Acetaminophen cysteine (BioDeep_00001876781)
代谢物信息卡片
化学式: C11H14N2O3S (254.0725)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)NC1=CC=C(C=C1)SCC(C(=O)O)N
InChI: InChI=1S/C11H14N2O3S/c1-7(14)13-8-2-4-9(5-3-8)17-6-10(12)11(15)16/h2-5,10H,6,12H2,1H3,(H,13,14)(H,15,16)/t10-/m0/s1
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Yu-Xin Wang, Yi DU, Xia-Fei Liu, Fang-Xiu Yang, Xiao Wu, Li Tan, Yi-Hong Lu, Jing-Wei Zhang, Fang Zhou, Guang-Ji Wang. A hepatoprotection study of Radix Bupleuri on acetaminophen-induced liver injury based on CYP450 inhibition.
Chinese journal of natural medicines.
2019 Jul; 17(7):517-524. doi:
10.1016/s1875-5364(19)30073-1
. [PMID: 31514983] - Michael H Court, Zhaohui Zhu, Gina Masse, Su X Duan, Laura P James, Jerold S Harmatz, David J Greenblatt. Race, Gender, and Genetic Polymorphism Contribute to Variability in Acetaminophen Pharmacokinetics, Metabolism, and Protein-Adduct Concentrations in Healthy African-American and European-American Volunteers.
The Journal of pharmacology and experimental therapeutics.
2017 09; 362(3):431-440. doi:
10.1124/jpet.117.242107
. [PMID: 28663312] - Sarah F Cook, Chris Stockmann, Samira Samiee-Zafarghandy, Amber D King, Nina Deutsch, Elaine F Williams, Diana G Wilkins, Catherine M T Sherwin, John N van den Anker. Neonatal Maturation of Paracetamol (Acetaminophen) Glucuronidation, Sulfation, and Oxidation Based on a Parent-Metabolite Population Pharmacokinetic Model.
Clinical pharmacokinetics.
2016 11; 55(11):1395-1411. doi:
10.1007/s40262-016-0408-1
. [PMID: 27209292] - Anne van Rongen, Pyry A J Välitalo, Mariska Y M Peeters, Djamila Boerma, Fokko W Huisman, Bert van Ramshorst, Eric P A van Dongen, Johannes N van den Anker, Catherijne A J Knibbe. Morbidly Obese Patients Exhibit Increased CYP2E1-Mediated Oxidation of Acetaminophen.
Clinical pharmacokinetics.
2016 07; 55(7):833-847. doi:
10.1007/s40262-015-0357-0
. [PMID: 26818482] - Kennon Heard, Jody L Green, Victoria Anderson, Becki Bucher-Bartelson, Richard C Dart. Paracetamol (acetaminophen) protein adduct concentrations during therapeutic dosing.
British journal of clinical pharmacology.
2016 Mar; 81(3):562-8. doi:
10.1111/bcp.12831
. [PMID: 26584404] - Steven C Curry, Angela Padilla-Jones, Ayrn D O'Connor, Anne-Michelle Ruha, Dale S Bikin, Diana G Wilkins, Douglas E Rollins, Matthew H Slawson, Richard D Gerkin. Prolonged Acetaminophen-Protein Adduct Elimination During Renal Failure, Lack of Adduct Removal by Hemodiafiltration, and Urinary Adduct Concentrations After Acetaminophen Overdose.
Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2015 Jun; 11(2):169-78. doi:
10.1007/s13181-014-0431-2
. [PMID: 25288219] - Sean M Frey, Timothy J Wiegand, Jody L Green, Kennon J Heard, Diana G Wilkins, Rachel M Gorodetsky, Richard C Dart. Confirming the Causative Role of Acetaminophen in Indeterminate Acute Liver Failure Using Acetaminophen-Cysteine Adducts.
Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2015 Jun; 11(2):218-22. doi:
10.1007/s13181-015-0476-x
. [PMID: 25896948] - Sun J Kim, Min Y Lee, Do Y Kwon, Sung Y Kim, Young C Kim. Alteration in metabolism and toxicity of acetaminophen upon repeated administration in rats.
Journal of pharmacological sciences.
2009 Oct; 111(2):175-81. doi:
10.1254/jphs.09151fp
. [PMID: 19834287] - David Reith, Natalie J Medlicott, Rohana Kumara De Silva, Lin Yang, Jeremy Hickling, Mathew Zacharias. Simultaneous modelling of the Michaelis-Menten kinetics of paracetamol sulphation and glucuronidation.
Clinical and experimental pharmacology & physiology.
2009 Jan; 36(1):35-42. doi:
10.1111/j.1440-1681.2008.05029.x
. [PMID: 18759860] - S Koling, G Hempel, C Lanvers, J Boos, G Würthwein. Monitoring paracetamol metabolism after single and repeated administration in pediatric patients with neoplastic diseases.
International journal of clinical pharmacology and therapeutics.
2007 Sep; 45(9):496-503. doi:
10.5414/cpp45496
. [PMID: 17907592] - Jeeranut Tankanitlert, Thad A Howard, Anusorn Temsakulphong, Pornpan Sirankapracha, Noppawan Phumala Morales, Yupin Sanvarinda, Pranee Fucharoen, Russell E Ware, Suthat Fucharoen, Udom Chantharaksri. A pharmacokinetic study of paracetamol in Thai beta-thalassemia/HbE patients.
European journal of clinical pharmacology.
2006 Sep; 62(9):743-8. doi:
10.1007/s00228-006-0167-2
. [PMID: 16845508] - Laura P James, Estella M Alonso, Linda S Hynan, Jack A Hinson, Timothy J Davern, William M Lee, Robert H Squires. Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate cause.
Pediatrics.
2006 Sep; 118(3):e676-81. doi:
10.1542/peds.2006-0069
. [PMID: 16950959] - Stephan T Stern, Mary K Bruno, Gayle E Hennig, Robert A Horton, Jeanette C Roberts, Steven D Cohen. Contribution of acetaminophen-cysteine to acetaminophen nephrotoxicity in CD-1 mice: I. Enhancement of acetaminophen nephrotoxicity by acetaminophen-cysteine.
Toxicology and applied pharmacology.
2005 Jan; 202(2):151-9. doi:
10.1016/j.taap.2004.06.030
. [PMID: 15629190] - Stephan T Stern, Mary K Bruno, Robert A Horton, Dennis W Hill, Jeanette C Roberts, Steven D Cohen. Contribution of acetaminophen-cysteine to acetaminophen nephrotoxicity II. Possible involvement of the gamma-glutamyl cycle.
Toxicology and applied pharmacology.
2005 Jan; 202(2):160-71. doi:
10.1016/j.taap.2004.06.029
. [PMID: 15629191] - G S Lau, J A Critchley. The estimation of paracetamol and its major metabolites in both plasma and urine by a single high-performance liquid chromatography assay.
Journal of pharmaceutical and biomedical analysis.
1994 Dec; 12(12):1563-72. doi:
10.1016/0731-7085(94)00859-0
. [PMID: 7696381] - U Martin, R M Temple, R J Winney, L F Prescott. The disposition of paracetamol and its conjugates during multiple dosing in patients with end-stage renal failure maintained on haemodialysis.
European journal of clinical pharmacology.
1993; 45(2):141-5. doi:
10.1007/bf00315495
. [PMID: 8223835] - C Madhu, C D Klaassen. Protective effect of pregnenolone-16 alpha-carbonitrile on acetaminophen-induced hepatotoxicity in hamsters.
Toxicology and applied pharmacology.
1991 Jun; 109(2):305-13. doi:
10.1016/0041-008x(91)90177-g
. [PMID: 2068728]