Amocarzine (BioDeep_00001875871)

   


代谢物信息卡片


Amocarzine

化学式: C18H21N5O2S (371.14158860000003)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1CCN(CC1)C(=S)NC2=CC=C(C=C2)NC3=CC=C(C=C3)[N+](=O)[O-]
InChI: InChI=1S/C18H21N5O2S/c1-21-10-12-22(13-11-21)18(26)20-16-4-2-14(3-5-16)19-15-6-8-17(9-7-15)23(24)25/h2-9,19H,10-13H2,1H3,(H,20,26)

描述信息

D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C250 - Antihelminthic Agent

同义名列表

1 个代谢物同义名

Amocarzine



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • J B Lecaillon, J Godbillon, R Guderian, A Guevara, S Cascante, A A Poltera. Concentrations of amocarzine in plasma of 71 Ecuadorian patients of two different races receiving 3 mg/kg b.i.d. and 5 mg/kg o.d. oral postprandial doses for 3 days. Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ). 1991 Sep; 42(3):291-3. doi: NULL. [PMID: 1801155]
  • G Zea-Flores, F Beltranena, A A Poltera, M Lopez, M Moran, C E Zea-Flores, I de Ramirez, J B Lecaillon, F Zak, M Palomo. Amocarzine investigated as oral onchocercacidal drug in 272 adult male patients from Guatemala. Results from three dose regimens spread over three days. Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ). 1991 Sep; 42(3):240-62. doi: NULL. [PMID: 1801152]
  • R H Guderian, M Anselmi, R Proaño, A Naranjo, A A Poltera, M Moran, J B Lecaillon, F Zak, S Cascante. Onchocercacidal effect of three drug regimens of amocarzine in 148 patients of two races and both sexes from Esmeraldas, Ecuador. Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ). 1991 Sep; 42(3):263-85. doi: NULL. [PMID: 1801153]
  • J B Lecaillon, A A Poltera, G Zea-Flores, I de Ramirez, A Nowell de Arevalo. Influence of food related to dose on the pharmacokinetics of amocarzine and of its N-oxide metabolite, CGP 13 231, after oral administration to 20 onchocerciasis male patients from Guatemala. Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ). 1991 Sep; 42(3):286-90. doi: NULL. [PMID: 1801154]
  • J B Lecaillon, J P Dubois, K Awadzi, A A Poltera, C D Ginger. Pharmacokinetics of CGP 6140 (amocarzine) after oral administration of single 100-1600 mg doses to patients with onchocerciasis. British journal of clinical pharmacology. 1990 Oct; 30(4):625-8. doi: 10.1111/j.1365-2125.1990.tb03824.x. [PMID: 2291876]
  • J B Lecaillon, J P Dubois, G Soula, E Pichard, A A Poltera, C D Ginger. The influence of food on the pharmacokinetics of CGP 6140 (amocarzine) after oral administration of a 1200 mg single dose to patients with onchocerciasis. British journal of clinical pharmacology. 1990 Oct; 30(4):629-33. doi: 10.1111/j.1365-2125.1990.tb03825.x. [PMID: 2291877]
  • G Strote. Electron microscopic studies on the effects of CGP 6140 and CGP 20376 on microfilariae and third stage larvae of Onchocerca volvulus. Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ). 1989 Sep; 40(3):304-10. doi: NULL. [PMID: 2617038]
  • S Townson, K E Shay, A R Dobinson, C Connelly, J C Comley, G Zea-Flores. Onchocerca gutturosa and O. volvulus: studies on the viability and drug responses of cryopreserved adult worms in vitro. Transactions of the Royal Society of Tropical Medicine and Hygiene. 1989 Sep; 83(5):664-9. doi: 10.1016/0035-9203(89)90393-3. [PMID: 2617629]
  • G Strote. Studies on the activity of the Ciba Geigy compounds CGP 6140, 20376, 20309 and 21833 against third and fourth stage larvae of Onchocerca volvulus. Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ). 1989 Mar; 40(1):51-6. doi: NULL. [PMID: 2740728]
  • S Kumar, K L Bhatia. Characterization of buffalo lactotransferrin by polyacrylamide gel electrophoresis in 6 M urea. Journal of chromatography. 1988 Dec; 434(1):228-31. doi: 10.1016/0378-4347(88)80080-x. [PMID: 3243819]
  • M C Rouan, J Campestrini, J B Lecaillon, J P Dubois, M Lamontagne, B Pichon. Fully automated analytical system using liquid-solid extraction and liquid chromatography for the determination of CGP 6140 in plasma. Journal of chromatography. 1988 Dec; 456(1):45-51. doi: 10.1016/0021-9673(86)80005-x. [PMID: 3243870]
  • S Townson, C Connelly, A Dobinson, R Muller. Drug activity against Onchocerca gutturosa males in vitro: a model for chemotherapeutic research on onchocerciasis. Journal of helminthology. 1987 Dec; 61(4):271-81. doi: 10.1017/s0022149x00010178. [PMID: 3437107]
  • G Strote. In vitro study on the effect of the new chemotherapeutic agents CGP 6140 and CGP 20376 on the microfilariae of Onchocerca volvulus. Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ). 1987 Sep; 38(3):211-3. doi: NULL. [PMID: 3432958]
  • J P Court, M Martin-Short, G M Lees. A comparison of the response of Dipetalonema viteae and Brugia pahangi adult worms to antifilarial agents in vitro. Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ). 1986 Dec; 37(4):375-80. doi: NULL. [PMID: 3563317]