8-OH-DPAT (BioDeep_00001875850)
代谢物信息卡片
8-OH-DPAT
化学式: C16H25NO (247.193604)
中文名称: 8-OH-DPAT
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
InChI: InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
描述信息
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists
8-OH-DPAT is a potent and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A and a Ki of 466 nM for 5-HT7; 8-OH-DPAT weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50 <5).
同义名列表
2 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:73364
- PubChem: 1220
- ChEMBL: CHEMBL56
- MeSH: 8-Hydroxy-2-(di-n-propylamino)tetralin
- CAS: 105558-30-3
- CAS: 78950-78-4
- medchemexpress: HY-112061
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Eun-Joo Shin, Ji Hoon Jeong, Bao-Trong Nguyen, Naveen Sharma, Cuong Ngoc Kim Tran, Seung-Yeol Nah, Yi Lee, Jae Kyung Byun, Sung Kwon Ko, Hyoung-Chun Kim. Ginsenoside Re attenuates 8-OH-DPAT-induced serotonergic behaviors in mice via interactive modulation between PKCδ gene and Nrf2.
Drug and chemical toxicology.
2023 Mar; 46(2):281-296. doi:
10.1080/01480545.2021.2022689. [PMID: 35707918] - Claudia Cervantes-Durán, Miguel Avalos-Viveros, Luz Torner, Sandra-Guadalupe Sánchez-Ceja, Alain-Raimundo Rodríguez-Orozco, Héctor-Eduardo Martínez-Flores, Martha-Estrella García-Pérez. The 5-HT1A receptor agonist, 8-OH-DPAT, attenuates long-lasting pain in imiquimod-induced psoriasis in mice.
Experimental dermatology.
2022 04; 31(4):600-607. doi:
10.1111/exd.14492. [PMID: 34726306] - Xiaokang Li, Jinwen Li, Yunyuan Huang, Qi Gong, Yan Fu, Yixiang Xu, Junyang Huang, Haolan You, Dong Zhang, Dan Zhang, Fei Mao, Jin Zhu, Huan Wang, Haiyan Zhang, Jian Li. The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression.
European journal of medicinal chemistry.
2022 Feb; 229(?):114045. doi:
10.1016/j.ejmech.2021.114045. [PMID: 34922191] - Ryota Araki, Akira Yasubuchi, Marina Ikegaya, Chihiro Hojo, Hayato Tachioka, Kentaro Kawai, Masaaki Omote, Ayami Kita, Takeshi Yabe. Ferulic acid alleviates abnormal behaviors in isolation-reared mice via 5-HT1A receptor partial agonist activity.
Psychopharmacology.
2021 Aug; 238(8):2147-2154. doi:
10.1007/s00213-021-05839-2. [PMID: 33829309] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - PinFen Chua, William K Lim. Optimisation of a PC12 cell-based in vitro stroke model for screening neuroprotective agents.
Scientific reports.
2021 04; 11(1):8096. doi:
10.1038/s41598-021-87431-4. [PMID: 33854099] - Yoko Hagino, Frank Scott Hall, George R Uhl, Ichiro Sora, Kazutaka Ikeda. Dual actions of 5-MeO-DIPT at the serotonin transporter and serotonin 5-HT1A receptor in the mouse striatum and prefrontal cortex.
Neuropsychopharmacology reports.
2021 03; 41(1):91-101. doi:
10.1002/npr2.12161. [PMID: 33547882] - Laura Rombolà, Damiana Scuteri, Chizuko Watanabe, Shinobu Sakurada, Kengo Hamamura, Tsukasa Sakurada, Paolo Tonin, Maria Tiziana Corasaniti, Giacinto Bagetta, Luigi Antonio Morrone. Role of 5-HT1A Receptor in the Anxiolytic-Relaxant Effects of Bergamot Essential Oil in Rodent.
International journal of molecular sciences.
2020 Apr; 21(7):. doi:
10.3390/ijms21072597. [PMID: 32283606] - Arvind Negi, Ciaran O Reilly, Dilip V Jarikote, Jian Zhou, Paul V Murphy. Multi-targeting protein-protein interaction inhibitors: Evolution of macrocyclic ligands with embedded carbohydrates (MECs) to improve selectivity.
European journal of medicinal chemistry.
2019 Aug; 176(?):292-309. doi:
10.1016/j.ejmech.2019.04.064. [PMID: 31112891] - Silke Pfitzer, Andrew P Woodward, Liesel Laubscher, Kristin Warren, Rebecca Vaughan-Higgins, Jacobus P Raath, Michael Laurence. Pharmacokinetics and bioavailability after intramuscular injection of the 5-HT1A serotonin agonist R-8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) in domestic goats (Capra aegagrus hircus).
Journal of veterinary pharmacology and therapeutics.
2019 May; 42(3):251-257. doi:
10.1111/jvp.12741. [PMID: 30656714] - Maureen L Petrunich-Rutherford, Francisca Garcia, George Battaglia. 5-HT1A receptor-mediated activation of neuroendocrine responses and multiple protein kinase pathways in the peripubertal rat hypothalamus.
Neuropharmacology.
