(+/-)AMETHOPTERIN (BioDeep_00001876045)
代谢物信息卡片
4-(3-Tert-Butylamino-2-hydroxypropoxy)benzimidazol-2-one
化学式: C14H21N3O3 (279.1582836)
中文名称: CGP 12177盐酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C)NCC(COC1=CC=CC2=C1NC(=O)N2)O
InChI: InChI=1S/C14H21N3O3/c1-14(2,3)15-7-9(18)8-20-11-6-4-5-10-12(11)17-13(19)16-10/h4-6,9,15,18H,7-8H2,1-3H3,(H2,16,17,19)
描述信息
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
同义名列表
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - C T Schäff, D Rohrbeck, J Steinhoff-Wagner, E Kanitz, H Sauerwein, R M Bruckmaier, H M Hammon. Effects of colostrum versus formula feeding on hepatic glucocorticoid and α₁- and β₂-adrenergic receptors in neonatal calves and their effect on glucose and lipid metabolism.
Journal of dairy science.
2014 Oct; 97(10):6344-57. doi:
10.3168/jds.2014-8359. [PMID: 25108854] - Sam D Perez, Brooke Kozic, Christine A Molinaro, Srinivasan Thyagarajan, Mark Ghamsary, Cheri L Lubahn, Dianne Lorton, Denise L Bellinger. Chronically lowering sympathetic activity protects sympathetic nerves in spleens from aging F344 rats.
Journal of neuroimmunology.
2012 Jun; 247(1-2):38-51. doi:
10.1016/j.jneuroim.2012.03.022. [PMID: 22546498] - Masanao Naya, Takahiro Tsukamoto, Koichi Morita, Chietsugu Katoh, Kenichi Nishijima, Hiroshi Komatsu, Satoshi Yamada, Yuji Kuge, Nagara Tamaki, Hiroyuki Tsutsui. Myocardial beta-adrenergic receptor density assessed by 11C-CGP12177 PET predicts improvement of cardiac function after carvedilol treatment in patients with idiopathic dilated cardiomyopathy.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2009 Feb; 50(2):220-5. doi:
10.2967/jnumed.108.056341. [PMID: 19164238] - Wim Vrydag, Astrid E Alewijnse, Martin C Michel. Do gene polymorphisms alone or in combination affect the function of human beta3-adrenoceptors?.
British journal of pharmacology.
2009 Jan; 156(1):127-34. doi:
10.1111/j.1476-5381.2008.00014.x. [PMID: 19133996] - Takahiro Horinouchi, Shigeru Morishima, Takashi Tanaka, Fumiko Suzuki, Yoshio Tanaka, Katsuo Koike, Soichi Miwa, Ikunobu Muramatsu. Different changes of plasma membrane beta-adrenoceptors in rat heart after chronic administration of propranolol, atenolol and bevantolol.
Life sciences.
2007 Jul; 81(5):399-404. doi:
10.1016/j.lfs.2007.06.003. [PMID: 17628611] - Marta Dziedzicka-Wasylewska, Agata Faron-Górecka, Maciej Kuśmider, Elzbieta Drozdowska, Zofia Rogóz, Joanna Siwanowicz, Marc G Caron, Heinz Bönisch. Effect of antidepressant drugs in mice lacking the norepinephrine transporter.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2006 Nov; 31(11):2424-32. doi:
10.1038/sj.npp.1301064. [PMID: 16554743] - Karsten Brandt, Nori Geary, Wolfgang Langhans, Monika Leonhardt. Mercaptoacetate fails to block the feeding-inhibitory effect of the beta3-adrenergic receptor agonist CGP 12177A.
Physiology & behavior.
2006 Sep; 89(2):128-32. doi:
10.1016/j.physbeh.2006.06.015. [PMID: 16872643] - Atso Raasmaja, David A York. Pharmacological characterization of alpha1- and beta-adrenergic synergism of 5'DII activity in rat brown adipocytes.
Archives of physiology and biochemistry.
