goralatide (BioDeep_00001875848)
代谢物信息卡片
goralatide
化学式: C20H33N5O9 (487.2278)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)NC(CO)C(=O)NC(CC(=O)O)C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)O
InChI: InChI=1S/C20H33N5O9/c1-11(27)22-14(10-26)18(31)24-13(9-16(28)29)17(30)23-12(5-2-3-7-21)19(32)25-8-4-6-15(25)20(33)34/h12-15,26H,2-10,21H2,1H3,(H,22,27)(H,23,30)(H,24,31)(H,28,29)(H,33,34)/t12-,13-,14-,15-/m0/s1
描述信息
D020011 - Protective Agents > D011837 - Radiation-Protective Agents
D006133 - Growth Substances > D006131 - Growth Inhibitors
C26170 - Protective Agent
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:191178
- ChEBI: CHEBI:168934
- PubChem: 65938
- ChEMBL: CHEMBL420741
- CAS: 120081-14-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Benjamin Kably, Eliane M Billaud, Audrey Derobertmasure, Anne Blanchard, Pierre Boutouyrie, Michel Azizi. Urine N-acetyl-Ser-Asp-Lys-Pro measurement as a versatile biomarker to assess adherence to angiotensin-converting enzyme inhibitors.
Journal of hypertension.
2022 02; 40(2):348-355. doi:
10.1097/hjh.0000000000003018. [PMID: 34508023] - Flávio de Castro Magalhães, Tiago Fernandes, Vinícius Bassaneze, Katt Coelho Mattos, Isolmar Schettert, Fabio Luiz Navarro Marques, José Eduardo Krieger, Roberto Nava, Valério Garrone Barauna, Edilamar Menezes de Oliveira. High-volume endurance exercise training stimulates hematopoiesis by increasing ACE NH2-terminal activity.
Clinical science (London, England : 1979).
2021 10; 135(20):2377-2391. doi:
10.1042/cs20210739. [PMID: 34608942] - Jorge F Giani, Luciana C Veiras, Justin Z Y Shen, Ellen A Bernstein, DuoYao Cao, Derick Okwan-Duodu, Zakir Khan, Romer A Gonzalez-Villalobos, Kenneth E Bernstein. Novel roles of the renal angiotensin-converting enzyme.
Molecular and cellular endocrinology.
2021 06; 529(?):111257. doi:
10.1016/j.mce.2021.111257. [PMID: 33781839] - Jinpeng Li, Haijie Liu, Swayam Prakash Srivastava, Qiongying Hu, Rongfen Gao, Shaolan Li, Munehiro Kitada, Gaosong Wu, Daisuke Koya, Keizo Kanasaki. Endothelial FGFR1 (Fibroblast Growth Factor Receptor 1) Deficiency Contributes Differential Fibrogenic Effects in Kidney and Heart of Diabetic Mice.
Hypertension (Dallas, Tex. : 1979).
2020 12; 76(6):1935-1944. doi:
10.1161/hypertensionaha.120.15587. [PMID: 33131311] - Swayam Prakash Srivastava, Julie E Goodwin, Keizo Kanasaki, Daisuke Koya. Metabolic reprogramming by N-acetyl-seryl-aspartyl-lysyl-proline protects against diabetic kidney disease.
British journal of pharmacology.
2020 08; 177(16):3691-3711. doi:
10.1111/bph.15087. [PMID: 32352559] - Keizo Kanasaki. N-acetyl-seryl-aspartyl-lysyl-proline is a valuable endogenous antifibrotic peptide for kidney fibrosis in diabetes: An update and translational aspects.
Journal of diabetes investigation.
2020 May; 11(3):516-526. doi:
10.1111/jdi.13219. [PMID: 31997585] - Swayam Prakash Srivastava, Julie E Goodwin, Keizo Kanasaki, Daisuke Koya. Inhibition of Angiotensin-Converting Enzyme Ameliorates Renal Fibrosis by Mitigating DPP-4 Level and Restoring Antifibrotic MicroRNAs.
Genes.
2020 02; 11(2):. doi:
10.3390/genes11020211. [PMID: 32085655] - Jin Wang, Ye Qian, Xuemin Gao, Na Mao, Yucong Geng, Gaojie Lin, Guibin Zhang, Han Li, Fang Yang, Hong Xu. Synthesis and Identification of a Novel Peptide, Ac-SDK (Biotin) Proline, That Can Elicit Anti-Fibrosis Effects in Rats Suffering from Silicosis.
Drug design, development and therapy.
2020; 14(?):4315-4326. doi:
10.2147/dddt.s262716. [PMID: 33116418] - Sina Pejman, Maryam Kamarehei, Gholamhossein Riazi, Shahriar Pooyan, Saeed Balalaie. Ac-SDKP ameliorates the progression of experimental autoimmune encephalomyelitis via inhibition of ER stress and oxidative stress in the hippocampus of C57BL/6 mice.
Brain research bulletin.
2020 01; 154(?):21-31. doi:
10.1016/j.brainresbull.2019.09.014. [PMID: 31589901] - Bonan Zhang, Hong Xu, Yi Zhang, Xue Yi, Guizhen Zhang, Xin Zhang, Dingjie Xu, Xuemin Gao, Shifeng Li, Ying Zhu, Hui Zhang, Zhongqiu Wei, Shumin Li, Lijuan Zhang, Ruimin Wang, Fang Yang. Targeting the RAS axis alleviates silicotic fibrosis and Ang II-induced myofibroblast differentiation via inhibition of the hedgehog signaling pathway.
Toxicology letters.
