Danatrol (BioDeep_00001876538)
代谢物信息卡片
Danatrol
化学式: C22H27NO2 (337.2041682)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC12CCC3C(C1CCC2(C#C)O)CCC4=CC5=C(CC34C)C=NO5
InChI: InChI=1S/C22H27NO2/c1-4-22(24)10-8-18-16-6-5-15-11-19-14(13-23-25-19)12-20(15,2)17(16)7-9-21(18,22)3/h1,11,13,16-18,24H,5-10,12H2,2-3H3
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D004965 - Estrogen Antagonists
同义名列表
1 个代谢物同义名
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- John A Mackintosh, Maria Pietsch, Viviana Lutzky, Debra Enever, Sandra Bancroft, Simon H Apte, Maxine Tan, Stephanie T Yerkovich, Joanne L Dickinson, Hilda A Pickett, Hiran Selvadurai, Christopher Grainge, Nicole S Goh, Peter Hopkins, Ian Glaspole, Paul N Reynolds, Jeremy Wrobel, Adam Jaffe, Tamera J Corte, Daniel C Chambers. TELO-SCOPE study: a randomised, double-blind, placebo-controlled, phase 2 trial of danazol for short telomere related pulmonary fibrosis.
BMJ open respiratory research.
2021 12; 8(1):. doi:
10.1136/bmjresp-2021-001127. [PMID: 34857525] - N Mete Gökmen, O Kuman Tunçel, G Boğatekin, G Bulut, S Demir, A Gelincik, C Tunakan Dalgıç, D Mungan. Psychiatric and Clinical Characteristics of Hereditary Angioedema Patients Who Experienced Attacks During COVID-19.
Journal of investigational allergology & clinical immunology.
2021 Jul; 31(4):356-357. doi:
10.18176/jiaci.0701. [PMID: 33949951] - Vladimir Katev, Zahari Vinarov, Slavka Tcholakova. Mechanisms of drug solubilization by polar lipids in biorelevant media.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2021 Apr; 159(?):105733. doi:
10.1016/j.ejps.2021.105733. [PMID: 33497822] - Kazumasa Iwamoto, Beverley Yamamoto, Isao Ohsawa, Daisuke Honda, Takahiko Horiuchi, Akira Tanaka, Atsushi Fukunaga, Junichi Maehara, Kouhei Yamashita, Tomoyuki Akita, Michihiro Hide. The diagnosis and treatment of hereditary angioedema patients in Japan: A patient reported outcome survey.
Allergology international : official journal of the Japanese Society of Allergology.
2021 Apr; 70(2):235-243. doi:
10.1016/j.alit.2020.09.008. [PMID: 33168485] - Shivank Madan, Mandeep R Mehra. Rhabdomyolysis with the combined use of danazol and rosuvastatin in left ventricular assist devices.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.
2020 05; 39(5):498-500. doi:
10.1016/j.healun.2020.02.006. [PMID: 32122697] - Shuang Liu, Qun Xu, Yingyang Xu, Xue Wang, Yuxiang Zhi. Current status of the management of hereditary angioedema in China: a patient-based, cross-sectional survey.
European journal of dermatology : EJD.
2020 Apr; 30(2):169-176. doi:
10.1684/ejd.2020.3758. [PMID: 32538357] - Andrea Zanichelli, Mario Ghezzi, Ivan Santicchia, Romualdo Vacchini, Marco Cicardi, Antonella Sparaco, Girolamo Donati, Vito Ranìa, Alberto Busa. Short-term prophylaxis in patients with angioedema due to C1-inhibitor deficiency undergoing dental procedures: An observational study.
PloS one.
2020; 15(3):e0230128. doi:
10.1371/journal.pone.0230128. [PMID: 32163480] - Minda Ju, Liu Yang, Jing Zhu, Zhejun Chen, Mizhen Zhang, Jin Yu, Zhanzhuang Tian. MiR-664-2 impacts pubertal development in a precocious-puberty rat model through targeting the NMDA receptor-1†.
Biology of reproduction.
2019 06; 100(6):1536-1548. doi:
10.1093/biolre/ioz044. [PMID: 30916745] - Janneke Keemink, Elin Mårtensson, Christel A S Bergström. Lipolysis-Permeation Setup for Simultaneous Study of Digestion and Absorption in Vitro.
Molecular pharmaceutics.
2019 03; 16(3):921-930. doi:
10.1021/acs.molpharmaceut.8b00811. [PMID: 30628771] - Zsuzsa Nebenführer, Erika Szabó, Erika Kajdácsi, Kinga Viktória Kőhalmi, István Karádi, András Zsáry, Henriette Farkas, László Cervenak. Flow-mediated vasodilation assay indicates no endothelial dysfunction in hereditary angioedema patients with C1-inhibitor deficiency.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2019 01; 122(1):86-92. doi:
10.1016/j.anai.2018.10.004. [PMID: 30312677] - Harshit Khurana, Pankaj Malhotra, Man Updesh Sachdeva, Neelam Varma, Parveen Bose, Uday Yanamandra, Subhash Varma, Alka Khadwal, Deepesh Lad, Gaurav Prakash. Danazol increases T regulatory cells in patients with aplastic anemia.
