4-Hydroxyphenobarbital (BioDeep_00001875995)
代谢物信息卡片
2,4,6(1H,3H,5H)-Pyrimidinetrione,5-ethyl-5-(4-hydroxyphenyl)-
化学式: C12H12N2O4 (248.07970319999998)
中文名称: 4-羟基苯巴比妥
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC1(C(=O)NC(=O)NC1=O)C2=CC=C(C=C2)O
InChI: InChI=1S/C12H12N2O4/c1-2-12(7-3-5-8(15)6-4-7)9(16)13-11(18)14-10(12)17/h3-6,15H,2H2,1H3,(H2,13,14,16,17,18)
描述信息
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Adnan Kadi, Mohamed Hefnawy, Saeed Julkhuf, Mohammed Abounassif, Gamal Mostafa, Mohamed G Kassem, Sabry Attia, Ali Al-Ghamdi. Sample stacking microemulsion electrokinetic capillary chromatography induced by reverse migrating pseudostationary phase for the quantification of phenobarbital and its p-hydroxyphenobarbital metabolite in rat urine.
The Analyst.
2011 Jul; 136(13):2858-65. doi:
10.1039/c0an00768d. [PMID: 21607283] - Hao Xiong, Hiroshi Suzuki, Yuichi Sugiyama, Peter J Meier, Gary M Pollack, Kim L R Brouwer. Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatment.
Drug metabolism and disposition: the biological fate of chemicals.
2002 Sep; 30(9):962-9. doi:
10.1124/dmd.30.9.962. [PMID: 12167560] - V Ferranti, C Chabenat, H Marchais, S Ménager, H Hue, A M Orecchioni, O Lafont. Effects of encapsulation of primidone on its oxidative metabolism in rats.
Drug metabolism and drug interactions.
2001; 18(3-4):191-208. doi:
10.1515/dmdi.2001.18.3-4.191. [PMID: 11791884] - V Ferranti, C Chabenat, S Ménager, O Lafont. Simultaneous determination of primidone and its three major metabolites in rat urine by high-performance liquid chromatography using solid-phase extraction.
Journal of chromatography. B, Biomedical sciences and applications.
1998 Oct; 718(1):199-204. doi:
10.1016/s0378-4347(98)00356-9. [PMID: 9832377] - S G Paibir, W H Soine. High-performance liquid chromatographic analysis of phenobarbital and phenobarbital metabolites in human urine.
Journal of chromatography. B, Biomedical sciences and applications.
1997 Mar; 691(1):111-7. doi:
10.1016/s0378-4347(96)00437-9. [PMID: 9140764] - P Reidenberg, P Glue, C R Banfield, R D Colucci, J W Meehan, E Radwanski, P Mojavarian, C C Lin, J Nezamis, M Guillaume. Effects of felbamate on the pharmacokinetics of phenobarbital.
Clinical pharmacology and therapeutics.
1995 Sep; 58(3):279-87. doi:
10.1016/0009-9236(95)90244-9. [PMID: 7554701] - G D Anderson, R H Levy. The effect of valproate on the metabolism of phenobarbital in the rat.
Pharmaceutical research.
1992 Dec; 9(12):1622-8. doi:
10.1023/a:1015876727795. [PMID: 1488407] - A M Stijnen, M Danhof, C F Van Bezooijen. Increased sensitivity to the anesthetic effect of phenobarbital in aging BN/BiRij rats.
The Journal of pharmacology and experimental therapeutics.
1992 Apr; 261(1):81-7. doi:
NULL. [PMID: 1560386] - W H Soine, P J Soine, T M England, J W Ferkany, B E Agriesti. Identification of phenobarbital N-glucosides as urinary metabolites of phenobarbital in mice.
Journal of pharmaceutical sciences.
1991 Feb; 80(2):99-103. doi:
10.1002/jps.2600800202. [PMID: 1646877] - W H Soine, P J Soine, T M England, D F Welty, J H Wood. LC determination of the diastereomers of 1-(beta-D-glucopyranosyl)phenobarbital in human urine.
Journal of pharmaceutical and biomedical analysis.
1990; 8(4):365-72. doi:
10.1016/0731-7085(90)80051-p. [PMID: 2100211] - J Dingemanse, J B van Bree, M Danhof. Pharmacokinetic modeling of the anticonvulsant action of phenobarbital in rats.
The Journal of pharmacology and experimental therapeutics.
1989 May; 249(2):601-8. doi:
NULL. [PMID: 2724142] - J Mounié, L Champion, H Goudonnet, A Escousse, R C Truchot. Inductive effects of fenofibrate and metabolism of phenobarbital.
Fundamental & clinical pharmacology.
1988; 2(4):259-65. doi:
10.1111/j.1472-8206.1988.tb00637.x. [PMID: 3220422] - V O Bhargava, L K Garrettson. Development of phenobarbital glucosidation in the human neonate.
