Bay 41-2272 (BioDeep_00001875856)
代谢物信息卡片
Bay 41-2272
化学式: C20H17FN6 (360.1499)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC1C2=CN=C(N=C2N)C3=NN(C4=C3C=CC=N4)CC5=CC=CC=C5F
InChI: InChI=1S/C20H17FN6/c21-16-6-2-1-4-13(16)11-27-20-14(5-3-9-23-20)17(26-27)19-24-10-15(12-7-8-12)18(22)25-19/h1-6,9-10,12H,7-8,11H2,(H2,22,24,25)
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Julia Vogel, Philip Boehme, Susanne Homann, Mario Boehm, Katharina Andrea Schütt, Katharina Boden, Jakob Balitzki, Jörg Hüser, Wilfried Dinh, Hubert Truebel, Peter Sandner, Thomas Mondritzki. sGC stimulation lowers elevated blood pressure in a new canine model of resistant hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension.
2021 12; 44(12):1568-1577. doi:
10.1038/s41440-021-00748-5. [PMID: 34548653] - Fabio Henrique Silva, Kleber Yotsumoto Fertrin, Eduardo Costa Alexandre, Fabiano Beraldi Calmasini, Carla Fernanda Franco-Penteado, Fernando Ferreira Costa. Impairment of Nitric Oxide Pathway by Intravascular Hemolysis Plays a Major Role in Mice Esophageal Hypercontractility: Reversion by Soluble Guanylyl Cyclase Stimulator.
The Journal of pharmacology and experimental therapeutics.
2018 11; 367(2):194-202. doi:
10.1124/jpet.118.249581. [PMID: 30108160] - Takashi Shimosato, Masashi Tawa, Hirotaka Iwasaki, Takeshi Imamura, Tomio Okamura. Aging does not affect soluble guanylate cyclase redox state in mouse aortas.
Physiological reports.
2016 May; 4(10):. doi:
10.14814/phy2.12816. [PMID: 27233303] - Aline Vuckovic, Susanne Herber-Jonat, Andreas W Flemmer, Brigitte Strizek, Alexander C Engels, Jacques C Jani. Antenatal BAY 41-2272 reduces pulmonary hypertension in the rabbit model of congenital diaphragmatic hernia.
American journal of physiology. Lung cellular and molecular physiology.
2016 04; 310(7):L658-69. doi:
10.1152/ajplung.00178.2015. [PMID: 26873974] - Kenia Pedrosa Nunes, Cleber E Teixeira, Fernanda B M Priviero, Haroldo A Toque, R Clinton Webb. Beneficial effect of the soluble guanylyl cyclase stimulator BAY 41-2272 on impaired penile erection in db/db-/- type II diabetic and obese mice.
The Journal of pharmacology and experimental therapeutics.
2015 May; 353(2):330-9. doi:
10.1124/jpet.114.220970. [PMID: 25740897] - Johannes-Peter Stasch, Jens Schlossmann, Berthold Hocher. Renal effects of soluble guanylate cyclase stimulators and activators: a review of the preclinical evidence.
Current opinion in pharmacology.
2015 Apr; 21(?):95-104. doi:
10.1016/j.coph.2014.12.014. [PMID: 25645316] - Kaikai Shen, Lili Ji, Bin Lu, Chong Xu, Chenyuan Gong, Grant Morahan, Zhengtao Wang. Andrographolide inhibits tumor angiogenesis via blocking VEGFA/VEGFR2-MAPKs signaling cascade.
Chemico-biological interactions.
2014 Jul; 218(?):99-106. doi:
10.1016/j.cbi.2014.04.020. [PMID: 24814888] - Antonio Celso S Ramos-Filho, Juliana A Faria, Fabiano B Calmasini, Simone A Teixeira, Fabíola Z Mónica, Marcelo N Muscará, José A R Gontijo, Gabriel Forato Anhê, Angelina Zanesco, Edson Antunes. The renin-angiotensin system plays a major role in voiding dysfunction of ovariectomized rats.
Life sciences.
2013 Nov; 93(22):820-9. doi:
10.1016/j.lfs.2013.09.008. [PMID: 24050930] - Carlos A Dias-Junior, Stefany B A Cau, Alisson M Oliveira, Michele M Castro, Marcelo F Montenegro, Raquel F Gerlach, Jose E Tanus-Santos. Nitrite or sildenafil, but not BAY 41-2272, blunt acute pulmonary embolism-induced increases in circulating matrix metalloproteinase-9 and oxidative stress.
Thrombosis research.