Hematology (Amsterdam, Netherlands).
2018 Sep; 23(8):496-500. doi:
10.1080/10245332.2018.1435045. [PMID: 29415633] - Álvaro José Mayorga, Gerardo José Ayestas-Moreno. [Hereditary angioedema by C1 inhibitor-deficit: Diagnostic and therapeutic challenges. Case report].
Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993).
2017 Oct; 64(4):493-498. doi:
10.29262/ram.v64i4.310. [PMID: 29249111] - A T Larsen, R Holm, A Müllertz. Solution or suspension - Does it matter for lipid based systems? In vivo studies of chase dosing lipid vehicles with aqueous suspensions of a poorly soluble drug.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2017 Aug; 117(?):308-314. doi:
10.1016/j.ejpb.2017.04.023. [PMID: 28465239] - Suman Jyoti Deka, Ashalata Roy, Vibin Ramakrishnan, Debasis Manna, Vishal Trivedi. Danazol has potential to cause PKC translocation, cell cycle dysregulation, and apoptosis in breast cancer cells.
Chemical biology & drug design.
2017 06; 89(6):953-963. doi:
10.1111/cbdd.12921. [PMID: 27933735] - Mette D Mosgaard, Philip J Sassene, Huiling Mu, Thomas Rades, Anette Müllertz. High-Throughput Lipolysis in 96-Well Plates for Rapid Screening of Lipid-Based Drug Delivery Systems.
Journal of pharmaceutical sciences.
2017 04; 106(4):1183-1186. doi:
10.1016/j.xphs.2016.12.026. [PMID: 28057543] - Woldeamanuel A Birru, Dallas B Warren, Sifei Han, Hassan Benameur, Christopher J H Porter, Colin W Pouton, David K Chalmers. Computational Models of the Gastrointestinal Environment. 2. Phase Behavior and Drug Solubilization Capacity of a Type I Lipid-Based Drug Formulation after Digestion.
Molecular pharmaceutics.
2017 03; 14(3):580-592. doi:
10.1021/acs.molpharmaceut.6b00887. [PMID: 27936778] - Rumesh Chandar, Venkatesh Chandrasekaran, Barath Jagadisan, Delhi Kumar, Niranjan Biswal. Hemophagocytic Lymphohistiocytosis in A Child With Very Severe Aplastic Anemia: Double Jeopardy Resulting in Fatality.
Journal of pediatric hematology/oncology.
2017 01; 39(1):e43-e45. doi:
10.1097/mph.0000000000000671. [PMID: 27548335] - P J Sassene, M H Michaelsen, M D Mosgaard, M K Jensen, E Van Den Broek, K M Wasan, H Mu, T Rades, A Müllertz. In Vivo Precipitation of Poorly Soluble Drugs from Lipid-Based Drug Delivery Systems.
Molecular pharmaceutics.
2016 10; 13(10):3417-3426. doi:
10.1021/acs.molpharmaceut.6b00413. [PMID: 27533712] - S Rzeppa, L Viet. Analysis of sulfate metabolites of the doping agents oxandrolone and danazol using high performance liquid chromatography coupled to tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Sep; 1029-1030(?):1-9. doi:
10.1016/j.jchromb.2016.06.028. [PMID: 27394004] - Ibolya Czaller, Dorottya Csuka, Zsuzsanna Zotter, Nóra Veszeli, Edit Takács, Éva Imreh, Lilian Varga, Henriette Farkas. Thyroid hormones and complement parameters in hereditary angioedema with C1-inhibitor deficiency.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2016 08; 117(2):175-9. doi:
10.1016/j.anai.2016.06.005. [PMID: 27364943] - Danielle M Townsley, Bogdan Dumitriu, Delong Liu, Angélique Biancotto, Barbara Weinstein, Christina Chen, Nathan Hardy, Andrew D Mihalek, Shilpa Lingala, Yun Ju Kim, Jianhua Yao, Elizabeth Jones, Bernadette R Gochuico, Theo Heller, Colin O Wu, Rodrigo T Calado, Phillip Scheinberg, Neal S Young. Danazol Treatment for Telomere Diseases.
The New England journal of medicine.
