7-Oxo-7h-Benzimidazo[2,1-A]benz[de]isoquinoline-3-Carboxylic Acid (BioDeep_00001876789)
代谢物信息卡片
7-Oxo-7h-Benzimidazo[2,1-A]benz[de]isoquinoline-3-Carboxylic Acid
化学式: C19H10N2O3 (314.06913900000006)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C2C(=C1)N=C3N2C(=O)C4=CC=CC5=C(C=CC3=C54)C(=O)O
InChI: InChI=1S/C19H10N2O3/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18/h1-9H,(H,23,24)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
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Plant Reactome(0)
INOH(0)
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COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ji Li, Xuedong Wang, Xiangyu Meng, Xin Zhou, Han Huang, Yi Feng, Yujie Fu, Xinxin Liu, Bo Yu. Geraniin targeting CaMKK2 inhibits lipid accumulation in 3T3-L1 adipocytes by suppressing lipogenesis.
Chemico-biological interactions.
2023 Feb; 372(?):110364. doi:
10.1016/j.cbi.2023.110364. [PMID: 36706894] - Nutthapoom Pathomthongtaweechai, Sunhapas Soodvilai, Rath Pichyangkura, Chatchai Muanprasat. Novel Potential Application of Chitosan Oligosaccharide for Attenuation of Renal Cyst Growth in the Treatment of Polycystic Kidney Disease.
Molecules (Basel, Switzerland).
2020 Nov; 25(23):. doi:
10.3390/molecules25235589. [PMID: 33261193] - Wei Yang, Adam C Munhall, Steven W Johnson. Dopamine Evokes a Trace Amine Receptor-dependent Inward Current that is Regulated by AMP Kinase in Substantia Nigra Dopamine Neurons.
Neuroscience.
2020 02; 427(?):77-91. doi:
10.1016/j.neuroscience.2019.11.044. [PMID: 31883822] - Ryosuke Kamikubo, Kenji Kai, Kentaro Tsuji-Naito, Mitsugu Akagawa. β-Caryophyllene attenuates palmitate-induced lipid accumulation through AMPK signaling by activating CB2 receptor in human HepG2 hepatocytes.
Molecular nutrition & food research.
2016 10; 60(10):2228-2242. doi:
10.1002/mnfr.201600197. [PMID: 27234712] - Elizabeth C Bowdridge, Madhusudan P Goravanahally, E Keith Inskeep, Jorge A Flores. Activation of Adenosine Monophosphate-Activated Protein Kinase Is an Additional Mechanism That Participates in Mediating Inhibitory Actions of Prostaglandin F2Alpha in Mature, but Not Developing, Bovine Corpora Lutea.
Biology of reproduction.
2015 Jul; 93(1):7. doi:
10.1095/biolreprod.115.129411. [PMID: 25972015] - Shiliu Tian, Xinfa Ge, Ke Wu, Huabing Yang, Yu Liu. Ramipril protects the endothelium from high glucose-induced dysfunction through CaMKKβ/AMPK and heme oxygenase-1 activation.
The Journal of pharmacology and experimental therapeutics.
2014 Jul; 350(1):5-13. doi:
10.1124/jpet.114.212928. [PMID: 24741076] - Charles D Anderson, Derek M Kendig, Mohammad Al-Qudah, Sunila Mahavadi, Karnam S Murthy, John R Grider. Role of various kinases in muscarinic M3 receptor-mediated contraction of longitudinal muscle of rat colon.
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.
2014; 50(?):103-19. doi:
10.1540/jsmr.50.103. [PMID: 25891767] - Yong Pil Hwang, Hyung Gyun Kim, Jae Ho Choi, Minh Truong Do, Young Chul Chung, Tae Cheon Jeong, Hye Gwang Jeong. S-allyl cysteine attenuates free fatty acid-induced lipogenesis in human HepG2 cells through activation of the AMP-activated protein kinase-dependent pathway.
The Journal of nutritional biochemistry.
2013 Aug; 24(8):1469-78. doi:
10.1016/j.jnutbio.2012.12.006. [PMID: 23465592] - Yong Pil Hwang, Jae Ho Choi, Hyung Gyun Kim, Tilak Khanal, Gye Young Song, Myoung Soo Nam, Hyun-Sun Lee, Young Chul Chung, Young Chun Lee, Hye Gwang Jeong. Saponins, especially platycodin D, from Platycodon grandiflorum modulate hepatic lipogenesis in high-fat diet-fed rats and high glucose-exposed HepG2 cells.