2019 Oct; 313(?):30-41. doi:
10.1016/j.toxlet.2019.05.023. [PMID: 31181250] - Xuemin Gao, Hong Xu, Bonan Zhang, Tao Tao, Yalou Liu, Dingjie Xu, Wenchen Cai, Zhongqiu Wei, Shifeng Li, Hui Zhang, Na Mao, Guizhen Zhang, Dan Li, Fuyu Jin, Shumin Li, Lijuan Zhang, Heliang Liu, Xiaohui Hao, Fang Yang. Interaction of N-acetyl-seryl-aspartyl-lysyl-proline with the angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas axis attenuates pulmonary fibrosis in silicotic rats.
Experimental physiology.
2019 10; 104(10):1562-1574. doi:
10.1113/ep087515. [PMID: 31290182] - Kyoko Nitta, Takako Nagai, Yuiko Mizunuma, Munehiro Kitada, Atsushi Nakagawa, Masaru Sakurai, Masao Toyoda, Masakazu Haneda, Keizo Kanasaki, Daisuke Koya. N-Acetyl-seryl-aspartyl-lysyl-proline is a potential biomarker of renal function in normoalbuminuric diabetic patients with eGFR ≥ 30 ml/min/1.73 m2.
Clinical and experimental nephrology.
2019 Aug; 23(8):1004-1012. doi:
10.1007/s10157-019-01733-6. [PMID: 30949886] - Li Shifeng, Xu Hong, Yi Xue, Niu Siyu, Zhang Qiaodan, Xu Dingjie, Zhang Lijuan, Wei Zhongqiu, Gao Xuemin, Cai Wenchen, Zhang Guizhen, Li Dan, Wang Ruimin, Yang Fang. Ac-SDKP increases α-TAT 1 and promotes the apoptosis in lung fibroblasts and epithelial cells double-stimulated with TGF-β1 and silica.
Toxicology and applied pharmacology.
2019 04; 369(?):17-29. doi:
10.1016/j.taap.2019.02.015. [PMID: 30826375] - Cesar A Romero, Nitin Kumar, Pablo Nakagawa, Morel E Worou, Tang-Dong Liao, Edward L Peterson, Oscar A Carretero. Renal release of N-acetyl-seryl-aspartyl-lysyl-proline is part of an antifibrotic peptidergic system in the kidney.
American journal of physiology. Renal physiology.
2019 01; 316(1):F195-F203. doi:
10.1152/ajprenal.00270.2018. [PMID: 30403163] - Masahiro Eriguchi, Ellen A Bernstein, Luciana C Veiras, Zakir Khan, Duo Yao Cao, Sebastien Fuchs, Alicia A McDonough, Jorge E Toblli, Romer A Gonzalez-Villalobos, Kenneth E Bernstein, Jorge F Giani. The Absence of the ACE N-Domain Decreases Renal Inflammation and Facilitates Sodium Excretion during Diabetic Kidney Disease.
Journal of the American Society of Nephrology : JASN.
2018 10; 29(10):2546-2561. doi:
10.1681/asn.2018030323. [PMID: 30185469] - Nitin Kumar, Congcong Yin. The anti-inflammatory peptide Ac-SDKP: Synthesis, role in ACE inhibition, and its therapeutic potential in hypertension and cardiovascular diseases.
Pharmacological research.
2018 08; 134(?):268-279. doi:
10.1016/j.phrs.2018.07.006. [PMID: 29990624] - Mani Maheshwari, Cesar A Romero, Sumit R Monu, Nitin Kumar, Tang-Dong Liao, Edward L Peterson, Oscar A Carretero. Renal Protective Effects of N-Acetyl-Seryl-Aspartyl-Lysyl-Proline (Ac-SDKP) in Obese Rats on a High-Salt Diet.
American journal of hypertension.
2018 07; 31(8):902-909. doi:
10.1093/ajh/hpy052. [PMID: 29722788] - Lijuan Zhang, Dingjie Xu, Qian Li, Yi Yang, Hong Xu, Zhongqiu Wei, Ruimin Wang, Wenli Zhang, Yan Liu, Yucong Geng, Shifeng Li, Xuemin Gao, Fang Yang. N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) attenuates silicotic fibrosis by suppressing apoptosis of alveolar type II epithelial cells via mediation of endoplasmic reticulum stress.
Toxicology and applied pharmacology.
2018 07; 350(?):1-10. doi:
10.1016/j.taap.2018.04.025. [PMID: 29684394] - Gary C W Chan, Hao Jia Wu, Kam Wa Chan, Wai Han Yiu, Ailis Zou, Xiao Ru Huang, Hui Yao Lan, Kar Neng Lai, Sydney C W Tang. N-acetyl-seryl-aspartyl-lysyl-proline mediates the anti-fibrotic properties of captopril in unilateral ureteric obstructed BALB/C mice.
Nephrology (Carlton, Vic.).
2018 Apr; 23(4):297-307. doi:
10.1111/nep.13000. [PMID: 28075040] - Janelisa Musaya, Enock Matovu, Edward Senga, Moffat Nyirenda, John Chisi. AcSDKP is down-regulated in anaemia induced by Trypanosoma brucei infection in mice.
Malawi medical journal : the journal of Medical Association of Malawi.
2017 09; 29(3):259-264. doi:
10.4314/mmj.v29i3.6. [PMID: 29872517] - Pablo Nakagawa, Juan X Masjoan-Juncos, Heba Basha, Branislava Janic, Morel E Worou, Tang-Dong Liao, Cesar A Romero, Edward L Peterson, Oscar A Carretero. Effects of N-acetyl-seryl-asparyl-lysyl-proline on blood pressure, renal damage, and mortality in systemic lupus erythematosus.
Physiological reports.
2017 Jan; 5(2):. doi:
10.14814/phy2.13084. [PMID: 28126732] - Matthieu Monge, Valérie Paquet, Damien Bergerot, Valentina Zhygalina, Anne Blanchard. Dose-effect relationship of perindopril 10, 14 and 20mg assessed by urine and plasma AcSDKP levels in mildly sodium-depleted healthy volunteers.