2006 Feb; 112(1):23-30. doi:
10.1080/13813450500500464. [PMID: 16754200] - Johan Hoffstedt, Mikael Rydén, Hans Wahrenberg, Vanessa van Harmelen, Peter Arner. Upstream transcription factor-1 gene polymorphism is associated with increased adipocyte lipolysis.
The Journal of clinical endocrinology and metabolism.
2005 Sep; 90(9):5356-60. doi:
10.1210/jc.2005-0399. [PMID: 15985485] - J Carron, C Morel, J W Blum, H M Hammon. Effects of dexamethasone and colostrum feeding on mRNA levels and binding capacities of beta-adrenergic receptors in the liver of neonatal calves.
Domestic animal endocrinology.
2005 Apr; 28(3):257-71. doi:
10.1016/j.domaniend.2004.10.001. [PMID: 15760667] - Amal Robay, Gilles Toumaniantz, Véronique Leblais, Chantal Gauthier. Transfected beta3- but not beta2-adrenergic receptors regulate cystic fibrosis transmembrane conductance regulator activity via a new pathway involving the mitogen-activated protein kinases extracellular signal-regulated kinases.
Molecular pharmacology.
2005 Mar; 67(3):648-54. doi:
10.1124/mol.104.002097. [PMID: 15563584] - Sarah J O'Meara, B Therese Kinsella. The effect of the farnesyl protein transferase inhibitor SCH66336 on isoprenylation and signalling by the prostacyclin receptor.
The Biochemical journal.
2005 Feb; 386(Pt 1):177-89. doi:
10.1042/bj20041290. [PMID: 15469414] - N Soudani, J Gharbi-Chihi, N Srairi-Abid, H Kaabi, A Margotat, J Torresani, M El Ayeb. Identification of second lipolysis activating protein from scorpion Buthus occitanus tunetanus.
Archives de l'Institut Pasteur de Tunis.
2005; 82(1-4):39-46. doi:
NULL. [PMID: 16929753] - Sarah J O'Meara, B Therese Kinsella. Effect of the statin atorvastatin on intracellular signalling by the prostacyclin receptor in vitro and in vivo.
British journal of pharmacology.
2004 Sep; 143(2):292-302. doi:
10.1038/sj.bjp.0705947. [PMID: 15326037] - A L Katynski, M M Vijayan, S W Kennedy, T W Moon. 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) impacts hepatic lipid peroxidation, membrane fluidity and beta-adrenoceptor kinetics in chick embryos.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2004 Jan; 137(1):81-93. doi:
10.1016/j.cca.2003.11.004. [PMID: 14984707] - I N Santos, F K Marcondes, R C Spadari-Bratfisch. The beta1-adrenoceptor site activated by CGP12177 varies in behavior according to the estrous cycle phase and stress.
Canadian journal of physiology and pharmacology.
2003 May; 81(5):459-68. doi:
10.1139/y03-057. [PMID: 12774852] - Andreas Bundkirchen, Klara Brixius, Birgit Bölck, Quang Nguyen, Robert H G Schwinger. Beta 1-adrenoceptor selectivity of nebivolol and bisoprolol. A comparison of [3H]CGP 12.177 and [125I]iodocyanopindolol binding studies.
European journal of pharmacology.
2003 Jan; 460(1):19-26. doi:
10.1016/s0014-2999(02)02875-3. [PMID: 12535855] - Kousaku Iwatsubo, Yang Tao, Takeshi Onda, Yoshiyuki Toya, Carsten Schwencke, Takayuki Fujita, Toshiaki Ebina, Tamio Iwamoto, Hideaki Hori, Susumu Minamisawa, Satoshi Umemura, Yoshihiro Ishikawa. Characterization of beta-adrenergic receptor sequestration by newly developed whole cell binding assays.
Journal of cardiovascular pharmacology.
