Hydroxyhexamide (BioDeep_00001876702)
代谢物信息卡片
化学式: C15H22N2O4S (326.13)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C1=CC=C(C=C1)S(=O)(=O)NC(=O)NC2CCCCC2)O
InChI: InChI=1S/C15H22N2O4S/c1-11(18)12-7-9-14(10-8-12)22(20,21)17-15(19)16-13-5-3-2-4-6-13/h7-11,13,18H,2-6H2,1H3,(H2,16,17,19)
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Satoshi Endo, Namiki Miyagi, Toshiyuki Matsunaga, Akira Ikari. Rabbit dehydrogenase/reductase SDR family member 11 (DHRS11): Its identity with acetohexamide reductase with broad substrate specificity and inhibitor sensitivity, different from human DHRS11.
Chemico-biological interactions.
2019 May; 305(?):12-20. doi:
10.1016/j.cbi.2019.03.026. [PMID: 30926317] - Yorishige Imamura, Miho Kaneko, Hidenori Takada, Masaki Otagiri, Hideaki Shimada, Hiroyuki Akita. Sex-dependent pharmacokinetics of S(-)-hydroxyhexamide, a pharmacologically active metabolite of acetohexamide, in rats.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2002 Dec; 133(4):587-92. doi:
10.1016/s1532-0456(02)00177-1. [PMID: 12458186] - Y Imamura, K Sanai, K Seri, H Akita. Hypoglycemic effect of S(-)-hydroxyhexamide, a major metabolite of acetohexamide, and its enantiomer R(+)-hydroxyhexamide.
Life sciences.
2001 Sep; 69(16):1947-55. doi:
10.1016/s0024-3205(01)01284-x. [PMID: 11693275] - K Seri, K Sanai, K Kurashima, Y Imamura, H Akita. (R)-ACX is a novel sufonylurea compound with potent, quick and short-lasting hypoglycemic activity.
European journal of pharmacology.
2000 Feb; 389(2-3):253-6. doi:
10.1016/s0014-2999(99)00922-x. [PMID: 10688991] - Y Shibutani, T Yokota. A case of acetohexamide-induced hypoglycemia: the influence of hypothyroidism on the metabolism of acetohexamide.
Nihon Naibunpi Gakkai zasshi.
1991 Jan; 67(1):42-9. doi:
10.1507/endocrine1927.67.1_42. [PMID: 2013345] - Y Imamura, H Abe, Y Kojima, M Otagiri. In vivo and in vitro binding of (-)-hydroxyhexamide, a major metabolite of acetohexamide, to rabbit serum.
Journal of pharmacobio-dynamics.
1989 Aug; 12(8):503-7. doi:
10.1248/bpb1978.12.503. [PMID: 2614641] - Y Kojima, Y Imamura, M Otagiri. Metabolic reduction of acetohexamide in rat kidney: sex difference and effect of streptozotocin-induced diabetes.
Journal of pharmacobio-dynamics.
1988 May; 11(5):309-13. doi:
10.1248/bpb1978.11.309. [PMID: 2971793] - Y Imamura, Y Kojima, H Ichibagase. Effect of simultaneous administration of drugs on absorption and excretion. XIX. Binding of acetohexamide and its major metabolite, (-)-hydroxyhexamide, to human serum albumin.
Chemical & pharmaceutical bulletin.
1985 Mar; 33(3):1281-4. doi:
10.1248/cpb.33.1281. [PMID: 4028305] - M Yamada, J Takahashi. Effect of dietary DL-ethionine on postnatal growth, and activities of liver and kidney enzymes of male chickens, Gallus domesticus.
Comparative biochemistry and physiology. C: Comparative pharmacology.
1977; 58(2C):177-81. doi:
10.1016/0306-4492(77)90101-0. [PMID: 23931]
