2-Methoxyidazoxan (BioDeep_00001875909)

   


代谢物信息卡片


2-Methoxyidazoxan

化学式: C12H14N2O3 (234.1004374)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1(COC2=CC=CC=C2O1)C3=NCCN3
InChI: InChI=1S/C12H14N2O3/c1-15-12(11-13-6-7-14-11)8-16-9-4-2-3-5-10(9)17-12/h2-5H,6-8H2,1H3,(H,13,14)

描述信息

D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists

同义名列表

1 个代谢物同义名

2-Methoxyidazoxan



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • M Julia García-Fuster, Jesús A García-Sevilla. Effects of anti-depressant treatments on FADD and p-FADD protein in rat brain cortex: enhanced anti-apoptotic p-FADD/FADD ratio after chronic desipramine and fluoxetine administration. Psychopharmacology. 2016 Aug; 233(15-16):2955-71. doi: 10.1007/s00213-016-4342-6. [PMID: 27259485]
  • Hilary R Smith, Thomas J R Beveridge, Michael A Nader, Linda J Porrino. Effects of abstinence from chronic cocaine self-administration on nonhuman primate dorsal and ventral noradrenergic bundle terminal field structures. Brain structure & function. 2016 06; 221(5):2703-15. doi: 10.1007/s00429-015-1066-z. [PMID: 26013302]
  • Jan Anker Jahnsen, Staffan Uhlén. The predicted N-terminal signal sequence of the human α₂C-adrenoceptor does not act as a functional cleavable signal peptide. European journal of pharmacology. 2012 Jun; 684(1-3):51-8. doi: 10.1016/j.ejphar.2012.03.044. [PMID: 22503931]
  • C A F Andrade, L O Margatho, G M F Andrade-Franzé, L A De Luca, J Antunes-Rodrigues, J V Menani. Moxonidine into the lateral parabrachial nucleus reduces renal and hormonal responses to cell dehydration. Neuroscience. 2012 Apr; 208(?):69-78. doi: 10.1016/j.neuroscience.2012.02.013. [PMID: 22373877]
  • Mercè Masana, Analía Bortolozzi, Francesc Artigas. Selective enhancement of mesocortical dopaminergic transmission by noradrenergic drugs: therapeutic opportunities in schizophrenia. The international journal of neuropsychopharmacology. 2011 Feb; 14(1):53-68. doi: 10.1017/s1461145710000908. [PMID: 20701825]
  • Yia-Ping Liu, Yu-Lung Lin, Chia-Hsin Chuang, Yu-Cheng Kao, Shang-Tang Chang, Che-Se Tung. Alpha adrenergic modulation on effects of norepinephrine transporter inhibitor reboxetine in five-choice serial reaction time task. Journal of biomedical science. 2009 Aug; 16(?):72. doi: 10.1186/1423-0127-16-72. [PMID: 19678962]
  • Candy K S Chan, Sandra L Burke, Geoffrey A Head. Contribution of imidazoline receptors and alpha2-adrenoceptors in the rostral ventrolateral medulla to sympathetic baroreflex inhibition by systemic rilmenidine. Journal of hypertension. 2007 Jan; 25(1):147-55. doi: 10.1097/hjh.0b013e3280105ef0. [PMID: 17143186]
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  • R Gilsbach, A Faron-Górecka, Z Rogóz, M Brüss, M G Caron, M Dziedzicka-Wasylewska, H Bönisch. Norepinephrine transporter knockout-induced up-regulation of brain alpha2A/C-adrenergic receptors. Journal of neurochemistry. 2006 Feb; 96(4):1111-20. doi: 10.1111/j.1471-4159.2005.03598.x. [PMID: 16417582]
  • Patricia Szot, Sylvia S White, J Lynne Greenup, James B Leverenz, Elaine R Peskind, Murray A Raskind. Compensatory changes in the noradrenergic nervous system in the locus ceruleus and hippocampus of postmortem subjects with Alzheimer's disease and dementia with Lewy bodies. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006 Jan; 26(2):467-78. doi: 10.1523/jneurosci.4265-05.2006. [PMID: 16407544]
  • David P Finn, Alan L Hudson, Hiroshi Kinoshita, Toni L Coventry, David S Jessop, David J Nutt, Michael S Harbuz. Imidazoline2 (I2) receptor- and alpha2-adrenoceptor-mediated modulation of hypothalamic-pituitary-adrenal axis activity in control and acute restraint stressed rats. Journal of psychopharmacology (Oxford, England). 2004 Mar; 18(1):47-53. doi: 10.1177/0269881104040231. [PMID: 15107184]
