1-(2,6-Dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea (BioDeep_00001875907)
代谢物信息卡片
1-(2,6-Dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea
化学式: C17H19Cl2N7O (407.1028064)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=NN(C2=C1C(=CC(=N2)NNC(=O)NC3=CC(=NC(=C3)Cl)Cl)C(C)C)C
InChI: InChI=1S/C17H19Cl2N7O/c1-8(2)11-7-14(22-16-15(11)9(3)25-26(16)4)23-24-17(27)20-10-5-12(18)21-13(19)6-10/h5-8H,1-4H3,(H,22,23)(H2,20,21,24,27)
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yosuke Osawa, Hironari Kawai, Keigo Nakashima, Yuichi Nakaseko, Daisuke Suto, Keisuke Yanagida, Tomomi Hashidate-Yoshida, Taizo Mori, Sachiyo Yoshio, Takaaki Ohtake, Hideo Shindou, Tatsuya Kanto. Sphingosine-1-phosphate promotes liver fibrosis in metabolic dysfunction-associated steatohepatitis.
PloS one.
2024; 19(5):e0303296. doi:
10.1371/journal.pone.0303296. [PMID: 38753743] - Lihua Cui, Caixia Li, Guixian Zhang, Lanqiu Zhang, Guowang Yao, Yuzhen Zhuo, Naiqiang Cui, Shukun Zhang. S1P/S1PR2 promote pancreatic stellate cell activation and pancreatic fibrosis in chronic pancreatitis by regulating autophagy and the NLRP3 inflammasome.
Chemico-biological interactions.
2023 May; 380(?):110541. doi:
10.1016/j.cbi.2023.110541. [PMID: 37169277] - Melissa R Pitman, Alexander C Lewis, Lorena T Davies, Paul A B Moretti, Dovile Anderson, Darren J Creek, Jason A Powell, Stuart M Pitson. The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism.
Scientific reports.
2022 01; 12(1):454. doi:
10.1038/s41598-021-04009-w. [PMID: 35013382] - Qian Chen, Jalees Rehman, Manwai Chan, Panfeng Fu, Steven M Dudek, Viswanathan Natarajan, Asrar B Malik, Yuru Liu. Angiocrine Sphingosine-1-Phosphate Activation of S1PR2-YAP Signaling Axis in Alveolar Type II Cells Is Essential for Lung Repair.
Cell reports.
2020 06; 31(13):107828. doi:
10.1016/j.celrep.2020.107828. [PMID: 32610129] - Satomi Igawa, Jae Eun Choi, Zhenping Wang, Yu-Ling Chang, Chia-Chi Wu, Tyler Werbel, Akemi Ishida-Yamamoto, Anna Di Nardo. Human Keratinocytes Use Sphingosine 1-Phosphate and its Receptors to Communicate Staphylococcus aureus Invasion and Activate Host Defense.
The Journal of investigative dermatology.
2019 08; 139(8):1743-1752.e5. doi:
10.1016/j.jid.2019.02.010. [PMID: 30807768] - Wei Chen, Hong Xiang, Ruifang Chen, Jie Yang, Xiaoping Yang, Jianda Zhou, Hengdao Liu, Shaoli Zhao, Jie Xiao, Pan Chen, Alex F Chen, Shuhua Chen, Hongwei Lu. S1PR2 antagonist ameliorate high glucose-induced fission and dysfunction of mitochondria in HRGECs via regulating ROCK1.
BMC nephrology.
2019 04; 20(1):135. doi:
10.1186/s12882-019-1323-0. [PMID: 30999892] - Jing Yin, Yu-Ming Guo, Ping Chen, He Xiao, Xing-Huan Wang, Michael E DiSanto, Xin-Hua Zhang. Testosterone regulates the expression and functional activity of sphingosine-1-phosphate receptors in the rat corpus cavernosum.
Journal of cellular and molecular medicine.
