5-Aminoisoquinolin-1(2H)-one (BioDeep_00001875846)
代谢物信息卡片
化学式: C9H8N2O (160.0637)
中文名称: 5-氨基-2H-异喹啉-1-酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC2=C(C=CNC2=O)C(=C1)N
InChI: InChI=1S/C9H8N2O/c10-8-3-1-2-7-6(8)4-5-11-9(7)12/h1-5H,10H2,(H,11,12)
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Sheikh Fayaz Ahmad, Khairy M A Zoheir, Mushtaq Ahmad Ansari, Hesham M Korashy, Saleh A Bakheet, Abdelkader E Ashour, Othman A Al-Shabanah, Mohammed M Al-harbi, Sabry M Attia. The role of poly(ADP-ribose) polymerase-1 inhibitor in carrageenan-induced lung inflammation in mice.
Molecular immunology.
2015 Feb; 63(2):394-405. doi:
10.1016/j.molimm.2014.09.009
. [PMID: 25304310] - Michael D Threadgill. 5-Aminoisoquinolin-1-one (5-AIQ), a Water-Soluble Inhibitor of the Poly(ADP-Ribose)Polymerases (PARPs).
Current medicinal chemistry.
2015; 22(33):3807-29. doi:
10.2174/0929867322666151002110602
. [PMID: 26429070] - Marek Banasik, Todd Stedeford, Robert P Strosznajder, Masanori Takehashi, Seigo Tanaka, Kunihiro Ueda. Inhibition of poly(ADP-ribose) polymerase-1 attenuates the toxicity of carbon tetrachloride.
Journal of enzyme inhibition and medicinal chemistry.
2011 Dec; 26(6):883-9. doi:
10.3109/14756366.2011.557315
. [PMID: 21395487] - James D McCluskey, Dmytro Sava, Stephen C Harbison, Carlos A Muro-Cacho, Johnson T Giffe, Xu Ping, Raymond D Harbison. Hepatoprotective effects of select water-soluble PARP inhibitors in a carbon tetrachloride model.
International journal of critical illness and injury science.
2011 Jul; 1(2):97-103. doi:
10.4103/2229-5151.84788
. [PMID: 22229131] - Rosanna Di Paola, Tiziana Genovese, Achille P Caputi, Mike Threadgill, Christoph Thiemermann, Salvatore Cuzzocrea. Beneficial effects of 5-aminoisoquinolinone, a novel, potent, water-soluble, inhibitor of poly (ADP-ribose) polymerase, in a rat model of splanchnic artery occlusion and reperfusion.
European journal of pharmacology.
2004 May; 492(2-3):203-10. doi:
10.1016/j.ejphar.2004.03.033
. [PMID: 15178366] - Andrej Khandoga, Peter Biberthaler, Georg Enders, Fritz Krombach. 5-Aminoisoquinolinone, a novel inhibitor of poly(adenosine disphosphate-ribose) polymerase, reduces microvascular liver injury but not mortality rate after hepatic ischemia-reperfusion.
Critical care medicine.
2004 Feb; 32(2):472-7. doi:
10.1097/01.ccm.0000109448.51468.e3
. [PMID: 14758166] - Prabal K Chatterjee, Bristi E Chatterjee, Helene Pedersen, Ahila Sivarajah, Michelle C McDonald, Helder Mota-Filipe, Paul A J Brown, Keith N Stewart, Salvatore Cuzzocrea, Michael D Threadgill, Christoph Thiemermann. 5-Aminoisoquinolinone reduces renal injury and dysfunction caused by experimental ischemia/reperfusion.
Kidney international.
2004 Feb; 65(2):499-509. doi:
10.1111/j.1523-1755.2004.00415.x
. [PMID: 14717920] - Helder Mota-Filipe, Bruno Sepodes, Michelle C McDonald, Salvatore Cuzzocrea, Rui Pinto, Christoph Thiemermann. The novel PARP inhibitor 5-aminoisoquinolinone reduces the liver injury caused by ischemia and reperfusion in the rat.
Medical science monitor : international medical journal of experimental and clinical research.
2002 Nov; 8(11):BR444-53. doi:
NULL
. [PMID: 12444369] - Salvatore Cuzzocrea, Michelle C McDonald, Emanuela Mazzon, Laura Dugo, Ivana Serraino, Mike Threadgill, Achille P Caputi, Christoph Thiemermann. Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury.
Biochemical pharmacology.
2002 Jan; 63(2):293-304. doi:
10.1016/s0006-2952(01)00864-4
. [PMID: 11841805] - M C McDonald, H Mota-Filipe, J A Wright, M Abdelrahman, M D Threadgill, A S Thompson, C Thiemermann. Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock.
British journal of pharmacology.
2000 Jun; 130(4):843-50. doi:
10.1038/sj.bjp.0703391
. [PMID: 10864891]