4-amino-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one (BioDeep_00001876296)
代谢物信息卡片
4-amino-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
化学式: C8H12N4O4 (228.08585119999998)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(C(OC1N2C=NC(=NC2=O)N)CO)O
InChI: InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)
描述信息
D009676 - Noxae > D000963 - Antimetabolites
D000970 - Antineoplastic Agents
D004791 - Enzyme Inhibitors
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:95165
- PubChem: 16886
- ChEMBL: CHEMBL117470
- MeSH: Decitabine
- CAS: 22432-95-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- W U Jieya, Hou Li, Zhang Xiaoyuan, Elizabeth Gullen, Gao Chong, Wang Jing. Efficacy of Yisui granule on myelodysplastic syndromes in SKM-1 mouse xenograft model through suppressing Wnt/β-catenin signaling pathway.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2024 Feb; 44(1):78-87. doi:
10.19852/j.cnki.jtcm.20231204.003. [PMID: 38213242] - Liu Liu, Yaqiong Zhou, Dan Luo, Xiaoying Sun, Hongjin Li, Yi Lu, Jiao Wang, Miao Zhang, Naixuan Lin, Chengqian Yin, Xin Li. Aberrant promoter methylation of Wnt inhibitory factor-1 gene is a potential target for treating psoriasis.
Clinical immunology (Orlando, Fla.).
2023 Mar; 250(?):109294. doi:
10.1016/j.clim.2023.109294. [PMID: 36925027] - Yanlong Zhao, Xiaorong Zeng, Xinli Xu, Wenjing Wang, Lei Xu, Yiying Wu, Hang Li. Low-dose 5-aza-2'-deoxycytidine protects against early renal injury by increasing klotho expression.
Epigenomics.
2022 11; 14(22):1411-1425. doi:
10.2217/epi-2022-0430. [PMID: 36695107] - Yadi Xu, Zelin Li, Tian Huai, Xiuhao Huo, Hongliang Wang, Erbao Bian, Bing Zhao. DNMT1 Mediated CAHM Repression Promotes Glioma Invasion via SPAK/JNK Pathway.
Cellular and molecular neurobiology.
2022 Nov; 42(8):2643-2653. doi:
10.1007/s10571-021-01125-z. [PMID: 34227028] - Congmeng Lin, Yongxin Xie, Wenwen Huang, Dayi Lin, Luhui Lin. 5-Aza-dC promotes T-cell acute lymphoblastic leukemia cell invasion via downregulation of DNMT1 and upregulation of MMP-2 and MMP-9.
Experimental hematology.
2022 10; 114(?):43-53.e2. doi:
10.1016/j.exphem.2022.07.301. [PMID: 35908628] - Pawan Upadhyay, Jeremy Beales, Nakul M Shah, Agata Gruszczynska, Christopher A Miller, Allegra A Petti, Sai Mukund Ramakrishnan, Daniel C Link, Timothy J Ley, John S Welch. Recurrent transcriptional responses in AML and MDS patients treated with decitabine.
Experimental hematology.
2022 Jul; 111(?):50-65. doi:
10.1016/j.exphem.2022.04.002. [PMID: 35429619] - Jonathan Wong, Emily Gruber, Belinda Maher, Mark Waltham, Zahra Sabouri-Thompson, Ian Jong, Quinton Luong, Sidney Levy, Beena Kumar, Daniella Brasacchio, Wendy Jia, Joan So, Hugh Skinner, Alexander Lewis, Simon J Hogg, Stephin Vervoort, Carmen DiCorleto, Micheleine Uhe, Jeanette Gamgee, Stephen Opat, Gareth P Gregory, Galina Polekhina, John Reynolds, Eliza A Hawkes, Gajan Kailainathan, Robin Gasiorowski, Lev M Kats, Jake Shortt. Integrated clinical and genomic evaluation of guadecitabine (SGI-110) in peripheral T-cell lymphoma.
Leukemia.
2022 06; 36(6):1654-1665. doi:
10.1038/s41375-022-01571-8. [PMID: 35459873] - Sankalp Arora, Carl Zainaldin, Srilakshmi Bathini, Udita Gupta, Sarah Worth, Kimo Bachiashvili, Ravi Bhatia, Kelly Godby, Omer Jamy, Sravanti Rangaraju, Barry Diamond, Josh D Oliver, Donna Salzman, Antonio Di Stasi, Pankit Vachhani. Tumor lysis syndrome and infectious complications during treatment with venetoclax combined with azacitidine or decitabine in patients with acute myeloid leukemia.
Leukemia research.
2022 06; 117(?):106844. doi:
10.1016/j.leukres.2022.106844. [PMID: 35487134] - Roxane Verdikt, Maryam Bendoumou, Sophie Bouchat, Lorena Nestola, Alexander O Pasternak, Gilles Darcis, Véronique Avettand-Fenoel, Caroline Vanhulle, Amina Aït-Ammar, Marion Santangelo, Estelle Plant, Valentin Le Douce, Nadège Delacourt, Aurelija Cicilionytė, Coca Necsoi, Francis Corazza, Caroline Pereira Bittencourt Passaes, Christian Schwartz, Martin Bizet, François Fuks, Asier Sáez-Cirión, Christine Rouzioux, Stéphane De Wit, Ben Berkhout, Virginie Gautier, Olivier Rohr, Carine Van Lint. Novel role of UHRF1 in the epigenetic repression of the latent HIV-1.
EBioMedicine.
2022 May; 79(?):103985. doi:
10.1016/j.ebiom.2022.103985. [PMID: 35429693] - Bei Zhang, Zhixin Pei, Hongxia Wang, Huimin Wu, Junjie Wang, Junjun Bai, Qinglin Song. Chidamide and Decitabine in Combination with a HAG Priming Regimen for Acute Myeloid Leukemia with TP53 Mutation.
Acta medica Okayama.
2022 Feb; 76(1):63-70. doi:
10.18926/amo/63213. [PMID: 35237000] - Meghali Goswami, Gege Gui, Laura W Dillon, Katherine E Lindblad, Julie Thompson, Janet Valdez, Dong-Yun Kim, Jack Y Ghannam, Karolyn A Oetjen, Christin B Destefano, Dana M Smith, Hanna Tekleab, Yeusheng Li, Pradeep Dagur, Thomas Hughes, Jennifer L Marté, Jaydira Del Rivero, Joanna Klubo-Gwiezdzinksa, James L Gulley, Katherine R Calvo, Catherine Lai, Christopher S Hourigan. Pembrolizumab and decitabine for refractory or relapsed acute myeloid leukemia.