2003 Jan; 41 Suppl 1(?):S53-6. doi:
NULL. [PMID: 12688397] - Jacques Delforge, Didier Mesangeau, Frédéric Dolle, Pascal Merlet, Christian Loc'h, Michel Bottlaender, Régine Trebossen, André Syrota. In vivo quantification and parametric images of the cardiac beta-adrenergic receptor density.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2002 Feb; 43(2):215-26. doi:
NULL. [PMID: 11850488] - E Herrera, E Amusquivar, J Cacho. Changes in dietary fatty acids modify the decreased lipolytic beta3-adrenergic response to hyperinsulinemia in adipocytes from pregnant and nonpregnant rats.
Metabolism: clinical and experimental.
2000 Sep; 49(9):1180-7. doi:
10.1053/meta.2000.8618. [PMID: 11016901] - A J McLean, G Milligan. Ligand regulation of green fluorescent protein-tagged forms of the human beta(1)- and beta(2)-adrenoceptors; comparisons with the unmodified receptors.
British journal of pharmacology.
2000 Aug; 130(8):1825-32. doi:
10.1038/sj.bjp.0703506. [PMID: 10952671] - J M Fredriksson, J M Lindquist, G E Bronnikov, J Nedergaard. Norepinephrine induces vascular endothelial growth factor gene expression in brown adipocytes through a beta -adrenoreceptor/cAMP/protein kinase A pathway involving Src but independently of Erk1/2.
The Journal of biological chemistry.
2000 May; 275(18):13802-11. doi:
10.1074/jbc.275.18.13802. [PMID: 10788502] - E Farias-Silva, D M Grassi-Kassisse, V Wolf-Nunes, R C Spadari-Bratfisch. Stress-induced alteration in the lipolytic response to beta-adrenoceptor agonists in rat white adipocytes.
Journal of lipid research.
1999 Sep; 40(9):1719-27. doi:
10.1016/s0022-2275(20)33419-2. [PMID: 10484620] - G Re, L Bergamasco, P Badino, M Borgarelli, R Odore, A Tarducci, R Zanatta, C Girardi. Canine dilated cardiomyopathy: lymphocyte and cardiac alpha(1)- and beta-adrenoceptor concentrations in normal and affected great danes.
Veterinary journal (London, England : 1997).
1999 Sep; 158(2):120-7. doi:
10.1053/tvjl.1999.0364. [PMID: 10489268] - R H Moore, H S Hall, J L Rosenfeld, W Dai, B J Knoll. Specific changes in beta2-adrenoceptor trafficking kinetics and intracellular sorting during downregulation.
European journal of pharmacology.
1999 Mar; 369(1):113-23. doi:
10.1016/s0014-2999(99)00055-2. [PMID: 10204689] - L Bourová, J Novotn, P Svoboda. The decrease in the short variant of gsalpha protein is associated with an increase in [3H]CGP12177 binding, [3H]ouabain binding and Na, K-ATPase activity in brown adipose tissue plasma membranes of cold-acclimated hamsters.
Journal of molecular endocrinology.
1999 Feb; 22(1):55-64. doi:
10.1677/jme.0.0220055. [PMID: 9924180] - D Bergström, S O Jacobsson, C J Fowler. The effect of hydrogen peroxide upon beta-adrenoceptor density and function in C6 rat glioma cells.
Neurochemistry international.
1999 Jan; 34(1):63-70. doi:
10.1016/s0197-0186(98)00070-9. [PMID: 10100197] - K E Hadri, C Charon, J Pairault, S Hauguel-De Mouzon, A Quignard-Boulangé, B Fève. Down-regulation of beta3-adrenergic receptor expression in rat adipose tissue during the fasted/fed transition: evidence for a role of insulin.
The Biochemical journal.
1997 Apr; 323 ( Pt 2)(?):359-64. doi:
10.1042/bj3230359. [PMID: 9163324] - J Hoffstedt, P Arner, G Hellers, F Lönnqvist. Variation in adrenergic regulation of lipolysis between omental and subcutaneous adipocytes from obese and non-obese men.
Journal of lipid research.
1997 Apr; 38(4):795-804. doi:
10.1016/s0022-2275(20)37246-1. [PMID: 9144094] - T Yoshida, M Hayashi, T Monkawa, T Saruta. Regulation of obese mRNA expression by hormonal factors in primary cultures of rat adipocytes.
