DL-3,3,5-Triiodothyronine (BioDeep_00001875475)
代谢物信息卡片
DL-3,3,5-Triiodothyronine
化学式: C15H12I3NO4 (650.7900602)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=C(C=C1CC(C(=O)O)N)I)OC2=CC(=C(C(=C2)I)O)I
InChI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
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相关代谢途径
Reactome(7)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Andreas Jurik, Barbara Zdrazil, Marion Holy, Thomas Stockner, Harald H Sitte, Gerhard F Ecker. A binding mode hypothesis of tiagabine confirms liothyronine effect on γ-aminobutyric acid transporter 1 (GAT1).
Journal of medicinal chemistry.
2015 Mar; 58(5):2149-58. doi:
10.1021/jm5015428. [PMID: 25679268] - Alessandro Marsili, Edith Sanchez, Praful Singru, John W Harney, Ann Marie Zavacki, Ronald M Lechan, P R Larsen. Thyroxine-induced expression of pyroglutamyl peptidase II and inhibition of TSH release precedes suppression of TRH mRNA and requires type 2 deiodinase.
The Journal of endocrinology.
2011 Oct; 211(1):73-8. doi:
10.1530/joe-11-0248. [PMID: 21788297] - Jesper Svanfelt, Johan Eriksson, Leif Kronberg. Analysis of thyroid hormones in raw and treated waste water.
Journal of chromatography. A.
2010 Oct; 1217(42):6469-74. doi:
10.1016/j.chroma.2010.08.032. [PMID: 20850122] - Dongli Wang, Heather M Stapleton. Analysis of thyroid hormones in serum by liquid chromatography-tandem mass spectrometry.
Analytical and bioanalytical chemistry.
2010 Jul; 397(5):1831-9. doi:
10.1007/s00216-010-3705-9. [PMID: 20437035] - W Edward Visser, Jurgen Jansen, Edith C H Friesema, Monique H A Kester, Edna Mancilla, Johan Lundgren, Marjo S van der Knaap, Roelineke J Lunsing, Oebele F Brouwer, Theo J Visser. Novel pathogenic mechanism suggested by ex vivo analysis of MCT8 (SLC16A2) mutations.
Human mutation.
2009 Jan; 30(1):29-38. doi:
10.1002/humu.20808. [PMID: 18636565] - Paul J Davis, Jack L Leonard, Faith B Davis. Mechanisms of nongenomic actions of thyroid hormone.
Frontiers in neuroendocrinology.
2008 May; 29(2):211-8. doi:
10.1016/j.yfrne.2007.09.003. [PMID: 17983645] - Maria Moreno, Pieter de Lange, Assunta Lombardi, Elena Silvestri, Antonia Lanni, Fernando Goglia. Metabolic effects of thyroid hormone derivatives.
Thyroid : official journal of the American Thyroid Association.
2008 Feb; 18(2):239-53. doi:
10.1089/thy.2007.0248. [PMID: 18279024] - Peter H M Klaren, José M Guzmán, Sjoerd J Reutelingsperger, Juan M Mancera, Gert Flik. Low salinity acclimation and thyroid hormone metabolizing enzymes in gilthead seabream (Sparus auratus).
General and comparative endocrinology.
2007 Jun; 152(2-3):215-22. doi:
10.1016/j.ygcen.2007.02.010. [PMID: 17382943] - Xu Wang, Hui Chen, Jin-Ming Lin, Xitang Ying. Development of a highly sensitive and selective microplate chemiluminescence enzyme immunoassay for the determination of free thyroxine in human serum.
International journal of biological sciences.
2007 Apr; 3(5):274-80. doi:
10.7150/ijbs.3.274. [PMID: 17505537] - Yoko Takeuchi, Daisuke Suzuki, Sen-Ichi Oda, Samuel Refetoff, Koji Seki, Katsuhiko Tsunekawa, Takayuki Kasahara, Masami Murakami, Yoshiharu Murata. Unique regulation of thyroid hormone metabolism during fasting in the house musk shrew (Suncus murinus, Insectivora: Soricidae).
General and comparative endocrinology.
