Diamantane (BioDeep_00001876716)
代谢物信息卡片
Congressane
化学式: C14H20 (188.15649200000001)
中文名称: 双金刚烷
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C2CC3C4C1C5CC(C4)CC3C5C2
InChI: InChI=1S/C14H20/c1-7-2-12-10-4-8-5-11(9(1)10)13(3-7)14(12)6-8/h7-14H,1-6H2
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yangchen Tang, Mengli Yan, Zemin Fang, Song Jin, Tingjuan Xu. Effects of metformin, saxagliptin and repaglinide on gut microbiota in high-fat diet/streptozocin-induced type 2 diabetic mice.
BMJ open diabetes research & care.
2024 May; 12(3):. doi:
10.1136/bmjdrc-2023-003837. [PMID: 38719505] - Maria A Lapshina, Elena F Shevtsova, Vladimir V Grigoriev, Aleksey Yu Aksinenko, Aleksey A Ustyugov, Daniil A Steinberg, Grigoriy V Maleev, Elena S Dubrovskaya, Tatiana V Goreva, Tatiana A Epishina, Vladimir L Zamoyski, Galina F Makhaeva, Vladimir P Fisenko, Ivan M Veselov, Daria V Vinogradova, Sergey O Bachurin. New Adamantane-Containing Edaravone Conjugates as Potential Neuroprotective Agents for ALS Treatments.
Molecules (Basel, Switzerland).
2023 Nov; 28(22):. doi:
10.3390/molecules28227567. [PMID: 38005288] - Dehong Li, Seyed-Omar Zaraei, Rawan M Sbenati, Anil Ravi, Yingjie Wen, Lingda Zeng, Jiali Wang, Mohammed I El-Gamal, Hanhong Xu. Synthesis and Biological Activity of Sulfamate-Adamantane Derivatives as Glucosinolate Sulfatase Inhibitors.
Journal of agricultural and food chemistry.
2023 Oct; 71(42):15476-15484. doi:
10.1021/acs.jafc.3c04879. [PMID: 37818663] - V V Grigoriev, E F Shevtsova, A Yu Aksinenko, I M Veselov, T V Goreva, A V Gabrelyan, S O Bachurin. New Hybrid Structures Based on Memanthine and Edaravone Molecules.
Doklady. Biochemistry and biophysics.
2023 Oct; 512(1):284-287. doi:
10.1134/s1607672923700461. [PMID: 38093132] - Marina Sherif Fam, Christine Adel Sedky, Nancy Osama Turky, Hans-Georg Breitinger, Ulrike Breitinger. Channel activity of SARS-CoV-2 viroporin ORF3a inhibited by adamantanes and phenolic plant metabolites.
Scientific reports.
2023 Apr; 13(1):5328. doi:
10.1038/s41598-023-31764-9. [PMID: 37005439] - Vladimir Burmistrov, Christophe Morisseau, Denis A Babkov, Tatiana Golubeva, Dmitry Pitushkin, Elena V Sokolova, Vladimir Vasipov, Yaroslav Kuznetsov, Sergey V Bazhenov, Uliana S Novoyatlova, Nikolay A Bondarev, Ilya V Manukhov, Victoria Osipova, Nadezhda Berberova, Alexander A Spasov, Gennady M Butov, Bruce D Hammock. Anti-Inflammatory Activity of Soluble Epoxide Hydrolase Inhibitors Based on Selenoureas Bearing an Adamantane Moiety.
International journal of molecular sciences.
2022 Sep; 23(18):. doi:
10.3390/ijms231810710. [PMID: 36142611] - Cheng Gao, Conghui Liu, Qian Chen, Yan Wang, Cheryl H T Kwong, Qingfu Wang, Beibei Xie, Simon M Y Lee, Ruibing Wang. Cyclodextrin-mediated conjugation of macrophage and liposomes for treatment of atherosclerosis.
Journal of controlled release : official journal of the Controlled Release Society.
2022 09; 349(?):2-15. doi:
10.1016/j.jconrel.2022.06.053. [PMID: 35779655] - Morgan A Butrovich, Weifeng Tang, David W Boulton, Thomas D Nolin, Pradeep Sharma. Use of Physiologically Based Pharmacokinetic Modeling to Evaluate the Impact of Chronic Kidney Disease on CYP3A4-Mediated Metabolism of Saxagliptin.
Journal of clinical pharmacology.
2022 Aug; 62(8):1018-1029. doi:
10.1002/jcph.2043. [PMID: 35247279] - Dao-Wei Liu, Yan-Song Ye, Chao-Guang Huang, Qian Lu, Ling Yang, Qian Wang, Huan Wang, Xia Liu, Chuan-Bo Jing, Gang Xu, Wen-Yong Xiong. Sampsonione F suppresses adipogenesis via activating p53 pathway during the mitotic clonal expansion progression of adipocyte differentiation.
European journal of pharmacology.
2022 Jun; 925(?):175002. doi:
10.1016/j.ejphar.2022.175002. [PMID: 35526567] - Suat Tekin, Asiye Beytur, Murat Cakir, Aslı Taslıdere, Yavuz Erden, Cigdem Tekin, Suleyman Sandal. Protective effect of saxagliptin against renal ischaemia reperfusion injury in rats.
Archives of physiology and biochemistry.
2022 Jun; 128(3):608-618. doi:
10.1080/13813455.2020.1715442. [PMID: 31979992] - Wenjing Ni, Yan Pan, Huijuan Yang, Wei Li, Yan Sun, Yu Xu, Weidong Chen. [Saxagliptin alleviates kidney injury in diabetic rats by down-regulating the expression of mammalian target of rapamycin (mTOR)].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2022 May; 38(5):406-411. doi:
NULL. [PMID: 35603648] - Katharine A Collins, Azrin N Abd-Rahman, Louise Marquart, Emma Ballard, Nathalie Gobeau, Paul Griffin, Stephan Chalon, Jörg J Möhrle, James S McCarthy. Antimalarial Activity of Artefenomel Against Asexual Parasites and Transmissible Gametocytes During Experimental Blood-Stage Plasmodium vivax Infection.