European journal of endocrinology.
1996 Nov; 135(5):619-25. doi:
10.1530/eje.0.1350619. [PMID: 8980166] - L Choudhury, S D Rosen, D C Lefroy, P Nihoyannopoulos, C M Oakley, P G Camici. Myocardial beta adrenoceptor density in primary and secondary left ventricular hypertrophy.
European heart journal.
1996 Nov; 17(11):1703-9. doi:
10.1093/oxfordjournals.eurheartj.a014754. [PMID: 8922919] - K J Morrison, R H Moore, N D Carsrud, J Trial, E E Millman, M Tuvim, R B Clark, R Barber, B F Dickey, B J Knoll. Repetitive endocytosis and recycling of the beta 2-adrenergic receptor during agonist-induced steady state redistribution.
Molecular pharmacology.
1996 Sep; 50(3):692-9. doi:
NULL. [PMID: 8794912] - S D Rosen, H Boyd, C G Rhodes, J C Kaski, P G Camici. Myocardial beta-adrenoceptor density and plasma catecholamines in syndrome X.
The American journal of cardiology.
1996 Jul; 78(1):37-42. doi:
10.1016/s0002-9149(96)00223-8. [PMID: 8712115] - C Deng, A Paoloni-Giacobino, F Kuehne, O Boss, J P Revelli, M Moinat, M A Cawthorne, P Muzzin, J P Giacobino. Respective degree of expression of beta 1-, beta 2- and beta 3-adrenoceptors in human brown and white adipose tissues.
British journal of pharmacology.
1996 Jun; 118(4):929-34. doi:
10.1111/j.1476-5381.1996.tb15488.x. [PMID: 8799564] - L Ménard, S S Ferguson, L S Barak, L Bertrand, R T Premont, A M Colapietro, R J Lefkowitz, M G Caron. Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration.
Biochemistry.
1996 Apr; 35(13):4155-60. doi:
10.1021/bi952961+. [PMID: 8672451] - M Reverte, L Rivas-Cabañero. Effects of the beta 3-adrenoceptor agonist BRL 37344 on lipomobilization and plasma glucose levels in conscious fasted rabbits.
Canadian journal of physiology and pharmacology.
1996 Mar; 74(3):251-6. doi:
10.1139/y96-015. [PMID: 8773403] - A Cases, M Bono, J Gaya, W Jimenez, J Calls, N Esforzado, F Rivera, L Revert. Reversible decrease of surface beta 2-adrenoceptor number and response in lymphocytes of patients with pheochromocytoma.
Clinical and experimental hypertension (New York, N.Y. : 1993).
1995 Apr; 17(3):537-49. doi:
10.3109/10641969509037423. [PMID: 7613527] - F Lönnqvist, A Thöme, K Nilsell, J Hoffstedt, P Arner. A pathogenic role of visceral fat beta 3-adrenoceptors in obesity.
The Journal of clinical investigation.
1995 Mar; 95(3):1109-16. doi:
10.1172/jci117758. [PMID: 7883959] - A van Waarde, R L Anthonio, T J Visser, P H Elsinga, H Posthumus, A M Weemaes, P K Blanksma, G M Visser, A M Paans, W Vaalburg. Quantification of an 11C-labelled beta-adrenoceptor ligand, S-(-)CGP 12177, in plasma of humans and rats.
Journal of chromatography. B, Biomedical applications.
1995 Jan; 663(2):361-9. doi:
10.1016/0378-4347(94)00442-8. [PMID: 7735484] - Y Kajiyama, M Ui. Switching from alpha 1- to beta-subtypes in adrenergic response during primary culture of adult-rat hepatocytes as affected by the cell-to-cell interaction through plasma membranes.
The Biochemical journal.
1994 Oct; 303 ( Pt 1)(?):313-21. doi:
10.1042/bj3030313. [PMID: 7945257] - Y Yin, R Vassy, P Nicolas, G Y Perret, S Laurent. Antagonism between T3 and amiodarone on the contractility and the density of beta-adrenoceptors of chicken cardiac myocytes.
