SB431542 (BioDeep_00001875836)
代谢物信息卡片
4-(4-(Benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide
化学式: C22H16N4O3 (384.12223459999996)
中文名称: SB 431542
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
InChI: InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
描述信息
同义名列表
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hirotaka Matsuo, Hitomi Kawakami, Naoko Anjiki, Noriaki Kawano, Hiroyuki Fuchino, Nobuo Kawahara, Kayo Yoshimatsu. Screening of growth inhibitors for epithelial-mesenchymal transition-induced cells by TGF-β from plant-based sources identified the active compound hydroxychavicol from Piper bitle.
Journal of natural medicines.
2024 Jun; 78(3):774-783. doi:
10.1007/s11418-024-01785-3. [PMID: 38418720] - Jia Ying, Peipei Wang, Xiao Jin, Li Luo, Keshuang Lai, Jun Li. TGF-β1 Mediates the EndoMt in High Glucose-Treated Human Retinal Microvascular Endothelial Cells.
Seminars in ophthalmology.
2024 May; 39(4):312-319. doi:
10.1080/08820538.2023.2300806. [PMID: 38192082] - S U Chengguo, Zhao Xiaoyan, Y E Jiangnan, Zhang Xin, Jiang Yuqing, Guo Junjie, Zhang Xiyuan, Q I Wenchuan, Zhu Jun. Effect of Tuina along 'bladder meridian' alleviating intervertebral disc degeneration by regulating the transforming growth factor-β1/Smad signaling pathway in a rabbit model.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2023 10; 43(5):991-1000. doi:
10.19852/j.cnki.jtcm.2023.05.005. [PMID: 37679987] - Lei Li, Jie Guan, Rongjun Lin, Fang Wang, Hui Ma, Chenggang Mao, Xingqing Guo, Zhenghai Qu, Renzheng Guan. Astragaloside IV alleviates lung inflammation in Klebsiella pneumonia rats by suppressing TGF-β1/Smad pathway.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
2023; 56(?):e12203. doi:
10.1590/1414-431x2023e12203. [PMID: 37493767] - Danielle Kamato, Mai Gabr, Hirushi Kumarapperuma, Zheng J Chia, Wenhua Zheng, Suowen Xu, Narin Osman, Peter J Little. Gαq Is the Specific Mediator of PAR-1 Transactivation of Kinase Receptors in Vascular Smooth Muscle Cells.
International journal of molecular sciences.
2022 Nov; 23(22):. doi:
10.3390/ijms232214425. [PMID: 36430902] - Saurabh Pal, Neha Singh, Indra Dev, Vineeta Sharma, Pankaj Ramji Jagdale, Anjaneya Ayanur, Kausar Mahmood Ansari. TGF-β/Smad signaling pathway plays a crucial role in patulin-induced pro-fibrotic changes in rat kidney via modulation of slug and snail expression.
Toxicology and applied pharmacology.
2022 01; 434(?):115819. doi:
10.1016/j.taap.2021.115819. [PMID: 34896196] - Alireza Mardomi, Marzieh Ghollasi, Mohsen Korani, Mahsa Panahi, Mohammad Parsa-Kondelaji, Mehdi Sabzichi, Ali Salimi. Blockade of TGF-βR improves the efficacy of doxorubicin by modulating the tumor cell motility and affecting the immune cells in a melanoma model.
Naunyn-Schmiedeberg's archives of pharmacology.
2021 11; 394(11):2309-2322. doi:
10.1007/s00210-021-02134-x. [PMID: 34499199] - Franz Ewendt, Martina Feger, Michael Föller. Myostatin regulates the production of fibroblast growth factor 23 (FGF23) in UMR106 osteoblast-like cells.
Pflugers Archiv : European journal of physiology.
2021 06; 473(6):969-976. doi:
10.1007/s00424-021-02561-y. [PMID: 33895875] - Dongjie Sun, Zhehao Huang, Jinying Xu, Yiqing Wang, Lin Chen, Yi Hou, Guangfan Chi. HaCaT‑conditioned medium supplemented with the small molecule inhibitors SB431542 and CHIR99021 and the growth factor PDGF‑AA prevents the dedifferentiation of dermal papilla cells in vitro.