2016 May; 374(20):1922-31. doi:
10.1056/nejmoa1515319. [PMID: 27192671] - Niels Erik Olesen, Peter Westh, René Holm. A heuristic model to quantify the impact of excess cyclodextrin on oral drug absorption from aqueous solution.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2016 May; 102(?):142-51. doi:
10.1016/j.ejpb.2016.03.011. [PMID: 26969263] - Aiqin Gong, Xiashi Zhu. Miniaturized ionic liquid dispersive liquid-liquid microextraction in a coupled-syringe system combined with UV for extraction and determination of danazol in danazol capsule and mice serum.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2016 Apr; 159(?):163-8. doi:
10.1016/j.saa.2016.01.053. [PMID: 26845583] - Mette D Mosgaard, Philip Sassene, Huiling Mu, Thomas Rades, Anette Müllertz. Development of a high-throughput in vitro intestinal lipolysis model for rapid screening of lipid-based drug delivery systems.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2015 Aug; 94(?):493-500. doi:
10.1016/j.ejpb.2015.06.028. [PMID: 26159837] - Marc A Riedl. Critical appraisal of androgen use in hereditary angioedema: a systematic review.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2015 Apr; 114(4):281-288.e7. doi:
10.1016/j.anai.2015.01.003. [PMID: 25707325] - George A Vilos, Jennifer L Marks-Adams, Angelos G Vilos, Ayman Oraif, Basim Abu-Rafea, Robert F Casper. Medical treatment of ureteral obstruction associated with ovarian remnants and/or endometriosis: report of three cases and review of the literature.
Journal of minimally invasive gynecology.
2015 Mar; 22(3):462-8. doi:
10.1016/j.jmig.2014.12.153. [PMID: 25533869] - Henriette Farkas, Kinga Viktoria Kohalmi, Nora Veszeli, Zsuzsanna Zotter, Lilian Varga. Successful prophylaxis with recombinant human C1 inhibitor in a patient with hereditary angioedema.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2015 Jan; 114(1):64-5. doi:
10.1016/j.anai.2014.10.002. [PMID: 25454013] - Azadeh Alinaghi, Angel Tan, Shasha Rao, Clive A Prestidge. Impact of solidification on the performance of lipid-based colloidal carriers: oil-based versus self-emulsifying systems.
Current drug delivery.
2015; 12(1):16-25. doi:
10.2174/1567201811666140716122644. [PMID: 25030115] - Verena Gounden, Diala El-Maouche, Brian R Stolze, Ranganath Muniyappa, Steven J Soldin. LC-MS/MS detection of increased androstenedione levels in patients receiving danazol therapy.
Therapeutic drug monitoring.
2014 Dec; 36(6):828-9. doi:
10.1097/ftd.0000000000000086. [PMID: 24819967] - Mette U Anby, Tri-Hung Nguyen, Yan Yan Yeap, Orlagh M Feeney, Hywel D Williams, Hassan Benameur, Colin W Pouton, Christopher J H Porter. An in vitro digestion test that reflects rat intestinal conditions to probe the importance of formulation digestion vs first pass metabolism in Danazol bioavailability from lipid based formulations.
Molecular pharmaceutics.
2014 Nov; 11(11):4069-83. doi:
10.1021/mp500197b. [PMID: 25265395] - Philip Sassene, Karen Kleberg, Hywel D Williams, Jean-Claude Bakala-N'Goma, Frédéric Carrière, Marilyn Calderone, Vincent Jannin, Annabel Igonin, Anette Partheil, Delphine Marchaud, Eduardo Jule, Jan Vertommen, Mario Maio, Ross Blundell, Hassan Benameur, Christopher J H Porter, Colin W Pouton, Anette Müllertz. Toward the establishment of standardized in vitro tests for lipid-based formulations, part 6: effects of varying pancreatin and calcium levels.
The AAPS journal.
2014 Nov; 16(6):1344-57. doi:
10.1208/s12248-014-9672-x. [PMID: 25274609] - Orlagh M Feeney, Hywel D Williams, Colin W Pouton, Christopher J H Porter. 'Stealth' lipid-based formulations: poly(ethylene glycol)-mediated digestion inhibition improves oral bioavailability of a model poorly water soluble drug.
Journal of controlled release : official journal of the Controlled Release Society.
2014 Oct; 192(?):219-27. doi:
10.1016/j.jconrel.2014.07.037. [PMID: 25058571] - Eun Ju Cho, Ha Jung Lee, Kyung Un Park, Uk-Yeon Kim, Hak Jong Lee, Soo Mee Bang. Immune thrombocytopenic purpura in a patient with renal cell carcinoma.
The Korean journal of internal medicine.
2014 Sep; 29(5):671-4. doi:
10.3904/kjim.2014.29.5.671. [PMID: 25228845] - Maya K Nanda, Umesh Singh, Joyce Wilmot, Jonathan A Bernstein. A cross-sectional questionnaire assessing patient and physician use of short-term prophylaxis for hereditary angioedema.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2014 Aug; 113(2):198-203. doi:
10.1016/j.anai.2014.05.009. [PMID: 24928306] - Mette U Anby, Hywel D Williams, Orlagh Feeney, Glenn A Edwards, Hassan Benameur, Colin W Pouton, Christopher J H Porter. Non-linear increases in danazol exposure with dose in older vs. younger beagle dogs: the potential role of differences in bile salt concentration, thermodynamic activity, and formulation digestion.
