N-amidinoaspartic acid (BioDeep_00001876369)

   


代谢物信息卡片


N-amidinoaspartic acid

化学式: C5H9N3O4 (175.0593034)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C(C(=O)O)N=C(N)N)C(=O)O
InChI: InChI=1S/C5H9N3O4/c6-5(7)8-2(4(11)12)1-3(9)10/h2H,1H2,(H,9,10)(H,11,12)(H4,6,7,8)

描述信息

同义名列表

1 个代谢物同义名

N-amidinoaspartic acid



数据库引用编号

2 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Mahim I Qureshi, Michele Greco, Panagiotis A Vorkas, Elaine Holmes, Alun H Davies. Application of Metabolic Profiling to Abdominal Aortic Aneurysm Research. Journal of proteome research. 2017 07; 16(7):2325-2332. doi: 10.1021/acs.jproteome.6b00894. [PMID: 28287739]
  • Liqiang Gu, Xiaofan Wang, Yuanyuan Zhang, Yu Jiang, Huan Lu, Kaishun Bi, Xiaohui Chen. Determination of 12 potential nephrotoxicity biomarkers in rat serum and urine by liquid chromatography with mass spectrometry and its application to renal failure induced by Semen Strychni. Journal of separation science. 2014 May; 37(9-10):1058-66. doi: 10.1002/jssc.201400053. [PMID: 24610835]
  • S A Majidano, M Y Khuhawar. Gas chromatographic determination of guanidino compounds in uremic patients using glyoxal as derivatizing reagent. Journal of chromatographic science. 2012 May; 50(5):380-6. doi: 10.1093/chromsci/bms013. [PMID: 22392369]
  • Masanori Tachikawa, Saori Ikeda, Jun Fujinawa, Shirou Hirose, Shin-ichi Akanuma, Ken-ichi Hosoya. γ-Aminobutyric acid transporter 2 mediates the hepatic uptake of guanidinoacetate, the creatine biosynthetic precursor, in rats. PloS one. 2012; 7(2):e32557. doi: 10.1371/journal.pone.0032557. [PMID: 22384273]
  • Michal Ciborowski, Joanna Teul, Jose Luis Martin-Ventura, Jesús Egido, Coral Barbas. Metabolomics with LC-QTOF-MS permits the prediction of disease stage in aortic abdominal aneurysm based on plasma metabolic fingerprint. PloS one. 2012; 7(2):e31982. doi: 10.1371/journal.pone.0031982. [PMID: 22384120]
  • Takafumi Toyohara, Takaaki Abe. [Analysis of transporter function and development to clinical application]. Seikagaku. The Journal of Japanese Biochemical Society. 2011 Apr; 83(4):323-8. doi: NULL. [PMID: 21626887]
  • Daisuke Saigusa, Naoto Suzuki, Mai Takahashi, Kanako Shiba, Satoshi Tanaka, Takaaki Abe, Takanori Hishinuma, Yoshihisa Tomioka. Simultaneous determination of guanidinosuccinic acid and guanidinoacetic acid in urine using high performance liquid chromatography/tandem mass spectrometry. Analytica chimica acta. 2010 Sep; 677(2):169-75. doi: 10.1016/j.aca.2010.08.005. [PMID: 20837184]
  • Eva Schepers, Griet Glorieux, Laetitia Dou, Claire Cerini, Nathalie Gayrard, Loïc Louvet, Charlotte Maugard, Pierre Preus, Maria Rodriguez-Ortiz, Angel Argiles, Philippe Brunet, Gerald Cohen, Joachim Jankowski, Vera Jankowski, Ziad Massy, Mariano Rodriguez, Raymond Vanholder. Guanidino compounds as cause of cardiovascular damage in chronic kidney disease: an in vitro evaluation. Blood purification. 2010; 30(4):277-87. doi: 10.1159/000320765. [PMID: 21079396]
  • Min Fu, Zhao-Hui Sun, Huan-Cong Zuo. Neuroprotective effect of piperine on primarily cultured hippocampal neurons. Biological & pharmaceutical bulletin. 2010; 33(4):598-603. doi: 10.1248/bpb.33.598. [PMID: 20410592]
  • Kazuharu Ienaga, Hiroki Mikami, Takako Yokozawa. First indications demonstrating the preventive effects of NZ-419, a novel intrinsic antioxidant, on the initiation and/or progression of chronic renal failure in rats. Biological & pharmaceutical bulletin. 2009 Jul; 32(7):1204-8. doi: 10.1248/bpb.32.1204. [PMID: 19571386]