Journal for immunotherapy of cancer.
2022 01; 10(1):. doi:
10.1136/jitc-2021-003392. [PMID: 35017151] - Chun Tong, Fang Ye, Ning-Ning Li, Huan Wang, Ya-Nan Shu, Ling Wang, Li-Nan Zhang. [Efficacy and Safety of Different Dosages of Decitabine in the Treatment of High-Risk Patients with Myelodysplastic Syndrome].
Zhongguo shi yan xue ye xue za zhi.
2021 Dec; 29(6):1845-1850. doi:
10.19746/j.cnki.issn.1009-2137.2021.06.026. [PMID: 34893121] - Peipei Han, Yifang Wang, Wenqi Luo, Yunliang Lu, Xiaohui Zhou, Yanping Yang, Qian Zheng, Danping Li, Shu Wu, Limei Li, Haishan Zhang, Jun Zhao, Zhe Zhang, Liudmila Matskova, Ping Li, Xiaoying Zhou. Epigenetic inactivation of hydroxymethylglutaryl CoA synthase reduces ketogenesis and facilitates tumor cell motility in clear cell renal carcinoma.
Pathology, research and practice.
2021 Nov; 227(?):153622. doi:
10.1016/j.prp.2021.153622. [PMID: 34624592] - Nemat Ali, Kartikay Prasad, Abdullah F AlAsmari, Metab Alharbi, Summya Rashid, Vijay Kumar. Genomics-guided targeting of stress granule proteins G3BP1/2 to inhibit SARS-CoV-2 propagation.
International journal of biological macromolecules.
2021 Nov; 190(?):636-648. doi:
10.1016/j.ijbiomac.2021.09.018. [PMID: 34517025] - Hiroshi Ureshino, Yuki Kurahashi, Tatsuro Watanabe, Satoshi Yamashita, Kazuharu Kamachi, Yuta Yamamoto, Yuki Fukuda-Kurahashi, Nao Yoshida-Sakai, Naoko Hattori, Yoshihiro Hayashi, Atsushi Kawaguchi, Kaoru Tohyama, Seiji Okada, Hironori Harada, Toshikazu Ushijima, Shinya Kimura. Silylation of Deoxynucleotide Analog Yields an Orally Available Drug with Antileukemia Effects.
Molecular cancer therapeutics.
2021 08; 20(8):1412-1421. doi:
10.1158/1535-7163.mct-20-1125. [PMID: 34045225] - Akemi Kosaka, Yuki Yajima, Mayumi Hatayama, Katsuya Ikuta, Takaaki Sasaki, Noriko Hirai, Syunsuke Yasuda, Marino Nagata, Ryusuke Hayashi, Shohei Harabuchi, Kenzo Ohara, Mizuho Ohara, Takumi Kumai, Kei Ishibashi, Yui Hirata-Nozaki, Toshihiro Nagato, Kensuke Oikawa, Yasuaki Harabuchi, Esteban Celis, Toshikatsu Okumura, Yoshinobu Ohsaki, Hiroya Kobayashi, Takayuki Ohkuri. A stealth antigen SPESP1, which is epigenetically silenced in tumors, is a suitable target for cancer immunotherapy.
Cancer science.
2021 Jul; 112(7):2705-2713. doi:
10.1111/cas.14973. [PMID: 34009705] - Rueyhung R Weng, Hsuan-Hsuan Lu, Chien-Ting Lin, Chia-Chi Fan, Rong-Shan Lin, Tai-Chung Huang, Shu-Yung Lin, Yi-Jhen Huang, Yi-Hsiu Juan, Yi-Chieh Wu, Zheng-Ci Hung, Chi Liu, Xuan-Hui Lin, Wan-Chen Hsieh, Tzu-Yuan Chiu, Jung-Chi Liao, Yen-Ling Chiu, Shih-Yu Chen, Chong-Jen Yu, Hsing-Chen Tsai. Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer.
Nature communications.
2021 04; 12(1):2163. doi:
10.1038/s41467-021-22433-4. [PMID: 33846331] - Xiumin Chen, Mingjie Xing. Effects of 5-Aza-2'-deoxycytidine on hormone secretion and epigenetic regulation in sika deer ovarian granulosa cells.
Reproduction in domestic animals = Zuchthygiene.
2021 Feb; 56(2):360-369. doi:
10.1111/rda.13873. [PMID: 33254280] - Chaoyang Li, Lizhen Li, Meng Sun, Jianzhi Sun, Linlin Shao, Miao Xu, Yu Hou, Jun Peng, Lin Wang, Ming Hou. Predictive Value of High ICAM-1 Level for Poor Treatment Response to Low-Dose Decitabine in Adult Corticosteroid Resistant ITP Patients.
Frontiers in immunology.
2021; 12(?):689663. doi:
10.3389/fimmu.2021.689663. [PMID: 34326842] - Jian-Ping Shao, Feng Su, Shu-Peng Zhang, He-Kai Chen, Zhao-Jin Li, Guo-Qiang Xing, Hong-Jie Liu, Yong-Yuan Li. miR-212 as potential biomarker suppresses the proliferation of gastric cancer via targeting SOX4.
Journal of clinical laboratory analysis.
2020 Dec; 34(12):e23511. doi:
10.1002/jcla.23511. [PMID: 32862489] - Tze-Hong Wong, Ting-Yu Chen, Kuo-Yun Tseng, Zih-Ying Chen, Chung-Hsing Chen, Feng-Huei Lin, Hung-Ming Wu, Shankung Lin. Decorin inhibits the insulin-like growth factor I signaling in bone marrow mesenchymal stem cells of aged humans.
Aging.
2020 11; 13(1):578-597. doi:
10.18632/aging.202166. [PMID: 33257596] - Ai-Bo Qin, Ying Tan, Tao Su. Decitabine-induced kidney thrombotic microangiopathy with glomerular crescents formation and tubular necrosis: A case report.
Medicine.
2020 Oct; 99(43):e22901. doi:
10.1097/md.0000000000022901. [PMID: 33120841] - Xinping Zhou, Chen Mei, Jin Zhang, Ying Lu, Jianping Lan, Shengyun Lin, Yuefeng Zhang, Yuemin Kuang, Yanling Ren, Liya Ma, Juying Wei, Li Ye, Weilai Xu, Kongfei Li, Chenxi Lu, Jie Jin, Hongyan Tong. Epigenetic priming with decitabine followed by low dose idarubicin and cytarabine in acute myeloid leukemia evolving from myelodysplastic syndromes and higher-risk myelodysplastic syndromes: a prospective multicenter single-arm trial.
