PF-573228 (BioDeep_00001875873)

   


代谢物信息卡片


3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone

化学式: C22H20F3N5O3S (491.1238886000001)
中文名称: PF-573228
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CS(=O)(=O)C1=CC=CC(=C1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)CC4
InChI: InChI=1S/C22H20F3N5O3S/c1-34(32,33)16-4-2-3-13(9-16)11-26-20-17(22(23,24)25)12-27-21(30-20)28-15-6-7-18-14(10-15)5-8-19(31)29-18/h2-4,6-7,9-10,12H,5,8,11H2,1H3,(H,29,31)(H2,26,27,28,30)

描述信息

同义名列表

2 个代谢物同义名

3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone; PF-573228



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yu-Sen Peng, Jhih-Pu Syu, Sheng-De Wang, Pie-Chun Pan, Hsiu-Ni Kung. BSA-bounded p-cresyl sulfate potentiates the malignancy of bladder carcinoma by triggering cell migration and EMT through the ROS/Src/FAK signaling pathway. Cell biology and toxicology. 2020 08; 36(4):287-300. doi: 10.1007/s10565-019-09509-0. [PMID: 31873818]
  • Qinggang Wang, Shyam K More, Emilie E Vomhof-DeKrey, Mikhail Y Golovko, Marc D Basson. Small molecule FAK activator promotes human intestinal epithelial monolayer wound closure and mouse ulcer healing. Scientific reports. 2019 10; 9(1):14669. doi: 10.1038/s41598-019-51183-z. [PMID: 31604999]
  • Hannah E Steele, Yunxia Guo, Bai-Yan Li, Sungsoo Na. Mechanotransduction of mitochondrial AMPK and its distinct role in flow-induced breast cancer cell migration. Biochemical and biophysical research communications. 2019 06; 514(2):524-529. doi: 10.1016/j.bbrc.2019.04.191. [PMID: 31060777]
  • Arturo Matamoros-Volante, Ayelen Moreno-Irusta, Paulina Torres-Rodriguez, Laura Giojalas, María G Gervasi, Pablo E Visconti, Claudia L Treviño. Semi-automatized segmentation method using image-based flow cytometry to study sperm physiology: the case of capacitation-induced tyrosine phosphorylation. Molecular human reproduction. 2018 02; 24(2):64-73. doi: 10.1093/molehr/gax062. [PMID: 29186618]
  • Edmund Cheung So, King Chuen Wu, Chia-Hua Liang, Jen-Yin Chen, Sheng-Nan Wu. Evidence for activation of BK Ca channels by a known inhibitor of focal adhesion kinase, PF573228. Life sciences. 2011 Nov; 89(19-20):691-701. doi: 10.1016/j.lfs.2011.08.013. [PMID: 21925512]
  • Mamiko Hatta, Tomoko Matsuzaki, Yoko Morioka, Yoko Yoshida, Makoto Noda. Density- and serum-dependent regulation of the Reck tumor suppressor in mouse embryo fibroblasts. Cellular signalling. 2009 Dec; 21(12):1885-93. doi: 10.1016/j.cellsig.2009.08.005. [PMID: 19720143]