Hawkinsin (BioDeep_00001875952)

   


代谢物信息卡片


Hawkinsin

化学式: C11H17NO6S (291.07765420000004)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(CC(=O)O)(C(CC1O)SCC(C(=O)O)N)O
InChI: InChI=1S/C11H17NO6S/c12-7(10(16)17)5-19-8-3-6(13)1-2-11(8,18)4-9(14)15/h1-2,6-8,13,18H,3-5,12H2,(H,14,15)(H,16,17)

描述信息

A cysteine derivative that is cysteine in which the thiol group is substituted by a [2-(carboxymethyl)-2,5-dihydroxycyclohex-3-en-1-yl]sulfanediyl group. Hawkinsinuria is an inherited disorder which is characterized by the inability to break down the amino acid tyrosine. This results in the finding of certain metabolites in the urine, such as hawkinsin.

同义名列表

1 个代谢物同义名

Hawkinsin



数据库引用编号

5 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • June M Brownlee, Brian Heinz, Judith Bates, Graham R Moran. Product analysis and inhibition studies of a causative Asn to Ser variant of 4-hydroxyphenylpyruvate dioxygenase suggest a simple route to the treatment of Hawkinsinuria. Biochemistry. 2010 Aug; 49(33):7218-26. doi: 10.1021/bi1008112. [PMID: 20677779]
  • Chike Bellarmine Item, Ivana Mihalek, Oliver Lichtarge, Anil Jalan, Julia Vodopiutz, Adolf Muhl, Olaf A Bodamer. Manifestation of hawkinsinuria in a patient compound heterozygous for hawkinsinuria and tyrosinemia III. Molecular genetics and metabolism. 2007 Aug; 91(4):379-83. doi: 10.1016/j.ymgme.2007.04.008. [PMID: 17560158]
  • K Tomoeda, H Awata, T Matsuura, I Matsuda, E Ploechl, T Milovac, A Boneh, C R Scott, D M Danks, F Endo. Mutations in the 4-hydroxyphenylpyruvic acid dioxygenase gene are responsible for tyrosinemia type III and hawkinsinuria. Molecular genetics and metabolism. 2000 Nov; 71(3):506-10. doi: 10.1006/mgme.2000.3085. [PMID: 11073718]
  • W Lehnert, W Stögmann, U Engelke, R A Wevers, G B van den Berg. Long-term follow up of a new case of hawkinsinuria. European journal of pediatrics. 1999 Jul; 158(7):578-82. doi: 10.1007/s004310051151. [PMID: 10412819]
  • F Endo. [Hawkinsinuria]. Ryoikibetsu shokogun shirizu. 1998; ?(18 Pt 1):141-3. doi: NULL. [PMID: 9590009]
  • M Borden, J Holm, J Leslie, L Sweetman, W L Nyhan, L Fleisher, H Nadler, D Lewis, C R Scott. Hawkinsinuria in two families. American journal of medical genetics. 1992 Sep; 44(1):52-6. doi: 10.1002/ajmg.1320440113. [PMID: 1519651]
  • C H Hocart, B Halpern, L A Hick, C O Wong. Hawkinsinuria--identification of quinolacetic acid and pyroglutamic acid during an acidotic phase. Journal of chromatography. 1983 Jul; 275(2):237-43. doi: 10.1016/s0378-4347(00)84371-6. [PMID: 6619234]
  • B Wilcken, J W Hammond, N Howard, T Bohane, C Hocart, B Halpern. Hawkinsinuria: a dominantly inherited defect of tyrosine metabolism with severe effects in infancy. The New England journal of medicine. 1981 Oct; 305(15):865-8. doi: 10.1056/nejm198110083051505. [PMID: 7278885]
  • A Niederwieser, S K Wadman, D M Danks. Excretion of cis- and trans-4-hydroxycyclohexylacetic acid in addition to hawkinsin in a family with a postulated defect of 4-hydroxyphenylpyruvate dioxygenase. Clinica chimica acta; international journal of clinical chemistry. 1978 Dec; 90(2):195-200. doi: 10.1016/0009-8981(78)90522-3. [PMID: 719903]
  • A Niederwieser, A Matasović, F Neuheiser, E Wetzel. New tyrosine metabolites in humans: hawkinsin and cis- and trans-4-hydroxycyclohexylacetic acids. Unusual adsorption of deuterated and non-deuterated hawkinsin during gas chromatography. Journal of chromatography. 1978 Sep; 146(2):207-12. doi: 10.1016/s0378-4347(00)81886-1. [PMID: 701419]
  • A Niederwieser, A Matasovic, P Tippett, D M Danks. A new sulfur amino acid, named hawkinsin, identified in a baby with transient tyrosinemia and her mother. Clinica chimica acta; international journal of clinical chemistry. 1977 May; 76(3):345-56. doi: 10.1016/0009-8981(77)90161-9. [PMID: 858207]
  • H Christensen, S Felby. Dibenzepine and its metabolites in blood, muscle, liver, vitreous body and urine from fatal poisoning. Acta pharmacologica et toxicologica. 1975 Nov; 37(5):393-401. doi: 10.1111/j.1600-0773.1975.tb00858.x. [PMID: 888]
  • A C Buck. Disorders of micturition in bacterial prostatitis. Proceedings of the Royal Society of Medicine. 1975 Aug; 68(8):508-11. doi: NULL. [PMID: 681]