Hematological oncology.
2020 Oct; 38(4):531-540. doi:
10.1002/hon.2755. [PMID: 32469434] - Blanca L Valle, Sebastian Rodriguez-Torres, Elisabetta Kuhn, Teresa Díaz-Montes, Edgardo Parrilla-Castellar, Fahcina P Lawson, Oluwasina Folawiyo, Carmen Ili-Gangas, Priscilla Brebi-Mieville, James R Eshleman, James Herman, Ie-Ming Shih, David Sidransky, Rafael Guerrero-Preston. HIST1H2BB and MAGI2 Methylation and Somatic Mutations as Precision Medicine Biomarkers for Diagnosis and Prognosis of High-grade Serous Ovarian Cancer.
Cancer prevention research (Philadelphia, Pa.).
2020 09; 13(9):783-794. doi:
10.1158/1940-6207.capr-19-0412. [PMID: 32581010] - Chang Su, Shaoqun Liu, Xiaoying Ma, Xiaotong Yang, Jianwen Liu, Peiyong Zheng, Yiou Cao. Decitabine attenuates dextran sodium sulfate‑induced ulcerative colitis through regulation of immune regulatory cells and intestinal barrier.
International journal of molecular medicine.
2020 Aug; 46(2):583-594. doi:
10.3892/ijmm.2020.4605. [PMID: 32468024] - Anna Nowicka, Barbara Tokarz, Jana Zwyrtková, Eva Dvořák Tomaštíková, Klára Procházková, Ugur Ercan, Andreas Finke, Wilfried Rozhon, Brigitte Poppenberger, Miroslav Otmar, Igor Niezgodzki, Marcela Krečmerová, Ingo Schubert, Ales Pecinka. Comparative analysis of epigenetic inhibitors reveals different degrees of interference with transcriptional gene silencing and induction of DNA damage.
The Plant journal : for cell and molecular biology.
2020 04; 102(1):68-84. doi:
10.1111/tpj.14612. [PMID: 31733119] - Jingyi Wang, Na He, Ruiqing Wang, Tian Tian, Fengjiao Han, Chaoqin Zhong, Chen Zhang, Mingqiang Hua, Chunyan Ji, Daoxin Ma. Analysis of TET2 and EZH2 gene functions in chromosome instability in acute myeloid leukemia.
Scientific reports.
2020 02; 10(1):2706. doi:
10.1038/s41598-020-59365-w. [PMID: 32066746] - Jing Xiao, Yankun Liu, Fuxia Wu, Ruiyan Liu, Yongli Xie, Qian Yang, Yufeng Li, Min Liu, Shengping Li, Hua Tang. miR-639 Expression Is Silenced by DNMT3A-Mediated Hypermethylation and Functions as a Tumor Suppressor in Liver Cancer Cells.
Molecular therapy : the journal of the American Society of Gene Therapy.
2020 02; 28(2):587-598. doi:
10.1016/j.ymthe.2019.11.021. [PMID: 31843451] - Daniel Chen, Daniel L Chao, Lorena Rocha, Matthew Kolar, Viet Anh Nguyen Huu, Michal Krawczyk, Manish Dasyani, Tina Wang, Maryam Jafari, Mary Jabari, Kevin D Ross, Alan Saghatelian, Bruce A Hamilton, Kang Zhang, Dorota Skowronska-Krawczyk. The lipid elongation enzyme ELOVL2 is a molecular regulator of aging in the retina.
Aging cell.
2020 02; 19(2):e13100. doi:
10.1111/acel.13100. [PMID: 31943697] - Luxi Cao, Tingting Zhu, Xiabing Lang, Sha Jia, Yi Yang, Chaohong Zhu, Yucheng Wang, Shi Feng, Cuili Wang, Ping Zhang, Jianghua Chen, Hong Jiang. Inhibiting DNA Methylation Improves Survival in Severe Sepsis by Regulating NF-κB Pathway.
Frontiers in immunology.
2020; 11(?):1360. doi:
10.3389/fimmu.2020.01360. [PMID: 32714333] - Lu Chen, Zeyang Wang, Qingwen Xu, Yuxi Liu, Le Chen, Suhang Guo, Hua Wang, Kui Zeng, Junqing Liu, Su Zeng, Lushan Yu. The failure of DAC to induce OCT2 expression and its remission by hemoglobin-based nanocarriers under hypoxia in renal cell carcinoma.
Theranostics.
2020; 10(8):3562-3578. doi:
10.7150/thno.39944. [PMID: 32206108] - Pei-Min Shi, Chun-Mei Ye, Zheng-Dong Wu, Zhi-Chao Zhang. [Relation of miR-140 Expression Level with Therapeutic Effect of Decitabine and Its Mechanism].
Zhongguo shi yan xue ye xue za zhi.
2019 Oct; 27(5):1424-1430. doi:
10.19746/j.cnki.issn.1009-2137.2019.05.011. [PMID: 31607293] - Juan Chen, Xuan Chen, Jianfeng Yao, Ming Li, Xiaoyu Yang. The combination of Decitabine and EPZ-6438 effectively facilitate adipogenic differentiation of induced pluripotent stem cell-derived mesenchymal stem cells.
Biochemical and biophysical research communications.
2019 08; 516(1):307-312. doi:
10.1016/j.bbrc.2019.06.093. [PMID: 31256938] - Qianying Zhu, Lushan Yu, Zhiyuan Qin, Lu Chen, Haihong Hu, Xiaoli Zheng, Su Zeng. Regulation of OCT2 transcriptional repression by histone acetylation in renal cell carcinoma.
Epigenetics.
2019 08; 14(8):791-803. doi:
10.1080/15592294.2019.1615354. [PMID: 31088315] - Taoyan Yuan, Wanqiu Zhao, Yifan Niu, Yan Fu, Lizhi Lu, Dong Niu. Exploration of the temporal-spatial expression pattern and DNA methylation-related regulation of the duck telomerase reverse transcriptase gene.
Poultry science.