Molecular medicine reports.
2021 05; 23(5):. doi:
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Nature methods.
2021 01; 18(1):84-91. doi:
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2019 12; 34(12):2430-2442. doi:
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Toxicology and applied pharmacology.
2019 10; 380(?):114696. doi:
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2019 09; 62(17):7961-7975. doi:
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Molecular and cellular endocrinology.
2019 08; 493(?):110485. doi:
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Molecules (Basel, Switzerland).
2019 Jan; 24(1):. doi:
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2018 10; 504(4):857-864. doi:
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Archives of toxicology.
2018 09; 92(9):2935-2946. doi:
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Cytokine.
2018 06; 106(?):45-53. doi:
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Endocrinology.
2018 04; 159(4):1644-1657. doi:
10.1210/en.2017-03127. [PMID: 29462303] - Jun Chen, Zhangzhe Peng, Miaomiao Lu, Xuan Xiong, Zhuo Chen, Qianbin Li, Zeneng Cheng, Dejian Jiang, Lijian Tao, Gaoyun Hu. Discovery of 1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one, an orally active multi-target agent for the treatment of diabetic nephropathy.
Bioorganic & medicinal chemistry letters.
2018 01; 28(2):222-229. doi:
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PloS one.
2018; 13(8):e0202577. doi:
10.1371/journal.pone.0202577. [PMID: 30138414] - Lili Cheng, Mengmeng Ge, Zhou Lan, Zhilong Ma, Wenna Chi, Wenhua Kuang, Kun Sun, Xinbin Zhao, Ye Liu, Yaqian Feng, Yuedong Huang, Maoguo Luo, Liping Li, Bin Zhang, Xiaoyu Hu, Lina Xu, Xiaohui Liu, Yi Huo, Haiteng Deng, Jinliang Yang, Qiaoran Xi, Yonghui Zhang, Julie A Siegenthaler, Ligong Chen. Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity.
Archives of toxicology.
2018 Jan; 92(1):469-485. doi:
10.1007/s00204-017-2048-0. [PMID: 28871336] - Lei Peng, Xiaoqing Jia, Jianjian Zhao, Ruibing Cui, Ming Yan. Substance P promotes hepatic stellate cell proliferation and activation via the TGF-β1/Smad-3 signaling pathway.
Toxicology and applied pharmacology.
2017 08; 329(?):293-300. doi:
10.1016/j.taap.2017.06.020. [PMID: 28647476] - Fan Li, Lisha Li, Jun Hao, Shuxia Liu, Huijun Duan. Src Homology 2 Domain-Containing Inositol 5'-Phosphatase Ameliorates High Glucose-Induced Extracellular Matrix Deposition via the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway in Renal Tubular Epithelial Cells.
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Scientific reports.
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Molecular and cellular biochemistry.
2017 May; 429(1-2):113-122. doi:
10.1007/s11010-017-2940-1. [PMID: 28181132] - Hao Bai, Yongxing Gao, Dixie L Hoyle, Tao Cheng, Zack Z Wang. Suppression of Transforming Growth Factor-β Signaling Delays Cellular Senescence and Preserves the Function of Endothelial Cells Derived from Human Pluripotent Stem Cells.
Stem cells translational medicine.
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Oncotarget.
2016 Nov; 7(44):71341-71352. doi:
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Chinese medical journal.
2016 09; 129(17):2040-4. doi:
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Journal of bone and mineral metabolism.
2016 Sep; 34(5):517-25. doi:
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Scientific reports.
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10.1038/srep27093. [PMID: 27256073] - Xiuji Li, Zongli Diao, Jiaxiang Ding, Ruixia Liu, Liyan Wang, Wen Huang, Wenhu Liu. The downregulation of SnoN expression in human renal proximal tubule epithelial cells under high-glucose conditions is mediated by an increase in Smurf2 expression through TGF-β1 signaling.
International journal of molecular medicine.
2016 Feb; 37(2):415-22. doi:
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Journal of natural products.