2018 09; 139(?):173-181. doi:
10.1016/j.neuropharm.2018.07.008. [PMID: 30005975] - Jun Guo, Bin Yan, Fu Wang, Qing-He Gao, Xiu-Ju Zhang, Guo-Jin Yu, Yin Zeng, Jun-Feng Qiu, Qiang Geng, Qiang Han. [Qiaoshao Prescription improves premature ejaculation in male rats by increasing the content of 5-hydroxytryptamine].
Zhonghua nan ke xue = National journal of andrology.
2018 08; 24(8):724-728. doi:
. [PMID: 30173433] - Ewa Bromek, Marta Rysz, Anna Haduch, Jacek Wójcikowski, Władysława A Daniel. Activation of 5-HT1A Receptors in the Hypothalamic Paraventricular Nuclei Negatively Regulates Cytochrome P450 Expression and Activity in Rat Liver.
Drug metabolism and disposition: the biological fate of chemicals.
2018 06; 46(6):786-793. doi:
10.1124/dmd.117.079632. [PMID: 29555828] - Julien Volle, Tatiana Bregman, Brian Scott, Mustansir Diwan, Roger Raymond, Paul J Fletcher, José N Nobrega, Clement Hamani. Deep brain stimulation and fluoxetine exert different long-term changes in the serotonergic system.
Neuropharmacology.
2018 06; 135(?):63-72. doi:
10.1016/j.neuropharm.2018.03.005. [PMID: 29505786] - Jun Guo, Bin Yan, Fu Wang, Qing-He Gao, Xiu-Ju Zhang, Guo-Jin Yu, Yin Zeng, Jun-Feng Qiu, Qiang Geng, Qiang Han. [Establishment of a rat model of premature ejaculation with 8-OH-DPAT].
Zhonghua nan ke xue = National journal of andrology.
2018 Feb; 24(2):104-108. doi:
". [PMID: 30156067] - Md Jafurulla, Suman Bandari, Thomas J Pucadyil, Amitabha Chattopadhyay. Sphingolipids modulate the function of human serotonin1A receptors: Insights from sphingolipid-deficient cells.
Biochimica et biophysica acta. Biomembranes.
2017 Apr; 1859(4):598-604. doi:
10.1016/j.bbamem.2016.10.016. [PMID: 27984018] - Christopher E Stamper, James E Hassell, Adam J Kapitz, Kenneth J Renner, Miles Orchinik, Christopher A Lowry. Activation of 5-HT1A receptors in the rat dorsomedial hypothalamus inhibits stress-induced activation of the hypothalamic-pituitary-adrenal axis.
Stress (Amsterdam, Netherlands).
2017 03; 20(2):223-230. doi:
10.1080/10253890.2017.1301426. [PMID: 28345385] - Rebecca H Larke, Nicole Maninger, Benjamin J Ragen, Sally P Mendoza, Karen L Bales. Serotonin 1A agonism decreases affiliative behavior in pair-bonded titi monkeys.
Hormones and behavior.
2016 11; 86(?):71-77. doi:
10.1016/j.yhbeh.2016.10.001. [PMID: 27712925] - Noreen Samad, Muhammad Abdul Haleem, Darakhshan Jabeen Haleem. Report: Protective effects of rice bran oil in haloperidol-induced tardive dyskinesia and serotonergic responses in rats.
Pakistan journal of pharmaceutical sciences.
2016 Jul; 29(4 Suppl):1467-71. doi:
". [PMID: 27592482] - Shih-Ching Chen, Tsung-Hsun Hsieh, Wen-Jia Fan, Chien-Hung Lai, Chih-Wei Peng. Does pharmacological activation of 5-HT1A receptors improve urine flow rate in female rats?.
American journal of physiology. Renal physiology.
2016 07; 311(1):F166-75. doi:
10.1152/ajprenal.00469.2015. [PMID: 27147676] - Donald R Gehlert, Janice Shaw. 5-Hydroxytryptamine 1A (5HT1A) receptors mediate increases in plasma glucose independent of corticosterone.
European journal of pharmacology.
2014 Dec; 745(?):91-7. doi:
10.1016/j.ejphar.2014.10.010. [PMID: 25446927] - R A Prosser, A Stowie, M Amicarelli, A G Nackenoff, R D Blakely, J D Glass. Cocaine modulates mammalian circadian clock timing by decreasing serotonin transport in the SCN.
Neuroscience.
2014 Sep; 275(?):184-93. doi:
10.1016/j.neuroscience.2014.06.012. [PMID: 24950119] - Christine Saunders, Michael Siuta, Sabrina D Robertson, Adeola R Davis, Jennifer Sauer, Heinrich J G Matthies, Paul J Gresch, David Airey, Craig W Lindsley, John A Schetz, Kevin D Niswender, Jeremy M Veenstra-Vanderweele, Aurelio Galli. Neuronal ablation of p-Akt at Ser473 leads to altered 5-HT1A/2A receptor function.
Neurochemistry international.
2014 Jul; 73(?):113-121. doi:
10.1016/j.neuint.2013.09.015. [PMID: 24090638] - Lea R Medeiros, Maria C Cartolano, M Danielle McDonald. Crowding stress inhibits serotonin 1A receptor-mediated increases in corticotropin-releasing factor mRNA expression and adrenocorticotropin hormone secretion in the Gulf toadfish.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology.