  • Don J Durzan. Arginine, scurvy and Cartier's 'tree of life'. Journal of ethnobiology and ethnomedicine. 2009 Feb; 5(?):5. doi: 10.1186/1746-4269-5-5. [PMID: 19187550]
  • Olivier Levillain, Bart Marescau, Ilse Possemiers, Peter Paul De Deyn. Accumulation of methylguanidine and changes in guanidino compound levels in plasma, urine, and kidneys of furosemide-treated rats. Metabolism: clinical and experimental. 2008 Jun; 57(6):802-10. doi: 10.1016/j.metabol.2008.01.025. [PMID: 18502263]
  • Youri E C Taes, Bart Marescau, An De Vriese, Peter P De Deyn, Eva Schepers, Raymond Vanholder, Joris R Delanghe. Guanidino compounds after creatine supplementation in renal failure patients and their relation to inflammatory status. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2008 Apr; 23(4):1330-5. doi: 10.1093/ndt/gfm793. [PMID: 18048424]
  • Burton D Cohen. Premature aging in uremia. Molecular and cellular biochemistry. 2007 Apr; 298(1-2):195-8. doi: 10.1007/s11010-006-9351-z. [PMID: 17136440]
  • R Gatti, M G Gioia. Anisoin: a useful pre-chromatographic derivatization fluorogenic reagent for LC analysis of guanidino compounds. Journal of pharmaceutical and biomedical analysis. 2006 Sep; 42(1):11-6. doi: 10.1016/j.jpba.2005.12.035. [PMID: 16460903]
  • A Torremans, B Marescau, B Kränzlin, N Gretz, J-M Billiouw, R Vanholder, R De Smet, K Bouwman, R Brouns, P P De Deyn. Biochemical validation of a rat model for polycystic kidney disease: comparison of guanidino compound profile with the human condition. Kidney international. 2006 Jun; 69(11):2003-12. doi: 10.1038/sj.ki.5000443. [PMID: 16641922]
  • R O Law. Cerebrocellular swelling in the presence of uraemic guanidino compounds: ameliorative effects of taurine. Neurochemical research. 2005 Dec; 30(12):1465-70. doi: 10.1007/s11064-005-8823-y. [PMID: 16362765]
  • Sunny Eloot, An Torremans, Rita De Smet, Bart Marescau, Dirk De Wachter, Peter Paul De Deyn, Norbert Lameire, Pascal Verdonck, Raymond Vanholder. Kinetic behavior of urea is different from that of other water-soluble compounds: the case of the guanidino compounds. Kidney international. 2005 Apr; 67(4):1566-75. doi: 10.1111/j.1523-1755.2005.00238.x. [PMID: 15780113]
  • Birgitta C Burckhardt, Julia Lorenz, Christoph Kobbe, Gerhard Burckhardt. Substrate specificity of the human renal sodium dicarboxylate cotransporter, hNaDC-3, under voltage-clamp conditions. American journal of physiology. Renal physiology. 2005 Apr; 288(4):F792-9. doi: 10.1152/ajprenal.00360.2004. [PMID: 15561973]
  • An Torremans, Bart Marescau, Debby Van Dam, Chris Van Ginneken, Frans Van Meir, Pierre-Paul Van Bogaert, Rudi D'Hooge, Jan de Vente, Peter Paul De Deyn. GSA: behavioral, histological, electrophysiological and neurochemical effects. Physiology & behavior. 2005 Feb; 84(2):251-64. doi: 10.1016/j.physbeh.2004.12.001. [PMID: 15708777]
  • Wim Derave, Bart Marescau, Els Vanden Eede, Bert O Eijnde, Peter P De Deyn, Peter Hespel. Plasma guanidino compounds are altered by oral creatine supplementation in healthy humans. Journal of applied physiology (Bethesda, Md. : 1985). 2004 Sep; 97(3):852-7. doi: 10.1152/japplphysiol.00206.2004. [PMID: 15107411]
  • Griet L Glorieux, Annemieke W Dhondt, Peter Jacobs, Joke Van Langeraert, Norbert H Lameire, Peter Paul De Deyn, Raymond C Vanholder. In vitro study of the potential role of guanidines in leukocyte functions related to atherogenesis and infection. Kidney international. 2004 Jun; 65(6):2184-92. doi: 10.1111/j.1523-1755.2004.00631.x. [PMID: 15149331]