2009 Jul; 124(3):349-55. doi:
10.1016/j.thromres.2008.12.006. [PMID: 19150571] - Fernanda B M Priviero, Saiprasad M Zemse, Cleber E Teixeira, R Clinton Webb. Oxidative stress impairs vasorelaxation induced by the soluble guanylyl cyclase activator BAY 41-2272 in spontaneously hypertensive rats.
American journal of hypertension.
2009 May; 22(5):493-9. doi:
10.1038/ajh.2009.18. [PMID: 19247264] - Stefany B A Cau, Carlos A Dias-Junior, Marcelo F Montenegro, Gilberto de Nucci, Edson Antunes, Jose E Tanus-Santos. Dose-dependent beneficial hemodynamic effects of BAY 41-2272 in a canine model of acute pulmonary thromboembolism.
European journal of pharmacology.
2008 Feb; 581(1-2):132-7. doi:
10.1016/j.ejphar.2007.11.030. [PMID: 18076875] - Cristiane F Freitas, Rafael P Morganti, Joyce M Annichino-Bizzacchi, Gilberto De Nucci, Edson Antunes. Effect of BAY 41-2272 in the pulmonary hypertension induced by heparin-protamine complex in anaesthetized dogs.
Clinical and experimental pharmacology & physiology.
2007 Jan; 34(1-2):10-4. doi:
10.1111/j.1440-1681.2007.04524.x. [PMID: 17201729] - Yingrui Wang, Stephanie Krämer, Tanja Loof, Sebastian Martini, Susanne Kron, Hiroshi Kawachi, Fuijo Shimizu, Hans-H Neumayer, Harm Peters. Enhancing cGMP in experimental progressive renal fibrosis: soluble guanylate cyclase stimulation vs. phosphodiesterase inhibition.
American journal of physiology. Renal physiology.
2006 Jan; 290(1):F167-76. doi:
10.1152/ajprenal.00197.2005. [PMID: 16048904] - Yingrui Wang, Stephanie Krämer, Tanja Loof, Sebastian Martini, Susanne Kron, Hiroshi Kawachi, Fuijo Shimizu, Hans-H Neumayer, Harm Peters. Stimulation of soluble guanylate cyclase slows progression in anti-thy1-induced chronic glomerulosclerosis.
Kidney international.
2005 Jul; 68(1):47-61. doi:
10.1111/j.1523-1755.2005.00380.x. [PMID: 15954895] - Bernd Hohenstein, Christoph Daniel, Andrea Wagner, Johannes-Peter Stasch, Christian Hugo. Stimulation of soluble guanylyl cyclase inhibits mesangial cell proliferation and matrix accumulation in experimental glomerulonephritis.
American journal of physiology. Renal physiology.
2005 Apr; 288(4):F685-93. doi:
10.1152/ajprenal.00280.2004. [PMID: 15561976] - Harm Peters, Yingrui Wang, Tanja Loof, Sebastian Martini, Susanne Kron, Stephanie Krämer, Hans-H Neumayer. Expression and activity of soluble guanylate cyclase in injury and repair of anti-thy1 glomerulonephritis.
Kidney international.
2004 Dec; 66(6):2224-36. doi:
10.1111/j.1523-1755.2004.66012.x. [PMID: 15569311] - Florian Mullershausen, Michael Russwurm, Andreas Friebe, Doris Koesling. Inhibition of phosphodiesterase type 5 by the activator of nitric oxide-sensitive guanylyl cyclase BAY 41-2272.
Circulation.
2004 Apr; 109(14):1711-3. doi:
10.1161/01.cir.0000126286.47618.bd. [PMID: 15066950] - Adrian J Hobbs, Salvador Moncada. Antiplatelet properties of a novel, non-NO-based soluble guanylate cyclase activator, BAY 41-2272.
Vascular pharmacology.
2003 Oct; 40(3):149-54. doi:
10.1016/s1537-1891(03)00046-6. [PMID: 13678646] - Guido Boerrigter, Lisa C Costello-Boerrigter, Alessandro Cataliotti, Toshihiro Tsuruda, Gail J Harty, Harald Lapp, Johannes-Peter Stasch, John C Burnett. Cardiorenal and humoral properties of a novel direct soluble guanylate cyclase stimulator BAY 41-2272 in experimental congestive heart failure.
Circulation.
2003 Feb; 107(5):686-9. doi:
10.1161/01.cir.0000055737.15443.f8. [PMID: 12578869] - Johannes-Peter Stasch, Cristina Alonso-Alija, Heiner Apeler, Klaus Dembowsky, Achim Feurer, Torsten Minuth, Elisabeth Perzborn, Matthias Schramm, Alexander Straub. Pharmacological actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vitro studies.
British journal of pharmacology.
2002 Jan; 135(2):333-43. doi:
10.1038/sj.bjp.0704484. [PMID: 11815368]