2014 Feb; 184(2):259-71. doi:
10.1007/s00360-013-0793-9. [PMID: 24362954] - Hernán Pessoa-Mahana, Christian González-Lira, Angélica Fierro, Gerald Zapata-Torres, C David Pessoa-Mahana, Javiera Ortiz-Severin, Patricio Iturriaga-Vásquez, Miguel Reyes-Parada, Paul Silva-Matus, Claudio Saitz-Barría, Ramiro Araya-Maturana. Synthesis, docking and pharmacological evaluation of novel homo- and hetero-bis 3-piperazinylpropylindole derivatives at SERT and 5-HT1A receptor.
Bioorganic & medicinal chemistry.
2013 Dec; 21(24):7604-11. doi:
10.1016/j.bmc.2013.10.036. [PMID: 24262884] - Chao-Chuan Wang, Hui-Ching Lin, Yun-Han Chan, Po-Wu Gean, Yen Kung Yang, Po See Chen. 5-HT1A-receptor agonist modified amygdala activity and amygdala-associated social behavior in a valproate-induced rat autism model.
The international journal of neuropsychopharmacology.
2013 Oct; 16(9):2027-39. doi:
10.1017/s1461145713000473. [PMID: 23823694] - Jan E Lim, Cosima S Porteus, Nicholas J Bernier. Serotonin directly stimulates cortisol secretion from the interrenals in goldfish.
General and comparative endocrinology.
2013 Oct; 192(?):246-55. doi:
10.1016/j.ygcen.2013.08.008. [PMID: 24013027] - Yang-Hee Jung, Ri-Ra Ha, Seung-Hwan Kwon, Sa-Ik Hong, Kun-Ho Lee, Sun-Yeou Kim, Seok-Yong Lee, Choon-Gon Jang. Anxiolytic effects of Julibroside C1 isolated from Albizzia julibrissin in mice.
Progress in neuro-psychopharmacology & biological psychiatry.
2013 Jul; 44(?):184-92. doi:
10.1016/j.pnpbp.2013.02.012. [PMID: 23481219] - Meredith A Fox, Micaella G Panessiti, F Scott Hall, George R Uhl, Dennis L Murphy. An evaluation of the serotonin system and perseverative, compulsive, stereotypical, and hyperactive behaviors in dopamine transporter (DAT) knockout mice.
Psychopharmacology.
2013 Jun; 227(4):685-95. doi:
10.1007/s00213-013-2988-x. [PMID: 23417514] - Lea R Chioca, Marcelo M Ferro, Irinéia P Baretta, Sara M Oliveira, Cássia R Silva, Juliano Ferreira, Estela M Losso, Roberto Andreatini. Anxiolytic-like effect of lavender essential oil inhalation in mice: participation of serotonergic but not GABAA/benzodiazepine neurotransmission.
Journal of ethnopharmacology.
2013 May; 147(2):412-8. doi:
10.1016/j.jep.2013.03.028. [PMID: 23524167] - Enrica Audero, Boris Mlinar, Gilda Baccini, Zhiva K Skachokova, Renato Corradetti, Cornelius Gross. Suppression of serotonin neuron firing increases aggression in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2013 May; 33(20):8678-88. doi:
10.1523/jneurosci.2067-12.2013. [PMID: 23678112] - Lea R Medeiros, M Danielle McDonald. Cortisol-mediated downregulation of the serotonin 1A receptor subtype in the Gulf toadfish, Opsanus beta.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
2013 Apr; 164(4):612-21. doi:
10.1016/j.cbpa.2013.01.014. [PMID: 23360731] - Shengyuan Ding, Li Li, Fu-Ming Zhou. Presynaptic serotonergic gating of the subthalamonigral glutamatergic projection.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2013 Mar; 33(11):4875-85. doi:
10.1523/jneurosci.4111-12.2013. [PMID: 23486958] - Yosuke Nakatani, Michiyuki Suzuki, Masaki Tokunaga, Jun Maeda, Miyuki Sakai, Hiroki Ishihara, Takashi Yoshinaga, Osamu Takenaka, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi. A small-animal pharmacokinetic/pharmacodynamic PET study of central serotonin 1A receptor occupancy by a potential therapeutic agent for overactive bladder.
PloS one.
2013; 8(9):e75040. doi:
10.1371/journal.pone.0075040. [PMID: 24086433] - Otto Kalliokoski, Kirsten R Jacobsen, Huda S Darusman, Trine Henriksen, Allan Weimann, Henrik E Poulsen, Jann Hau, Klas S P Abelson. Mice do not habituate to metabolism cage housing--a three week study of male BALB/c mice.
PloS one.
2013; 8(3):e58460. doi:
10.1371/journal.pone.0058460. [PMID: 23505511] - Yang-Hee Jung, Seung-Hwan Kwon, Sa-Ik Hong, Sung-Ok Lee, Sun-Yeou Kim, Seok-Yong Lee, Choon-Gon Jang. 5-HT(1A) receptor binding in the dorsal raphe nucleus is implicated in the anxiolytic-like effects of Cinnamomum cassia.
Pharmacology, biochemistry, and behavior.
2012 Dec; 103(2):367-72. doi:
10.1016/j.pbb.2012.09.004. [PMID: 22982739] - Laurent Descarries, Mustaph Riad. Effects of the antidepressant fluoxetine on the subcellular localization of 5-HT1A receptors and SERT.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences.