2016 Jan; 79(1):149-55. doi:
10.1021/acs.jnatprod.5b00814. [PMID: 26677752] - Yinliang Xie, Hao Bai, Yanfeng Liu, Dixie L Hoyle, Tao Cheng, Zack Z Wang. Cooperative Effect of Erythropoietin and TGF-β Inhibition on Erythroid Development in Human Pluripotent Stem Cells.
Journal of cellular biochemistry.
2015 Dec; 116(12):2735-43. doi:
10.1002/jcb.25233. [PMID: 26012423] - Huiming Xu, Yonghui Wang, Zuping He, Hao Yang, Wei-Qiang Gao. Direct conversion of mouse fibroblasts to GABAergic neurons with combined medium without the introduction of transcription factors or miRNAs.
Cell cycle (Georgetown, Tex.).
2015 Aug; 14(15):2451-60. doi:
10.1080/15384101.2015.1060382. [PMID: 26114472] - Matthias Zimmermann, Jordi Caballé-Serrano, Dieter D Bosshardt, Hendrik J Ankersmit, Daniel Buser, Reinhard Gruber. Bone-Conditioned Medium Changes Gene Expression in Bone-Derived Fibroblasts.
The International journal of oral & maxillofacial implants.
2015 Jul; 30(4):953-8. doi:
10.11607/jomi.4060. [PMID: 26252049] - Guenther Schuldt Filho, Jordi Caballé-Serrano, Kosaku Sawada, Dieter D Bosshardt, Marco Aurélio Bianchini, Daniel Buser, Reinhard Gruber. Conditioned medium of demineralized freeze-dried bone activates gene expression in periodontal fibroblasts in vitro.
Journal of periodontology.
2015 Jun; 86(6):827-34. doi:
10.1902/jop.2015.140676. [PMID: 25786563] - Hsun-Ming Chang, Lanlan Fang, Jung-Chien Cheng, Christian Klausen, Ying-Pu Sun, Peter C K Leung. Growth differentiation factor 8 down-regulates pentraxin 3 in human granulosa cells.
Molecular and cellular endocrinology.
2015 Mar; 404(?):82-90. doi:
10.1016/j.mce.2015.01.036. [PMID: 25641196] - Omar García-Sánchez, Sandra M Sancho-Martínez, José Miguel López-Novoa, Francisco J López-Hernández. Activation of the ALK-5 Pathway is not per se Sufficient for the Antiproliferative Effect of TGF-β1 on Renal Tubule Epithelial Cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2015; 37(4):1231-9. doi:
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Pancreas.
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Annals of neurology.
2014 Jun; 75(6):864-75. doi:
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Stem cells and development.
2014 May; 23(10):1050-61. doi:
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Current pharmaceutical biotechnology.
2014; 15(2):120-6. doi:
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European cytokine network.
2013 Oct; 24(4):139-47. doi:
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Journal of cellular biochemistry.
2013 Sep; 114(9):2101-13. doi:
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Experimental physiology.
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PloS one.
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Toxicological sciences : an official journal of the Society of Toxicology.
2012 Jun; 127(2):425-37. doi:
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European journal of clinical pharmacology.
2012 Jun; 68(6):923-35. doi:
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Cellular signalling.
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Stem cells translational medicine.
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Translational research : the journal of laboratory and clinical medicine.
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Molecular reproduction and development.
2011 Jun; 78(6):391-402. doi:
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International journal of molecular medicine.
2010 Sep; 26(3):325-32. doi:
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Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2010 Jun; 25(6):1216-33. doi:
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Journal of ethnopharmacology.
2010 Feb; 127(3):631-40. doi:
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The International journal of developmental biology.
2010; 54(4):731-6. doi:
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Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
2009 Sep; 27(9):1258-62. doi:
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Journal of receptor and signal transduction research.
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2007 Nov; 15(11):840-4. doi:
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European journal of pharmacology.
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Journal of cell science.
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Biochemical and biophysical research communications.
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The Journal of pathology.
2005 Oct; 207(2):232-42. doi:
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Kidney international.
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