International journal of cardiology.
2016 Nov; 222(?):648-653. doi:
10.1016/j.ijcard.2016.07.164. [PMID: 27517656] - Swayam Prakash Srivastava, Sen Shi, Megumi Kanasaki, Takako Nagai, Munehiro Kitada, Jianhua He, Yuka Nakamura, Yasuhito Ishigaki, Keizo Kanasaki, Daisuke Koya. Effect of Antifibrotic MicroRNAs Crosstalk on the Action of N-acetyl-seryl-aspartyl-lysyl-proline in Diabetes-related Kidney Fibrosis.
Scientific reports.
2016 07; 6(?):29884. doi:
10.1038/srep29884. [PMID: 27425816] - Yosuke Suzuki, Fumihiko Katagiri, Fuminori Sato, Kanako Fujioka, Yukie Sato, Takashi Fujioka, Yuhki Sato, Hiromitsu Mimata, Hiroki Itoh. Clinical Implications of Plasma N-acetyl-seryl-aspartyl-lysyl-proline Level in Stable Kidney Transplant Recipients.
Clinical laboratory.
2016 Jul; 62(7):1323-1328. doi:
10.7754/clin.lab.2015.151136. [PMID: 28164637] - Nitin Kumar, Pablo Nakagawa, Branislava Janic, Cesar A Romero, Morel E Worou, Sumit R Monu, Edward L Peterson, Jiajiu Shaw, Frederick Valeriote, Elimelda M Ongeri, Jean-Marie V Niyitegeka, Nour-Eddine Rhaleb, Oscar A Carretero. The anti-inflammatory peptide Ac-SDKP is released from thymosin-β4 by renal meprin-α and prolyl oligopeptidase.
American journal of physiology. Renal physiology.
2016 05; 310(10):F1026-34. doi:
10.1152/ajprenal.00562.2015. [PMID: 26962108] - Kyoko Nitta, Sen Shi, Takako Nagai, Megumi Kanasaki, Munehiro Kitada, Swayam Prakash Srivastava, Masakazu Haneda, Keizo Kanasaki, Daisuke Koya. Oral Administration of N-Acetyl-seryl-aspartyl-lysyl-proline Ameliorates Kidney Disease in Both Type 1 and Type 2 Diabetic Mice via a Therapeutic Regimen.
BioMed research international.
2016; 2016(?):9172157. doi:
10.1155/2016/9172157. [PMID: 27088094] - Morel E Worou, Tang-Dong Liao, Martin D'Ambrosio, Pablo Nakagawa, Branislava Janic, Edward L Peterson, Nour-Eddine Rhaleb, Oscar A Carretero. Renal protective effect of N-acetyl-seryl-aspartyl-lysyl-proline in dahl salt-sensitive rats.
Hypertension (Dallas, Tex. : 1979).
2015 Oct; 66(4):816-22. doi:
10.1161/hypertensionaha.115.05970. [PMID: 26324505] - Zhiliang Li, Iryna O Lebedyeva, Vita M Golubovskaya, William G Cance, Khalid A Alamry, Hassan M Faidallah, C Dennis Hall, Alan R Katritzky. Synthesis and bioactivity of a Goralatide analog with antileukemic activity.
Bioorganic & medicinal chemistry.
2015 Aug; 23(15):5056-5060. doi:
10.1016/j.bmc.2015.04.061. [PMID: 26048023] - Tang-Dong Liao, Pablo Nakagawa, Branislava Janic, Martin D'Ambrosio, Morel E Worou, Edward L Peterson, Nour-Eddine Rhaleb, Xiao-Ping Yang, Oscar A Carretero. N-Acetyl-Seryl-Aspartyl-Lysyl-Proline: mechanisms of renal protection in mouse model of systemic lupus erythematosus.
American journal of physiology. Renal physiology.
2015 May; 308(10):F1146-54. doi:
10.1152/ajprenal.00039.2015. [PMID: 25740596] - Takako Nagai, Kyoko Nitta, Megumi Kanasaki, Daisuke Koya, Keizo Kanasaki. The biological significance of angiotensin-converting enzyme inhibition to combat kidney fibrosis.
Clinical and experimental nephrology.
2015 Feb; 19(1):65-74. doi:
10.1007/s10157-014-1000-3. [PMID: 24975544] - Jaroslav Hrenak, Ludovit Paulis, Fedor Simko. N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP): Potential target molecule in research of heart, kidney and brain.
Current pharmaceutical design.
2015; 21(35):5135-43. doi:
10.2174/1381612821666150909093927. [PMID: 26350537] - Ayanda Trevor Mnguni, Mark E Engel, Megan S Borkum, Bongani M Mayosi. The Effects of Angiotensin Converting Enzyme Inhibitors (ACE-I) on Human N-Acetyl-Seryl-Aspartyl-Lysyl-Proline (Ac-SDKP) Levels: A Systematic Review and Meta-Analysis.
PloS one.
2015; 10(12):e0143338. doi:
10.1371/journal.pone.0143338. [PMID: 26656271] - Gary C W Chan, Wai Han Yiu, Hao Jia Wu, Dickson W L Wong, Miao Lin, Xiao Ru Huang, Hui Yao Lan, Sydney C W Tang. N-Acetyl-seryl-aspartyl-lysyl-proline Alleviates Renal Fibrosis Induced by Unilateral Ureteric Obstruction in BALB/C Mice.
Mediators of inflammation.
2015; 2015(?):283123. doi:
10.1155/2015/283123. [PMID: 26508815] - Pamella Huey Mei Wang, Maria Claudina Andrade, Beata Marie Redublo Quinto, Giovana Di Marco, Renato Arruda Mortara, Carlos P Vio, Dulce Elena Casarini. N-domain angiotensin-I converting enzyme is expressed in immortalized mesangial, proximal tubule and collecting duct cells.