European journal of pharmacology.
1994 Aug; 261(1-2):97-104. doi:
10.1016/0014-2999(94)90306-9. [PMID: 8001659] - A K Gamperl, M Wilkinson, R G Boutilier. Beta-adrenoreceptors in the trout (Oncorhynchus mykiss) heart: characterization, quantification, and effects of repeated catecholamine exposure.
General and comparative endocrinology.
1994 Aug; 95(2):259-72. doi:
10.1006/gcen.1994.1123. [PMID: 7958755] - M von Zastrow, B K Kobilka. Antagonist-dependent and -independent steps in the mechanism of adrenergic receptor internalization.
The Journal of biological chemistry.
1994 Jul; 269(28):18448-52. doi:
10.1016/s0021-9258(17)32329-3. [PMID: 7518433] - J Drímal. Identification of dihydropyridine (DHP) binding sites on cultured monkey renal cells (GMRC) with a photoaffinity probe (-)-[3H]-azidopine.
General physiology and biophysics.
1994 Apr; 13(2):137-48. doi:
. [PMID: 7528701] - O Moro, M S Shockley, J Lameh, W Sadée. Overlapping multi-site domains of the muscarinic cholinergic Hm1 receptor involved in signal transduction and sequestration.
The Journal of biological chemistry.
1994 Mar; 269(9):6651-5. doi:
10.1016/s0021-9258(17)37423-9. [PMID: 8120019] - N S Morgunov, Y D You, D J Hirsch. Response of mouse proximal straight tubule and medullary thick ascending limb to beta-agonist.
Journal of the American Society of Nephrology : JASN.
1993 Nov; 4(5):1151-8. doi:
10.1681/asn.v451151. [PMID: 7905754] - M L Vuori, T Ali-Melkkilä, T Kaila, E Iisalo, K M Saari. Beta 1- and beta 2-antagonist activity of topically applied betaxolol and timolol in the systemic circulation.
Acta ophthalmologica.
1993 Oct; 71(5):682-5. doi:
10.1111/j.1755-3768.1993.tb04661.x. [PMID: 7906474] - M P Law. Demonstration of the suitability of CGP 12177 for in vivo studies of beta-adrenoceptors.
British journal of pharmacology.
1993 Aug; 109(4):1101-9. doi:
10.1111/j.1476-5381.1993.tb13736.x. [PMID: 8104642] - J Galitzky, M Reverte, C Carpene, M Lafontan, M Berlan. Beta 3-adrenoceptors in dog adipose tissue: studies on their involvement in the lipomobilizing effect of catecholamines.
The Journal of pharmacology and experimental therapeutics.
1993 Jul; 266(1):358-66. doi:
NULL. [PMID: 8101220] - H Takahashi, H Ogata, K Kashiwada, M Ohira, K Someya. Dosing rate-dependent relationship between propranolol plasma concentration and beta-blockade.
The Journal of pharmacology and experimental therapeutics.
1993 May; 265(2):681-9. doi:
NULL. [PMID: 8496815] - T Kaila, R Marttila. Receptor occupancy in lumbar CSF as a measure of the antagonist activity of atenolol, metoprolol and propranolol in the CNS.
British journal of clinical pharmacology.
1993 May; 35(5):507-15. doi:
10.1111/j.1365-2125.1993.tb04177.x. [PMID: 8099803] - K Hosoda, R S Duman. Regulation of beta 1-adrenergic receptor mRNA and ligand binding by antidepressant treatments and norepinephrine depletion in rat frontal cortex.
Journal of neurochemistry.
1993 Apr; 60(4):1335-43. doi:
10.1111/j.1471-4159.1993.tb03294.x. [PMID: 8384247] - J M Elalouf, J M Buhler, C Tessiot, A C Bellanger, I Dublineau, C de Rouffignac. Predominant expression of beta 1-adrenergic receptor in the thick ascending limb of rat kidney. Absolute mRNA quantitation by reverse transcription and polymerase chain reaction.