The Journal of infectious diseases.
2022 03; 225(6):1062-1069. doi:
10.1093/infdis/jiaa287. [PMID: 32479608] - Konkanok Wattana, Natnicha Poonchuay, Suriyon Uitrakul. Efficacy of vildagliptin on 10-year cardiovascular risk reduction in Thai patients with type 2 diabetes mellitus: A real-world observational study.
Diabetes & metabolic syndrome.
2022 Mar; 16(3):102437. doi:
10.1016/j.dsx.2022.102437. [PMID: 35255292] - Marwa Mohsen, Ahmed A Elberry, Alaa Mohamed Rabea, Doaa Mahmoud Khalil, Mohamed E A Abdelrahim, Raghda R S Hussein. A New Clinical Utility for Tubular Markers to Identify Kidney Responders to Saxagliptin Treatment in Adults With Diabetic Nephropathy.
Canadian journal of diabetes.
2022 Mar; 46(2):134-141.e2. doi:
10.1016/j.jcjd.2021.07.004. [PMID: 35181219] - Weihua Qiu, Youzhong Guo. Analysis of the oligomeric state of mycobacterial membrane protein large 3 and its interaction with SQ109 with native cell membrane nanoparticles system.
Biochimica et biophysica acta. Biomembranes.
2022 02; 1864(1):183793. doi:
10.1016/j.bbamem.2021.183793. [PMID: 34655545] - Qing-Tian Ji, Xian-Fu Mu, De-Kun Hu, Li-Jun Fan, Shu-Zhen Xiang, Hao-Jie Ye, Xiu-Hui Gao, Pei-Yi Wang. Fabrication of Host-Guest Complexes between Adamantane-Functionalized 1,3,4-Oxadiazoles and β-Cyclodextrin with Improved Control Efficiency against Intractable Plant Bacterial Diseases.
ACS applied materials & interfaces.
2022 Jan; 14(2):2564-2577. doi:
10.1021/acsami.1c19758. [PMID: 34981928] - Marilena Vlachou, Angeliki-Sofia Foscolos, Angeliki Siamidi, Angeliki Syriopoulou, Nikitas Georgiou, Aikaterini Dedeloudi, Antonis D Tsiailanis, Andreas G Tzakos, Thomas Mavromoustakos, Ioannis P Papanastasiou. Biophysical Evaluation and In Vitro Controlled Release of Two Isomeric Adamantane Phenylalkylamines with Antiproliferative/Anticancer and Analgesic Activity.
Molecules (Basel, Switzerland).
2021 Dec; 27(1):. doi:
10.3390/molecules27010007. [PMID: 35011245] - Roger F Butterworth. Potential for the Repurposing of Adamantane Antivirals for COVID-19.
Drugs in R&D.
2021 Sep; 21(3):267-272. doi:
10.1007/s40268-021-00351-6. [PMID: 34152583] - Hany H Arab, Ahmed M Ashour, Amany M Gad, Ayman M Mahmoud, Ahmed M Kabel. Activation of AMPK/mTOR-driven autophagy and inhibition of NLRP3 inflammasome by saxagliptin ameliorate ethanol-induced gastric mucosal damage.
Life sciences.
2021 Sep; 280(?):119743. doi:
10.1016/j.lfs.2021.119743. [PMID: 34166711] - A T Uloko, O A Salawu, A E Uloko, I D Gezawa. Comparison of the Efficacy, Tolerability and Side Effect Profile of Vildagliptin-Metformin with Metformin-GlibenclamideMamong Nigerian.
West African journal of medicine.
2021 08; 38(8):756-761. doi:
NULL. [PMID: 34503324] - Yuzhan Zhang, Ke Li, Yan Li, Weihao Zhao, Li Wang, Zhao Chen, Xiaotao Ma, Tian Yao, Jinhua Wang, Wei Dong, Xiancheng Li, Xuefei Tian, Rongguo Fu. Profibrotic mechanisms of DPP8 and DPP9 highly expressed in the proximal renal tubule epithelial cells.
Pharmacological research.
2021 07; 169(?):105630. doi:
10.1016/j.phrs.2021.105630. [PMID: 33932609] - Herbert Nar, Gisela Schnapp, Oliver Hucke, Timothy C Hardman, Thomas Klein. Action of Dipeptidyl Peptidase-4 Inhibitors on SARS-CoV-2 Main Protease.
ChemMedChem.
2021 05; 16(9):1425-1426. doi:
10.1002/cmdc.202000921. [PMID: 33348462] - Mohammed M S Wassel, Yousry A Ammar, Gameel A M Elhag Ali, Amany Belal, Ahmed B M Mehany, Ahmed Ragab. Development of adamantane scaffold containing 1,3,4-thiadiazole derivatives: Design, synthesis, anti-proliferative activity and molecular docking study targeting EGFR.
Bioorganic chemistry.
2021 05; 110(?):104794. doi:
10.1016/j.bioorg.2021.104794. [PMID: 33735711] - Ji-Yoon Lee, Kiho Lee, Kyeong Lee, Jong Soon Kang, Min Ju Kim, Dong Gu Yoo, Jung Ah Kim, Eun Jin Shin, Soo Jin Oh. Pharmacokinetic Characterization of LW6, a Novel Hypoxia-Inducible Factor-1α (HIF-1α) Inhibitor in Mice.
Molecules (Basel, Switzerland).
2021 Apr; 26(8):. doi:
10.3390/molecules26082226. [PMID: 33921487] - Amel Rezki, Marinos Fysekidis, Sabrina Chiheb, Eric Vicaut, Emmanuel Cosson, Paul Valensi. Acute and long-term effects of saxagliptin on post-prandial glycemic response in obese patients with impaired glucose tolerance.