Pharmaceutical research.
2014 Jun; 31(6):1536-52. doi:
10.1007/s11095-013-1260-8. [PMID: 24477676] - Amani M Marzouk, Galal T Maatooq. Microbial metabolism of danazol: a contribution to doping analysis.
Zeitschrift fur Naturforschung. C, Journal of biosciences.
2014 May; 69(5-6):245-52. doi:
10.5560/znc.2013-0135. [PMID: 25069163] - Murat Kilic, Jennifer Dressman. A simplified method to screen for in-vivo performance of oral lipid formulations.
The Journal of pharmacy and pharmacology.
2014 May; 66(5):615-23. doi:
10.1111/jphp.12182. [PMID: 24313318] - Ravi Devraj, Hywel D Williams, Dallas B Warren, Christopher J H Porter, Colin W Pouton. Choice of nonionic surfactant used to formulate type IIIA self-emulsifying drug delivery systems and the physicochemical properties of the drug have a pronounced influence on the degree of drug supersaturation that develops during in vitro digestion.
Journal of pharmaceutical sciences.
2014 Apr; 103(4):1050-63. doi:
10.1002/jps.23856. [PMID: 24470073] - M Szubert, J Suzin, M Duechler, A Szuławska, M Czyż, K Kowalczyk-Amico. Evaluation of selected angiogenic and inflammatory markers in endometriosis before and after danazol treatment.
Reproduction, fertility, and development.
2014 Mar; 26(3):414-20. doi:
10.1071/rd12258. [PMID: 23544741] - Hywel D Williams, Yasemin Sahbaz, Leigh Ford, Tri-Hung Nguyen, Peter J Scammells, Christopher J H Porter. Ionic liquids provide unique opportunities for oral drug delivery: structure optimization and in vivo evidence of utility.
Chemical communications (Cambridge, England).
2014 Feb; 50(14):1688-90. doi:
10.1039/c3cc48650h. [PMID: 24394756] - Constantinos Markopoulos, Georgios Imanidis, Maria Vertzoni, Mira Symillides, Neil Parrott, Christos Reppas. In vitro and ex vivo investigation of the impact of luminal lipid phases on passive permeability of lipophilic small molecules using PAMPA.
Pharmaceutical research.
2013 Dec; 30(12):3145-53. doi:
10.1007/s11095-013-1141-1. [PMID: 23893021] - Yan Yan Yeap, Natalie L Trevaskis, Christopher J H Porter. The potential for drug supersaturation during intestinal processing of lipid-based formulations may be enhanced for basic drugs.
Molecular pharmaceutics.
2013 Jul; 10(7):2601-15. doi:
10.1021/mp400035z. [PMID: 23697606] - Ravi Devraj, Hywel D Williams, Dallas B Warren, Anette Mullertz, Christopher J H Porter, Colin W Pouton. In vitro digestion testing of lipid-based delivery systems: calcium ions combine with fatty acids liberated from triglyceride rich lipid solutions to form soaps and reduce the solubilization capacity of colloidal digestion products.
International journal of pharmaceutics.
2013 Jan; 441(1-2):323-33. doi:
10.1016/j.ijpharm.2012.11.024. [PMID: 23178598] - Terry Gernsheimer, Andra H James, Roberto Stasi. How I treat thrombocytopenia in pregnancy.
Blood.
2013 Jan; 121(1):38-47. doi:
10.1182/blood-2012-08-448944. [PMID: 23149846] - Hywel D Williams, Mette U Anby, Philip Sassene, Karen Kleberg, Jean-Claude Bakala-N'Goma, Marilyn Calderone, Vincent Jannin, Annabel Igonin, Anette Partheil, Delphine Marchaud, Eduardo Jule, Jan Vertommen, Mario Maio, Ross Blundell, Hassan Benameur, Frédéric Carrière, Anette Müllertz, Colin W Pouton, Christopher J H Porter. Toward the establishment of standardized in vitro tests for lipid-based formulations. 2. The effect of bile salt concentration and drug loading on the performance of type I, II, IIIA, IIIB, and IV formulations during in vitro digestion.
Molecular pharmaceutics.
2012 Nov; 9(11):3286-300. doi:
10.1021/mp300331z. [PMID: 23030411] - Johannes Parmentier, Nicky Thomas, Anette Müllertz, Gert Fricker, Thomas Rades. Exploring the fate of liposomes in the intestine by dynamic in vitro lipolysis.
International journal of pharmaceutics.
2012 Nov; 437(1-2):253-63. doi:
10.1016/j.ijpharm.2012.08.018. [PMID: 22939968] - Michiel Van Speybroeck, Hywel D Williams, Tri-Hung Nguyen, Mette U Anby, Christopher J H Porter, Patrick Augustijns. Incomplete desorption of liquid excipients reduces the in vitro and in vivo performance of self-emulsifying drug delivery systems solidified by adsorption onto an inorganic mesoporous carrier.