2012 Sep; 367(1601):2416-25. doi:
10.1098/rstb.2011.0361. [PMID: 22826342] - Daniela Hernandez, Ciara A Torres, Wanda Setlik, Carolina Cebrián, Eugene V Mosharov, Guomei Tang, Hsiao-Chun Cheng, Nikolai Kholodilov, Olga Yarygina, Robert E Burke, Michael Gershon, David Sulzer. Regulation of presynaptic neurotransmission by macroautophagy.
Neuron.
2012 Apr; 74(2):277-84. doi:
10.1016/j.neuron.2012.02.020. [PMID: 22542182] - S L Diaz, S Doly, N Narboux-Nême, S Fernández, P Mazot, S M Banas, K Boutourlinsky, I Moutkine, A Belmer, A Roumier, L Maroteaux. 5-HT(2B) receptors are required for serotonin-selective antidepressant actions.
Molecular psychiatry.
2012 Feb; 17(2):154-63. doi:
10.1038/mp.2011.159. [PMID: 22158014] - M Jerry Wright, Deepshikha Angrish, Shawn M Aarde, Deborah J Barlow, Matthew W Buczynski, Kevin M Creehan, Sophia A Vandewater, Loren H Parsons, Karen L Houseknecht, Tobin J Dickerson, Michael A Taffe. Effect of ambient temperature on the thermoregulatory and locomotor stimulant effects of 4-methylmethcathinone in Wistar and Sprague-Dawley rats.
PloS one.
2012; 7(8):e44652. doi:
10.1371/journal.pone.0044652. [PMID: 22952999] - Prajitha Thampi, Haripriya Vittal Rao, Sayak K Mitter, Jun Cai, Haoyu Mao, Hong Li, Soojung Seo, Xiaoping Qi, Alfred S Lewin, Carl Romano, Michael E Boulton. The 5HT1a receptor agonist 8-Oh DPAT induces protection from lipofuscin accumulation and oxidative stress in the retinal pigment epithelium.
PloS one.
2012; 7(4):e34468. doi:
10.1371/journal.pone.0034468. [PMID: 22509307] - Baojun Gu, Gang Wu, Jieming Si, Yuemin Xu, Karl-Erik Andersson. Improving voiding efficiency in the diabetic rat by a 5-HT1A serotonin receptor agonist.
Neurourology and urodynamics.
2012 Jan; 31(1):168-73. doi:
10.1002/nau.21182. [PMID: 21780177] - Carla S Lima, André L Nunes-Freitas, Anderson Ribeiro-Carvalho, Cláudio C Filgueiras, Alex C Manhães, Armando Meyer, Yael Abreu-Villaça. Exposure to methamidophos at adulthood adversely affects serotonergic biomarkers in the mouse brain.
Neurotoxicology.
2011 Dec; 32(6):718-24. doi:
10.1016/j.neuro.2011.08.002. [PMID: 21871486] - Irina P Voronova, Vladimir S Naumenko, Galina M Khramova, Tamara V Kozyreva, Nina K Popova. Central 5-HT3 receptor-induced hypothermia is associated with reduced metabolic rate and increased heat loss.
Neuroscience letters.
2011 Oct; 504(3):209-14. doi:
10.1016/j.neulet.2011.09.024. [PMID: 21964386] - Jouji Horiuchi, Alp Atik, Kamon Iigaya, Lachlan M McDowall, Suzanne Killinger, Roger A L Dampney. Activation of 5-hydroxytryptamine-1A receptors suppresses cardiovascular responses evoked from the paraventricular nucleus.
American journal of physiology. Regulatory, integrative and comparative physiology.
2011 Oct; 301(4):R1088-97. doi:
10.1152/ajpregu.00144.2011. [PMID: 21753144] - Oliver W Ackaert, Jeroen De Graan, Shanna Shi, Rob Vreeken, Oscar E Della Pasqua, Durk Dijkstra, Ben H Westerink, Meindert Danhof, Joke A Bouwstra. The pharmacokinetics and pharmacological effect of (S)-5-OH-DPAT following controlled delivery with transdermal iontophoresis.
Journal of pharmaceutical sciences.
2011 Jul; 100(7):2996-3009. doi:
10.1002/jps.22492. [PMID: 21283984] - Jasmin M Dao, Susan C McQuown, Sandra E Loughlin, James D Belluzzi, Frances M Leslie. Nicotine alters limbic function in adolescent rat by a 5-HT1A receptor mechanism.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2011 Jun; 36(7):1319-31. doi:
10.1038/npp.2011.8. [PMID: 21412223] - América A Scopinho, Francisco S Guimarães, Fernando M A Corrêa, Leonardo B M Resstel. Cannabidiol inhibits the hyperphagia induced by cannabinoid-1 or serotonin-1A receptor agonists.
Pharmacology, biochemistry, and behavior.
2011 Apr; 98(2):268-72. doi:
10.1016/j.pbb.2011.01.007. [PMID: 21238476] - Jin-Jye Feng, Fong-Chi Cheng, Chun-Hsiung Lin, Jiann-Wu Wei, Shiaw-Der Yang. Characterization of 5-HT transporter and receptor system in HeLaS3 cells by [(3)H]8-OH-DPAT and other serotonergic ligands.
Archives of biochemistry and biophysics.
2011 Feb; 506(1):66-72. doi:
10.1016/j.abb.2010.10.024. [PMID: 21056540] - Johnny S W Chan, Eelke M S Snoeren, Edwin Cuppen, Marcel D Waldinger, Berend Olivier, Ronald S Oosting. The serotonin transporter plays an important role in male sexual behavior: a study in serotonin transporter knockout rats.