International journal of biological macromolecules.
2015 Jan; 72(?):380-90. doi:
10.1016/j.ijbiomac.2014.07.043. [PMID: 25193099] - Shifeng Li, Shipu Du, Xinxin Xue, Dingjie Xu, Hong Xu, Yue Sun, Haijing Deng, Yi Yang, Zhongqiu Wei, Jingrui Tian, Fang Yang. [Inhibition effect of N-acetyl-seryl-aspartyl-lysyl-proline on myofibroblast differentiation of MRC-5 human fetal lung fibroblasts inuced by Ang II].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases.
2014 Nov; 32(11):801-5. doi:
NULL. [PMID: 25579022] - Zhongqiu Wei, Yue Sun, Hua Cheng, Wendong Ma, Hong Xu, Qian Li, Lijuan Zhang, Ruimin Wang, Fang Yang. [Anti-fibrotic role of AcSDKP through inhibition of P38MAPK pathway activity mediated transforming growth beta receptors in rat with silicosis].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases.
2014 May; 32(5):340-7. doi:
NULL. [PMID: 25169087] - Li Zhang, Michael Chopp, Hua Teng, Guangliang Ding, Quan Jiang, Xiao Ping Yang, Nour Eddine Rhaleb, Zheng Gang Zhang. Combination treatment with N-acetyl-seryl-aspartyl-lysyl-proline and tissue plasminogen activator provides potent neuroprotection in rats after stroke.
Stroke.
2014 Apr; 45(4):1108-14. doi:
10.1161/strokeaha.113.004399. [PMID: 24549864] - Yosuke Suzuki, Fumihiko Katagiri, Fuminori Sato, Kanako Fujioka, Yukie Sato, Takashi Fujioka, Yuhki Sato, Hiromitsu Mimata, Hiroki Itoh. Significant decrease in plasma N-acetyl-seryl-aspartyl-lysyl-proline level in patients with end stage renal disease after kidney transplantation.
Biological & pharmaceutical bulletin.
2014; 37(6):1075-9. doi:
10.1248/bpb.b13-00992. [PMID: 24882420] - Takako Nagai, Megumi Kanasaki, Swayam Prakash Srivastava, Yuka Nakamura, Yasuhito Ishigaki, Munehiro Kitada, Sen Shi, Keizo Kanasaki, Daisuke Koya. N-acetyl-seryl-aspartyl-lysyl-proline inhibits diabetes-associated kidney fibrosis and endothelial-mesenchymal transition.
BioMed research international.
2014; 2014(?):696475. doi:
10.1155/2014/696475. [PMID: 24783220] - Germán E González, Nour-Eddine Rhaleb, Pablo Nakagawa, Tang-Dong Liao, Yunhe Liu, Pablo Leung, Xiangguo Dai, Xiao-Ping Yang, Oscar A Carretero. N-acetyl-seryl-aspartyl-lysyl-proline reduces cardiac collagen cross-linking and inflammation in angiotensin II-induced hypertensive rats.
Clinical science (London, England : 1979).
2014 Jan; 126(1):85-94. doi:
10.1042/cs20120619. [PMID: 23834332] - Yiqin Zuo, Bongkwon Chun, Sebastian A Potthoff, Naj Kazi, Tyler J Brolin, Diclehan Orhan, Hai-Chun Yang, Li-Jun Ma, Valentina Kon, Timo Myöhänen, Nour-Eddine Rhaleb, Oscar A Carretero, Agnes B Fogo. Thymosin β4 and its degradation product, Ac-SDKP, are novel reparative factors in renal fibrosis.
Kidney international.
2013 Dec; 84(6):1166-75. doi:
10.1038/ki.2013.209. [PMID: 23739235] - Yuan Yuan, Fang Yang, Hong Xu, Wan-ying Yu, Yue Sun, Hai-jing Deng, Wen-dong Ma, Zhong-qiu Wei, Rui-min Wang. [Effect of N-acetyl-seryl-aspartyl-lysyl-proline on differentiation from pulmonary fibroblast to myofibroblast mediated by Rho-associated coiled-coil forming protein kinase pathway].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases.
2013 Sep; 31(9):654-60. doi:
NULL. [PMID: 24064119] - G Castoldi, C R T di Gioia, C Bombardi, C Preziuso, M Leopizzi, S Maestroni, B Corradi, G Zerbini, A Stella. Renal antifibrotic effect of N-acetyl-seryl-aspartyl-lysyl-proline in diabetic rats.
American journal of nephrology.
2013; 37(1):65-73. doi:
10.1159/000346116. [PMID: 23327833] - Hechang Tan, Jijun Zhao, Shuang Wang, Lili Zhang, Hongyue Wang, Bin Huang, Yingjie Liang, Xueqing Yu, Niansheng Yang. Ac-SDKP ameliorates the progression of lupus nephritis in MRL/lpr mice.
International immunopharmacology.
2012 Dec; 14(4):401-9. doi:
10.1016/j.intimp.2012.07.023. [PMID: 22922317] - Lei Zhang, Lei-Ming Xu, Yuan-Wen Chen, Qian-Wen Ni, Min Zhou, Chun-Ying Qu, Yi Zhang. Antifibrotic effect of N-acetyl-seryl-aspartyl-lysyl-proline on bile duct ligation induced liver fibrosis in rats.
World journal of gastroenterology.
2012 Oct; 18(37):5283-8. doi:
10.3748/wjg.v18.i37.5283. [PMID: 23066324] - Daniela Macconi, Susanna Tomasoni, Paola Romagnani, Piera Trionfini, Fabio Sangalli, Benedetta Mazzinghi, Paola Rizzo, Elena Lazzeri, Mauro Abbate, Giuseppe Remuzzi, Ariela Benigni. MicroRNA-324-3p promotes renal fibrosis and is a target of ACE inhibition.