Molecular pharmaceutics.
2012 Sep; 9(9):2750-60. doi:
10.1021/mp300298z. [PMID: 22870936] - Hywel D Williams, Philip Sassene, Karen Kleberg, Jean-Claude Bakala-N'Goma, Marilyn Calderone, Vincent Jannin, Annabel Igonin, Anette Partheil, Delphine Marchaud, Eduardo Jule, Jan Vertommen, Mario Maio, Ross Blundell, Hassan Benameur, Frédéric Carrière, Anette Müllertz, Christopher J H Porter, Colin W Pouton. Toward the establishment of standardized in vitro tests for lipid-based formulations, part 1: method parameterization and comparison of in vitro digestion profiles across a range of representative formulations.
Journal of pharmaceutical sciences.
2012 Sep; 101(9):3360-80. doi:
10.1002/jps.23205. [PMID: 22644939] - Konrad Bork. Current management options for hereditary angioedema.
Current allergy and asthma reports.
2012 Aug; 12(4):273-80. doi:
10.1007/s11882-012-0273-4. [PMID: 22729959] - Jie Zou, Zheng Guan, Wei-yi Zhang. [Comparison of the effects of sanjie zhentong capsule and danazol on the endometriosis rats].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2012 Aug; 32(8):1112-6. doi:
NULL. [PMID: 23173264] - Mette U Anby, Hywel D Williams, Michelle McIntosh, Hassan Benameur, Glenn A Edwards, Colin W Pouton, Christopher J H Porter. Lipid digestion as a trigger for supersaturation: evaluation of the impact of supersaturation stabilization on the in vitro and in vivo performance of self-emulsifying drug delivery systems.
Molecular pharmaceutics.
2012 Jul; 9(7):2063-79. doi:
10.1021/mp300164u. [PMID: 22656917] - Andrew Flower, Jian Ping Liu, George Lewith, Paul Little, Qing Li. Chinese herbal medicine for endometriosis.
The Cochrane database of systematic reviews.
2012 May; ?(5):CD006568. doi:
10.1002/14651858.cd006568.pub3. [PMID: 22592712] - Maria Vertzoni, Constantinos Markopoulos, Moira Symillides, Constantinos Goumas, Georgios Imanidis, Christos Reppas. Luminal lipid phases after administration of a triglyceride solution of danazol in the fed state and their contribution to the flux of danazol across Caco-2 cell monolayers.
Molecular pharmaceutics.
2012 May; 9(5):1189-98. doi:
10.1021/mp200479f. [PMID: 22482927] - Michael Linn, Eva-Maria Collnot, Dejan Djuric, Katja Hempel, Eric Fabian, Karl Kolter, Claus-Michael Lehr. Soluplus® as an effective absorption enhancer of poorly soluble drugs in vitro and in vivo.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2012 Feb; 45(3):336-43. doi:
10.1016/j.ejps.2011.11.025. [PMID: 22172603] - Hetal N Prajapati, Damon M Dalrymple, Abu T M Serajuddin. A comparative evaluation of mono-, di- and triglyceride of medium chain fatty acids by lipid/surfactant/water phase diagram, solubility determination and dispersion testing for application in pharmaceutical dosage form development.
Pharmaceutical research.
2012 Jan; 29(1):285-305. doi:
10.1007/s11095-011-0541-3. [PMID: 21861203] - Zan-Hua Zhou, Qing Weng, Jian-Hong Zhou, Jue Zhou. Extracts of Salvia miltiorrhiza Bunge on the cytokines of rat endometriosis models.
African journal of traditional, complementary, and alternative medicines : AJTCAM.
2012; 9(3):303-14. doi:
10.4314/ajtcam.v9i3.2. [PMID: 23983360] - Paula Lehto, Hanna Kortejärvi, Anni Liimatainen, Krista Ojala, Heli Kangas, Jouni Hirvonen, Veli Pekka Tanninen, Leena Peltonen. Use of conventional surfactant media as surrogates for FaSSIF in simulating in vivo dissolution of BCS class II drugs.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2011 Aug; 78(3):531-8. doi:
10.1016/j.ejpb.2011.02.007. [PMID: 21329757] - Michael M Frank. Update on preventive therapy (prophylaxis) of hereditary angioedema.
Allergy and asthma proceedings.
2011 Jan; 32(1):17-21. doi:
10.2500/aap.2011.32.3412. [PMID: 21262094] - Rafael Firszt, Michael M Frank. An overview of novel therapies for acute hereditary angioedema.
American journal of clinical dermatology.
2010 Dec; 11(6):383-8. doi:
10.2165/11537030-000000000-00000. [PMID: 20866113] - Dallas B Warren, Hassan Benameur, Christopher J H Porter, Colin W Pouton. Using polymeric precipitation inhibitors to improve the absorption of poorly water-soluble drugs: A mechanistic basis for utility.