2019 Aug; 98(8):3257-3267. doi:
10.3382/ps/pez240. [PMID: 31064004] - Yulong Jin, Li Xu, Xiaodong Wu, Juan Feng, Mimi Shu, Hongtao Gu, Guangxun Gao, Jinyi Zhang, Baoxia Dong, Xiequn Chen. Synergistic Efficacy of the Demethylation Agent Decitabine in Combination With the Protease Inhibitor Bortezomib for Treating Multiple Myeloma Through the Wnt/β-Catenin Pathway.
Oncology research.
2019 Jun; 27(6):729-737. doi:
10.3727/096504018x15443011011637. [PMID: 30837032] - Janis Szeremeta, Jessica Karlsson, Mireille Alhouayek, Christopher J Fowler. Low mRNA expression and activity of monoacylglycerol lipase in human SH-SY5Y neuroblastoma cells.
Prostaglandins & other lipid mediators.
2019 06; 142(?):59-67. doi:
10.1016/j.prostaglandins.2019.04.003. [PMID: 30978461] - Gao-Yan Tang, Guo-Jun Tang, Lu Yin, Chen Chao, Ren Zhou, Guo-Ping Ren, Jia-Yu Chen, Wei Zhang. ECRG4 acts as a tumor suppressor gene frequently hypermethylated in human breast cancer.
Bioscience reports.
2019 05; 39(5):. doi:
10.1042/bsr20190087. [PMID: 30918105] - Bumjun Kim, Caroline D Pena, Debra T Auguste. Targeted Lipid Nanoemulsions Encapsulating Epigenetic Drugs Exhibit Selective Cytotoxicity on CDH1-/FOXM1+ Triple Negative Breast Cancer Cells.
Molecular pharmaceutics.
2019 05; 16(5):1813-1826. doi:
10.1021/acs.molpharmaceut.8b01065. [PMID: 30883132] - Yuan Wei, Xiang-Ming Lao, Xiao Xiao, Xu-Yan Wang, Zong-Jian Wu, Qiu-Hui Zeng, Cai-Yuan Wu, Rui-Qi Wu, Zhen-Xin Chen, Limin Zheng, Bo Li, Dong-Ming Kuang. Plasma Cell Polarization to the Immunoglobulin G Phenotype in Hepatocellular Carcinomas Involves Epigenetic Alterations and Promotes Hepatoma Progression in Mice.
Gastroenterology.
2019 05; 156(6):1890-1904.e16. doi:
10.1053/j.gastro.2019.01.250. [PMID: 30711627] - Ramya T Kolli, Travis C Glenn, Bradley T Brown, Sukhneeraj P Kaur, Lillie M Barnett, Lawrence H Lash, Brian S Cummings. Bromate-induced Changes in p21 DNA Methylation and Histone Acetylation in Renal Cells.
Toxicological sciences : an official journal of the Society of Toxicology.
2019 04; 168(2):460-473. doi:
10.1093/toxsci/kfz016. [PMID: 30649504] - Yu-Wei Chang, Kamaleshwar P Singh. Arsenic induces fibrogenic changes in human kidney epithelial cells potentially through epigenetic alterations in DNA methylation.
Journal of cellular physiology.
2019 04; 234(4):4713-4725. doi:
10.1002/jcp.27244. [PMID: 30191986] - Michael R Savona, Olatoyosi Odenike, Philip C Amrein, David P Steensma, Amy E DeZern, Laura C Michaelis, Stefan Faderl, Wael Harb, Hagop Kantarjian, James Lowder, Aram Oganesian, Mohammad Azab, Guillermo Garcia-Manero. An oral fixed-dose combination of decitabine and cedazuridine in myelodysplastic syndromes: a multicentre, open-label, dose-escalation, phase 1 study.
The Lancet. Haematology.
2019 Apr; 6(4):e194-e203. doi:
10.1016/s2352-3026(19)30030-4. [PMID: 30926081] - Jeroen Roosendaal, Kai Wang, Hilde Rosing, Luc Lucas, Abadi Gebretensae, Aram Oganesian, Jan H M Schellens, Jos H Beijnen, Zhongping John Lin. Development and validation of LC-MS/MS methods for the quantification of the novel anticancer agent guadecitabine and its active metabolite β‑decitabine in human plasma, whole blood and urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Mar; 1109(?):132-141. doi:
10.1016/j.jchromb.2019.01.011. [PMID: 30754019] - Thomas Briot, Emilie Roger, Naila Bou Haidar, Jerome Bejaud, Nolwenn Lautram, Catherine Guillet, Sylvain Thépot, Samuel Legeay, Frederic Lagarce. Di-O-lauroyl-decitabine-lipid nanocapsules: toward extending decitabine activity.
International journal of nanomedicine.
2019; 14(?):2091-2102. doi:
10.2147/ijn.s190482. [PMID: 30988610] - Huilin Li, Weijia Zhang, Fang Zhong, Gokul C Das, Yifan Xie, Zhengzhe Li, Weijing Cai, Gengru Jiang, Jae Choi, Mohamad Sidani, Deborah P Hyink, Kyung Lee, Paul E Klotman, John Cijiang He. Epigenetic regulation of RCAN1 expression in kidney disease and its role in podocyte injury.
Kidney international.
2018 12; 94(6):1160-1176. doi:
10.1016/j.kint.2018.07.023. [PMID: 30366682] - Changqing Ma, Bowen Liang, Bo Chang, Li Liu, Jiuying Yan, Yazhou Yang, Zhengyang Zhao. Transcriptome Profiling Reveals Transcriptional Regulation by DNA Methyltransferase Inhibitor 5-Aza-2'-Deoxycytidine Enhancing Red Pigmentation in Bagged 'Granny Smith' Apples (Malus domestica).
International journal of molecular sciences.
2018 Oct; 19(10):. doi:
10.3390/ijms19103133. [PMID: 30322020] - Yu Yuan Li, Dan Tang, Yan Lei Du, Chuang Yu Cao, Yu Qiang Nie, Jie Cao, Yong Jian Zhou. Fatty liver mediated by peroxisome proliferator-activated receptor-α DNA methylation can be reversed by a methylation inhibitor and curcumin.
Journal of digestive diseases.
2018 Jul; 19(7):421-430. doi:
10.1111/1751-2980.12610. [PMID: 29802754] - Changqing Ma, Chenjuan Jing, Bo Chang, Jiuying Yan, Bowen Liang, Li Liu, Yazhou Yang, Zhengyang Zhao. The effect of promoter methylation on MdMYB1 expression determines the level of anthocyanin accumulation in skins of two non-red apple cultivars.