Journal of the American Society of Nephrology : JASN.
2012 Sep; 23(9):1496-505. doi:
10.1681/asn.2011121144. [PMID: 22822076] - Yosuke Suzuki, Hiroki Itoh, Fumihiko Katagiri, Fuminori Sato, Kanako Kawasaki, Yuhki Sato, Hiromitsu Mimata, Masaharu Takeyama. Establishment and clinical application of a highly sensitive enzyme immunoassay for determination of N-acetyl-seryl-aspartyl-lysyl-proline.
Journal of peptide science : an official publication of the European Peptide Society.
2012 Apr; 18(4):276-81. doi:
10.1002/psc.2400. [PMID: 22396066] - Koichi Inoue, Ayaka Ikemura, Yoshinari Tsuruta, Kaname Tsutsumiuchi, Tomoaki Hino, Hisao Oka. On-line solid-phase extraction LC-MS/MS for the determination of Ac-SDKP peptide in human plasma from hemodialysis patients.
Biomedical chromatography : BMC.
2012 Feb; 26(2):137-41. doi:
10.1002/bmc.1636. [PMID: 21503938] - Cédric Mesmin, Sophie Cholet, Anne Blanchard, Yann Chambon, Michel Azizi, Eric Ezan. Mass spectrometric quantification of AcSDKP-NH2 in human plasma and urine and comparison with an immunoassay.
Rapid communications in mass spectrometry : RCM.
2012 Jan; 26(2):163-72. doi:
10.1002/rcm.5326. [PMID: 22173804] - Megumi Kanasaki, Takako Nagai, Munehiro Kitada, Daisuke Koya, Keizo Kanasaki. Elevation of the antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline: a blood pressure-independent beneficial effect of angiotensin I-converting enzyme inhibitors.
Fibrogenesis & tissue repair.
2011 Nov; 4(?):25. doi:
10.1186/1755-1536-4-25. [PMID: 22126210] - T T Myöhänen, J Tenorio-Laranga, B Jokinen, R Vázquez-Sánchez, M J Moreno-Baylach, J A García-Horsman, P T Männistö. Prolyl oligopeptidase induces angiogenesis both in vitro and in vivo in a novel regulatory manner.
British journal of pharmacology.
2011 Aug; 163(8):1666-78. doi:
10.1111/j.1476-5381.2010.01146.x. [PMID: 21133893] - Koichi Inoue, Ayaka Ikemura, Yoshinari Tsuruta, Kazuki Watanabe, Kaname Tsutsumiuchi, Tomoaki Hino, Hisao Oka. Quantification of N-acetyl-seryl-aspartyl-lysyl-proline in hemodialysis patients administered angiotensin-converting enzyme inhibitors by stable isotope dilution liquid chromatography-tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2011 Mar; 54(4):765-71. doi:
10.1016/j.jpba.2010.10.009. [PMID: 21074346] - Nour-Eddine Rhaleb, Saraswati Pokharel, Umesh Sharma, Oscar A Carretero. Renal protective effects of N-acetyl-Ser-Asp-Lys-Pro in deoxycorticosterone acetate-salt hypertensive mice.
Journal of hypertension.
2011 Feb; 29(2):330-8. doi:
10.1097/hjh.0b013e32834103ee. [PMID: 21052020] - Mingao Wang, Ruichan Liu, Xibei Jia, Suhong Mu, Rujuan Xie. N-acetyl-seryl-aspartyl-lysyl-proline attenuates renal inflammation and tubulointerstitial fibrosis in rats.
International journal of molecular medicine.
2010 Dec; 26(6):795-801. doi:
10.3892/ijmm_00000527. [PMID: 21042772] - Yuan-Wen Chen, Bo-Wei Liu, Yu-Jian Zhang, Ying-Wei Chen, Guo-Fang Dong, Xiao-Dong Ding, Lei-Ming Xu, Betty Pat, Jiang-Gao Fan, Ding-Guo Li. Preservation of basal AcSDKP attenuates carbon tetrachloride-induced fibrosis in the rat liver.
Journal of hepatology.
2010 Sep; 53(3):528-36. doi:
10.1016/j.jhep.2010.03.027. [PMID: 20646773] - Jolanta Malyszko, Edyta Zbroch, Jacek Malyszko, Michal Mysliwiec, Adrian Iaina. The cardio-renal-anaemia syndrome predicts survival in peritoneally dialyzed patients.
Archives of medical science : AMS.
2010 Aug; 6(4):539-44. doi:
10.5114/aoms.2010.14465. [PMID: 22371797] - José L Miguel-Carrasco, Sonia Zambrano, Antonio J Blanca, Alfonso Mate, Carmen M Vázquez. Captopril reduces cardiac inflammatory markers in spontaneously hypertensive rats by inactivation of NF-kB.
Journal of inflammation (London, England).
2010 May; 7(?):21. doi:
10.1186/1476-9255-7-21. [PMID: 20462420] - Jofre Tenorio-Laranga, Francisco Coret-Ferrer, Buenaventura Casanova-Estruch, María Burgal, J Arturo García-Horsman. Prolyl oligopeptidase is inhibited in relapsing-remitting multiple sclerosis.
Journal of neuroinflammation.
2010 Apr; 7(?):23. doi:
10.1186/1742-2094-7-23. [PMID: 20370893] - Tang-Dong Liao, Xiao-Ping Yang, Martin D'Ambrosio, Yanlu Zhang, Nour-Eddine Rhaleb, Oscar A Carretero. N-acetyl-seryl-aspartyl-lysyl-proline attenuates renal injury and dysfunction in hypertensive rats with reduced renal mass: council for high blood pressure research.