  • Staffan Uhlén, Jonas Lindblom, Anna Kindlundh, Paul Mugisha, Fred Nyberg. Nandrolone treatment decreases the level of rat kidney alpha(1B)-adrenoceptors. Naunyn-Schmiedeberg's archives of pharmacology. 2003 Aug; 368(2):91-8. doi: 10.1007/s00210-003-0763-y. [PMID: 12861436]
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  • D P Finn, M D Lalies, M S Harbuz, D S Jessop, A L Hudson, D J Nutt. Imidazoline(2) (I(2)) binding site- and alpha(2)-adrenoceptor-mediated modulation of central noradrenergic and HPA axis function in control rats and chronically stressed rats with adjuvant-induced arthritis. Neuropharmacology. 2002 Jun; 42(7):958-65. doi: 10.1016/s0028-3908(02)00046-1. [PMID: 12069906]
  • Daniel Cussac, Stéphane Schaak, Céline Gales, Christodoulos Flordellis, Colette Denis, Hervé Paris. alpha(2B)-Adrenergic receptors activate MAPK and modulate proliferation of primary cultured proximal tubule cells. American journal of physiology. Renal physiology. 2002 May; 282(5):F943-52. doi: 10.1152/ajprenal.0108.2001. [PMID: 11934705]
  • Francesco Gentili, Pascal Bousquet, Livio Brasili, Mariangela Caretto, Antonio Carrieri, Monique Dontenwill, Mario Giannella, Gabriella Marucci, Marina Perfumi, Alessandro Piergentili, Wilma Quaglia, Carla Rascente, Maria Pigini. Alpha2-adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole. Journal of medicinal chemistry. 2002 Jan; 45(1):32-40. doi: 10.1021/jm0110082. [PMID: 11754577]
  • Mostafa Khalid, Norelyaquine Ilhami, Yves Giudicelli, Jean-Pierre Dausse. Testosterone dependence of salt-induced hypertension in Sabra rats and role of renal alpha(2)-adrenoceptor subtypes. The Journal of pharmacology and experimental therapeutics. 2002 Jan; 300(1):43-9. doi: 10.1124/jpet.300.1.43. [PMID: 11752095]
  • S Gesta, J Hejnova, M Berlan, D Daviaud, F Crampes, V Stich, P Valet, J S Saulnier-Blache. In vitro and in vivo impairment of alpha2-adrenergic receptor-dependent antilipolysis by fatty acids in human adipose tissue. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2001 Dec; 33(12):701-7. doi: 10.1055/s-2001-19140. [PMID: 11753754]
  • T Olli-Lähdesmäki, J Kallio, M Scheinin. Receptor subtype-induced targeting and subtype-specific internalization of human alpha(2)-adrenoceptors in PC12 cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1999 Nov; 19(21):9281-8. doi: 10.1523/jneurosci.19-21-09281.1999. [PMID: 10531432]
  • G Flügge. Effects of cortisol on brain alpha2-adrenoceptors: potential role in stress. Neuroscience and biobehavioral reviews. 1999 Nov; 23(7):949-56. doi: 10.1016/s0149-7634(99)00028-7. [PMID: 10580309]
  • B Sjöholm, J Lähdesmäki, K Pyykkö, M Hillilä, M Scheinin. Non-adrenergic binding of [3H]atipamezole in rat kidney--regional distribution and comparison to alpha2-adrenoceptors. British journal of pharmacology. 1999 Nov; 128(6):1215-22. doi: 10.1038/sj.bjp.0702917. [PMID: 10578134]
  • W Zhang, V Klimek, J T Farley, M Y Zhu, G A Ordway. alpha2C adrenoceptors inhibit adenylyl cyclase in mouse striatum: potential activation by dopamine. The Journal of pharmacology and experimental therapeutics. 1999 Jun; 289(3):1286-92. doi: NULL. [PMID: 10336518]
  • L F Callado, A M Gabilondo, J J Meana. Differential modulation of alpha2-adrenoceptor subtypes in rat kidney by chronic desipramine treatment. Life sciences. 1999; 64(25):2327-39. doi: 10.1016/s0024-3205(99)00186-1. [PMID: 10374896]
  • R M Cleale, J M Ingling, D J Search, J R Hadcock, M H Pausch. Effects of alpha2-adrenoceptor antagonists on metabolic processes of swine: I. Effects on nonesterified fatty acid and plasma urea nitrogen concentrations in jugularly catheterized pigs. Journal of animal science. 1998 Jul; 76(7):1838-48. doi: 10.2527/1998.7671838x. [PMID: 9690639]
  • R M Cleale, J M Ingling, D J Search, J R Hadcock, M H Pausch. Effects of alpha2-adrenoceptor antagonists on metabolic processes of swine: II. Nitrogen balance responses. Journal of animal science. 1998 Jul; 76(7):1849-58. doi: 10.2527/1998.7671849x. [PMID: 9690640]