The journal of sexual medicine.
2011 Jan; 8(1):97-108. doi:
10.1111/j.1743-6109.2010.01961.x. [PMID: 20704641] - Chen Liu, Takashi Maejima, Steven C Wyler, Gemma Casadesus, Stefan Herlitze, Evan S Deneris. Pet-1 is required across different stages of life to regulate serotonergic function.
Nature neuroscience.
2010 Oct; 13(10):1190-8. doi:
10.1038/nn.2623. [PMID: 20818386] - Lea R Medeiros, Edward M Mager, Martin Grosell, M Danielle McDonald. The serotonin subtype 1A receptor regulates cortisol secretion in the Gulf toadfish, Opsanus beta.
General and comparative endocrinology.
2010 Sep; 168(3):377-87. doi:
10.1016/j.ygcen.2010.05.004. [PMID: 20488186] - M Picard, S Morisset, J F Cloix, J C Bizot, M Guerin, V Beneteau, G Guillaumet, T K Hevor. Pharmacological, neurochemical, and behavioral profile of JB-788, a new 5-HT1A agonist.
Neuroscience.
2010 Sep; 169(3):1337-46. doi:
10.1016/j.neuroscience.2010.05.040. [PMID: 20580787] - Kentaro Kaneko, Masashi Iwasaki, Masaaki Yoshikawa, Kousaku Ohinata. Orally administered soymorphins, soy-derived opioid peptides, suppress feeding and intestinal transit via gut mu(1)-receptor coupled to 5-HT(1A), D(2), and GABA(B) systems.
American journal of physiology. Gastrointestinal and liver physiology.
2010 Sep; 299(3):G799-805. doi:
10.1152/ajpgi.00081.2010. [PMID: 20616303] - N K Popova, V S Naumenko, A S Cybko, D V Bazovkina. Receptor-genes cross-talk: effect of chronic 5-HT(1A) agonist 8-hydroxy-2-(di-n-propylamino) tetralin treatment on the expression of key genes in brain serotonin system and on behavior.
Neuroscience.
2010 Aug; 169(1):229-35. doi:
10.1016/j.neuroscience.2010.04.044. [PMID: 20423722] - Tomonori Fujiwara, Masumi Snada, Takefumi Kofuji, Takeo Yoshikawa, Kimio Akagawa. HPC-1/syntaxin 1A gene knockout mice show abnormal behavior possibly related to a disruption in 5-HTergic systems.
The European journal of neuroscience.
2010 Jul; 32(1):99-107. doi:
10.1111/j.1460-9568.2010.07269.x. [PMID: 20576034] - Paolo Magnani, Anita Conforti, Elisabetta Zanolin, Marta Marzotto, Paolo Bellavite. Dose-effect study of Gelsemium sempervirens in high dilutions on anxiety-related responses in mice.
Psychopharmacology.
2010 Jul; 210(4):533-45. doi:
10.1007/s00213-010-1855-2. [PMID: 20401745] - O W Ackaert, J De Graan, R Capancioni, O E Della Pasqua, D Dijkstra, B H Westerink, M Danhof, J A Bouwstra. The in vitro and in vivo evaluation of new synthesized prodrugs of 5-OH-DPAT for iontophoretic delivery.
Journal of controlled release : official journal of the Controlled Release Society.
2010 Jun; 144(3):296-305. doi:
10.1016/j.jconrel.2010.03.004. [PMID: 20230864] - Venkateswarlu Karicheti, Christopher L Langdale, Masashi Ukai, Karl B Thor. Characterization of a spinal, urine storage reflex, inhibitory center and its regulation by 5-HT1A receptors in female cats.
American journal of physiology. Regulatory, integrative and comparative physiology.
2010 May; 298(5):R1198-208. doi:
10.1152/ajpregu.00599.2009. [PMID: 20164207] - V R Sela, I Hattanda, C M Albrecht, C B De Almeida, S Obici, D A Cortez, E A Audi. Effect of xanthone from Kielmeyera coriacea stems on serotonergic neurons of the median raphe nucleus.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2010 Mar; 17(3-4):274-8. doi:
10.1016/j.phymed.2009.07.002. [PMID: 19674881] - Zhili Liu, Hai Zhang, Na Ye, Jing Zhang, QianQian Wu, Peihua Sun, Linyong Li, Xuechu Zhen, Ao Zhang. Synthesis of dihydrofuroaporphine derivatives: identification of a potent and selective serotonin 5-HT 1A receptor agonist.
Journal of medicinal chemistry.
2010 Feb; 53(3):1319-28. doi:
10.1021/jm9015763. [PMID: 20041669] - Meredith A Fox, Alison R Stein, Helen T French, Dennis L Murphy. Functional interactions between 5-HT2A and presynaptic 5-HT1A receptor-based responses in mice genetically deficient in the serotonin 5-HT transporter (SERT).
British journal of pharmacology.
2010 Feb; 159(4):879-87. doi:
10.1111/j.1476-5381.2009.00578.x. [PMID: 20128812] - M G Cascio, L A Gauson, L A Stevenson, R A Ross, R G Pertwee. Evidence that the plant cannabinoid cannabigerol is a highly potent alpha2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist.