Hypertension (Dallas, Tex. : 1979).
2010 Feb; 55(2):459-67. doi:
10.1161/hypertensionaha.109.144568. [PMID: 20026760] - Jian-Miao Liu, Joanna Gora-Tybor, Olga Grzybowska-Izydorczyk, Jerome Bignon, Tadeusz Robak, Joanna Wdzieczak-Bakala. Elevated plasma levels of the angiogenic tetrapeptide acetyl-ser-asp-lys-pro are found in some patients with hematologic malignancies.
Leukemia & lymphoma.
2009 Dec; 50(12):2096-7. doi:
10.3109/10428190903331074. [PMID: 19863169] - Xiaojun Liu, Christopher O C Bellamy, Matthew A Bailey, Linda J Mullins, Donald R Dunbar, Christopher J Kenyon, Gillian Brooker, Surasak Kantachuvesiri, Klio Maratou, Ali Ashek, Allan F Clark, Stewart Fleming, John J Mullins. Angiotensin-converting enzyme is a modifier of hypertensive end organ damage.
The Journal of biological chemistry.
2009 Jun; 284(23):15564-72. doi:
10.1074/jbc.m806584200. [PMID: 19307186] - Li-Jun Ma, Agnes B Fogo. PAI-1 and kidney fibrosis.
Frontiers in bioscience (Landmark edition).
2009 01; 14(6):2028-41. doi:
10.2741/3361. [PMID: 19273183] - Chun-Xia Lin, Nour-Eddine Rhaleb, Xiao-Ping Yang, Tang-Dong Liao, Martin A D'Ambrosio, Oscar A Carretero. Prevention of aortic fibrosis by N-acetyl-seryl-aspartyl-lysyl-proline in angiotensin II-induced hypertension.
American journal of physiology. Heart and circulatory physiology.
2008 Sep; 295(3):H1253-H1261. doi:
10.1152/ajpheart.00481.2008. [PMID: 18641275] - Jian-Miao Liu, Michal Kusinski, Vesna Ilic, Jérôme Bignon, Neila Hajem, Jan Komorowski, Krzysztof Kuzdak, Henryk Stepien, Joanna Wdzieczak-Bakala. Overexpression of the angiogenic tetrapeptide AcSDKP in human malignant tumors.
Anticancer research.
2008 Sep; 28(5A):2813-7. doi:
NULL. [PMID: 19035315] - Umesh Sharma, Nour-Eddine Rhaleb, Saraswati Pokharel, Pamela Harding, Saman Rasoul, Hongmei Peng, Oscar A Carretero. Novel anti-inflammatory mechanisms of N-Acetyl-Ser-Asp-Lys-Pro in hypertension-induced target organ damage.
American journal of physiology. Heart and circulatory physiology.
2008 Mar; 294(3):H1226-32. doi:
10.1152/ajpheart.00305.2007. [PMID: 18178715] - Amir Hayat, Dhiren Haria, Moro O Salifu. Erythropoietin stimulating agents in the management of anemia of chronic kidney disease.
Patient preference and adherence.
2008 Feb; 2(?):195-200. doi:
10.2147/ppa.s2356. [PMID: 19920963] - S C W Tang, J C K Leung, L Y Y Chan, A A Eddy, K N Lai. Angiotensin converting enzyme inhibitor but not angiotensin receptor blockade or statin ameliorates murine adriamycin nephropathy.
Kidney international.
2008 Feb; 73(3):288-99. doi:
10.1038/sj.ki.5002674. [PMID: 18033243] - Michel Azizi, Grégoire Wuerzner. Rationale for combining blockers of the renin-angiotensin system.
Seminars in nephrology.
2007 Sep; 27(5):544-54. doi:
10.1016/j.semnephrol.2007.07.002. [PMID: 17868792] - Maria A Cavasin, Tang-Dong Liao, Xiao-Ping Yang, James J Yang, Oscar A Carretero. Decreased endogenous levels of Ac-SDKP promote organ fibrosis.
Hypertension (Dallas, Tex. : 1979).
2007 Jul; 50(1):130-6. doi:
10.1161/hypertensionaha.106.084103. [PMID: 17470726] - Hongmei Peng, Oscar A Carretero, Tang-Dong Liao, Edward L Peterson, Nour-Eddine Rhaleb. Role of N-acetyl-seryl-aspartyl-lysyl-proline in the antifibrotic and anti-inflammatory effects of the angiotensin-converting enzyme inhibitor captopril in hypertension.
Hypertension (Dallas, Tex. : 1979).
2007 Mar; 49(3):695-703. doi:
10.1161/01.hyp.0000258406.66954.4f. [PMID: 17283252] - Jian-Miao Liu, Jérôme Bignon, Vesna Ilic, Cecilia Briscoe, Jean-Yves Lallemand, Andrew Riches, Joanna Wdzieczak-Bakala. Evidence for an association of high levels of endogenous Acetyl-Ser-Asp-Lys-Pro, a potent mediator of angiogenesis, with acute myeloid leukemia development.
Leukemia & lymphoma.
2006 Sep; 47(9):1915-20. doi:
10.1080/10428190600688131. [PMID: 17065006] - Michel Azizi, Joël Ménard, Séverine Peyrard, Michel Lièvre, Michel Marre, Gilles Chatellier. Assessment of patients' and physicians' compliance to an ACE inhibitor treatment based on urinary N-acetyl Ser-Asp-Lys-Pro determination in the Noninsulin-Dependent Diabetes, Hypertension, Microalbuminuria, Proteinuria, Cardiovascular Events, and Ramipril (DIABHYCAR) study.
Diabetes care.