Journal of drug targeting.
2010 Dec; 18(10):704-31. doi:
10.3109/1061186x.2010.525652. [PMID: 20973755] - Hua Yi, Yue Lu, Jian-kun Chen, Biao-yan Du, Ai-jun Liu, Hui Luo. [Effect of sinomenine on tumor necrosis factor-alpha and nuclear factor-kappaB in the heterotopic tissue in rats with endometriosis].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2010 Aug; 30(8):1874-6. doi:
". [PMID: 20813690] - Ivan Stankovic, Alja Vlahovic-Stipac, Biljana Putnikovic, Zorica Cvetkovic, Aleksandar N Neskovic. Concomitant administration of simvastatin and danazol associated with fatal rhabdomyolysis.
Clinical therapeutics.
2010 May; 32(5):909-14. doi:
10.1016/j.clinthera.2010.04.017. [PMID: 20685498] - Renata Simões Moraes, Aurea Simone Barros Vieira, Laura Guimarães Primo. Management of a dentigerous cyst in a child with hereditary angioedema.
Journal of dentistry for children (Chicago, Ill.).
2010 Jan; 77(1):59-63. doi:
NULL. [PMID: 20359432] - Stefano Luisi, Sandro Razzi, Lucia Lazzeri, Caterina Bocchi, Filiberto M Severi, Felice Petraglia. Efficacy of vaginal danazol treatment in women with menorrhagia during fertile age.
Fertility and sterility.
2009 Oct; 92(4):1351-1354. doi:
10.1016/j.fertnstert.2008.08.017. [PMID: 18930222] - Wolfhart Kreuz, Inmaculada Martinez-Saguer, Emel Aygören-Pürsün, Eva Rusicke, Christine Heller, Thomas Klingebiel. C1-inhibitor concentrate for individual replacement therapy in patients with severe hereditary angioedema refractory to danazol prophylaxis.
Transfusion.
2009 Sep; 49(9):1987-95. doi:
10.1111/j.1537-2995.2009.02230.x. [PMID: 19497056] - Hongbo Wang, Nowiah Gorpudolo, Barry Behr. The role of prolactin- and endometriosis-associated infertility.
Obstetrical & gynecological survey.
2009 Aug; 64(8):542-7. doi:
10.1097/ogx.0b013e3181ab5479. [PMID: 19624865] - Konrad Bork. Hereditary angioedema with normal c1 inhibition.
Current allergy and asthma reports.
2009 Jul; 9(4):280-5. doi:
10.1007/s11882-009-0039-9. [PMID: 19656474] - Anne Larsen, René Holm, Mette Lund Pedersen, Anette Müllertz. Lipid-based formulations for danazol containing a digestible surfactant, Labrafil M2125CS: in vivo bioavailability and dynamic in vitro lipolysis.
Pharmaceutical research.
2008 Dec; 25(12):2769-77. doi:
10.1007/s11095-008-9641-0. [PMID: 18592356] - Rakesh S Birjmohun, G Kees Hovingh, Erik S G Stroes, Jorit J Hofstra, Geesje M Dallinga-Thie, Joost C M Meijers, John J P Kastelein, Marcel Levi. Effects of short-term and long-term danazol treatment on lipoproteins, coagulation, and progression of atherosclerosis: two clinical trials in healthy volunteers and patients with hereditary angioedema.
Clinical therapeutics.
2008 Dec; 30(12):2314-23. doi:
10.1016/j.clinthera.2008.12.021. [PMID: 19167590] - Xinmei Zhang, Hong Yuan, Lin Deng, Fuqiang Hu, Junyan Ma, Jun Lin. Evaluation of the efficacy of a danazol-loaded intrauterine contraceptive device on adenomyosis in an ICR mouse model.
Human reproduction (Oxford, England).
2008 Sep; 23(9):2024-30. doi:
10.1093/humrep/den208. [PMID: 18552364] - E M Persson, A Nordgren, P Forsell, L Knutson, C Ohgren, S Forssén, H Lennernäs, B Abrahamsson. Improved understanding of the effect of food on drug absorption and bioavailability for lipophilic compounds using an intestinal pig perfusion model.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2008 May; 34(1):22-9. doi:
10.1016/j.ejps.2008.02.002. [PMID: 18387789] - Timothy J Craig. Appraisal of danazol prophylaxis for hereditary angioedema.
Allergy and asthma proceedings.
2008 May; 29(3):225-31. doi:
10.2500/aap.2008.29.3107. [PMID: 18387221] - Róbert Szegedi, Gábor Széplaki, Lilian Varga, Zoltán Prohászka, Zoltán Széplaki, István Karádi, George Füst, Henriette Farkas. Long-term danazol prophylaxis does not lead to increased carotid intima-media thickness in hereditary angioedema patients.
Atherosclerosis.