Nutrition, metabolism, and cardiovascular diseases : NMCD.
2021 04; 31(4):1257-1266. doi:
10.1016/j.numecd.2020.12.025. [PMID: 33618922] - Junko Toyoshima, Mai Shibata, Atsunori Kaibara, Yuichiro Kaneko, Hiroyuki Izutsu, Tetsuya Nishimura. Population pharmacokinetic analysis of peficitinib in patients with rheumatoid arthritis.
British journal of clinical pharmacology.
2021 04; 87(4):2014-2022. doi:
10.1111/bcp.14605. [PMID: 33068028] - Nasima Arshad, Aamer Saeed, Fouzia Perveen, Rabail Ujan, Shahid I Farooqi, Pervaiz Ali Channar, Ghulam Shabir, Hesham R El-Seedi, Aneela Javed, Maham Yamin, Michael Bolte, Tuncer Hökelek. Synthesis, X-ray, Hirshfeld surface analysis, exploration of DNA binding, urease enzyme inhibition and anticancer activities of novel adamantane-naphthyl thiourea conjugate.
Bioorganic chemistry.
2021 04; 109(?):104707. doi:
10.1016/j.bioorg.2021.104707. [PMID: 33639362] - Jan Madacki, Martin Kopál, Mary Jackson, Jana Korduláková. Mycobacterial Epoxide Hydrolase EphD Is Inhibited by Urea and Thiourea Derivatives.
International journal of molecular sciences.
2021 Mar; 22(6):. doi:
10.3390/ijms22062884. [PMID: 33809178] - Paul J Besseling, Tobias T Pieters, Isabel T N Nguyen, Petra M de Bree, Nel Willekes, Adele H Dijk, Dominique M Bovée, Ewout J Hoorn, Maarten B Rookmaaker, Karin G Gerritsen, Marianne C Verhaar, Hendrik Gremmels, Jaap A Joles. A plasma creatinine- and urea-based equation to estimate glomerular filtration rate in rats.
American journal of physiology. Renal physiology.
2021 03; 320(3):F518-F524. doi:
10.1152/ajprenal.00656.2020. [PMID: 33522412] - Marwa Mohsen, Ahmed A Elberry, Alaa Mohamed Rabea, Mohamed E A Abdelrahim, Raghda R S Hussein. Saxagliptin and vildagliptin lowered albuminuria in patients with diabetes and hypertension independent on glycaemic control.
International journal of clinical practice.
2021 Mar; 75(3):e13769. doi:
10.1111/ijcp.13769. [PMID: 33068301] - Raafat A Abdel-Aal, Mahran S Abdel-Rahman, Soad Al Bayoumi, Laila A Ali. Effect of stevia aqueous extract on the antidiabetic activity of saxagliptin in diabetic rats.
Journal of ethnopharmacology.
2021 Jan; 265(?):113188. doi:
10.1016/j.jep.2020.113188. [PMID: 32783985] - Moon Ho Park, Do Young Kwon. A retrospective review of memantine use and COVID-19-associated mortality from a national database.
Journal of medical virology.
2021 01; 93(1):168-169. doi:
10.1002/jmv.26266. [PMID: 32633865] - Akhtar Rasul, Safirah Maheen, Hafeez Ullah Khan, Maria Rasool, Shahid Shah, Ghulam Abbas, Khurram Afzal, Fatima Tariq, Irum Shahzadi, Muhammad Hassham Hassan Bin Asad. Formulation, Optimization, In Vitro and In Vivo Evaluation of Saxagliptin-Loaded Lipospheres for an Improved Pharmacokinetic Behavior.
BioMed research international.
2021; 2021(?):3849093. doi:
10.1155/2021/3849093. [PMID: 34722762] - Chuanjie Zhang, Li Chen, Yihan Liu, Jingyi Huang, Ao Liu, Yang Xu, Yan Shen, Hongchao He, Danfeng Xu. Downregulated METTL14 accumulates BPTF that reinforces super-enhancers and distal lung metastasis via glycolytic reprogramming in renal cell carcinoma.
Theranostics.
2021; 11(8):3676-3693. doi:
10.7150/thno.55424. [PMID: 33664855] - Wei Wei, Yinghua Liu, Chun-Ling Dai, Narjes Baazaoui, Yunn Chyn Tung, Fei Liu, Khalid Iqbal. Neurotrophic Treatment Initiated During Early Postnatal Development Prevents the Alzheimer-Like Behavior and Synaptic Dysfunction.
Journal of Alzheimer's disease : JAD.
2021; 82(2):631-646. doi:
10.3233/jad-201599. [PMID: 34057082] - Mohammad Vatanparast, Shabbir Ahmed, Dong-Hee Lee, Sung Hee Hwang, Bruce Hammock, Yonggyun Kim. EpOMEs act as immune suppressors in a lepidopteran insect, Spodoptera exigua.
Scientific reports.
2020 11; 10(1):20183. doi:
10.1038/s41598-020-77325-2. [PMID: 33214688] - Tuan-Wu Cao, Xia Liu, Yan-SongYe, Hui-Min Zhou, Dao-Wei Liu, Wen-Yong Xiong, Gang Xu. Anti-adipogenicadamantane type polycyclic polyprenylated acylphloroglucinols from Hypericum subsessile.
Fitoterapia.
2020 Nov; 147(?):104755. doi:
10.1016/j.fitote.2020.104755. [PMID: 33069835] - Inhyub Kim, Minkyoung Kim, Min Kyung Park, Ravi Naik, Jae Hyung Park, Bo-Kyung Kim, Yongseok Choi, Kwan Young Chang, Misun Won, Hyun Seung Ban, Kyeong Lee. The disubstituted adamantyl derivative LW1564 inhibits the growth of cancer cells by targeting mitochondrial respiration and reducing hypoxia-inducible factor (HIF)-1α accumulation.
