6-Nitroquipazine (BioDeep_00001875899)
代谢物信息卡片
6-NITRO-2-PIPERAZIN-1-YL-QUINOLINE
化学式: C13H14N4O2 (258.1116704)
中文名称: 6-马来酸硝基喹嗪盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CN(CCN1)C2=NC3=C(C=C2)C=C(C=C3)[N+](=O)[O-]
InChI: InChI=1S/C13H14N4O2/c18-17(19)11-2-3-12-10(9-11)1-4-13(15-12)16-7-5-14-6-8-16/h1-4,9,14H,5-8H2
描述信息
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Mari Gabrielsen, Karol Wołosewicz, Anna Zawadzka, Jerzy Kossakowski, Gabriel Nowak, Małgorzata Wolak, Katarzyna Stachowicz, Agata Siwek, Aina W Ravna, Irina Kufareva, Lech Kozerski, Elżbieta Bednarek, Jerzy Sitkowski, Wojciech Bocian, Ruben Abagyan, Andrzej J Bojarski, Ingebrigt Sylte, Zdzisław Chilmonczyk. Synthesis, antidepressant evaluation and docking studies of long-chain alkylnitroquipazines as serotonin transporter inhibitors.
Chemical biology & drug design.
2013 Jun; 81(6):695-706. doi:
10.1111/cbdd.12116. [PMID: 23574807] - Małgorzata Jarończyk, Karol Wołosewicz, Mari Gabrielsen, Gabriel Nowak, Irina Kufareva, Aleksander P Mazurek, Aina W Ravna, Ruben Abagyan, Andrzej J Bojarski, Ingebrigt Sylte, Zdzisław Chilmonczyk. Synthesis, in vitro binding studies and docking of long-chain arylpiperazine nitroquipazine analogues, as potential serotonin transporter inhibitors.
European journal of medicinal chemistry.
2012 Mar; 49(?):200-10. doi:
10.1016/j.ejmech.2012.01.012. [PMID: 22309909] - Liaoyuan A Hu, Tian Zhou, Jinwoo Ahn, Shuli Wang, Julia Zhou, Yi Hu, Qingyun Liu. Human and mouse trace amine-associated receptor 1 have distinct pharmacology towards endogenous monoamines and imidazoline receptor ligands.
The Biochemical journal.
2009 Oct; 424(1):39-45. doi:
10.1042/bj20090998. [PMID: 19725810] - Yunhang Guo, Xiangji Chen, Hongmei Jia, Xinmin Ji, Boli Liu. Synthesis and biological evaluation of one novel technetium-99m-labeled nitroquipazine derivative as an imaging agent for serotonin transporter.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.
2008 Dec; 66(12):1804-9. doi:
10.1016/j.apradiso.2008.06.009. [PMID: 18684634] - Jae Hak Lee, Yong Hyun Choi, Yoo Jin Lim, Byoung Se Lee, Dae Yoon Chi, Changbae Jin. Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 5: 2'-Substituted 6-nitroquipazines.
Bioorganic & medicinal chemistry.
2007 May; 15(10):3499-504. doi:
10.1016/j.bmc.2007.03.001. [PMID: 17376695] - Roberto Perrone, Francesco Berardi, Nicola A Colabufo, Enza Lacivita, Carmela Larizza, Marcello Leopoldo, Vincenzo Tortorella. Design and synthesis of long-chain arylpiperazines with mixed affinity for serotonin transporter (SERT) and 5-HT(1A) receptor.
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