2008 May; 198(1):184-91. doi:
10.1016/j.atherosclerosis.2007.09.025. [PMID: 17977544] - Jean F Cuiné, Claire L McEvoy, William N Charman, Colin W Pouton, Glenn A Edwards, Hassan Benameur, Christopher J H Porter. Evaluation of the impact of surfactant digestion on the bioavailability of danazol after oral administration of lipidic self-emulsifying formulations to dogs.
Journal of pharmaceutical sciences.
2008 Feb; 97(2):995-1012. doi:
10.1002/jps.21246. [PMID: 18064698] - Aleena Banerji, David E Sloane, Albert L Sheffer. Hereditary angioedema: a current state-of-the-art review, V: attenuated androgens for the treatment of hereditary angioedema.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2008 Jan; 100(1 Suppl 2):S19-22. doi:
10.1016/s1081-1206(10)60582-0. [PMID: 18220148] - Pierre Philippe. [Autoimmune hemolytic anemia: diagnosis and management].
Presse medicale (Paris, France : 1983).
2007 Dec; 36(12 Pt 3):1959-69. doi:
10.1016/j.lpm.2007.03.035. [PMID: 17481848] - V Thon, P Härle, J Schölmerich, P Kuklinek, J Lokaj, R H Straub. Lack of dehydroepiandrosterone in type I and II hereditary angioedema and role of danazol in steroid hormone conversion.
Allergy.
2007 Nov; 62(11):1320-5. doi:
10.1111/j.1398-9995.2007.01477.x. [PMID: 17919148] - Lilian Varga, Adrienn Bíró, Gábor Széplaki, Luca Tóth, Anna Horváth, George Füst, Henriette Farkas. Anti-cholesterol antibody levels in hereditary angioedema.
Journal of cellular and molecular medicine.
2007 Nov; 11(6):1377-83. doi:
10.1111/j.1582-4934.2007.00124.x. [PMID: 18205707] - Cheng-Zhi Lei, Yang Xiang, Guo-Kun Ao, Li Li, Ying-Chang Shi, Yi-Rong Bao, Cong-Jian Xu, Hong Hong, Jing-He Lang. [Impact of uterine fibroid embolization with danazol alginate microsphere on ovarian function and subsequent pregnancy].
Zhonghua fu chan ke za zhi.
2007 Oct; 42(10):701-4. doi:
. [PMID: 18241548] - Sandro Razzi, Stefano Luisi, Francesco Calonaci, Aldo Altomare, Caterina Bocchi, Felice Petraglia. Efficacy of vaginal danazol treatment in women with recurrent deeply infiltrating endometriosis.
Fertility and sterility.
2007 Oct; 88(4):789-94. doi:
10.1016/j.fertnstert.2006.12.077. [PMID: 17544421] - A Srivastava, R E Mansel, N Arvind, K Prasad, A Dhar, A Chabra. Evidence-based management of Mastalgia: a meta-analysis of randomised trials.
Breast (Edinburgh, Scotland).
2007 Oct; 16(5):503-12. doi:
10.1016/j.breast.2007.03.003. [PMID: 17509880] - J Pedraz, E Daudén, A García-Diez. [Practical management of C1 inhibitor deficiency].
Actas dermo-sifiliograficas.
2007 May; 98(4):240-9. doi:
10.1016/s1578-2190(07)70437-7. [PMID: 17506955] - Jean F Cuiné, William N Charman, Colin W Pouton, Glenn A Edwards, Christopher J H Porter. Increasing the proportional content of surfactant (Cremophor EL) relative to lipid in self-emulsifying lipid-based formulations of danazol reduces oral bioavailability in beagle dogs.
Pharmaceutical research.
2007 Apr; 24(4):748-57. doi:
10.1007/s11095-006-9194-z. [PMID: 17372700] - Ken Kusakabe, Shoko Morishima, Nobuaki Nakamuta, Zhong-Lian Li, Yoshinori Otsuki. Effect of danazol on NK cells and cytokines in the mouse uterus.
The Journal of reproduction and development.
2007 Feb; 53(1):87-94. doi:
10.1262/jrd.18074. [PMID: 17077583] - Michael M Sachse, Amor Khachemoune, Kjetil K Guldbakke, Michael Kirschfink. Hereditary angioedema.
Journal of drugs in dermatology : JDD.
2006 Oct; 5(9):848-52. doi:
NULL. [PMID: 17039649] - Cecilia Yvonne García Cobas, Sandra N González Díaz, Alfredo Arias Cruz, Alejandra Macías Weinman, María del Carmen Zárate Hernández. [Atypical presentation of hereditary angioedema. A report of a case and literature review].
Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993).
2006 Sep; 53(5):189-93. doi:
NULL. [PMID: 17357566] - Kazuhito Nomura, Koichi Murakami, Makio Shozu, Tsuyoshi Nakama, Nobuhiko Yui, Masaki Inoue. Local application of danazol-loaded hyaluronic acid hydrogel to endometriosis in a rat model.