Experimental & molecular medicine.
2020 11; 52(11):1845-1856. doi:
10.1038/s12276-020-00523-5. [PMID: 33235318] - Steven R Brenner. The potential of memantine and related adamantanes such as amantadine, to reduce the neurotoxic effects of COVID-19, including ARDS and to reduce viral replication through lysosomal effects.
Journal of medical virology.
2020 11; 92(11):2341-2342. doi:
10.1002/jmv.26030. [PMID: 32436995] - Botheina Ghandour, Claudio Pisano, Nadine Darwiche, Ghassan Dbaibo. Restoration of ceramide de novo synthesis by the synthetic retinoid ST1926 as it induces adult T-cell leukemia cell death.
Bioscience reports.
2020 10; 40(10):. doi:
10.1042/bsr20200050. [PMID: 33048123] - Sergey Bukhdruker, Tatsiana Varaksa, Irina Grabovec, Egor Marin, Polina Shabunya, Maria Kadukova, Sergei Grudinin, Anton Kavaleuski, Anastasiia Gusach, Andrei Gilep, Valentin Borshchevskiy, Natallia Strushkevich. Hydroxylation of Antitubercular Drug Candidate, SQ109, by Mycobacterial Cytochrome P450.
International journal of molecular sciences.
2020 Oct; 21(20):. doi:
10.3390/ijms21207683. [PMID: 33081390] - Xiu Feng, Qingwei Gu, Gu Gao, Lu Yuan, Qian Li, Ying Zhang. The plasma levels of atrial natriuretic peptide and brain natriuretic peptide in type 2 diabetes treated with sodium-glucose cotransporter-2 inhibitor.
Annales d'endocrinologie.
2020 Oct; 81(5):476-481. doi:
10.1016/j.ando.2020.07.1113. [PMID: 32822653] - Yuejuan Qin, John Adams, Carolina Solis-Herrera, Curtis Triplitt, Ralph DeFronzo, Eugenio Cersosimo. Clinical Parameters, Fuel Oxidation, and Glucose Kinetics in Patients With Type 2 Diabetes Treated With Dapagliflozin Plus Saxagliptin.
Diabetes care.
2020 10; 43(10):2519-2527. doi:
10.2337/dc19-1993. [PMID: 32694214] - Ayano Kubo, Teruo Hidaka, Maiko Nakayama, Yu Sasaki, Miyuki Takagi, Hitoshi Suzuki, Yusuke Suzuki. Protective effects of DPP-4 inhibitor on podocyte injury in glomerular diseases.
BMC nephrology.
2020 09; 21(1):402. doi:
10.1186/s12882-020-02060-9. [PMID: 32948146] - Christina Tzitzoglaki, Kelly McGuire, Panagiotis Lagarias, Athina Konstantinidi, Anja Hoffmann, Natalie A Fokina, Chulong Ma, Ioannis P Papanastasiou, Peter R Schreiner, Santiago Vázquez, Michaela Schmidtke, Jun Wang, David D Busath, Antonios Kolocouris. Chemical Probes for Blocking of Influenza A M2 Wild-type and S31N Channels.
ACS chemical biology.
2020 09; 15(9):2331-2337. doi:
10.1021/acschembio.0c00553. [PMID: 32786258] - Radoslav Chayrov, Nikolaos A Parisis, Maria V Chatziathanasiadou, Eleni Vrontaki, Kalliopi Moschovou, Georgia Melagraki, Hristina Sbirkova-Dimitrova, Boris Shivachev, Michaela Schmidtke, Yavor Mitrev, Martin Sticha, Thomas Mavromoustakos, Andreas G Tzakos, Ivanka Stankova. Synthetic Analogues of Aminoadamantane as Influenza Viral Inhibitors-In Vitro, In Silico and QSAR Studies.
Molecules (Basel, Switzerland).
2020 Sep; 25(17):. doi:
10.3390/molecules25173989. [PMID: 32883012] - Mateja Manček-Keber, Rosana Ribić, Fernando Chain, Davy Sinnaeve, José C Martins, Roman Jerala, Srđanka Tomić, Krisztina Fehér. Adamantane Containing Peptidoglycan Fragments Enhance RANTES and IL-6 Production in Lipopolysaccharide-Induced Macrophages.
Molecules (Basel, Switzerland).
2020 Aug; 25(16):. doi:
10.3390/molecules25163707. [PMID: 32823878] - Daisuke Miyatake, Tomohisa Shibata, Junko Toyoshima, Yuichiro Kaneko, Kazuo Oda, Tetsuya Nishimura, Masataka Katashima, Masashi Sakaki, Kazuaki Inoue, Takayoshi Ito, Naoki Uchida, Kenichi Furihata, Akinori Urae. Pharmacokinetics and Safety of a Single Oral Dose of Peficitinib (ASP015K) in Japanese Subjects With Normal and Impaired Hepatic Function.
Clinical pharmacology in drug development.
2020 08; 9(6):699-708. doi:
10.1002/cpdd.751. [PMID: 31833184] - Mai Shibata, Junko Toyoshima, Yuichiro Kaneko, Kazuo Oda, Tetsuya Nishimura. A drug-drug interaction study to evaluate the impact of peficitinib on OCT1- and MATE1-mediated transport of metformin in healthy volunteers.
European journal of clinical pharmacology.
2020 Aug; 76(8):1135-1141. doi:
10.1007/s00228-020-02876-2. [PMID: 32472157] - Clement Lo, Tadashi Toyama, Megumi Oshima, Min Jun, Ken L Chin, Carmel M Hawley, Sophia Zoungas. Glucose-lowering agents for treating pre-existing and new-onset diabetes in kidney transplant recipients.
The Cochrane database of systematic reviews.