  • S Uhlén, M Dambrova, J Näsman, H B Schiöth, Y Gu, A Wikberg-Matsson, J E Wikberg. [3H]RS79948-197 binding to human, rat, guinea pig and pig alpha2A-, alpha2B- and alpha2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine. European journal of pharmacology. 1998 Feb; 343(1):93-101. doi: 10.1016/s0014-2999(97)01521-5. [PMID: 9551719]
  • L F Callado, J J Meana. Low-affinity conditions for agonists increase the binding of the antagonist [3H]RX821002 to the alpha(2B/C)-adrenoceptor subtypes in human brain and rat kidney. European journal of pharmacology. 1997 Jul; 332(1):109-12. doi: 10.1016/s0014-2999(97)01105-9. [PMID: 9298931]
  • C J Bol, A P IJzerman, M Danhof, J W Mandema. Determination of dexmedetomidine in rat plasma by a sensitive [3H]clonidine radioreceptor assay. Journal of pharmaceutical sciences. 1997 Jul; 86(7):822-6. doi: 10.1021/js960478u. [PMID: 9232523]
  • S Bétuing, P Valet, S Lapalu, D Peyroulan, G Hickson, D Daviaud, M Lafontan, J S Saulnier-Blache. Functional consequences of constitutively active alpha2A-adrenergic receptor expression in 3T3F442A preadipocytes and adipocytes. Biochemical and biophysical research communications. 1997 Jun; 235(3):765-73. doi: 10.1006/bbrc.1997.6887. [PMID: 9207236]
  • H D Intengan, D D Smyth. Alpha-2a/d adrenoceptor subtype stimulation by guanfacine increases osmolar clearance. The Journal of pharmacology and experimental therapeutics. 1997 Apr; 281(1):48-53. doi: NULL. [PMID: 9103479]
  • L F Callado, A M Gabilondo, J J Meana. [3H]RX821002 (2-methoxyidazoxan) binds to alpha 2-adrenoceptor subtypes and a non-adrenoceptor imidazoline binding site in rat kidney. European journal of pharmacology. 1996 Dec; 316(2-3):359-68. doi: 10.1016/s0014-2999(96)00692-9. [PMID: 8982708]
  • C A Herman, G Luczy, J E Wikberg, S Uhlén. Characterization of adrenoceptor types and subtypes in American bullfrogs acclimated to warm or cold temperature. General and comparative endocrinology. 1996 Nov; 104(2):168-78. doi: 10.1006/gcen.1996.0159. [PMID: 8930607]
  • G Flügge. Alterations in the central nervous alpha 2-adrenoceptor system under chronic psychosocial stress. Neuroscience. 1996 Nov; 75(1):187-96. doi: 10.1016/0306-4522(96)00292-8. [PMID: 8923533]
  • C Vayssettes-Courchay, F Bouysset, A A Cordi, M Laubie, T J Verbeuren. A comparative study of the reversal by different alpha 2-adrenoceptor antagonists of the central sympatho-inhibitory effect of clonidine. British journal of pharmacology. 1996 Feb; 117(3):587-593. doi: 10.1111/j.1476-5381.1996.tb15231.x. [PMID: 8821553]
  • A Wikberg-Matsson, J E Wikberg, S Uhlén. Identification of drugs subtype-selective for alpha 2A-, alpha 2B-, and alpha 2C-adrenoceptors in the pig cerebellum and kidney cortex. European journal of pharmacology. 1995 Sep; 284(3):271-9. doi: 10.1016/0014-2999(95)00354-n. [PMID: 8666009]
  • R G Evans, W P Anderson. Renal effects of infusion of rilmenidine and guanabenz in conscious dogs: contribution of peripheral and central nervous system alpha 2-adrenoceptors. British journal of pharmacology. 1995 Sep; 116(1):1557-70. doi: 10.1111/j.1476-5381.1995.tb16373.x. [PMID: 8564219]
  • B Szabo, R Urban. Mechanism of sympathoinhibition by imidazolines. Annals of the New York Academy of Sciences. 1995 Jul; 763(?):552-65. doi: 10.1111/j.1749-6632.1995.tb32449.x. [PMID: 7677373]
  • W Erdbrügger, M Raulf, T Otto, M C Michel. Does [3H]2-methoxy-idazoxan (RX 821002) detect more alpha-2-adrenoceptor agonist high-affinity sites than [3H]rauwolscine? A comparison of nine tissues and cell lines. The Journal of pharmacology and experimental therapeutics. 1995 Jun; 273(3):1287-94. doi: . [PMID: 7791100]