Developmental pharmacology and therapeutics.
1988; 11(1):8-13. doi:
10.1159/000457658. [PMID: 3383723] - Y Benchekroun, B Ribon, M Desage, J L Brazier. Simultaneous quantitation of phenobarbitone and p-hydroxyphenobarbitone and their perdeuteroethyl analogues in biological fluids by combined gas chromatography-mass spectrometry.
Journal of chromatography.
1987 Sep; 420(2):287-96. doi:
10.1016/0378-4347(87)80185-8. [PMID: 3693502] - V O Bhargava. Quantitation of 1-(beta-D-glucopyranosyl)phenobarbital in plasma and bile.
Journal of chromatography.
1987 Aug; 419(?):421-5. doi:
10.1016/0378-4347(87)80310-9. [PMID: 3667802] - S S Levin, H M Vars, H Schleyer, D Y Cooper. The metabolism and excretion of enzyme-inducing doses of phenobarbital by rats with bile fistulas.
Xenobiotica; the fate of foreign compounds in biological systems.
1986 Mar; 16(3):213-24. doi:
10.3109/00498258609043524. [PMID: 3705618] - V O Bhargava, W H Soine, L K Garrettson. High-performance liquid chromatographic analysis of 1-(beta-D-glucopyranosyl)phenobarbital in urine.
Journal of chromatography.
1985 Sep; 343(1):219-23. doi:
10.1016/s0378-4347(00)84590-9. [PMID: 4066858] - M Danhof, M Hisaoka, G Levy. Kinetics of drug action in disease states. II. Effect of experimental renal dysfunction on phenobarbital concentrations in rats at onset of loss of righting reflect.
The Journal of pharmacology and experimental therapeutics.
1984 Sep; 230(3):627-31. doi:
NULL. [PMID: 6332189] - B K Tang, B Yilmaz, W Kalow. Determination of phenobarbital, p-hydroxyphenobarbital and phenobarbital-N-glucoside in urine by gas chromatography chemical ionization mass spectrometry.
Biomedical mass spectrometry.
1984 Sep; 11(9):462-5. doi:
10.1002/bms.1200110905. [PMID: 6509155] - M G Porro, H J Kupferberg, R J Porter, W H Theodore, M E Newmark. Phenytoin: an inhibitor and inducer of primidone metabolism in an epileptic patient.
British journal of clinical pharmacology.
1982 Aug; 14(2):294-7. doi:
10.1111/j.1365-2125.1982.tb01980.x. [PMID: 7104185] - A Van Langenhove, J E Biller, K Biemann, T R Browne. Simultaneous determination of phenobarbital and p-hydroxyphenobarbital and their stable isotope labeled analogs by gas chromatography mass spectrometry.
Biomedical mass spectrometry.
1982 May; 9(5):201-7. doi:
10.1002/bms.1200090505. [PMID: 7093441] - I M Kapetanović, H J Kupferberg. GC and GC-mass spectrometric determination of p-hydroxyphenobarbital extracted from plasma, urine, and hepatic microsomes.
Journal of pharmaceutical sciences.
1981 Nov; 70(11):1218-24. doi:
10.1002/jps.2600701110. [PMID: 7299667] - F Sarhan, J M Engasser, A M Batt, J Magdalou, G Siest. Effect of diphenylhydantoin and its main hydroxylated metabolite on the pharmacokinetics and the urinary and biliary excretion of phenobarbital and its p-hydroxy metabolite.
European journal of drug metabolism and pharmacokinetics.
1981; 6(2):99-108. doi:
10.1007/bf03189475. [PMID: 7306277] - R Riva, F Albani, A Baruzzi. Rapid quantitative determination of underivatized carbamazepine, phenytoin, phenobarbital and p-hydroxyphenobarbital in biological fluids by packed column gas chromatography.
Journal of chromatography.
1980 Nov; 221(1):75-84. doi:
10.1016/s0378-4347(00)81009-9. [PMID: 7451626] - I H Patel, R H Levy, J M Neal, W F Trager. Simultaneous analysis of phenobarbital and p-hydroxyphenobarbital in biological fluids by GLC-chemical-ionization mass spectrometry.
Journal of pharmaceutical sciences.
1980 Oct; 69(10):1218-9. doi:
10.1002/jps.2600691027. [PMID: 7420295] - H Nau, D Jesdinsky, W Wittfoht. Microassay for primidone and its metabolites phenylethylmalondiamide, phenobarbital and p-hydroxyphenobarbital in human serum, saliva, breast milk and tissues by gas chromatography--mass spectrometry using selected ion monitoring.
Journal of chromatography.
1980 Apr; 182(1):71-9. doi:
10.1016/s0378-4347(00)81652-7. [PMID: 7380904]