2020 07; 8(?):CD009966. doi:
10.1002/14651858.cd009966.pub3. [PMID: 32803882] - Safirah Maheen, Akhtar Rasul, Muhammad Hanif, Hafeez Ullah Khan. Lipospheres for Simultaneous Controlled Release and Improved Pharmacokinetic Profiles of Saxagliptin-Enalapril: Formulation, Optimization, and Comparative In Vitro-In Vivo Evaluation.
AAPS PharmSciTech.
2020 Jul; 21(5):188. doi:
10.1208/s12249-020-01733-w. [PMID: 32651896] - Malinda Salim, Gisela Ramirez, Kang-Yu Peng, Andrew J Clulow, Adrian Hawley, Hanu Ramachandruni, Stephane Beilles, Ben J Boyd. Lipid Compositions in Infant Formulas Affect the Solubilization of Antimalarial Drugs Artefenomel (OZ439) and Ferroquine during Digestion.
Molecular pharmaceutics.
2020 07; 17(7):2749-2759. doi:
10.1021/acs.molpharmaceut.0c00475. [PMID: 32574056] - Ziwei Zhang, Xiang Yan, Chao Wu, Xieyi Pei, Xia Li, Xiangbing Wang, Xiaohong Niu, Hongwei Jiang, Xiaomin Zeng, Zhiguang Zhou. Adding vitamin D3 to the dipeptidyl peptidase-4 inhibitor saxagliptin has the potential to protect β-cell function in LADA patients: A 1-year pilot study.
Diabetes/metabolism research and reviews.
2020 07; 36(5):e3298. doi:
10.1002/dmrr.3298. [PMID: 32043288] - Zhihui Chen, Jing Yu, Menglu Fu, Ruolan Dong, Yan Yang, Jinlan Luo, Shuiqing Hu, Wenhua Li, Xizhen Xu, Ling Tu. Dipeptidyl peptidase-4 inhibition improves endothelial senescence by activating AMPK/SIRT1/Nrf2 signaling pathway.
Biochemical pharmacology.
2020 07; 177(?):113951. doi:
10.1016/j.bcp.2020.113951. [PMID: 32251672] - Lars Johansson, Paul D Hockings, Eva Johnsson, Nalina Dronamraju, Jill Maaske, Ricardo Garcia-Sanchez, John P H Wilding. Dapagliflozin plus saxagliptin add-on to metformin reduces liver fat and adipose tissue volume in patients with type 2 diabetes.
Diabetes, obesity & metabolism.
2020 07; 22(7):1094-1101. doi:
10.1111/dom.14004. [PMID: 32072735] - Hui Fang, Fengmei Xu, Jin Du, Li Liang, Wei Li, Liya Shen, Xueying Wang, Chun Xu, Fang Bian, Yiming Mu. Impact of baseline characteristics on glycemic effects of add-on saxagliptin or acarbose to metformin therapy: Subgroup analysis of the SMART study in Chinese patients with type 2 diabetes mellitus.
Journal of diabetes investigation.
2020 Jul; 11(4):896-905. doi:
10.1111/jdi.13224. [PMID: 32020731] - Konrad Rejdak, Paweł Grieb. Adamantanes might be protective from COVID-19 in patients with neurological diseases: multiple sclerosis, parkinsonism and cognitive impairment.
Multiple sclerosis and related disorders.
2020 Jul; 42(?):102163. doi:
10.1016/j.msard.2020.102163. [PMID: 32388458] - Carlo Giannangelo, Ghizal Siddiqui, Amanda De Paoli, Bethany M Anderson, Laura E Edgington-Mitchell, Susan A Charman, Darren J Creek. System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion.
PLoS pathogens.
2020 06; 16(6):e1008485. doi:
10.1371/journal.ppat.1008485. [PMID: 32589689] - Nevio Cimolai. Potentially repurposing adamantanes for COVID-19.
Journal of medical virology.
2020 06; 92(6):531-532. doi:
10.1002/jmv.25752. [PMID: 32176361] - Vala Hamidi, Kayla Riggs, Liang Zhu, Karla Bermudez Saint Andre, Christian Westby, Sara Coverdale, Amy Dursteler, Hongyu Wang, Charles Miller Iii, Heinrich Taegtmeyer, Absalon D Gutierrez. Acute Exenatide Therapy Attenuates Postprandial Vasodilation in Humans with Prediabetes: A Randomized Controlled Trial.
Metabolic syndrome and related disorders.
2020 06; 18(5):225-233. doi:
10.1089/met.2019.0102. [PMID: 32228379] - Mai Shibata, Toshifumi Hatta, Masako Saito, Junko Toyoshima, Yuichiro Kaneko, Kazuo Oda, Tetsuya Nishimura. Pharmacokinetics, Pharmacodynamics, and Safety of Peficitinib (ASP015K) in Healthy Male Caucasian and Japanese Subjects.
Clinical drug investigation.
2020 May; 40(5):469-484. doi:
10.1007/s40261-020-00910-w. [PMID: 32274653] - Cong Xie, Xuyi Wang, Karen L Jones, Michael Horowitz, Zilin Sun, Tanya J Little, Christopher K Rayner, Tongzhi Wu. Role of endogenous glucagon-like peptide-1 enhanced by vildagliptin in the glycaemic and energy expenditure responses to intraduodenal fat infusion in type 2 diabetes.
Diabetes, obesity & metabolism.
2020 03; 22(3):383-392. doi:
10.1111/dom.13906. [PMID: 31693275] - Yuanyuan Hu, Shandong Ye, Yan Xing, Lijuan Lv, Wen Hu, Wan Zhou. Saxagliptin attenuates glomerular podocyte injury by increasing the expression of renal nephrin and podocin in type 2 diabetic rats.
Acta diabetologica.