2018 03; 22(3):1507-1516. doi:
10.1111/jcmm.13416. [PMID: 29266713] - Sayaka Yamamoto, Yuta Yako, Yoichiro Fujioka, Mihoko Kajita, Takeshi Kameyama, Shunsuke Kon, Susumu Ishikawa, Yusuke Ohba, Yusuke Ohno, Akio Kihara, Yasuyuki Fujita. A role of the sphingosine-1-phosphate (S1P)-S1P receptor 2 pathway in epithelial defense against cancer (EDAC).
Molecular biology of the cell.
2016 Feb; 27(3):491-9. doi:
10.1091/mbc.e15-03-0161. [PMID: 26631556] - Mei-Hong Li, Rolf Swenson, Miriam Harel, Sampa Jana, Erik Stolarzewicz, Timothy Hla, Linda H Shapiro, Fernando Ferrer. Antitumor Activity of a Novel Sphingosine-1-Phosphate 2 Antagonist, AB1, in Neuroblastoma.
The Journal of pharmacology and experimental therapeutics.
2015 Sep; 354(3):261-8. doi:
10.1124/jpet.115.224519. [PMID: 26105954] - Lukasz Japtok, Elisabeth I Schmitz, Susann Fayyaz, Stephanie Krämer, Leigh J Hsu, Burkhard Kleuser. Sphingosine 1-phosphate counteracts insulin signaling in pancreatic β-cells via the sphingosine 1-phosphate receptor subtype 2.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2015 Aug; 29(8):3357-69. doi:
10.1096/fj.14-263194. [PMID: 25911610] - Carole A Oskeritzian, Nitai C Hait, Piper Wedman, Alena Chumanevich, Elizabeth M Kolawole, Megan M Price, Yves T Falanga, Kuzhuvelil B Harikumar, John J Ryan, Sheldon Milstien, Roger Sabbadini, Sarah Spiegel. The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell-dependent acute allergic responses.
The Journal of allergy and clinical immunology.
2015 Apr; 135(4):1008-1018.e1. doi:
10.1016/j.jaci.2014.10.044. [PMID: 25512083] - Zhen Wang, Clark R Sims, Naeem K Patil, Neriman Gokden, Philip R Mayeux. Pharmacologic targeting of sphingosine-1-phosphate receptor 1 improves the renal microcirculation during sepsis in the mouse.
The Journal of pharmacology and experimental therapeutics.
2015 Jan; 352(1):61-6. doi:
10.1124/jpet.114.219394. [PMID: 25355645] - Takayuki Kamiya, Taiji Nagaoka, Tsuneaki Omae, Takafumi Yoshioka, Shinji Ono, Ichiro Tanano, Akitoshi Yoshida. Role of Ca2+ -dependent and Ca2+ -sensitive mechanisms in sphingosine 1-phosphate-induced constriction of isolated porcine retinal arterioles in vitro.
Experimental eye research.
2014 Apr; 121(?):94-101. doi:
10.1016/j.exer.2014.01.011. [PMID: 24486793] - K Alexa Orr Gandy, Mohamad Adada, Daniel Canals, Brittany Carroll, Patrick Roddy, Yusuf A Hannun, Lina M Obeid. Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2013 Aug; 27(8):3155-66. doi:
10.1096/fj.13-228460. [PMID: 23629860] - Guoqi Zhang, Li Yang, Gab Seok Kim, Kieran Ryan, Shulin Lu, Rebekah K O'Donnell, Katherine Spokes, Nathan Shapiro, William C Aird, Michael J Kluk, Kiichiro Yano, Teresa Sanchez. Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation.
Blood.
2013 Jul; 122(3):443-55. doi:
10.1182/blood-2012-11-467191. [PMID: 23723450] - Elena Germinario, Samantha Peron, Luana Toniolo, Romeo Betto, Francesca Cencetti, Chiara Donati, Paola Bruni, Daniela Danieli-Betto. S1P2 receptor promotes mouse skeletal muscle regeneration.
Journal of applied physiology (Bethesda, Md. : 1985).