BMC plant biology.
2018 Jun; 18(1):108. doi:
10.1186/s12870-018-1320-7. [PMID: 29871614] - Lauren B Levine, Julianna Vf Roddy, Miryoung Kim, Junan Li, Gary Phillips, Alison R Walker. A comparison of toxicities in acute myeloid leukemia patients with and without renal impairment treated with decitabine.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
2018 Jun; 24(4):290-298. doi:
10.1177/1078155217702213. [PMID: 28345491] - Naoya Uchida, Juan J Haro-Mora, Selami Demirci, Atsushi Fujita, Lydia Raines, Matthew M Hsieh, John F Tisdale. High-level embryonic globin production with efficient erythroid differentiation from a K562 erythroleukemia cell line.
Experimental hematology.
2018 06; 62(?):7-16.e1. doi:
10.1016/j.exphem.2018.02.007. [PMID: 29524566] - Diego Uribe, Andres Cardona, Davide Degli Esposti, Marie-Pierre Cros, Cyrille Cuenin, Zdenko Herceg, Mauricio Camargo, Fabian M Cortés-Mancera. Antiproliferative Effects of Epigenetic Modifier Drugs Through E-cadherin Up-regulation in Liver Cancer Cell Lines.
Annals of hepatology.
2018 May; 17(3):444-460. doi:
10.5604/01.3001.0011.7389. [PMID: 29735783] - Wenjin Xi, Xu Chen, Jinbo Sun, Wei Wang, Yi Huo, Guoxu Zheng, Jieheng Wu, Yufang Li, Angang Yang, Tao Wang. Combined Treatment with Valproic Acid and 5-Aza-2'-Deoxycytidine Synergistically Inhibits Human Clear Cell Renal Cell Carcinoma Growth and Migration.
Medical science monitor : international medical journal of experimental and clinical research.
2018 Feb; 24(?):1034-1043. doi:
10.12659/msm.906020. [PMID: 29457966] - João Heitor C Manfrão-Netto, Thiago M Mello-de-Sousa, Astrid R Mach-Aigner, Robert L Mach, Marcio J Poças-Fonseca. The DNA-methyltransferase inhibitor 5-aza-2-deoxycytidine affects Humicola grisea enzyme activities and the glucose-mediated gene repression.
Journal of basic microbiology.
2018 Feb; 58(2):144-153. doi:
10.1002/jobm.201700415. [PMID: 29193198] - Jolein Mijnes, Jürgen Veeck, Nadine T Gaisa, Eduard Burghardt, Tim C de Ruijter, Sonja Gostek, Edgar Dahl, David Pfister, Sebastian C Schmid, Ruth Knüchel, Michael Rose. Promoter methylation of DNA damage repair (DDR) genes in human tumor entities: RBBP8/CtIP is almost exclusively methylated in bladder cancer.
Clinical epigenetics.
2018; 10(?):15. doi:
10.1186/s13148-018-0447-6. [PMID: 29445424] - Yue-Qin Huang, Xue-Ya Zhang, Shi-Xin Wu, Xi-Zhe Guo, Jing-Xin Pan. [Curative Effect of Decitabine Combined with IAG Regimen for Senile Patients with Myelodysplastic Syndrome (MDS) Transformed Acute Myeloid Leukemia].
Zhongguo shi yan xue ye xue za zhi.
2017 Dec; 25(6):1641-1646. doi:
10.7534/j.issn.1009-2137.2017.06.011. [PMID: 29262890] - Chunyuan Guo, Lirong Pei, Xiao Xiao, Qingqing Wei, Jian-Kang Chen, Han-Fei Ding, Shuang Huang, Guoping Fan, Huidong Shi, Zheng Dong. DNA methylation protects against cisplatin-induced kidney injury by regulating specific genes, including interferon regulatory factor 8.
Kidney international.
2017 11; 92(5):1194-1205. doi:
10.1016/j.kint.2017.03.038. [PMID: 28709638] - Feng Jin, Jose Thaiparambil, Sri Ramya Donepudi, Venkatrao Vantaku, Danthasinghe Waduge Badrajee Piyarathna, Suman Maity, Rashmi Krishnapuram, Vasanta Putluri, Franklin Gu, Preeti Purwaha, Salil Kumar Bhowmik, Chandrashekar R Ambati, Friedrich-Carl von Rundstedt, Florian Roghmann, Sebastian Berg, Joachim Noldus, Kimal Rajapakshe, Daniel Gödde, Stephan Roth, Stephan Störkel, Stephan Degener, George Michailidis, Benny Abraham Kaipparettu, Balasubramanyam Karanam, Martha K Terris, Shyam M Kavuri, Seth P Lerner, Farrah Kheradmand, Cristian Coarfa, Arun Sreekumar, Yair Lotan, Randa El-Zein, Nagireddy Putluri. Tobacco-Specific Carcinogens Induce Hypermethylation, DNA Adducts, and DNA Damage in Bladder Cancer.
Cancer prevention research (Philadelphia, Pa.).
2017 Oct; 10(10):588-597. doi:
10.1158/1940-6207.capr-17-0198. [PMID: 28851690] - Elias Jabbour, Nicholas J Short, Guillermo Montalban-Bravo, Xuelin Huang, Carlos Bueso-Ramos, Wei Qiao, Hui Yang, Chong Zhao, Tapan Kadia, Gautam Borthakur, Naveen Pemmaraju, Koji Sasaki, Zeev Estrov, Jorge Cortes, Farhad Ravandi, Yesid Alvarado, Rami Komrokji, Mikkael A Sekeres, David P Steensma, Amy DeZern, Gail Roboz, Hagop Kantarjian, Guillermo Garcia-Manero. Randomized phase 2 study of low-dose decitabine vs low-dose azacitidine in lower-risk MDS and MDS/MPN.
Blood.
2017 09; 130(13):1514-1522. doi:
10.1182/blood-2017-06-788497. [PMID: 28774880] - Robert Molokie, Donald Lavelle, Michel Gowhari, Michael Pacini, Lani Krauz, Johara Hassan, Vinzon Ibanez, Maria A Ruiz, Kwok Peng Ng, Philip Woost, Tomas Radivoyevitch, Daisy Pacelli, Sherry Fada, Matthew Rump, Matthew Hsieh, John F Tisdale, James Jacobberger, Mitch Phelps, James Douglas Engel, Santhosh Saraf, Lewis L Hsu, Victor Gordeuk, Joseph DeSimone, Yogen Saunthararajah. Oral tetrahydrouridine and decitabine for non-cytotoxic epigenetic gene regulation in sickle cell disease: A randomized phase 1 study.