2020 Mar; 57(3):279-286. doi:
10.1007/s00592-019-01421-7. [PMID: 31535208] - Daisuke Miyatake, Tomohisa Shibata, Mai Shibata, Yuichiro Kaneko, Kazuo Oda, Tetsuya Nishimura, Masataka Katashima, Hisakuni Sekino, Kenichi Furihata, Akinori Urae. Pharmacokinetics and Safety of a Single Oral Dose of Peficitinib (ASP015K) in Japanese Subjects with Normal and Impaired Renal Function.
Clinical drug investigation.
2020 Feb; 40(2):149-159. doi:
10.1007/s40261-019-00873-7. [PMID: 31729626] - T M Garaev, A I Odnovorov, E S Kirillova, E I Burtseva, M P Finogenova, E A Mukasheva, T V Grebennikova. [Adamantan derivatives capable of inhibiting the reproduction of a Rimantadine resistant strain of influenza A(H1N1)pdm09 virus (Influenza A virus, Alphainfluenzavirus, Orthomyxoviridae).].
Voprosy virusologii.
2020 ; 65(1):16-20. doi:
10.36233/0507-4088-2020-65-1-16-20. [PMID: 32496716] - James S McCarthy, Thomas Rückle, Suzanne L Elliott, Emma Ballard, Katharine A Collins, Louise Marquart, Paul Griffin, Stephan Chalon, Jörg J Möhrle. A Single-Dose Combination Study with the Experimental Antimalarials Artefenomel and DSM265 To Determine Safety and Antimalarial Activity against Blood-Stage Plasmodium falciparum in Healthy Volunteers.
Antimicrobial agents and chemotherapy.
2019 12; 64(1):. doi:
10.1128/aac.01371-19. [PMID: 31685476] - Giancarlo Abis, Raúl Pacheco-Gómez, Tam T T Bui, Maria R Conte. Isothermal Titration Calorimetry Enables Rapid Characterization of Enzyme Kinetics and Inhibition for the Human Soluble Epoxide Hydrolase.
Analytical chemistry.
2019 12; 91(23):14865-14872. doi:
10.1021/acs.analchem.9b01847. [PMID: 31660733] - Mai M Helmy, Samar M Mouneir. Reno-protective effect of linagliptin against gentamycin nephrotoxicity in rats.
Pharmacological reports : PR.
2019 Dec; 71(6):1133-1139. doi:
10.1016/j.pharep.2019.06.017. [PMID: 31675669] - Wen Li, Ruixin Liu, Xuelin Li, Bei Tao, Nan Zhai, Xiaolin Wang, Qi Li, Yifei Zhang, Weiqiong Gu, Weiqing Wang, Guang Ning. Saxagliptin alters bile acid profiles and yields metabolic benefits in drug-naïve overweight or obese type 2 diabetes patient.
Journal of diabetes.
2019 Dec; 11(12):982-992. doi:
10.1111/1753-0407.12956. [PMID: 31141297] - Daniela Herrera Moro Chao, Yanan Wang, Ewout Foppen, Roelof Ottenhoff, Cindy van Roomen, Edwin T Parlevliet, Marco van Eijk, Marri Verhoek, Rolf Boot, Andre R Marques, Saskia Scheij, Mina Mirzaian, Sander Kooijman, Kirstin Jansen, Dawei Wang, Clarita Mergen, Randy J Seeley, Matthias H Tschöp, Herman Overkleeft, Patrick C N Rensen, Andries Kalsbeek, Johannes M F G Aerts, Chun-Xia Yi. The Iminosugar AMP-DNM Improves Satiety and Activates Brown Adipose Tissue Through GLP1.
Diabetes.
2019 12; 68(12):2223-2234. doi:
10.2337/db19-0049. [PMID: 31578192] - Yi-Min Kuo, Pei-Chien Hsu, Chia-Chi Hung, Ya-Yu Hu, Yu-Jie Huang, Yu-Ling Gan, Chun-Hua Lin, Feng-Shiun Shie, Wen-Kuei Chang, Lung-Sen Kao, Mei-Yung Tsou, Yi-Hsuan Lee. Soluble Epoxide Hydrolase Inhibition Attenuates Excitotoxicity Involving 14,15-Epoxyeicosatrienoic Acid-Mediated Astrocytic Survival and Plasticity to Preserve Glutamate Homeostasis.
Molecular neurobiology.
2019 Dec; 56(12):8451-8474. doi:
10.1007/s12035-019-01669-8. [PMID: 31257558] - David D Berg, Stephen D Wiviott, Benjamin M Scirica, Yared Gurmu, Ofri Mosenzon, Sabina A Murphy, Deepak L Bhatt, Lawrence A Leiter, Darren K McGuire, John P H Wilding, Per Johanson, Peter A Johansson, Anna Maria Langkilde, Itamar Raz, Eugene Braunwald, Marc S Sabatine. Heart Failure Risk Stratification and Efficacy of Sodium-Glucose Cotransporter-2 Inhibitors in Patients With Type 2 Diabetes Mellitus.
Circulation.
2019 11; 140(19):1569-1577. doi:
10.1161/circulationaha.119.042685. [PMID: 31474116] - J Koska, T Osredkar, K D'Souza, M Sands, S Sinha, W Zhang, C Meyer, P D Reaven. Effects of saxagliptin on adipose tissue inflammation and vascular function in overweight and obese people: a placebo-controlled study.
Diabetic medicine : a journal of the British Diabetic Association.
2019 11; 36(11):1399-1407. doi:
10.1111/dme.13889. [PMID: 30580454] - Nada M Kamel, Mai A Abd El Fattah, Hanan S El-Abhar, Dalaal M Abdallah. Novel repair mechanisms in a renal ischaemia/reperfusion model: Subsequent saxagliptin treatment modulates the pro-angiogenic GLP-1/cAMP/VEGF, ANP/eNOS/NO, SDF-1α/CXCR4, and Kim-1/STAT3/HIF-1α/VEGF/eNOS pathways.
European journal of pharmacology.