  • D Huangfu, W B Goodwin, P G Guyenet. Sympatholytic effect of tricyclic antidepressants: site and mechanism of action in anesthetized rats. The American journal of physiology. 1995 Jun; 268(6 Pt 2):R1429-41. doi: 10.1152/ajpregu.1995.268.6.r1429. [PMID: 7611519]
  • K Biyah, C Advenier. Effects of three alpha 2-adrenoceptor agonists, rilmenidine, UK 14304 and clonidine on bradykinin- and substance P-induced airway microvascular leakage in guinea-pigs. Neuropeptides. 1995 Apr; 28(4):197-207. doi: 10.1016/0143-4179(95)90023-3. [PMID: 7541119]
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  • I K Wright, N A Blaylock, D A Kendall, V G Wilson. The relationship between density of alpha-adrenoceptor binding sites and contractile responses in several porcine isolated blood vessels. British journal of pharmacology. 1995 Feb; 114(3):678-88. doi: 10.1111/j.1476-5381.1995.tb17192.x. [PMID: 7735695]
  • A Bouloumié, V Planat, J C Devedjian, P Valet, J S Saulnier-Blache, M Record, M Lafontan. Alpha 2-adrenergic stimulation promotes preadipocyte proliferation. Involvement of mitogen-activated protein kinases. The Journal of biological chemistry. 1994 Dec; 269(48):30254-9. doi: 10.1016/s0021-9258(18)43805-7. [PMID: 7982935]
  • A Bouloumié, P Valet, D Daviaud, H Prats, M Lafontan, J S Saulnier-Blache. Adipocyte alpha 2A-adrenoceptor is the only alpha 2-adrenoceptor regulated by testosterone. European journal of pharmacology. 1994 Sep; 269(1):95-103. doi: 10.1016/0922-4106(94)90031-0. [PMID: 7828661]
  • R G Evans, J M Haynes. Characterization of binding sites for [3H]-idazoxan, [3H]-P-aminoclonidine and [3H]-rauwolscine in the kidney of the dog. Clinical and experimental pharmacology & physiology. 1994 Aug; 21(8):649-58. doi: 10.1111/j.1440-1681.1994.tb02566.x. [PMID: 7813124]
  • M Noyer, F de Laveleye, G Vauquelin, J Gobert, E Wülfert. Mivazerol, a novel compound with high specificity for alpha 2 adrenergic receptors: binding studies on different human and rat membrane preparations. Neurochemistry international. 1994 Mar; 24(3):221-9. doi: 10.1016/0197-0186(94)90079-5. [PMID: 8025531]
  • B Szabo, R Urban, K Starke. Sympathoinhibition by rilmenidine in conscious rabbits: involvement of alpha 2-adrenoceptors. Naunyn-Schmiedeberg's archives of pharmacology. 1993 Dec; 348(6):593-600. doi: 10.1007/bf00167235. [PMID: 7907776]
  • M Berlan, R Le Verge, J Galitzky, P Le Corre. Alpha 2-adrenoceptor antagonist potencies of two hydroxylated metabolites of yohimbine. British journal of pharmacology. 1993 Apr; 108(4):927-32. doi: 10.1111/j.1476-5381.1993.tb13488.x. [PMID: 8097957]
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  • S Uhlén, J E Wikberg. Delineation of rat kidney alpha 2A- and alpha 2B-adrenoceptors with [3H]RX821002 radioligand binding: computer modelling reveals that guanfacine is an alpha 2A-selective compound. European journal of pharmacology. 1991 Sep; 202(2):235-43. doi: 10.1016/0014-2999(91)90299-6. [PMID: 1666366]
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  • J S Saulnier-Blache, D Larrouy, C Carpéné, N Quideau, M Dauzats, M Lafontan. Photoperiodic control of adipocyte alpha 2-adrenoceptors in Syrian hamsters: role of testosterone. Endocrinology. 1990 Sep; 127(3):1245-53. doi: 10.1210/endo-127-3-1245. [PMID: 1974846]
  • C Carpéné, J Galitzky, D Larrouy, D Langin, M Lafontan. Non-adrenergic sites for imidazolines are not directly involved in the alpha 2-adrenergic antilipolytic effect of UK 14304 in rat adipocytes. Biochemical pharmacology. 1990 Aug; 40(3):437-45. doi: 10.1016/0006-2952(90)90541-r. [PMID: 1974423]
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  • J S Saulnier-Blache, C Carpéné, D Langin, M Lafontan. Imidazolinic radioligands for the identification of hamster adipocyte alpha 2-adrenoceptors. European journal of pharmacology. 1989 Nov; 171(2-3):145-57. doi: 10.1016/0014-2999(89)90103-9. [PMID: 2575998]