Fertility and sterility.
2006 Apr; 85 Suppl 1(?):1157-67. doi:
10.1016/j.fertnstert.2005.08.057. [PMID: 16616088] - Rodny Montes de Oca Porto, Ariana Rodríguez Fernández, Dayamín Martínez Brito, Teresa Correa Vidal, Ahiram Lopez Diaz. Gas chromatography/mass spectrometry characterization of urinary metabolites of danazol after oral administration in human.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Jan; 830(1):178-83. doi:
10.1016/j.jchromb.2005.10.032. [PMID: 16288903] - N Jiménez Saab, J Gómez Vera, J López Tiro, S Nieto Martínez, C Pliego Reyes. [Hereditary angioedema. A report of a case and literature review].
Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993).
2006 Jan; 53(1):34-41. doi:
NULL. [PMID: 16634360] - Zhanzhuang Tian, Hong Zhao, Yan Sun, Depei Cai, Boying Chen. Evaluation of the true precocious puberty rats induced by neonatal administration of Danazol: therapeutic effects of nourishing 'Yin'-Removing 'Fire' Chinese herb mixture.
Reproductive biology and endocrinology : RB&E.
2005 Aug; 3(?):38. doi:
10.1186/1477-7827-3-38. [PMID: 16111504] - Maike P Tiede, Eugene R Ahn, Wenche Jy, Thomas Scagnelli, Carlos J Bidot, Lawrence L Horstman, Joaquin J Jimenez, Yeon S Ahn. Life-threatening hypercoagulable state following splenectomy in ITP: successful management with aggressive antithrombotic therapy and danazol.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.
2005 Jul; 11(3):347-52. doi:
10.1177/107602960501100316. [PMID: 16015423] - Ming-Huei Cheng, Bill Ken-Jen Yu, Sheng-Ping Chang, Peng-Hui Wang. A randomized, parallel, comparative study of the efficacy and safety of nafarelin versus danazol in the treatment of endometriosis in Taiwan.
Journal of the Chinese Medical Association : JCMA.
2005 Jul; 68(7):307-14. doi:
10.1016/s1726-4901(09)70166-2. [PMID: 16038370] - R Todd Stravitz, Harold Chung, Richard K Sterling, Velimir A Luketic, Arun J Sanyal, Angie S Price, Amy Purrington, Mitchell L Shiffman. Antibody-mediated pure red cell aplasia due to epoetin alfa during antiviral therapy of chronic hepatitis C.
The American journal of gastroenterology.
2005 Jun; 100(6):1415-9. doi:
10.1111/j.1572-0241.2005.41910.x. [PMID: 15929778] - Gábor Széplaki, Lilian Varga, Szilvia Valentin, Mónika Kleiber, István Karádi, László Romics, George Füst, Henriette Farkas. Adverse effects of danazol prophylaxis on the lipid profiles of patients with hereditary angioedema.
The Journal of allergy and clinical immunology.
2005 Apr; 115(4):864-9. doi:
10.1016/j.jaci.2004.12.1130. [PMID: 15806011] - Vibeke Hougaard Sunesen, Rune Vedelsdal, Henning Gjelstrup Kristensen, Lona Christrup, Anette Müllertz. Effect of liquid volume and food intake on the absolute bioavailability of danazol, a poorly soluble drug.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2005 Mar; 24(4):297-303. doi:
10.1016/j.ejps.2004.11.005. [PMID: 15734296] - M Al-Omar, A Al-Majed, M Sultan, E A Gadkariem, F Belal. Voltammetric study of danazol and its determination in capsules and spiked biological fluids.
Journal of pharmaceutical and biomedical analysis.
2005 Feb; 37(1):199-204. doi:
10.1016/j.jpba.2004.10.011. [PMID: 15664763] - Hua-jun Li, Jin-hua Leng, Jing-he Lang, Hui-lan Wang, Zhu-feng Liu, Da-wei Sun, Lan Zhu, Xiao-man Ding. [Correlative factors analysis of recurrence of endometriosis after conservative surgery].
Zhonghua fu chan ke za zhi.
2005 Jan; 40(1):13-6. doi:
. [PMID: 15774085] - S Gaur, J Cooley, L Aish, R Weinstein. Lymphoma-associated paraneoplastic angioedema with normal C1-inhibitor activity: does danazol work?.
American journal of hematology.
2004 Nov; 77(3):296-8. doi:
10.1002/ajh.20195. [PMID: 15495244] - Christopher J H Porter, Ann Marie Kaukonen, Ben J Boyd, Glenn A Edwards, William N Charman. Susceptibility to lipase-mediated digestion reduces the oral bioavailability of danazol after administration as a medium-chain lipid-based microemulsion formulation.
Pharmaceutical research.
2004 Aug; 21(8):1405-12. doi:
10.1023/b:pham.0000036914.22132.cc. [PMID: 15359575]