2012 Sep; 113(5):707-13. doi:
10.1152/japplphysiol.00300.2012. [PMID: 22744969] - Weihua Liu, Tian Lan, Xi Xie, Kaipeng Huang, Jing Peng, Juan Huang, Xiaoyan Shen, Peiqing Liu, Heqing Huang. S1P2 receptor mediates sphingosine-1-phosphate-induced fibronectin expression via MAPK signaling pathway in mesangial cells under high glucose condition.
Experimental cell research.
2012 May; 318(8):936-43. doi:
10.1016/j.yexcr.2012.02.020. [PMID: 22406263] - Elaine Studer, Xiqiao Zhou, Renping Zhao, Yun Wang, Kazuaki Takabe, Masayuki Nagahashi, William M Pandak, Paul Dent, Sarah Spiegel, Ruihua Shi, Weiren Xu, Xuyuan Liu, Pat Bohdan, Luyong Zhang, Huiping Zhou, Phillip B Hylemon. Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes.
Hepatology (Baltimore, Md.).
2012 Jan; 55(1):267-76. doi:
10.1002/hep.24681. [PMID: 21932398] - Athanasia Skoura, Jason Michaud, Dong-Soon Im, Shobha Thangada, Yuquan Xiong, Jonathan D Smith, Timothy Hla. Sphingosine-1-phosphate receptor-2 function in myeloid cells regulates vascular inflammation and atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology.
2011 Jan; 31(1):81-5. doi:
10.1161/atvbaha.110.213496. [PMID: 20947824] - Masaru Ishii, Junichi Kikuta, Yutaka Shimazu, Martin Meier-Schellersheim, Ronald N Germain. Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo.
The Journal of experimental medicine.
2010 Dec; 207(13):2793-8. doi:
10.1084/jem.20101474. [PMID: 21135136] - Jaclyn S Long, Yuko Fujiwara, Joanne Edwards, Claire L Tannahill, Gabor Tigyi, Susan Pyne, Nigel J Pyne. Sphingosine 1-phosphate receptor 4 uses HER2 (ERBB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells.
The Journal of biological chemistry.
2010 Nov; 285(46):35957-66. doi:
10.1074/jbc.m110.117945. [PMID: 20837468] - Tomas Blom, Nina Bergelin, Annika Meinander, Christoffer Löf, J Peter Slotte, John E Eriksson, Kid Törnquist. An autocrine sphingosine-1-phosphate signaling loop enhances NF-kappaB-activation and survival.
BMC cell biology.
2010 Jun; 11(?):45. doi:
10.1186/1471-2121-11-45. [PMID: 20573281] - Masanori Murakami, Akira Shiraishi, Kenichi Tabata, Norihisa Fujita. Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor.
Biochemical and biophysical research communications.
2008 Jul; 371(4):707-12. doi:
10.1016/j.bbrc.2008.04.145. [PMID: 18466763] - Takeshi Kawanabe, Tamihiro Kawakami, Yutaka Yatomi, Shinji Shimada, Yoshinao Soma. Sphingosine 1-phosphate accelerates wound healing in diabetic mice.
Journal of dermatological science.
2007 Oct; 48(1):53-60. doi:
10.1016/j.jdermsci.2007.06.002. [PMID: 17643267] - Hitoshi Ikeda, Kayo Nagashima, Mikio Yanase, Tomoaki Tomiya, Masahiro Arai, Yukiko Inoue, Kazuaki Tejima, Takako Nishikawa, Naoko Watanabe, Masao Omata, Kenji Fujiwara. Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation.
Biochemical and biophysical research communications.
2004 Jul; 320(3):754-9. doi:
10.1016/j.bbrc.2004.04.207. [PMID: 15240112] - Tsukasa Ohmori, Yutaka Yatomi, Makoto Osada, Fuminori Kazama, Toshiro Takafuta, Hitoshi Ikeda, Yukio Ozaki. Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2.
Cardiovascular research.
2003 Apr; 58(1):170-7. doi:
10.1016/s0008-6363(03)00260-8. [PMID: 12667959]