PLoS medicine.
2017 Sep; 14(9):e1002382. doi:
10.1371/journal.pmed.1002382. [PMID: 28880867] - Li Zhang, Qianmei Zhang, Shuangxin Liu, Yuanhan Chen, Ruizhao Li, Ting Lin, Chunping Yu, Hong Zhang, Zhongshun Huang, Xinchen Zhao, Xiaofan Tan, Zhuo Li, Zhiming Ye, Jianchao Ma, Bin Zhang, Wenjian Wang, Wei Shi, Xinling Liang. DNA methyltransferase 1 may be a therapy target for attenuating diabetic nephropathy and podocyte injury.
Kidney international.
2017 07; 92(1):140-153. doi:
10.1016/j.kint.2017.01.010. [PMID: 28318634] - Donghao Shang, Shaozhong Xian, Tiandong Han, Xuanhao Li, Yuting Liu. VHL-TGFBI signaling is involved in the synergy between 5-aza-2'-deoxycytidine and paclitaxel against human renal cell carcinoma.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology.
2017 Jul; 22(4):1038-1045. doi:
. [PMID: 28952225] - Katarzyna Szarc Vel Szic, Ken Declerck, René A J Crans, Jolien Diddens, David B Scherf, Clarissa Gerhäuser, Wim Vanden Berghe. Epigenetic silencing of triple negative breast cancer hallmarks by Withaferin A.
Oncotarget.
2017 Jun; 8(25):40434-40453. doi:
10.18632/oncotarget.17107. [PMID: 28467815] - Sophie Park, Jean-François Hamel, Andrea Toma, Charikleia Kelaidi, Sylvain Thépot, Maria Diez Campelo, Valeria Santini, Mikkael A Sekeres, Enrico Balleari, Jennifer Kaivers, Rosa Sapena, Katharina Götze, Catharina Müller-Thomas, Odile Beyne-Rauzy, Aspasia Stamatoullas, Ioannis Kotsianidis, Rami Komrokji, David P Steensma, Jaime Fensterl, Gail J Roboz, Teresa Bernal, Fernando Ramos, Marisa Calabuig, Agnès Guerci-Bresler, Dominique Bordessoule, Pascale Cony-Makhoul, Stéphane Cheze, Eric Wattel, Christian Rose, Norbert Vey, Daniela Gioia, Dario Ferrero, Gianluca Gaidano, Giovanni Cametti, Fabrizio Pane, Alessandro Sanna, Ulrich Germing, Guillermo F Sanz, François Dreyfus, Pierre Fenaux. Outcome of Lower-Risk Patients With Myelodysplastic Syndromes Without 5q Deletion After Failure of Erythropoiesis-Stimulating Agents.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2017 May; 35(14):1591-1597. doi:
10.1200/jco.2016.71.3271. [PMID: 28350519] - Donghao Shang, Shaozhong Xian, Tiandong Han, Xuanhao Li, Yuting Liu. VHL-TGFBI signaling is involved in the synergy between 5-aza-2'-deoxycytidine and paclitaxel against human renal cell carcinoma.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology.
2017 Mar; 22(2):500-507. doi:
. [PMID: 28534376] - Prathap Kumar S Mahalingaiah, Logeswari Ponnusamy, Kamaleshwar P Singh. Oxidative stress-induced epigenetic changes associated with malignant transformation of human kidney epithelial cells.
Oncotarget.
2017 Feb; 8(7):11127-11143. doi:
10.18632/oncotarget.12091. [PMID: 27655674] - Tongkun Liu, Ying Li, Weike Duan, Feiyi Huang, Xilin Hou. Cold acclimation alters DNA methylation patterns and confers tolerance to heat and increases growth rate in Brassica rapa.
Journal of experimental botany.
2017 02; 68(5):1213-1224. doi:
10.1093/jxb/erw496. [PMID: 28158841] - Thomas Briot, Emilie Roger, Nolwenn Lautram, Alexis Verger, Anne Clavreul, Frederic Lagarce. Development and in vitro evaluations of new decitabine nanocarriers for the treatment of acute myeloid leukemia.
International journal of nanomedicine.
2017; 12(?):8427-8442. doi:
10.2147/ijn.s147659. [PMID: 29200853] - Hyunsung Park, Haerim Chung, Jungyeon Lee, Jieun Jang, Yundeok Kim, Soo Jeong Kim, Jin Seok Kim, Yoo Hong Min, June Won Cheong. Decitabine as a First-Line Treatment for Older Adults Newly Diagnosed with Acute Myeloid Leukemia.
Yonsei medical journal.
2017 Jan; 58(1):35-42. doi:
10.3349/ymj.2017.58.1.35. [PMID: 27873493] - Yu-Wei Chang, Kamaleshwar P Singh. Long-term exposure to estrogen enhances chemotherapeutic efficacy potentially through epigenetic mechanism in human breast cancer cells.
PloS one.
2017; 12(3):e0174227. doi:
10.1371/journal.pone.0174227. [PMID: 28323900] - Lia Gore, Timothy J Triche, Jason E Farrar, Daniel Wai, Christophe Legendre, Gerald C Gooden, Winnie S Liang, John Carpten, David Lee, Frank Alvaro, Margaret E Macy, Carola Arndt, Philip Barnette, Todd Cooper, Laura Martin, Aru Narendran, Jessica Pollard, Soheil Meshinchi, Jessica Boklan, Robert J Arceci, Bodour Salhia. A multicenter, randomized study of decitabine as epigenetic priming with induction chemotherapy in children with AML.
Clinical epigenetics.
2017; 9(?):108. doi:
10.1186/s13148-017-0411-x. [PMID: 29034009] - Benjamin A Vervaet, Lies Moonen, Lode Godderis, Katrien Poels, Patrick C D'Haese. Untargeted DNA-Demethylation Therapy Neither Prevents Nor Attenuates Ischemia-Reperfusion-Induced Renal Fibrosis.
Nephron.