British journal of pharmacology.
2010 Jan; 159(1):129-41. doi:
10.1111/j.1476-5381.2009.00515.x. [PMID: 20002104] - Franciszek Herold, Łukasz Izbicki, Andrzej Chodkowski, Maciej Dawidowski, Marek Król, Jerzy Kleps, Jadwiga Turło, Irena Wolska, Gabriel Nowak, Katarzyna Stachowicz, Małgorzata Dybała, Agata Siwek, Mateusz Nowak, Elzbieta Pieniazek, Małgorzata Jarończyk, Ingebrigt Sylte, Aleksander P Mazurek. Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity: part 2.
European journal of medicinal chemistry.
2009 Nov; 44(11):4702-15. doi:
10.1016/j.ejmech.2009.07.007. [PMID: 19665823] - Umathe S N, Vaghasiya J M, Jain N S, Dixit P V. Neurosteroids modulate compulsive and persistent behavior in rodents: implications for obsessive-compulsive disorder.
Progress in neuro-psychopharmacology & biological psychiatry.
2009 Oct; 33(7):1161-6. doi:
10.1016/j.pnpbp.2009.06.013. [PMID: 19549549] - Nancy A Shanahan, Kerri A Holick Pierz, Virginia L Masten, Christian Waeber, Mark Ansorge, Jay A Gingrich, Mark A Geyer, Rene Hen, Stephanie C Dulawa. Chronic reductions in serotonin transporter function prevent 5-HT1B-induced behavioral effects in mice.
Biological psychiatry.
2009 Mar; 65(5):401-8. doi:
10.1016/j.biopsych.2008.09.026. [PMID: 19013555] - Jessica A Knight, Carol Smith, Nicole Toohey, Michael T Klein, Milt Teitler. Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5-Hydroxytryptamine7 receptor by risperidone, 9-OH-Risperidone, and other inactivating antagonists.
Molecular pharmacology.
2009 Feb; 75(2):374-80. doi:
10.1124/mol.108.052084. [PMID: 18996971] - Darakhshan Jabeen Haleem. Exaggerated feedback control decreases brain serotonin concentration and elicits hyperactivity in a rat model of diet-restriction-induced anorexia nervosa.
Appetite.
2009 Feb; 52(1):44-50. doi:
10.1016/j.appet.2008.07.009. [PMID: 18721836] - Daniel Anthony Johnson, Colin David Ingram, Emma Jane Grant, Mark Craighead, Sarah Elizabeth Gartside. Glucocorticoid receptor antagonism augments fluoxetine-induced downregulation of the 5-HT transporter.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2009 Jan; 34(2):399-409. doi:
10.1038/npp.2008.70. [PMID: 18496518] - Meredith A Fox, Catherine L Jensen, Helen T French, Alison R Stein, Su-Jan Huang, Teresa J Tolliver, Dennis L Murphy. Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice.
Psychopharmacology.
2008 Dec; 201(2):203-18. doi:
10.1007/s00213-008-1268-7. [PMID: 18712364] - Thibault Renoir, Eleni Païzanis, Malika El Yacoubi, Françoise Saurini, Naïma Hanoun, Maxette Melfort, Klaus Peter Lesch, Michel Hamon, Laurence Lanfumey. Differential long-term effects of MDMA on the serotoninergic system and hippocampal cell proliferation in 5-HTT knock-out vs. wild-type mice.
The international journal of neuropsychopharmacology.
2008 Dec; 11(8):1149-62. doi:
10.1017/s1461145708009048. [PMID: 18611291] - Nicole T Hatzenbuhler, Reinhardt Baudy, Deborah A Evrard, Amedeo Failli, Boyd L Harrison, Steven Lenicek, Richard E Mewshaw, Annmarie Saab, Uresh Shah, Jean Sze, Minsheng Zhang, Dahui Zhou, Michael Chlenov, Michael Kagan, Jeannette Golembieski, Geoffrey Hornby, Margaret Lai, Deborah L Smith, Kelly M Sullivan, Lee E Schechter, Terrance H Andree. Advances toward new antidepressants with dual serotonin transporter and 5-HT1A receptor affinity within a class of 3-aminochroman derivatives. Part 2.
Journal of medicinal chemistry.
2008 Nov; 51(21):6980-7004. doi:
10.1021/jm8007097. [PMID: 18834188] - Jouji Horiuchi, Lachlan M McDowall, Roger A L Dampney. Role of 5-HT(1A) receptors in the lower brainstem on the cardiovascular response to dorsomedial hypothalamus activation.
Autonomic neuroscience : basic & clinical.
2008 Nov; 142(1-2):71-6. doi:
10.1016/j.autneu.2008.06.004. [PMID: 18667366] - Patrícia de Souza Villa, José Vanderlei Menani, Gabriela Maria Pavan de Arruda Camargo, Luiz Antônio de Arruda Camargo, Wilson Abrão Saad. Activation of the serotonergic 5-HT1A receptor in the paraventricular nucleus of the hypothalamus inhibits water intake and increases urinary excretion in water-deprived rats.
Regulatory peptides.