The Journal of clinical investigation.
1993 Jan; 91(1):264-72. doi:
10.1172/jci116180. [PMID: 7678604] - N Fraeyman, A Van Ermen, E Van de Velde, P Vanscheeuwijck. Pharmacological characterization of a beta 3-receptor agonist (BRL 37,344) and a partial agonist (CGP 12,177A) in neonatal rat liver plasma membranes.
Biochemical pharmacology.
1992 Dec; 44(12):2333-8. doi:
10.1016/0006-2952(92)90677-b. [PMID: 1361733] - M M Bersohn, R N Doshi. Measurement of sarcolemmal vesicle orientation by beta-adrenergic receptor binding.
Journal of biochemical and biophysical methods.
1992 Oct; 25(2-3):133-8. doi:
10.1016/0165-022x(92)90005-u. [PMID: 1337086] - A van Waarde, J G Meeder, P K Blanksma, J Bouwer, G M Visser, P H Elsinga, A M Paans, W Vaalburg, K I Lie. Suitability of CGP-12177 and CGP-26505 for quantitative imaging of beta-adrenoceptors.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology.
1992 Oct; 19(7):711-8. doi:
10.1016/0883-2897(92)90130-q. [PMID: 1356953] - H J Mersmann, R L McNeel. Ligand binding to the porcine adipose tissue beta-adrenergic receptor.
Journal of animal science.
1992 Mar; 70(3):787-97. doi:
10.2527/1992.703787x. [PMID: 1348746] - P Muzzin, J P Revelli, C M Fraser, J P Giacobino. Radioligand binding studies of the atypical beta 3-adrenergic receptor in rat brown adipose tissue using [3H]CGP 12177.
FEBS letters.
1992 Feb; 298(2-3):162-4. doi:
10.1016/0014-5793(92)80046-j. [PMID: 1347503] - H A Jones, C G Rhodes, M P Law, J M Becket, J C Clark, A R Boobis, G W Taylor. Rapid analysis for metabolites of 11C-labelled drugs: fate of [11C]-S-4-(tert.-butylamino-2-hydroxypropoxy)-benzimidazol-2-one in the dog.
Journal of chromatography.
1991 Oct; 570(2):361-70. doi:
10.1016/0378-4347(91)80539-o. [PMID: 1686775] - D Langin, M P Portillo, J S Saulnier-Blache, M Lafontan. Coexistence of three beta-adrenoceptor subtypes in white fat cells of various mammalian species.
European journal of pharmacology.
1991 Jul; 199(3):291-301. doi:
10.1016/0014-2999(91)90492-9. [PMID: 1680716] - S D Reid, S F Perry. The effects and physiological consequences of raised levels of cortisol on rainbow trout (Oncorhynchus mykiss) erythrocyte beta-adrenoreceptors.
The Journal of experimental biology.
1991 Jul; 158(?):217-40. doi:
10.1242/jeb.158.1.217. [PMID: 1680955] - T Lenz, E Werle, G Strobel, H Weicker. O-Methylated and sulfoconjugated catecholamines: differential activities at human platelet alpha 2-adrenoceptors.
Canadian journal of physiology and pharmacology.
1991 Jul; 69(7):929-37. doi:
10.1139/y91-141. [PMID: 1683267] - S D Reid, T W Moon, S F Perry. Characterization of beta-adrenoreceptors of rainbow trout (Oncorhynchus mykiss) erythrocytes.
The Journal of experimental biology.
1991 Jul; 158(?):199-216. doi:
10.1242/jeb.158.1.199. [PMID: 1655944] - G Wallukat, F D Boehmer, U Engstroem, P Langen, M Hollenberg, J Behlke, H Kuehn, R Grosse. Modulation of the beta-adrenergic-response in cultured rat heart cells. II. Mammary-derived growth inhibitor (MDGI) blocks induction of beta-adrenergic supersensitivity. Dissociation from lipid-binding activity of MDGI.
Molecular and cellular biochemistry.