2006 Jun; 29(6):1331-6. doi:
10.2337/dc06-0255. [PMID: 16732017] - Keizo Kanasaki, Masakazu Haneda, Toshiro Sugimoto, Kazuyuki Shibuya, Motohide Isono, Keiji Isshiki, Shin-ichi Araki, Takashi Uzu, Atsunori Kashiwagi, Daisuke Koya. N-acetyl-seryl-aspartyl-lysyl-proline inhibits DNA synthesis in human mesangial cells via up-regulation of cell cycle modulators.
Biochemical and biophysical research communications.
2006 Apr; 342(3):758-65. doi:
10.1016/j.bbrc.2006.02.019. [PMID: 16497271] - Ludovic Waeckel, Jérôme Bignon, Jian-Miao Liu, Delphine Markovits, Téni G Ebrahimian, José Vilar, Barend Mees, Olivier Blanc-Brude, Véronique Barateau, Sophie Le Ricousse-Roussanne, Micheline Duriez, Gérard Tobelem, Joanna Wdzieczak-Bakala, Bernard I Lévy, Jean-Sébastien Silvestre. Tetrapeptide AcSDKP induces postischemic neovascularization through monocyte chemoattractant protein-1 signaling.
Arteriosclerosis, thrombosis, and vascular biology.
2006 Apr; 26(4):773-9. doi:
10.1161/01.atv.0000203510.96492.14. [PMID: 16410461] - Mitsugu Omata, Hajime Taniguchi, Daisuke Koya, Keizo Kanasaki, Rumiko Sho, Yoshimi Kato, Ryoji Kojima, Masakazu Haneda, Norio Inomata. N-acetyl-seryl-aspartyl-lysyl-proline ameliorates the progression of renal dysfunction and fibrosis in WKY rats with established anti-glomerular basement membrane nephritis.
Journal of the American Society of Nephrology : JASN.
2006 Mar; 17(3):674-85. doi:
10.1681/asn.2005040385. [PMID: 16452498] - Michel Azizi, Alvine Bissery, Séverine Peyrard, Than Tam Guyene, Marie-Laure Ozoux, Anne Floch, Joël Ménard. Pharmacokinetics and pharmacodynamics of the vasopeptidase inhibitor AVE7688 in humans.
Clinical pharmacology and therapeutics.
2006 Jan; 79(1):49-61. doi:
10.1016/j.clpt.2005.09.011. [PMID: 16413241] - S Mimouni, C Raffaitin, J-B Corcuff. [Ac-SDKP, a marker of the angiotensin-converting enzyme activity?].
Annales de biologie clinique.
2006 Jan; 64(1):11-6. doi:
NULL. [PMID: 16420987] - Manuel Praga. Therapeutic measures in proteinuric nephropathy.
Kidney international. Supplement.
2005 Dec; ?(99):S137-41. doi:
10.1111/j.1523-1755.2005.09925.x. [PMID: 16336567] - Hongmei Peng, Oscar A Carretero, Nikola Vuljaj, Tang-Dong Liao, Apurva Motivala, Edward L Peterson, Nour-Eddine Rhaleb. Angiotensin-converting enzyme inhibitors: a new mechanism of action.
Circulation.
2005 Oct; 112(16):2436-45. doi:
10.1161/circulationaha.104.528695. [PMID: 16216963] - Peter van der Meer, Erik Lipsic, B Daan Westenbrink, Ruud M A van de Wal, Regien G Schoemaker, Edo Vellenga, Dirk J van Veldhuisen, Adriaan A Voors, Wiek H van Gilst. Levels of hematopoiesis inhibitor N-acetyl-seryl-aspartyl-lysyl-proline partially explain the occurrence of anemia in heart failure.
Circulation.
2005 Sep; 112(12):1743-7. doi:
10.1161/circulationaha.105.549121. [PMID: 16172283] - Kazuyuki Shibuya, Keizo Kanasaki, Motohide Isono, Haruhisa Sato, Mitsugu Omata, Toshiro Sugimoto, Shin-ichi Araki, Keiji Isshiki, Atsunori Kashiwagi, Masakazu Haneda, Daisuke Koya. N-acetyl-seryl-aspartyl-lysyl-proline prevents renal insufficiency and mesangial matrix expansion in diabetic db/db mice.
Diabetes.
2005 Mar; 54(3):838-45. doi:
10.2337/diabetes.54.3.838. [PMID: 15734863] - Sabine Charrier, Annie Michaud, Sabrina Badaoui, Sébastien Giroux, Eric Ezan, Françoise Sainteny, Pierre Corvol, William Vainchenker. Inhibition of angiotensin I-converting enzyme induces radioprotection by preserving murine hematopoietic short-term reconstituting cells.
Blood.
2004 Aug; 104(4):978-85. doi:
10.1182/blood-2003-11-3828. [PMID: 15105290] - Maria A Cavasin, Nour-Eddine Rhaleb, Xiao-Ping Yang, Oscar A Carretero. Prolyl oligopeptidase is involved in release of the antifibrotic peptide Ac-SDKP.
Hypertension (Dallas, Tex. : 1979).
2004 May; 43(5):1140-5. doi:
10.1161/01.hyp.0000126172.01673.84. [PMID: 15037553] - V Bueno, M Palos, F A Ronchi, M C C Andrade, M Ginoza, D E Casarini. N-Domain angiotensin I-converting enzyme expression in renal artery of Wistar, Wistar Kyoto, and spontaneously hypertensive rats.
Transplantation proceedings.
2004 May; 36(4):1001-3. doi:
10.1016/j.transproceed.2004.03.081. [PMID: 15194348] - Sebastien Fuchs, Hong D Xiao, Justin M Cole, Jonathan W Adams, Kristen Frenzel, Annie Michaud, Hui Zhao, George Keshelava, Mario R Capecchi, Pierre Corvol, Kenneth E Bernstein. Role of the N-terminal catalytic domain of angiotensin-converting enzyme investigated by targeted inactivation in mice.
