Mopidamol (BioDeep_00001875878)

   


代谢物信息卡片


2-[[2-[bis(2-hydroxyethyl)amino]-4-piperidin-1-ylpyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol

化学式: C19H31N7O4 (421.2437)
中文名称: 莫哌达醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CCN(CC1)C2=NC(=NC3=CN=C(N=C32)N(CCO)CCO)N(CCO)CCO
InChI: InChI=1S/C19H31N7O4/c27-10-6-25(7-11-28)18-20-14-15-16(22-18)17(24-4-2-1-3-5-24)23-19(21-15)26(8-12-29)9-13-30/h14,27-30H,1-13H2

描述信息

C471 - Enzyme Inhibitor > C2019 - Dihydropyrimidine Dehydrogenase Inhibitor
D000970 - Antineoplastic Agents

同义名列表

2 个代谢物同义名

2-[[2-[bis(2-hydroxyethyl)amino]-4-piperidin-1-ylpyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol; Mopidamol



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • J P De la Cruz, C Olveira, J A Gonzalez-Correa, A Benítez, F Sánchez de la Cuesta. Inhibition of ferrous-induced lipid peroxidation by dipyridamole, RA-642 and mopidamol in human lung tissue. General pharmacology. 1996 Jul; 27(5):855-9. doi: 10.1016/0306-3623(95)02098-5. [PMID: 8842690]
  • K R Meehan, L R Zacharski, T E Moritz, F R Rickles. Pretreatment fibrinogen levels are associated with response to chemotherapy in patients with small cell carcinoma of the lung: Department of Veterans Affairs Cooperative Study 188. American journal of hematology. 1995 Jun; 49(2):143-8. doi: 10.1002/ajh.2830490208. [PMID: 7771466]
  • J P de la Cruz, A Moreno, F Mérida, J García-Campos, F Sánchez de la Cuesta. The pyrimido-pyrimidine derivatives, dipyridamole and RA-642, reduce opacification of crystalline lens in diabetic rats. Pharmacology & toxicology. 1994 Nov; 75(5):250-4. doi: 10.1111/j.1600-0773.1994.tb00356.x. [PMID: 7870694]
  • J P De La Cruz, G Ortega, F Sánchez de la Cuesta. Differential effects of the pyrimido-pyrimidine derivatives, dipyridamole and mopidamol, on platelet and vascular cyclooxygenase activity. Biochemical pharmacology. 1994 Jan; 47(2):209-15. doi: 10.1016/0006-2952(94)90008-6. [PMID: 8304965]
  • G N Tzanakakis, K C Agarwal, M P Vezeridis. Prevention of human pancreatic cancer cell-induced hepatic metastasis in nude mice by dipyridamole and its analog RA-233. Cancer. 1993 Apr; 71(8):2466-71. doi: 10.1002/1097-0142(19930415)71:8<2466::aid-cncr2820710807>3.0.co;2-q. [PMID: 8453569]
  • J P De La Cruz, M A Villalobos, T Carrasco, J M Smith-Agreda, F Sánchez de la Cuesta. The pyrimido-pyrimidine derivative RA-642 protects from brain injury in a combined model of permanent focal ischemia and global ischemia reperfusion. Brain research. 1992 Dec; 597(2):250-6. doi: 10.1016/0006-8993(92)91481-s. [PMID: 1472997]
  • J P de la Cruz, T Carrasco, G Ortega, F Sanchez de la Cuesta. Inhibition of ferrous-induced lipid peroxidation by pyrimido-pyrimidine derivatives in human liver membranes. Lipids. 1992 Mar; 27(3):192-4. doi: 10.1007/bf02536177. [PMID: 1522764]
  • I Bellido, J P de la Cruz, F Sánchez de la Cuesta. The pyrimido-pyrimidine derivative RA-642: a potent inhibitor of ferrous-induced lipid peroxidation in cell membranes. Methods and findings in experimental and clinical pharmacology. 1991 Jul; 13(6):371-5. doi: NULL. [PMID: 1881198]
  • R L Merriman, K A Shackelford, L R Tanzer, J B Campbell, K G Bemis, K Matsumoto. Drug treatments for metastasis of the Lewis lung carcinoma: lack of correlation between inhibition of lung metastasis and survival. Cancer research. 1989 Aug; 49(16):4509-16. doi: NULL. [PMID: 2743339]
  • R B Lichtner, G E Gallick, G L Nicolson. Pyrimido-pyrimidine modulation of EGF growth-promoting activity and p21ras expression in rat mammary adenocarcinoma cells. Journal of cellular physiology. 1988 Nov; 137(2):285-92. doi: 10.1002/jcp.1041370211. [PMID: 3056958]
  • L R Zacharski, T E Moritz, L A Baczek, F R Rickles, R L Edwards, W B Forman, R J Forcier, C J Cornell, C M Haakenson, H S Ballard. Effect of mopidamol on survival in carcinoma of the lung and colon: final report of Veterans Administration Cooperative Study No. 188. Journal of the National Cancer Institute. 1988 Mar; 80(2):90-7. doi: 10.1093/jnci/80.2.90. [PMID: 2830407]
  • K C Agarwal, R S Buckley, R E Parks. Role of plasma adenosine in the antiplatelet action of HL 725, a potent inhibitor of cAMP phosphodiesterase: species differences. Thrombosis research. 1987 Jul; 47(2):191-200. doi: 10.1016/0049-3848(87)90376-8. [PMID: 2821650]
  • C H Bamford, I P Middleton, K G Al-Lamee. Polymeric inhibitors of platelet aggregation. II. Copolymers of dipyridamole and related drugs with N-vinylpyrrolidone. Biochimica et biophysica acta. 1987 Apr; 924(1):38-44. doi: 10.1016/0304-4165(87)90068-7. [PMID: 3828396]
  • D D Dawicki, K C Agarwal, R E Parks. Potentiation of the antiplatelet action of adenosine in whole blood by dipyridamole or dilazep and the cAMP phosphodiesterase inhibitor, RA 233. Thrombosis research. 1986 Jul; 43(2):161-75. doi: 10.1016/0049-3848(86)90057-5. [PMID: 3016942]
  • D D Dawicki, K C Agarwal, R E Parks. Role of adenosine uptake and metabolism by blood cells in the antiplatelet actions of dipyridamole, dilazep and nitrobenzylthioinosine. Biochemical pharmacology. 1985 Nov; 34(22):3965-72. doi: 10.1016/0006-2952(85)90373-9. [PMID: 4062970]
  • J L Ambrus, C M Ambrus, H Gastpar. Effect of phosphodiesterase inhibitors on platelet aggregation and tumor metastasis. La Ricerca in clinica e in laboratorio. 1981; 11 Suppl 1(?):197-207. doi: NULL. [PMID: 6324323]
  • C R George, W F Clark, J S Cameron. The role of platelets in glomerulonephritis. Advances in nephrology from the Necker Hospital. 1975; 5(?):19-65. doi: NULL. [PMID: 242207]