2-({6-Amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl}sulfanyl)acetamide (BioDeep_00001875919)

   


代谢物信息卡片


2-({6-Amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl}sulfanyl)acetamide

化学式: C19H17N5O2S (379.1102902)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC1COC2=CC=C(C=C2)C3=C(C(=NC(=C3C#N)SCC(=O)N)N)C#N
InChI: InChI=1S/C19H17N5O2S/c20-7-14-17(12-3-5-13(6-4-12)26-9-11-1-2-11)15(8-21)19(24-18(14)23)27-10-16(22)25/h3-6,11H,1-2,9-10H2,(H2,22,25)(H2,23,24)

描述信息

D018377 - Neurotransmitter Agents > D058905 - Purinergic Agents > D058913 - Purinergic Agonists
BAY 60-6583 is a potent and high-affinity agonist of adenosine A2B receptor (EC50?= 3 nM) over A1, A2A, and A3 receptors. BAY 60-6583 binds to mouse, rabbit, and dog A2BAR with Ki values of 750 nM, 340 nM and 330 nM, respectively. BAY 60-6583 has a cardioprotective effect in a myocardial ischemia model[1][5].

同义名列表

2 个代谢物同义名

2-({6-Amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl}sulfanyl)acetamide; BAY 60-6583



数据库引用编号

5 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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文献列表

  • Samantha L Cooper, Edward S Wragg, Patrizia Pannucci, Mark Soave, Stephen J Hill, Jeanette Woolard. Regionally selective cardiovascular responses to adenosine A2A and A2B receptor activation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2022 04; 36(4):e22214. doi: 10.1096/fj.202101945r. [PMID: 35230706]
  • Elisabetta Coppi, Federica Cherchi, Irene Fusco, Ilaria Dettori, Lisa Gaviano, Giada Magni, Daniela Catarzi, Vittoria Colotta, Flavia Varano, Francesca Rossi, Caterina Bernacchioni, Chiara Donati, Paola Bruni, Felicita Pedata, Francesca Cencetti, Anna Maria Pugliese. Adenosine A2B receptors inhibit K+ currents and cell differentiation in cultured oligodendrocyte precursor cells and modulate sphingosine-1-phosphate signaling pathway. Biochemical pharmacology. 2020 07; 177(?):113956. doi: 10.1016/j.bcp.2020.113956. [PMID: 32251679]
  • Sonja Hinz, Wessam M Alnouri, Ulrich Pleiss, Christa E Müller. Tritium-labeled agonists as tools for studying adenosine A2B receptors. Purinergic signalling. 2018 09; 14(3):223-233. doi: 10.1007/s11302-018-9608-5. [PMID: 29752618]
  • Jessica M Wilson, Ellen Lorimer, Michael D Tyburski, Carol L Williams. β-Adrenergic receptors suppress Rap1B prenylation and promote the metastatic phenotype in breast cancer cells. Cancer biology & therapy. 2015; 16(9):1364-74. doi: 10.1080/15384047.2015.1070988. [PMID: 26209110]
  • Tomomi E Kimura, Aparna Duggirala, Charles C T Hindmarch, Richard C Hewer, Mei-Zhen Cui, Andrew C Newby, Mark Bond. Inhibition of Egr1 expression underlies the anti-mitogenic effects of cAMP in vascular smooth muscle cells. Journal of molecular and cellular cardiology. 2014 Jul; 72(?):9-19. doi: 10.1016/j.yjmcc.2014.02.001. [PMID: 24534707]
  • Sonja Hinz, Svenja K Lacher, Benjamin F Seibt, Christa E Müller. BAY60-6583 acts as a partial agonist at adenosine A2B receptors. The Journal of pharmacology and experimental therapeutics. 2014 Jun; 349(3):427-36. doi: 10.1124/jpet.113.210849. [PMID: 24633424]
  • Balázs Koscsó, Alexey Trepakov, Balázs Csóka, Zoltán H Németh, Pál Pacher, Holger K Eltzschig, György Haskó. Stimulation of A2B adenosine receptors protects against trauma-hemorrhagic shock-induced lung injury. Purinergic signalling. 2013 Sep; 9(3):427-32. doi: 10.1007/s11302-013-9362-7. [PMID: 23584760]
  • Almut Grenz, Hartmut Osswald, Tobias Eckle, Dan Yang, Hua Zhang, Zung Vu Tran, Karin Klingel, Katya Ravid, Holger K Eltzschig. The reno-vascular A2B adenosine receptor protects the kidney from ischemia. PLoS medicine. 2008 Jun; 5(6):e137. doi: 10.1371/journal.pmed.0050137. [PMID: 18578565]