The Journal of biological chemistry.
2004 Apr; 279(16):15946-53. doi:
10.1074/jbc.m400149200. [PMID: 14757757] - Saman Rasoul, Oscar A Carretero, Hongmei Peng, Maria A Cavasin, Jialong Zhuo, Alicia Sanchez-Mendoza, David R Brigstock, Nour-Eddine Rhaleb. Antifibrotic effect of Ac-SDKP and angiotensin-converting enzyme inhibition in hypertension.
Journal of hypertension.
2004 Mar; 22(3):593-603. doi:
10.1097/00004872-200403000-00023. [PMID: 15076166] - Fang Yang, Xiao-Ping Yang, Yun-He Liu, Jiang Xu, Oscar Cingolani, Nour-Eddine Rhaleb, Oscar A Carretero. Ac-SDKP reverses inflammation and fibrosis in rats with heart failure after myocardial infarction.
Hypertension (Dallas, Tex. : 1979).
2004 Feb; 43(2):229-36. doi:
10.1161/01.hyp.0000107777.91185.89. [PMID: 14691195] - Hongmei Peng, Oscar A Carretero, David R Brigstock, Nancy Oja-Tebbe, Nour-Eddine Rhaleb. Ac-SDKP reverses cardiac fibrosis in rats with renovascular hypertension.
Hypertension (Dallas, Tex. : 1979).
2003 Dec; 42(6):1164-70. doi:
10.1161/01.hyp.0000100423.24330.96. [PMID: 14581293] - Carlos P Vío, Valerie A Jeanneret. Local induction of angiotensin-converting enzyme in the kidney as a mechanism of progressive renal diseases.
Kidney international. Supplement.
2003 Oct; ?(86):S57-63. doi:
10.1046/j.1523-1755.64.s86.11.x. [PMID: 12969129] - Keizo Kanasaki, Daisuke Koya, Toshiro Sugimoto, Motohide Isono, Atsunori Kashiwagi, Masakazu Haneda. N-Acetyl-seryl-aspartyl-lysyl-proline inhibits TGF-beta-mediated plasminogen activator inhibitor-1 expression via inhibition of Smad pathway in human mesangial cells.
Journal of the American Society of Nephrology : JASN.
2003 Apr; 14(4):863-72. doi:
10.1097/01.asn.0000057544.95569.ec. [PMID: 12660320] - Michel Azizi, Maxime Lamarre-Cliche, Agnès Labatide-Alanore, Alvine Bissery, Than Tam Guyene, Joël Ménard. Physiologic consequences of vasopeptidase inhibition in humans: effect of sodium intake.
Journal of the American Society of Nephrology : JASN.
2002 Oct; 13(10):2454-63. doi:
10.1097/01.asn.0000030142.80452.11. [PMID: 12239234] - Michel Azizi, Christophe Junot, Eric Ezan, Marie-Charlotte Hallouin, Tam Guyene, Joël Ménard. Functional consequences of angiotensin-converting enzyme gene polymorphism on N-acetyl-Ser-Asp-Lys-Pro degradation and angiotensin II production.
Journal of molecular medicine (Berlin, Germany).
2002 Aug; 80(8):492-8. doi:
10.1007/s00109-002-0357-z. [PMID: 12185449] - Ali K Abu-Alfa, Mark A Perazella. Angiotensin-converting enzyme inhibitors and anemia in chronic kidney disease: a complex interaction.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2002 Apr; 39(4):896-7. doi:
10.1053/ajkd.2002.32163. [PMID: 11920360] - M Azizi, C Junot, E Ezan, J Ménard. Angiotensin I-converting enzyme and metabolism of the haematological peptide N-acetyl-seryl-aspartyl-lysyl-proline.
Clinical and experimental pharmacology & physiology.
2001 Dec; 28(12):1066-9. doi:
10.1046/j.1440-1681.2001.03560.x. [PMID: 11903317] - Y Le Meur, V Lorgeot, L Comte, J C Szelag, J C Aldigier, C Leroux-Robert, V Praloran. Plasma levels and metabolism of AcSDKP in patients with chronic renal failure: relationship with erythropoietin requirements.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2001 Sep; 38(3):510-7. doi:
10.1053/ajkd.2001.26839. [PMID: 11532682] - I C Macdougall. Ace inhibitors and erythropoietin responsiveness.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2001 Sep; 38(3):649-51. doi:
10.1053/ajkd.2001.28027. [PMID: 11532700] - N E Rhaleb, H Peng, X P Yang, Y H Liu, D Mehta, E Ezan, O A Carretero. Long-term effect of N-acetyl-seryl-aspartyl-lysyl-proline on left ventricular collagen deposition in rats with 2-kidney, 1-clip hypertension.
Circulation.
2001 Jun; 103(25):3136-41. doi:
10.1161/01.cir.103.25.3136. [PMID: 11425781] - C Junot, M F Gonzales, E Ezan, J Cotton, G Vazeux, A Michaud, M Azizi, S Vassiliou, A Yiotakis, P Corvol, V Dive. RXP 407, a selective inhibitor of the N-domain of angiotensin I-converting enzyme, blocks in vivo the degradation of hemoregulatory peptide acetyl-Ser-Asp-Lys-Pro with no effect on angiotensin I hydrolysis.
The Journal of pharmacology and experimental therapeutics.
2001 May; 297(2):606-11. doi:
NULL. [PMID: 11303049] - G Vazeux, J Cotton, P Cuniasse, V Dive. Potency and selectivity of RXP407 on human, rat, and mouse angiotensin-converting enzyme.
Biochemical pharmacology.
2001 Apr; 61(7):835-41. doi:
10.1016/s0006-2952(01)00550-0. [PMID: 11274969]