1991 Mar; 102(1):49-60. doi:
10.1007/bf00232157. [PMID: 1646956] - T Kaila. A sensitive radioligand binding assay for timolol in plasma.
Journal of pharmaceutical sciences.
1991 Mar; 80(3):296-9. doi:
10.1002/jps.2600800322. [PMID: 1675681] - T Kobatake, Y Watanabe, Y Matsuzawa, K Tokunaga, S Fujioka, T Kawamoto, Y Keno, S Tarui, H Yoshida. Age-related changes in adrenergic alpha 1, alpha 2, and beta receptors of rat white fat cell membranes: an analysis using [3H]bunazosin as a novel ligand for the alpha 1 adrenoceptor.
Journal of lipid research.
1991 Feb; 32(2):191-6. doi:
10.1016/s0022-2275(20)42079-6. [PMID: 1676718] - M E Symonds, J A Roe, C M Heywood, J M Harper, P J Buttery. Beta-adrenoceptors and the effect of beta-agonists on protein metabolism in ovine primary muscle cultures.
Biochemical pharmacology.
1990 Nov; 40(10):2271-6. doi:
10.1016/0006-2952(90)90722-w. [PMID: 1978776] - C J Fowler, G Brännström. Reduction in beta-adrenoceptor density in cultured rat glioma C6 cells after incubation with antidepressants is dependent upon the culturing conditions used.
Journal of neurochemistry.
1990 Jul; 55(1):245-50. doi:
10.1111/j.1471-4159.1990.tb08845.x. [PMID: 1972389] - N S Morgunov, D J Hirsch. Adenylate cyclase uncoupled beta-adrenergic receptors in salamander proximal tubules.
Canadian journal of physiology and pharmacology.
1990 Jul; 68(7):863-9. doi:
10.1139/y90-131. [PMID: 1974477] - R H Schwinger, M Böhm, E Erdmann. Evidence against spare or uncoupled beta-adrenoceptors in the human heart.
American heart journal.
1990 Apr; 119(4):899-904. doi:
10.1016/s0002-8703(05)80329-1. [PMID: 1969707] - T T Volker, I Pianet, J Labouesse, J Teissié. Signal transduction by membrane receptors in viable electropermeabilized cells: isoproterenol-stimulated cyclic AMP synthesis in C6 glioma cells.
Biochimica et biophysica acta.
1989 Sep; 984(2):243-51. doi:
10.1016/0005-2736(89)90223-x. [PMID: 2569894] - A Kashiwagi, Y Nishio, Y Saeki, Y Kida, M Kodama, Y Shigeta. Plasma membrane-specific deficiency in cardiac beta-adrenergic receptor in streptozocin-diabetic rats.
The American journal of physiology.
1989 Aug; 257(2 Pt 1):E127-32. doi:
10.1152/ajpendo.1989.257.2.e127. [PMID: 2569828] - G De Pergola, M Cignarelli, G Nardelli, G Garruti, M Corso, S Di Paolo, F Cardone, R Giorgino. Influence of lactate on isoproterenol-induced lipolysis and beta-adrenoceptors distribution in human fat cells.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
1989 Apr; 21(4):210-3. doi:
10.1055/s-2007-1009193. [PMID: 2568975] - Y Matsumori, M Ohyanagi, H Kawamoto, R Shibata, T Iwasaki. Intracellular distribution of cardiac beta-adrenoceptors in SHR and WKY.
Japanese circulation journal.
1989 Feb; 53(2):113-20. doi:
10.1253/jcj.53.113. [PMID: 2565986] - R K Studer, L Ganas. Adrenergic receptor properties of hepatocytes from male and female rats.
Biochimica et biophysica acta.
1988 Apr; 969(1):78-85. doi:
10.1016/0167-4889(88)90090-0. [PMID: 2894862] - C J Limas, C Limas. Altered intracellular adrenoceptor distribution in myocardium of spontaneously hypertensive rats.
The American journal of physiology.
