Methoctramine free base (BioDeep_00001876875)
代谢物信息卡片
化学式: C36H62N4O2 (582.4872512)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=CC=CC=C1CNCCCCCCNCCCCCCCCNCCCCCCNCC2=CC=CC=C2OC
InChI: InChI=1S/C36H62N4O2/c1-41-35-23-13-11-21-33(35)31-39-29-19-9-7-17-27-37-25-15-5-3-4-6-16-26-38-28-18-8-10-20-30-40-32-34-22-12-14-24-36(34)42-2/h11-14,21-24,37-40H,3-10,15-20,25-32H2,1-2H3
描述信息
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lu Wang, Yuan-Bo Fu, Yi Liu, Na-Na Yang, Si-Ming Ma, Xue-Rui Wang, Jin Huang, Guang-Xia Shi, Jing-Wen Yang, Cun-Zhi Liu. Moxibustion attenuates neurogenic detrusor overactivity in spinal cord injury rats by inhibiting M2/ATP/P2X3 pathway.
Brain research.
2022 08; 1788(?):147926. doi:
10.1016/j.brainres.2022.147926. [PMID: 35469847] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Mohammad Zarei, Saeed Mohammadi, Sajjad Jabbari, Siamak Shahidi. Intracerebroventricular microinjection of kaempferol on memory retention of passive avoidance learning in rats: involvement of cholinergic mechanism(s).
The International journal of neuroscience.
2019 Dec; 129(12):1203-1212. doi:
10.1080/00207454.2019.1653867. [PMID: 31393204] - Shankar P Parajuli, Georgi V Petkov. Activation of muscarinic M3 receptors inhibits large-conductance voltage- and Ca2+-activated K+ channels in rat urinary bladder smooth muscle cells.
American journal of physiology. Cell physiology.
2013 Jul; 305(2):C207-14. doi:
10.1152/ajpcell.00113.2013. [PMID: 23703523] - Keum Young So, Sang Hun Kim, Hong Moon Sohn, Soo Jin Choi, Shankar Prasad Parajuli, Seok Choi, Cheol Ho Yeum, Pyung Jin Yoon, Jae Yeoul Jun. Carbachol regulates pacemaker activities in cultured interstitial cells of Cajal from the mouse small intestine.
Molecules and cells.
2009 May; 27(5):525-31. doi:
10.1007/s10059-009-0076-1. [PMID: 19466600] - Elaine Campana Sanches Bornia, Erika Bando, Miguel Machinski, Monalisa Wolski Pereira, Wilson Alves-Do-Prado. Presynaptic M1, M2, and A1 receptors play roles in tetanic fade induced by pancuronium or cisatracurium.
Journal of anesthesia.
2009; 23(4):513-9. doi:
10.1007/s00540-009-0790-z. [PMID: 19921360] - Francisco J Teixeira Neto, Wayne N McDonell, William D Black, Aury N Moraes, Sumit Duronghphongtorn. Effects of a muscarinic type-2 antagonist on cardiorespiratory function and intestinal transit in horses anesthetized with halothane and xylazine.
American journal of veterinary research.
2004 Apr; 65(4):464-72. doi:
10.2460/ajvr.2004.65.464. [PMID: 15077689] - J Wang, P S Krysiak, L G Laurier, S M Sims, H G Preiksaitis. Human esophageal smooth muscle cells express muscarinic receptor subtypes M(1) through M(5).
American journal of physiology. Gastrointestinal and liver physiology.
2000 Nov; 279(5):G1059-69. doi:
10.1152/ajpgi.2000.279.5.g1059. [PMID: 11053004] - R W Mitchell, A J Halayko, S Kahraman, J Solway, M E Wylam. Selective restoration of calcium coupling to muscarinic M(3) receptors in contractile cultured airway myocytes.
American journal of physiology. Lung cellular and molecular physiology.
2000 May; 278(5):L1091-100. doi:
10.1152/ajplung.2000.278.5.l1091. [PMID: 10781442] - M Pelat, E Lazartigues, M A Tran, C Gharib, J L Montastruc, P Montastruc, O Rascol. Characterization of the central muscarinic cholinoceptors involved in the cholinergic pressor response in anesthetized dogs.
European journal of pharmacology.
1999 08; 379(2-3):117-24. doi:
10.1016/s0014-2999(99)00508-7. [PMID: 10497897] - A Chahdi, L Daeffler, J L Bueb, J P Gies, Y Landry. The M2 muscarinic receptor antagonist methoctramine activates mast cells via pertussis toxin-sensitive G proteins.
Naunyn-Schmiedeberg's archives of pharmacology.
1998 Apr; 357(4):357-62. doi:
10.1007/pl00005179. [PMID: 9606019] - A J Misle, I Lippo de Bécemberg, R González de Alfonzo, M J Alfonzo. Methoctramine binding sites sensitive to alkylation on muscarinic receptors from tracheal smooth muscle.
Biochemical pharmacology.
1994 Jul; 48(1):191-5. doi:
10.1016/0006-2952(94)90239-9. [PMID: 8043022] - Y Fukomoto, M Yoshida, R M Weiss, J Latifpour. Reversibility of diabetes- and diuresis-induced alterations in rat bladder dome muscarinic receptors.
Diabetes.
1994 Jun; 43(6):819-26. doi:
10.2337/diab.43.6.819. [PMID: 8194669] - C Polidori, P L Pompei, M Perfumi, C Melchiorre, M Massi. Natriuresis, kaliuresis and antidiuresis induced by central carbachol injection are mediated by muscarinic M1 receptors.
European journal of pharmacology.
1991 Mar; 195(1):139-43. doi:
10.1016/0014-2999(91)90391-3. [PMID: 2065708]