2017; 137(2):124-136. doi:
10.1159/000477507. [PMID: 28750405] - John S Welch, Allegra A Petti, Christopher A Miller, Catrina C Fronick, Michelle O'Laughlin, Robert S Fulton, Richard K Wilson, Jack D Baty, Eric J Duncavage, Bevan Tandon, Yi-Shan Lee, Lukas D Wartman, Geoffrey L Uy, Armin Ghobadi, Michael H Tomasson, Iskra Pusic, Rizwan Romee, Todd A Fehniger, Keith E Stockerl-Goldstein, Ravi Vij, Stephen T Oh, Camille N Abboud, Amanda F Cashen, Mark A Schroeder, Meagan A Jacoby, Sharon E Heath, Kierstin Luber, Megan R Janke, Andrew Hantel, Niloufer Khan, Madina J Sukhanova, Randall W Knoebel, Wendy Stock, Timothy A Graubert, Matthew J Walter, Peter Westervelt, Daniel C Link, John F DiPersio, Timothy J Ley. TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes.
The New England journal of medicine.
2016 11; 375(21):2023-2036. doi:
10.1056/nejmoa1605949. [PMID: 27959731] - Vincent F Taelman, Piotr Radojewski, Nicolas Marincek, Anat Ben-Shlomo, Andrea Grotzky, Cristina I Olariu, Aurel Perren, Christoph Stettler, Thomas Krause, Lorenz P Meier, Renzo Cescato, Martin A Walter. Upregulation of Key Molecules for Targeted Imaging and Therapy.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2016 Nov; 57(11):1805-1810. doi:
10.2967/jnumed.115.165092. [PMID: 27363833] - Stefan Mahrhold, Tomas Bergström, Daniel Stern, Brigitte G Dorner, Crister Åstot, Andreas Rummel. Only the complex N559-glycan in the synaptic vesicle glycoprotein 2C mediates high affinity binding to botulinum neurotoxin serotype A1.
The Biochemical journal.
2016 09; 473(17):2645-54. doi:
10.1042/bcj20160439. [PMID: 27313224] - Daman Kumari, Karen Usdin. Sustained expression of FMR1 mRNA from reactivated fragile X syndrome alleles after treatment with small molecules that prevent trimethylation of H3K27.
Human molecular genetics.
2016 09; 25(17):3689-3698. doi:
10.1093/hmg/ddw215. [PMID: 27378697] - S L Gao, L Li, X J Zhai, R W Guo, S S Gao. [Effects and related mechanism of 5-aza-2'-deoxycytidine on endothelial function in rats with hyperhomocysteinemia].
Zhonghua xin xue guan bing za zhi.
2016 Aug; 44(8):700-6. doi:
10.3760/cma.j.issn.0253-3758.2016.08.012. [PMID: 27545130] - Venera Kuci Emruli, Roger Olsson, Fredrik Ek, Sara Ek. Identification of V-ATPase as a molecular sensor of SOX11-levels and potential therapeutic target for mantle cell lymphoma.
BMC cancer.
2016 07; 16(?):493. doi:
10.1186/s12885-016-2550-4. [PMID: 27430213] - Martin Hruby, Khushboo Agrawal, Olivia Policianova, Jiri Brus, Jan Skopal, Pavel Svec, Miroslav Otmar, Petr Dzubak, Petr Stepanek, Marian Hajduch. Biodegradable system for drug delivery of hydrolytically labile azanucleoside drugs.
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia.
2016 Jun; 160(2):222-30. doi:
10.5507/bp.2016.013. [PMID: 27003313] - Nicole M Anders, Jianyong Liu, Teresia Wanjiku, Hugh Giovinazzo, Jianya Zhou, Ajay Vaghasia, William G Nelson, Srinivasan Yegnasubramanian, Michelle A Rudek. Simultaneous quantitative determination of 5-aza-2'-deoxycytidine genomic incorporation and DNA demethylation by liquid chromatography tandem mass spectrometry as exposure-response measures of nucleoside analog DNA methyltransferase inhibitors.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Jun; 1022(?):38-45. doi:
10.1016/j.jchromb.2016.03.029. [PMID: 27082761] - Florian Correard, Amandine Savry, Fabien Espitallier, Laurence Gauthier Villano, Pascale Pisano, Bertrand Pourroy. Keeping sterile 0.9\% sodium chloride, 5\% dextrose, and lactated Ringer's solutions for injection cold enough for dilution of decitabine in isolators.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2016 Jun; 73(11):748-50. doi:
10.2146/ajhp140625. [PMID: 27208058] - M P Greenwood, M Greenwood, B T Gillard, S Y Loh, J F R Paton, D Murphy. Epigenetic Control of the Vasopressin Promoter Explains Physiological Ability to Regulate Vasopressin Transcription in Dehydration and Salt Loading States in the Rat.
Journal of neuroendocrinology.
2016 04; 28(4):. doi:
10.1111/jne.12371. [PMID: 26833868] - Feng-Ping Pan, Hong-Kun Zhou, He-Qi Bu, Zi-Qiang Chen, Hao Zhang, Lu-Ping Xu, Jian Tang, Qing-Jiang Yu, Yong-Quan Chu, Jie Pan, Yong Fei, Sheng-Zhang Lin, Dian-Lei Liu, Liang Chen. Emodin enhances the demethylation by 5-Aza-CdR of pancreatic cancer cell tumor-suppressor genes P16, RASSF1A and ppENK.
Oncology reports.
2016 Apr; 35(4):1941-9. doi:
10.3892/or.2016.4554. [PMID: 26782786] - Yuanyuan Wang, Junli Hao, Xiaohong Liu, Hongxin Wang, Xin Zeng, Jing Yang, Lei Li, Xi Kuang, Tao Zhang. The mechanism of apoliprotein A1 down-regulated by Hepatitis B virus.
Lipids in health and disease.
2016 Mar; 15(?):64. doi:
10.1186/s12944-016-0232-5. [PMID: 27015844] - Shaofang Li, Lin Liu, Shengben Li, Lei Gao, Yuanyuan Zhao, Yun Ju Kim, Xuemei Chen. SUVH1, a Su(var)3-9 family member, promotes the expression of genes targeted by DNA methylation.
Nucleic acids research.
2016 Jan; 44(2):608-20. doi:
10.1093/nar/gkv958. [PMID: 26400170] - Chengbo Xu, Jianzhen Shen, Bin Liao, Haiying Fu, Huarong Zhou, Yan Qi, Zhenping Huangfu, Yining Chen, Jiawei Chen. [Promoter methylation status of SFRP genes and induced apoptosis by demethylation in Jurkat cells].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi.