2008 Oct; 150(1-3):14-20. doi:
10.1016/j.regpep.2008.05.003. [PMID: 18556076] - Judith R Homberg, Sietse F De Boer, Halfdan S Raasø, Jocelien D A Olivier, Mark Verheul, Eric Ronken, Alexander R Cools, Bart A Ellenbroek, Anton N M Schoffelmeer, Louk J M J Vanderschuren, Taco J De Vries, Edwin Cuppen. Adaptations in pre- and postsynaptic 5-HT1A receptor function and cocaine supersensitivity in serotonin transporter knockout rats.
Psychopharmacology.
2008 Oct; 200(3):367-80. doi:
10.1007/s00213-008-1212-x. [PMID: 18581099] - Benita Sjögren, Linda Csöregh, Per Svenningsson. Cholesterol reduction attenuates 5-HT1A receptor-mediated signaling in human primary neuronal cultures.
Naunyn-Schmiedeberg's archives of pharmacology.
2008 Oct; 378(4):441-6. doi:
10.1007/s00210-008-0323-6. [PMID: 18607571] - Marcello Leopoldo, Enza Lacivita, Paola De Giorgio, Claudia Fracasso, Sara Guzzetti, Silvio Caccia, Marialessandra Contino, Nicola A Colabufo, Francesco Berardi, Roberto Perrone. Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III.
Journal of medicinal chemistry.
2008 Sep; 51(18):5813-22. doi:
10.1021/jm800615e. [PMID: 18800769] - Jacob P R Jacobsen, Elsebet Ø Nielsen, Rene Hummel, John Paul Redrobe, Naheed Mirza, Pia Weikop. Insensitivity of NMRI mice to selective serotonin reuptake inhibitors in the tail suspension test can be reversed by co-treatment with 5-hydroxytryptophan.
Psychopharmacology.
2008 Aug; 199(2):137-50. doi:
10.1007/s00213-008-1142-7. [PMID: 18496675] - Jessica Shields, Jean A King. The role of 5-HT1A receptors in the behavioral responses associated with innate fear.
Behavioral neuroscience.
2008 Jun; 122(3):611-7. doi:
10.1037/0735-7044.122.3.611. [PMID: 18513131] - Hsiun-Ing Chen, Li-Chun Lin, Lung Yu, Yu-Fan Liu, Yu-Min Kuo, A-Min Huang, Jih-Ing Chuang, Fong-Sen Wu, Pao-Chi Liao, Chauying J Jen. Treadmill exercise enhances passive avoidance learning in rats: the role of down-regulated serotonin system in the limbic system.
Neurobiology of learning and memory.
2008 May; 89(4):489-96. doi:
10.1016/j.nlm.2007.08.004. [PMID: 17892954] - B Manéglier, G J Guillemin, P Clayette, C Rogez-Kreuz, B J Brew, D Dormont, C Advenier, P Therond, O Spreux-Varoquaux. Serotonin decreases HIV-1 replication in primary cultures of human macrophages through 5-HT(1A) receptors.
British journal of pharmacology.
2008 May; 154(1):174-82. doi:
10.1038/bjp.2008.80. [PMID: 18332855] - Daniela Popa, Clément Léna, Chloé Alexandre, Joëlle Adrien. Lasting syndrome of depression produced by reduction in serotonin uptake during postnatal development: evidence from sleep, stress, and behavior.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2008 Apr; 28(14):3546-54. doi:
10.1523/jneurosci.4006-07.2008. [PMID: 18385313] - Matthew S Milak, Alin J Severance, R Todd Ogden, Jaya Prabhakaran, J S Dileep Kumar, Vattoly J Majo, J John Mann, Ramin V Parsey. Modeling considerations for 11C-CUMI-101, an agonist radiotracer for imaging serotonin 1A receptor in vivo with PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2008 Apr; 49(4):587-96. doi:
10.2967/jnumed.107.046540. [PMID: 18344443] - M Riad, L Rbah, M Verdurand, N Aznavour, L Zimmer, L Descarries. Unchanged density of 5-HT(1A) autoreceptors on the plasma membrane of nucleus raphe dorsalis neurons in rats chronically treated with fluoxetine.
Neuroscience.
2008 Feb; 151(3):692-700. doi:
10.1016/j.neuroscience.2007.11.024. [PMID: 18166275] - Bruno P Guiard, Denis J P David, Thierry Deltheil, Franck Chenu, Erwan Le Maître, Thibault Renoir, Isabelle Leroux-Nicollet, Pierre Sokoloff, Laurence Lanfumey, Michel Hamon, Anne M Andrews, René Hen, Alain M Gardier. Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype.
The international journal of neuropsychopharmacology.
2008 Feb; 11(1):79-92. doi:
10.1017/s1461145707007857. [PMID: 17559709] - Rui Wang, Ying Xu, Hong-Li Wu, Ying-Bo Li, Yu-Hua Li, Jia-Bin Guo, Xue-Jun Li. The antidepressant effects of curcumin in the forced swimming test involve 5-HT1 and 5-HT2 receptors.
European journal of pharmacology.
2008 Jan; 578(1):43-50. doi:
10.1016/j.ejphar.2007.08.045. [PMID: 17942093] - Kwok Ho Christopher Choy, Maarten van den Buuse. Attenuated disruption of prepulse inhibition by dopaminergic stimulation after maternal deprivation and adolescent corticosterone treatment in rats.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2008 Jan; 18(1):1-13. doi:
10.1016/j.euroneuro.2007.03.011. [PMID: 17490864] - Meredith A Fox, Anne M Andrews, Jens R Wendland, Klaus-Peter Lesch, Andrew Holmes, Dennis L Murphy. A pharmacological analysis of mice with a targeted disruption of the serotonin transporter.