2006 May; 146(3):236-41. doi:
10.1016/j.ygcen.2005.11.013. [PMID: 16426605] - Robin P Peeters, Pieter J Wouters, Hans van Toor, Ellen Kaptein, Theo J Visser, Greet Van den Berghe. Serum 3,3',5'-triiodothyronine (rT3) and 3,5,3'-triiodothyronine/rT3 are prognostic markers in critically ill patients and are associated with postmortem tissue deiodinase activities.
The Journal of clinical endocrinology and metabolism.
2005 Aug; 90(8):4559-65. doi:
10.1210/jc.2005-0535. [PMID: 15886232] - Ewa Brzezińska-Slebodzińska, A B Slebodziński. Changes in thyroxine, 3,3',5-triiodothyronine and 3,3'5'-triiodothyronine content in the thyroid gland and in serum to thyroid tissue iodothyronine ratios during ontogenesis in the fetal pig.
Acta veterinaria Hungarica.
2004; 52(4):379-87. doi:
10.1556/avet.52.2004.4.1. [PMID: 15595272] - Edith C H Friesema, Sumita Ganguly, Amal Abdalla, Jocelyn E Manning Fox, Andrew P Halestrap, Theo J Visser. Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter.
The Journal of biological chemistry.
2003 Oct; 278(41):40128-35. doi:
10.1074/jbc.m300909200. [PMID: 12871948] - Keven P Gulikers, David L Panciera. Evaluation of the effects of clomipramine on canine thyroid function tests.
Journal of veterinary internal medicine.
2003 Jan; 17(1):44-9. doi:
10.1892/0891-6640(2003)017<0044:eoteoc>2.3.co;2. [PMID: 12564726] - S Bobek, A Sechman, J Niezgoda, T Jacek. Reverse 3,3',5'-triiodothyronine suppresses increase in free fatty acids in chickens elicited by dexamethasone or adrenaline.
Journal of veterinary medicine. A, Physiology, pathology, clinical medicine.
2002 Apr; 49(3):121-4. doi:
10.1046/j.1439-0442.2002.00343.x. [PMID: 12019951] - James C Plohman, Terry A Dick, J Geoffrey Eales. Thyroid of lake sturgeon, Acipenser fulvescens. II. Deiodination properties, distribution, and effects of diet, growth, and a T3 challenge.
General and comparative endocrinology.
2002 Jan; 125(1):56-66. doi:
10.1006/gcen.2001.7734. [PMID: 11825035] - C Tsoi, C N Falany, R Morgenstern, S Swedmark. Molecular cloning, expression, and characterization of a canine sulfotransferase that is a human ST1B2 ortholog.
Archives of biochemistry and biophysics.
2001 Jun; 390(1):87-92. doi:
10.1006/abbi.2001.2373. [PMID: 11368519] - C L VanPutte, D S MacKenzie, J G Eales. Characterization of hepatic low-K(m) outer-ring deiodination in red drum (Sciaenops ocellatus).
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.
2001 Mar; 128(3):413-23. doi:
10.1016/s1096-4959(00)00348-1. [PMID: 11250536] - P A Schueler, H L Schwartz, K A Strait, C N Mariash, J H Oppenheimer. Binding of 3,5,3'-triiodothyronine (T3) and its analogs to the in vitro translational products of c-erbA protooncogenes: differences in the affinity of the alpha- and beta-forms for the acetic acid analog and failure of the human testis and kidney alpha-2 products to bind T3.
Molecular endocrinology (Baltimore, Md.).
1990 Feb; 4(2):227-34. doi:
10.1210/mend-4-2-227. [PMID: 2158622] - M K Samson, R L Stephens, S Rivkin, M Opipari, T Maloney, C W Groppe, R Fisher. Vinblastine, bleomycin, and cis-dichlorodiammineplatinum(II) in disseminated testicular cancer: preliminary report of a Southwest Oncology Group Study.
Cancer treatment reports.
1979 Sep; 63(9-10):1663-7. doi:
. [PMID: 91435] - S W Dietrich, M B Bolger, P A Kollman, E C Jorgensen. Thyroxine analogues. 23. Quantitative structure-activity correlation studies of in vivo and in vitro thyromimetic activities.
Journal of medicinal chemistry.
1977 Jul; 20(7):863-80. doi:
10.1021/jm00217a001. [PMID: 195056]