Toxicology and applied pharmacology.
2013 Mar; 267(2):174-83. doi:
10.1016/j.taap.2013.01.001. [PMID: 23319015] - Hak Joo Lee, Meenalakshmi M Mariappan, Denis Feliers, Rita C Cavaglieri, Kavithalakshmi Sataranatarajan, Hanna E Abboud, Goutam Ghosh Choudhury, Balakuntalam S Kasinath. Hydrogen sulfide inhibits high glucose-induced matrix protein synthesis by activating AMP-activated protein kinase in renal epithelial cells.
The Journal of biological chemistry.
2012 Feb; 287(7):4451-61. doi:
10.1074/jbc.m111.278325. [PMID: 22158625] - Ying Ma, Fuzhen Yang, Ying Wang, Zhiyan Du, Daihua Liu, Hongxia Guo, Jingkang Shen, Hongli Peng. CaMKKβ is involved in AMP-activated protein kinase activation by baicalin in LKB1 deficient cell lines.
PloS one.
2012; 7(10):e47900. doi:
10.1371/journal.pone.0047900. [PMID: 23110126] - Yung-Chung Hsu, Margot M Ip. Conjugated linoleic acid-induced apoptosis in mouse mammary tumor cells is mediated by both G protein coupled receptor-dependent activation of the AMP-activated protein kinase pathway and by oxidative stress.
Cellular signalling.
2011 Dec; 23(12):2013-20. doi:
10.1016/j.cellsig.2011.07.015. [PMID: 21821121] - Lisa Miranda, Sarah Carpentier, Anna Platek, Nusrat Hussain, Marie-Agnès Gueuning, Didier Vertommen, Yurda Ozkan, Brice Sid, Louis Hue, Pierre J Courtoy, Mark H Rider, Sandrine Horman. AMP-activated protein kinase induces actin cytoskeleton reorganization in epithelial cells.
Biochemical and biophysical research communications.
2010 Jun; 396(3):656-61. doi:
10.1016/j.bbrc.2010.04.151. [PMID: 20438708] - Marcia J Abbott, Arthur M Edelman, Lorraine P Turcotte. CaMKK is an upstream signal of AMP-activated protein kinase in regulation of substrate metabolism in contracting skeletal muscle.
American journal of physiology. Regulatory, integrative and comparative physiology.
2009 Dec; 297(6):R1724-32. doi:
10.1152/ajpregu.00179.2009. [PMID: 19812359] - Wei Shen, Maria Ines Reyes, Linda Hanley-Bowdoin. Arabidopsis protein kinases GRIK1 and GRIK2 specifically activate SnRK1 by phosphorylating its activation loop.
Plant physiology.
2009 Jun; 150(2):996-1005. doi:
10.1104/pp.108.132787. [PMID: 19339507] - Natasha Cook, Scott A Fraser, Marina Katerelos, Frosa Katsis, Kurt Gleich, Peter F Mount, Gregory R Steinberg, Vicki Levidiotis, Bruce E Kemp, David A Power. Low salt concentrations activate AMP-activated protein kinase in mouse macula densa cells.
American journal of physiology. Renal physiology.
2009 Apr; 296(4):F801-9. doi:
10.1152/ajprenal.90372.2008. [PMID: 19176702] - Xiuyun Hou, Shanqin Xu, Karlene A Maitland-Toolan, Kaori Sato, Bingbing Jiang, Yasuo Ido, Fan Lan, Kenneth Walsh, Michel Wierzbicki, Tony J Verbeuren, Richard A Cohen, Mengwei Zang. SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase.
The Journal of biological chemistry.
2008 Jul; 283(29):20015-26. doi:
10.1074/jbc.m802187200. [PMID: 18482975] - Tao Pang, Zhen-Shan Zhang, Min Gu, Bei-Ying Qiu, Li-Fang Yu, Peng-Rong Cao, Wei Shao, Ming-Bo Su, Jing-Ya Li, Fa-Jun Nan, Jia Li. Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells.
The Journal of biological chemistry.
2008 Jun; 283(23):16051-60. doi:
10.1074/jbc.m710114200. [PMID: 18321858] - Rebecca L Hurley, Kristin A Anderson, Jeanne M Franzone, Bruce E Kemp, Anthony R Means, Lee A Witters. The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases.
The Journal of biological chemistry.
2005 Aug; 280(32):29060-6. doi:
10.1074/jbc.m503824200. [PMID: 15980064]