Psychopharmacology.
2007 Dec; 195(2):147-66. doi:
10.1007/s00213-007-0910-0. [PMID: 17712549] - Gino Giannaccini, Laura Betti, Andrea Pirone, Lionella Palego, Ortenzio Fabiani, Laura Fabbrini, Giovanni Mascia, Laura Giusti, Marco Macchia, Mario Giusiani, Claudia Martini, Antonio Lucacchini. Short-term effects of 3,4-methylen-dioxy-metamphetamine (MDMA) on 5-HT(1A) receptors in the rat hippocampus.
Neurochemistry international.
2007 Dec; 51(8):496-506. doi:
10.1016/j.neuint.2007.05.010. [PMID: 17602794] - Meredith A Fox, Catherine L Jensen, Pamela S Gallagher, Dennis L Murphy. Receptor mediation of exaggerated responses to serotonin-enhancing drugs in serotonin transporter (SERT)-deficient mice.
Neuropharmacology.
2007 Oct; 53(5):643-56. doi:
10.1016/j.neuropharm.2007.07.009. [PMID: 17765930] - Catherine A Thomas, Shachi Tyagi, Naoki Yoshimura, Michael B Chancellor, Pradeep Tyagi. Effect of hyperforin-enriched extract on pro-ejaculatory effect of 8-hydroxy-2-(di-N-propylamino)tetralin in anesthetized rats.
Urology.
2007 Oct; 70(4):813-6. doi:
10.1016/j.urology.2007.05.016. [PMID: 17991578] - Ming-Chin Lu, Ming-Tsuen Hsieh, Chi-Rei Wu, Hao-Yuan Cheng, Chia-Chang Hsieh, Yao-Tung Lin, Wen-Huang Peng. Ameliorating effect of emodin, a constitute of Polygonatum multiflorum, on cycloheximide-induced impairment of memory consolidation in rats.
Journal of ethnopharmacology.
2007 Jul; 112(3):552-6. doi:
10.1016/j.jep.2007.05.004. [PMID: 17572029] - Duk-Soo Kim, Ji-Eun Kim, Sung-Eun Kwak, Dae-Won Kim, Soo-Young Choi, Oh-Shin Kwon, Tae-Chon Kang. Seizure activity selectively reduces 5-HT1A receptor immunoreactivity in CA1 interneurons in the hippocampus of seizure-prone gerbils.
Brain research.
2007 Jun; 1154(?):181-93. doi:
10.1016/j.brainres.2007.03.084. [PMID: 17493597] - M R Thompson, P D Callaghan, G E Hunt, J L Cornish, I S McGregor. A role for oxytocin and 5-HT(1A) receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine ('ecstasy').
Neuroscience.
2007 May; 146(2):509-14. doi:
10.1016/j.neuroscience.2007.02.032. [PMID: 17383105] - Candace E Hofmann, Linda Ellis, Wayne K Yu, Joanne Weinberg. Hypothalamic-pituitary-adrenal responses to 5-HT1A and 5-HT2A/C agonists are differentially altered in female and male rats prenatally exposed to ethanol.
Alcoholism, clinical and experimental research.
2007 Feb; 31(2):345-55. doi:
10.1111/j.1530-0277.2006.00316.x. [PMID: 17250628] - Alexandre Julien Châu Loucif, Patricia Bonnavion, Béatrice Macri, Jean-Louis Golmard, Claudette Boni, Maxette Melfort, Grégoire Leonard, Klaus-Peter Lesch, Joëlle Adrien, Thierry Didier Jacquin. Gender-dependent regulation of G-protein-gated inwardly rectifying potassium current in dorsal raphe neurons in knock-out mice devoid of the 5-hydroxytryptamine transporter.
Journal of neurobiology.
2006 Nov; 66(13):1475-88. doi:
10.1002/neu.20321. [PMID: 17013926] - Ulrich W Laengle, Anne U Trendelenburg, Rudolf Markstein, Vicente Nogues, Anne Provencher-Bollinger, Danielle Roman. GLC756 decreases TNF-alpha via an alpha2 and beta2 adrenoceptor related mechanism.
Experimental eye research.
2006 Nov; 83(5):1246-51. doi:
10.1016/j.exer.2006.07.001. [PMID: 16938291] - Céline Faure, Ouissame Mnie-Filali, Hélène Scarna, Guy Debonnel, Nasser Haddjeri. Effects of the 5-HT7 receptor antagonist SB-269970 on rat hormonal and temperature responses to the 5-HT1A/7 receptor agonist 8-OH-DPAT.
Neuroscience letters.
2006 Aug; 404(1-2):122-6. doi:
10.1016/j.neulet.2006.05.023. [PMID: 16759802] - Arturo Zazpe, Inés Artaiz, Ana Innerárity, Elena Del Olmo, Elena Castro, Luis Labeaga, Angel Pazos, Aurelio Orjales. In vitro and in vivo characterization of F-97013-GD, a partial 5-HT1A agonist with antipsychotic- and antiparkinsonian-like properties.
Neuropharmacology.
2006 Jul; 51(1):129-40. doi:
10.1016/j.neuropharm.2006.03.008. [PMID: 16643965]