2019 Oct; 861(?):172620. doi:
10.1016/j.ejphar.2019.172620. [PMID: 31437429] - Julio Rosenstock, Shira Perl, Eva Johnsson, Ricardo García-Sánchez, Stephan Jacob. Triple therapy with low-dose dapagliflozin plus saxagliptin versus dual therapy with each monocomponent, all added to metformin, in uncontrolled type 2 diabetes.
Diabetes, obesity & metabolism.
2019 09; 21(9):2152-2162. doi:
10.1111/dom.13795. [PMID: 31144431] - Marwin Bannehr, Lena Löhr, Julia Gelep, Wilhelm Haverkamp, Wolf-Hagen Schunck, Maik Gollasch, Alexander Wutzler. Linoleic Acid Metabolite DiHOME Decreases Post-ischemic Cardiac Recovery in Murine Hearts.
Cardiovascular toxicology.
2019 08; 19(4):365-371. doi:
10.1007/s12012-019-09508-x. [PMID: 30725262] - Masato Kajikawa, Tatsuya Maruhashi, Takayuki Hidaka, Shogo Matsui, Haruki Hashimoto, Yuji Takaeko, Yukiko Nakano, Satoshi Kurisu, Yasuki Kihara, Farina Mohamad Yusoff, Shinji Kishimoto, Kazuaki Chayama, Chikara Goto, Kensuke Noma, Ayumu Nakashima, Takafumi Hiro, Atsushi Hirayama, Kazuki Shiina, Hirofumi Tomiyama, Shusuke Yagi, Rie Amano, Hirotsugu Yamada, Masataka Sata, Yukihito Higashi. Effect of Saxagliptin on Endothelial Function in Patients with Type 2 Diabetes: A Prospective Multicenter Study.
Scientific reports.
2019 07; 9(1):10206. doi:
10.1038/s41598-019-46726-3. [PMID: 31308448] - Zafer Sahin, Haluk Kelestimur. RF9: May it be a new therapeutic option for hypogonadotropic hypogonadism?.
Medical hypotheses.
2019 Jul; 128(?):54-57. doi:
10.1016/j.mehy.2019.05.016. [PMID: 31203909] - Qian Qiu, Qilin Feng, Xueying Tan, Mingxing Guo. JAK3-selective inhibitor peficitinib for the treatment of rheumatoid arthritis.
Expert review of clinical pharmacology.
2019 Jun; 12(6):547-554. doi:
10.1080/17512433.2019.1615443. [PMID: 31059310] - Katherine R Tuttle. SGLT2 inhibitor and incretin mimetic therapy for type 2 diabetes and chronic kidney disease.
The lancet. Diabetes & endocrinology.
2019 06; 7(6):414-415. doi:
10.1016/s2213-8587(19)30116-0. [PMID: 30992196] - Carol Pollock, Bergur Stefánsson, Daniel Reyner, Peter Rossing, C David Sjöström, David C Wheeler, Anna Maria Langkilde, Hiddo J L Heerspink. Albuminuria-lowering effect of dapagliflozin alone and in combination with saxagliptin and effect of dapagliflozin and saxagliptin on glycaemic control in patients with type 2 diabetes and chronic kidney disease (DELIGHT): a randomised, double-blind, placebo-controlled trial.
The lancet. Diabetes & endocrinology.
2019 06; 7(6):429-441. doi:
10.1016/s2213-8587(19)30086-5. [PMID: 30992195] - Malinda Salim, Jamal Khan, Gisela Ramirez, Mubtasim Murshed, Andrew J Clulow, Adrian Hawley, Hanu Ramachandruni, Stephane Beilles, Ben J Boyd. Impact of Ferroquine on the Solubilization of Artefenomel (OZ439) during in Vitro Lipolysis in Milk and Implications for Oral Combination Therapy for Malaria.
Molecular pharmaceutics.
2019 04; 16(4):1658-1668. doi:
10.1021/acs.molpharmaceut.8b01333. [PMID: 30830789] - Liao-Bin Dong, Xiao Zhang, Jeffrey D Rudolf, Ming-Rong Deng, Edward Kalkreuter, Alexis J Cepeda, Hans Renata, Ben Shen. Cryptic and Stereospecific Hydroxylation, Oxidation, and Reduction in Platensimycin and Platencin Biosynthesis.
Journal of the American Chemical Society.
2019 03; 141(9):4043-4050. doi:
10.1021/jacs.8b13452. [PMID: 30735041] - Ye Ye, Xing-Wei Yang, Yan Zhou, Gang Xu. homo-Adamantane type polycyclic polyprenylated acylphloroglucinols from Hypericum hookerianum.
Fitoterapia.
2019 Mar; 133(?):43-50. doi:
10.1016/j.fitote.2018.12.014. [PMID: 30576796] - Juan-Juan Li, Ping Zhang, Bing Fan, Xiu-Li Guo, Zhe-Shu Zheng. The efficacy of saxagliptin in T2DM patients with non-alcoholic fatty liver disease: preliminary data.
Revista da Associacao Medica Brasileira (1992).
2019 Jan; 65(1):33-37. doi:
10.1590/1806-9282.65.1.33. [PMID: 30758417] - Per Lundkvist, Maria J Pereira, Prasad G Kamble, Petros Katsogiannos, Anna Maria Langkilde, Russell Esterline, Eva Johnsson, Jan W Eriksson. Glucagon Levels During Short-Term SGLT2 Inhibition Are Largely Regulated by Glucose Changes in Patients With Type 2 Diabetes.
The Journal of clinical endocrinology and metabolism.
2019 01; 104(1):193-201. doi:
10.1210/jc.2018-00969. [PMID: 30137410] - Mariam Alsanafi, Samuel L Kelly, Karawan Jubair, Melissa McNaughton, Rothwelle J Tate, Alfred H Merrill, Susan Pyne, Nigel J Pyne. Native and Polyubiquitinated Forms of Dihydroceramide Desaturase Are Differentially Linked to Human Embryonic Kidney Cell Survival.
