad A Rahim, Simon N Waddington, Frances M Platt, Aarnoud C van der Spoel. β-Glucosidase 2 (GBA2) activity and imino sugar pharmacology. The Journal of biological chemistry. 2013 Sep; 288(36):26052-26066. doi: 10.1074/jbc.m113.463562. [PMID: 23880767]
  • Andrea Balreira, Marco Cavallari, Maria Clara Sá Miranda, Fernando A Arosa. Uncoupling between CD1d upregulation induced by retinoic acid and conduritol-B-epoxide and iNKT cell responsiveness. Immunobiology. 2010 Jun; 215(6):505-13. doi: 10.1016/j.imbio.2009.07.002. [PMID: 19651460]
  • Yaacov Kacher, Anthony H Futerman. Impaired IL-10 transcription and release in animal models of Gaucher disease macrophages. Blood cells, molecules & diseases. 2009 Jul; 43(1):134-7. doi: 10.1016/j.bcmd.2009.03.006. [PMID: 19380242]
  • Kazuyuki Kitatani, Kely Sheldon, Viviana Anelli, Russell W Jenkins, Ying Sun, Gregory A Grabowski, Lina M Obeid, Yusuf A Hannun. Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid. The Journal of biological chemistry. 2009 May; 284(19):12979-88. doi: 10.1074/jbc.m809500200. [PMID: 19279008]
  • Mario O Salazar, Ricardo L E Furlan. A rapid TLC autographic method for the detection of glucosidase inhibitors. Phytochemical analysis : PCA. 2007 May; 18(3):209-12. doi: 10.1002/pca.971. [PMID: 17500363]
  • M Lamghari, C C Barrias, C Sá Miranda, M A Barbosa. Recombinant glucocerebrosidase uptake by Gaucher disease human osteoblast culture model. Blood cells, molecules & diseases. 2005 Nov; 35(3):348-54. doi: 10.1016/j.bcmd.2005.07.009. [PMID: 16125984]
  • U H Schueler, T Kolter, C R Kaneski, G C Zirzow, K Sandhoff, R O Brady. Correlation between enzyme activity and substrate storage in a cell culture model system for Gaucher disease. Journal of inherited metabolic disease. 2004; 27(5):649-58. doi: 10.1023/b:boli.0000042959.44318.7c. [PMID: 15669681]
  • Jacques Bodennec, Dori Pelled, Christian Riebeling, Selena Trajkovic, Anthony H Futerman. Phosphatidylcholine synthesis is elevated in neuronal models of Gaucher disease due to direct activation of CTP:phosphocholine cytidylyltransferase by glucosylceramide. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2002 Nov; 16(13):1814-6. doi: 10.1096/fj.02-0149fje. [PMID: 12223447]
  • M Hrmova, J N Varghese, R De Gori, B J Smith, H Driguez, G B Fincher. Catalytic mechanisms and reaction intermediates along the hydrolytic pathway of a plant beta-D-glucan glucohydrolase. Structure (London, England : 1993). 2001 Nov; 9(11):1005-16. doi: 10.1016/s0969-2126(01)00673-6. [PMID: 11709165]
  • H Morjani, N Aouali, R Belhoussine, R J Veldman, T Levade, M Manfait. Elevation of glucosylceramide in multidrug-resistant cancer cells and accumulation in cytoplasmic droplets. International journal of cancer. 2001 Oct; 94(2):157-65. doi: 10.1002/ijc.1449. [PMID: 11668492]
  • A Falshaw, J B Hart, P C Tyler. New syntheses of 1D- and 1L-1,2-anhydro-myo-inositol and assessment of their glycosidase inhibitory activities. Carbohydrate research. 2000 Nov; 329(2):301-8. doi: 10.1016/s0008-6215(00)00192-0. [PMID: 11117313]
  • W S Hays, D E Wheeler, B Eghtesad, R H Glew, D E Johnston. Expression of cytosolic beta-glucosidase in guinea pig liver cells. Hepatology (Baltimore, Md.). 1998 Jul; 28(1):156-63. doi: 10.1002/hep.510280121. [PMID: 9657108]
  • K Hanley, Y Jiang, W M Holleran, P M Elias, M L Williams, K R Feingold. Glucosylceramide metabolism is regulated during normal and hormonally stimulated epidermal barrier development in the rat. Journal of lipid research. 1997 Mar; 38(3):576-84. doi: 10.1016/s0022-2275(20)37265-5. [PMID: 9101438]
  • E Kohen, C Kohen, J G Hirschberg, R Santus, G Grabowski, W Mangel, S Gatt, J Prince. An in situ study of beta-glucosidase activity in normal and Gaucher fibroblasts with fluorogenic probes. Cell biochemistry and function. 1993 Sep; 11(3):167-77. doi: 10.1002/cbf.290110304. [PMID: 8403230]
  • S Mahdiyoun, G D Deshmukh, A Abe, N S Radin, J A Shayman. Decreased formation of inositol trisphosphate in Madin-Darby canine kidney cells under conditions of beta-glucosidase inhibition. Archives of biochemistry and biophysics. 1992 Feb; 292(2):506-11. doi: 10.1016/0003-9861(92)90023-p. [PMID: 1731615]
  • M C Sa Miranda, J M Aerts, R A Pinto, J A Magalhaes, J A Barranger, J M Tager, A W Schram. Heterogeneity in human acid beta-glucosidase revealed by cellulose-acetate electrophoresis. Biochimica et biophysica acta. 1988 May; 965(2-3):163-8. doi: 10.1016/0304-4165(88)90052-9. [PMID: 3130106]
  • S C Datta, N S Radin. Glucosylceramide and the level of the glucosidase-stimulating proteins. Lipids. 1986 Nov; 21(11):702-9. doi: 10.1007/bf02537244. [PMID: 3099116]
  • J M Aerts, W E Donker-Koopman, M Koot, J A Barranger, J M Tager, A W Schram. Deficient activity of glucocerebrosidase in urine from patients with type 1 Gaucher disease. Clinica chimica acta; international journal of clinical chemistry. 1986 Jul; 158(2):155-63. doi: 10.1016/0009-8981(86)90231-7. [PMID: 2943536]
  • A Basu, R H Glew. Characterization of the phospholipid requirement of a rat liver beta-glucosidase. The Biochemical journal. 1984 Dec; 224(2):515-24. doi: 10.1042/bj2240515. [PMID: 6517862]
  • P Lalégerie, G Legler, J M Yon. The use of inhibitors in the study of glycosidases. Biochimie. 1982 Nov; 64(11-12):977-1000. doi: 10.1016/s0300-9084(82)80379-9. [PMID: 6819005]
  • M C Stephens, A Bernatsky, H Singh, J N Kanfer, G Legler. Distribution of conduritol B epoxide in the animal model for Gaucher's disease (Gaucher mouse). Biochimica et biophysica acta. 1981 Jan; 672(1):29-32. doi: 10.1016/0304-4165(81)90276-2. [PMID: 6783121]
  • A Hara, N S Radin. Destruction and resynthesis of mouse beta-glucosidases. Biochimica et biophysica acta. 1979 Feb; 582(3):412-22. doi: 10.1016/0304-4165(79)90133-8. [PMID: 33720]