2016 Jan; 37(1):51-5. doi:
10.3760/cma.j.issn.0253-2727.2016.01.010. [PMID: 26876254] - Ming Xu, Jia-Hui Lu. [Research Advances on Pathogenesis of Myelodysplastic Syndrome].
Zhongguo shi yan xue ye xue za zhi.
2015 Dec; 23(6):1800-7. doi:
10.7534/j.issn.1009-2137.2015.06.049. [PMID: 26708914] - Xiaoying Zhou, Jiazhang Wei, Fu Chen, Xue Xiao, Tingting Huang, Qian He, Shumin Wang, Chunping Du, Yingxi Mo, Longde Lin, Ying Xie, Lili Wei, Ying Lan, Mairiko Murata, Guangwu Huang, Ingemar Ernberg, Liudmila Matskova, Zhe Zhang. Epigenetic downregulation of the ISG15-conjugating enzyme UbcH8 impairs lipolysis and correlates with poor prognosis in nasopharyngeal carcinoma.
Oncotarget.
2015 Dec; 6(38):41077-91. doi:
10.18632/oncotarget.6218. [PMID: 26506425] - Shan-Shan Xue, Jin-Long He, Xu Zhang, Ya-Jin Liu, Feng-Xia Xue, Chun-Jiong Wang, Ding Ai, Yi Zhu. Metabolomic analysis revealed the role of DNA methylation in the balance of arachidonic acid metabolism and endothelial activation.
Biochimica et biophysica acta.
2015 Oct; 1851(10):1317-26. doi:
10.1016/j.bbalip.2015.07.001. [PMID: 26170200] - You-Ping Liao, Yu-Xia Liu, Qing-Zhao Li, Guo-Yu Hu. [Effect of Decitabine on Megakaryocyte Culture of Steroid-resistant ITP Patients].
Zhongguo shi yan xue ye xue za zhi.
2015 Aug; 23(4):1092-6. doi:
10.7534/j.issn.1009-2137.2015.04.036. [PMID: 26314452] - Qi Zhang, Lu Qian Wang, Kwan Yeung Wong, Zhen Yu Li, Chor Sang Chim. Infrequent DNA methylation of miR-9-1 and miR-9-3 in multiple myeloma.
Journal of clinical pathology.
2015 Jul; 68(7):557-61. doi:
10.1136/jclinpath-2014-202817. [PMID: 25855800] - Hai Zhou, Yu Hou, Xuena Liu, Jihua Qiu, Qi Feng, Yawen Wang, Xu Zhang, Yanan Min, Linlin Shao, Xinguang Liu, Guosheng Li, Lizhen Li, Lei Yang, Shuqian Xu, Heyu Ni, Jun Peng, Ming Hou. Low-dose decitabine promotes megakaryocyte maturation and platelet production in healthy controls and immune thrombocytopenia.
Thrombosis and haemostasis.
2015 May; 113(5):1021-34. doi:
10.1160/th14-04-0342. [PMID: 25566808] - Benjamin D Singer, Jason R Mock, Neil R Aggarwal, Brian T Garibaldi, Venkataramana K Sidhaye, Marcus A Florez, Eric Chau, Kevin W Gibbs, Pooja Mandke, Ashutosh Tripathi, Srinivasan Yegnasubramanian, Landon S King, Franco R D'Alessio. Regulatory T cell DNA methyltransferase inhibition accelerates resolution of lung inflammation.
American journal of respiratory cell and molecular biology.
2015 May; 52(5):641-52. doi:
10.1165/rcmb.2014-0327oc. [PMID: 25295995] - Yozo Mitsui, Hiroshi Hirata, Naoko Arichi, Miho Hiraki, Hiroaki Yasumoto, Inik Chang, Shinichiro Fukuhara, Soichiro Yamamura, Varahram Shahryari, Guoren Deng, Sharanjot Saini, Shahana Majid, Rajvir Dahiya, Yuichiro Tanaka, Hiroaki Shiina. Inactivation of bone morphogenetic protein 2 may predict clinical outcome and poor overall survival for renal cell carcinoma through epigenetic pathways.
Oncotarget.
2015 Apr; 6(11):9577-91. doi:
10.18632/oncotarget.3445. [PMID: 25797254] - Gu Shucheng, Chang Chunkang, Zhao Youshan, Guo Juan, Fei Chengming, Zhang Xi, Xiao Chao, Li Xiao. Decitabine treatment could ameliorate primary iron-overload in myelodysplastic syndrome patients.
Cancer investigation.
2015 Apr; 33(4):98-106. doi:
10.3109/07357907.2014.1001895. [PMID: 25699651] - Jean-Pierre Issa, Guillermo Garcia-Manero, Xuelin Huang, Jorge Cortes, Farhad Ravandi, Elias Jabbour, Gautam Borthakur, Mark Brandt, Sherry Pierce, Hagop M Kantarjian. Results of phase 2 randomized study of low-dose decitabine with or without valproic acid in patients with myelodysplastic syndrome and acute myelogenous leukemia.
Cancer.
2015 Feb; 121(4):556-61. doi:
10.1002/cncr.29085. [PMID: 25336333] - Tulika Tyagi, Justin N Treas, Prathap Kumar S Mahalingaiah, Kamaleshwar P Singh. Potentiation of growth inhibition and epigenetic modulation by combination of green tea polyphenol and 5-aza-2'-deoxycytidine in human breast cancer cells.
Breast cancer research and treatment.
2015 Feb; 149(3):655-68. doi:
10.1007/s10549-015-3295-5. [PMID: 25663548] - Da-Sheng Zhang, Yuan-Yi Li, Xiao-Jun Chen, Yu-Juan Li, Zhao-Ying Liu, Wen-Jian Xie, Zhi-Liang Sun. BCL2 promotor methylation and miR-15a/16-1 upregulation is associated with sanguinarine-induced apoptotic death in rat HSC-T6 cells.
Journal of pharmacological sciences.
2015 Jan; 127(1):135-44. doi:
10.1016/j.jphs.2014.11.012. [PMID: 25704029] - Xiaojun Zhu, Faxian Yi, Pengliang Chen, Ligang Chen, Xiaoli Zhang, Chunli Cao, Wanlong Tan. 5-Aza-2'-Deoxycytidine and CDDP Synergistically Induce Apoptosis in Renal Carcinoma Cells via Enhancing the APAF-1 Activity.
Clinical laboratory.
2015; 61(12):1821-30. doi:
10.7754/clin.lab.2015.150429. [PMID: 26882803]