Molecular and cellular biology.
2018 12; 38(23):. doi:
10.1128/mcb.00222-18. [PMID: 30224516] - Athina Konstantinidi, Nikolaos Naziris, Maria Chountoulesi, Sophia Kiriakidi, Barbara Sartori, Dimitris Kolokouris, Heinz Amentisch, Gregor Mali, Dimitrios Ntountaniotis, Costas Demetzos, Thomas Mavromoustakos, Antonios Kolocouris. Comparative Perturbation Effects Exerted by the Influenza A M2 WT Protein Inhibitors Amantadine and the Spiro[pyrrolidine-2,2'-adamantane] Variant AK13 to Membrane Bilayers Studied Using Biophysical Experiments and Molecular Dynamics Simulations.
The journal of physical chemistry. B.
2018 11; 122(43):9877-9895. doi:
10.1021/acs.jpcb.8b07071. [PMID: 30285441] - Sung Pyo Hong, Dongoh Han, Ki-Ho Chang, Soon Kil Ahn. A novel highly potent and selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, INU-101.
European journal of pharmacology.
2018 Sep; 835(?):169-178. doi:
10.1016/j.ejphar.2018.08.005. [PMID: 30096297] - Yang Yang, Yunhong Lu, Fei Han, Yunpeng Chang, Xiaoyu Li, Zhe Han, Mei Xue, Ying Cheng, Bei Sun, Liming Chen. Saxagliptin regulates M1/M2 macrophage polarization via CaMKKβ/AMPK pathway to attenuate NAFLD.
Biochemical and biophysical research communications.
2018 09; 503(3):1618-1624. doi:
10.1016/j.bbrc.2018.07.090. [PMID: 30060948] - Kuanlin Chen, Tiejun Zhuo, Jian Wang, Qing Mei. Saxagliptin Upregulates Nesfatin-1 Secretion and Ameliorates Insulin Resistance and Metabolic Profiles in Type 2 Diabetes Mellitus.
Metabolic syndrome and related disorders.
2018 09; 16(7):336-341. doi:
10.1089/met.2018.0010. [PMID: 29912623] - Maria Fesatidou, Panagiotis Zagaliotis, Charalampos Camoutsis, Anthi Petrou, Phaedra Eleftheriou, Christophe Tratrat, Micheline Haroun, Athina Geronikaki, Ana Ciric, Marina Sokovic. 5-Adamantan thiadiazole-based thiazolidinones as antimicrobial agents. Design, synthesis, molecular docking and evaluation.
Bioorganic & medicinal chemistry.
2018 09; 26(16):4664-4676. doi:
10.1016/j.bmc.2018.08.004. [PMID: 30107969] - Manar Gamal Helal, Marwa Mohamed Abdel Fattah Zaki, Eman Said. Nephroprotective effect of saxagliptin against gentamicin-induced nephrotoxicity, emphasis on anti-oxidant, anti-inflammatory and anti-apoptic effects.
Life sciences.
2018 Sep; 208(?):64-71. doi:
10.1016/j.lfs.2018.07.021. [PMID: 30012474] - Aline Fofonka, Patrícia Martins Bock, Karina Rabello Casali, Anderson Donelli da Silveira, Felipe Marques da Rosa, Gabriela Berlanda, Beatriz D Schaan. Impact of treatment with glibenclamide or vildagliptin on glucose variability after aerobic exercise in type 2 diabetes: A randomized controlled trial.
Diabetes research and clinical practice.
2018 Sep; 143(?):184-193. doi:
10.1016/j.diabres.2018.07.007. [PMID: 29990565] - Jessica Fernandes, M Vivek Ghate, Sanchari Basu Mallik, Shaila A Lewis. Amino acid conjugated chitosan nanoparticles for the brain targeting of a model dipeptidyl peptidase-4 inhibitor.
International journal of pharmaceutics.
2018 Aug; 547(1-2):563-571. doi:
10.1016/j.ijpharm.2018.06.031. [PMID: 29906562] - Dahee Kim, Ja-Il Goo, Mi Il Kim, Sung-Jin Lee, Moonju Choi, Thoa Thi Than, Phuong Hong Nguyen, Marc P Windisch, Kyeong Lee, Yongseok Choi, Choongho Lee. Suppression of Hepatitis C Virus Genome Replication and Particle Production by a Novel Diacylglycerol Acyltransferases Inhibitor.
Molecules (Basel, Switzerland).
2018 Aug; 23(8):. doi:
10.3390/molecules23082083. [PMID: 30127285] - Malinda Salim, Jamal Khan, Gisela Ramirez, Andrew J Clulow, Adrian Hawley, Hanu Ramachandruni, Ben J Boyd. Interactions of Artefenomel (OZ439) with Milk during Digestion: Insights into Digestion-Driven Solubilization and Polymorphic Transformations.
Molecular pharmaceutics.
2018 08; 15(8):3535-3544. doi:
10.1021/acs.molpharmaceut.8b00541. [PMID: 29932660] - Julio Rosenstock, Chantal Mathieu, Hungta Chen, Ricardo Garcia-Sanchez, Gabriela Luporini Saraiva. Dapagliflozin versus saxagliptin as add-on therapy in patients with type 2 diabetes inadequately controlled with metformin.
Archives of endocrinology and metabolism.
2018 08; 62(4):424-430. doi:
10.20945/2359-3997000000056. [PMID: 30304106] - Amir Mohamed Abdelhamid, Rania Ramadan Abdelaziz, Hatem Abdelrahman Ali Salem. Vildagliptin/pioglitazone combination improved the overall glycemic control in type I diabetic rats.
Canadian journal of physiology and pharmacology.
2018 Aug; 96(8):710-718. doi:
10.1139/cjpp-2017-0680. [PMID: 29510081]