  • Rudi D'Hooge, Gerda Van de Vijver, Pierre-Paul Van Bogaert, Bart Marescau, Raymond Vanholder, Peter P De Deyn. Involvement of voltage- and ligand-gated Ca2+ channels in the neuroexcitatory and synergistic effects of putative uremic neurotoxins. Kidney international. 2003 May; 63(5):1764-75. doi: 10.1046/j.1523-1755.2003.00912.x. [PMID: 12675852]
  • Burton D Cohen. Methyl group deficiency and guanidino production in uremia. Molecular and cellular biochemistry. 2003 Feb; 244(1-2):31-6. doi: . [PMID: 12701806]
  • Kazumasa Aoyagi. Inhibition of arginine synthesis by urea: a mechanism for arginine deficiency in renal failure which leads to increased hydroxyl radical generation. Molecular and cellular biochemistry. 2003 Feb; 244(1-2):11-5. doi: NULL. [PMID: 12701804]
  • Olivier Levillain, Bart Marescau, Ilse Possemiers, Paul De Deyn. Dehydration modifies guanidino compound concentrations in the different zones of the rat kidney. Pflugers Archiv : European journal of physiology. 2002 May; 444(1-2):143-52. doi: 10.1007/s00424-002-0787-z. [PMID: 11976926]
  • M Al Banchaabouchi, B Marescau, R D'Hooge, P P De Deyn. The effect of high protein diet on urea and guanidino compound levels in renal insufficient mice. Amino acids. 2001 Dec; 21(4):401-15. doi: 10.1007/s007260170005. [PMID: 11858699]
  • M Al Banchaabouchi, B Marescau, E Van Marck, R D'hooge, P P De Deyn. Long-term effect of partial nephrectomy on biological parameters, kidney histology, and guanidino compound levels in mice. Metabolism: clinical and experimental. 2001 Dec; 50(12):1418-25. doi: 10.1053/meta.2001.26763. [PMID: 11735086]
  • I Pietrzak, M Komarnicki, D Zaremba-Drobnik. Platelet aggregation and prostaglandin metabolism in uremic patients. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2001 Oct; 38(4 Suppl 1):S111-4. doi: 10.1053/ajkd.2001.27416. [PMID: 11576934]
  • M J Smogorzewski. Central nervous dysfunction in uremia. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2001 Oct; 38(4 Suppl 1):S122-8. doi: 10.1053/ajkd.2001.27419. [PMID: 11576937]
  • O Levillain, B Marescau, I Possemiers, M Al Banchaabouchi, P P De Deyn. Influence of 72\% injury in one kidney on several organs involved in guanidino compound metabolism: a time course study. Pflugers Archiv : European journal of physiology. 2001 Jul; 442(4):558-69. doi: 10.1007/s004240100581. [PMID: 11510889]
  • P P De Deyn, R D'Hooge, P P Van Bogaert, B Marescau. Endogenous guanidino compounds as uremic neurotoxins. Kidney international. Supplement. 2001 Feb; 78(?):S77-83. doi: 10.1046/j.1523-1755.2001.59780077.x. [PMID: 11168988]
  • K Aoyagi, S Shahrzad, S Iida, C Tomida, A Hirayama, S Nagase, K Takemura, A Koyama, S Ohba, M Narita, B D Cohen. Role of nitric oxide in the synthesis of guanidinosuccinic acid, an activator of the N-methyl-D-aspartate receptor. Kidney international. Supplement. 2001 Feb; 78(?):S93-6. doi: 10.1046/j.1523-1755.2001.59780093.x. [PMID: 11168991]
  • I Pietrzak, K Baczyk. Erythrocyte transketolase activity and guanidino compounds in hemodialysis patients. Kidney international. Supplement. 2001 Feb; 78(?):S97-101. doi: 10.1046/j.1523-1755.2001.59780097.x. [PMID: 11168992]
  • C Parikh, G Gyamlani, N Panlilio, C P Carvounis. Unmeasured cations: probable cause of relatively low anion gap in chronic renal failure. Renal failure. 2001 Jan; 23(1):91-6. doi: 10.1081/jdi-100001288. [PMID: 11256534]
  • M Maejima, S Takahashi, M Hatano. [Platelet aggregation in chronic renal failure--whole blood aggregation and effect of guanidino compounds]. Nihon Jinzo Gakkai shi. 1991 Feb; 33(2):201-12. doi: NULL. [PMID: 2051648]
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