1987 Oct; 253(4 Pt 2):H904-8. doi:
10.1152/ajpheart.1987.253.4.h904. [PMID: 2889373] - R E Shepherd, C H Lang, K H McDonough. Myocardial adrenergic responsiveness after lethal and nonlethal doses of endotoxin.
The American journal of physiology.
1987 Feb; 252(2 Pt 2):H410-6. doi:
10.1152/ajpheart.1987.252.2.h410. [PMID: 3028179] - Y Kawai, S M Graham, H Yoshioka, I J Arinze. Beta-adrenergic receptors in guinea-pig liver plasma membranes and thermal lability of [3H]dihydroalprenolol binding sites.
Biochemical pharmacology.
1986 Dec; 35(24):4387-93. doi:
10.1016/0006-2952(86)90753-7. [PMID: 3024648] - S Kassis, M Olasmaa, M Sullivan, P H Fishman. Desensitization of the beta-adrenergic receptor-coupled adenylate cyclase in cultured mammalian cells. Receptor sequestration versus receptor function.
The Journal of biological chemistry.
1986 Sep; 261(26):12233-7. doi:
10.1016/s0021-9258(18)67229-1. [PMID: 3017967] - A De Blasi, M Lipartiti, S Algeri, G Sacchetti, C Costantini, M Fratelli, S Cotecchia. Stress induced desensitization of lymphocyte beta-adrenoceptors in young and aged rats.
Pharmacology, biochemistry, and behavior.
1986 Apr; 24(4):991-8. doi:
10.1016/0091-3057(86)90447-8. [PMID: 3012603] - D Lacasa, P Mauriège, M Lafontan, M Berlan, Y Giudicelli. A reliable assay for beta-adrenoceptors in intact isolated human fat cells with a hydrophilic radioligand, [3H]CGP-12177.
Journal of lipid research.
1986 Apr; 27(4):368-76. doi:
10.1016/s0022-2275(20)38814-3. [PMID: 2873196] - A Wellstein, D Palm, G G Belz. Affinity and selectivity of beta-adrenoceptor antagonists in vitro.
Journal of cardiovascular pharmacology.
1986; 8 Suppl 11(?):S36-40. doi:
10.1097/00005344-198511001-00006. [PMID: 2439796] - C Hertel, M Portenier, M Staehelin. Evidence for the appearance of an uncoupled form of the beta-adrenergic receptor distinct from the internalized receptor.
Journal of cellular biochemistry.
1986; 30(3):219-25. doi:
10.1002/jcb.240300304. [PMID: 2871032] - C J Limas, C Limas. Carbachol induces desensitization of cardiac beta-adrenergic receptors through muscarinic M1 receptors.
Biochemical and biophysical research communications.
1985 Apr; 128(2):699-704. doi:
10.1016/0006-291x(85)90103-2. [PMID: 2986622] - A Wellstein, D Palm, H F Pitschner, G G Belz. Receptor binding of propranolol is the missing link between plasma concentration kinetics and the effect-time course in man.
European journal of clinical pharmacology.
1985; 29(2):131-47. doi:
10.1007/bf00547412. [PMID: 3000793] - M L Toews, G L Waldo, T K Harden, J P Perkins. Relationship between an altered membrane form and a low affinity form of the beta-adrenergic receptor occurring during catecholamine-induced desensitization. Evidence for receptor internalization.
The Journal of biological chemistry.
1984 Oct; 259(19):11844-50. doi:
NULL. [PMID: 6090447] - A Wellstein, D Palm, G Wiemer, M Schäfer-Korting, E Mutschler. Simple and reliable radioreceptor assay for beta-adrenoceptor antagonists and active metabolites in native human plasma.
European journal of clinical pharmacology.
1984; 27(5):545-53. doi:
10.1007/bf00556890. [PMID: 6151508] - C Hertel, P Müller, M Portenier, M Staehelin. Determination of the desensitization of beta-adrenergic receptors by [3H]CGP-12177.
The Biochemical journal.
1983 Dec; 216(3):669-74. doi:
10.1042/bj2160669. [PMID: 6141790]