3-(1-Propyl-3-piperidinyl)phenol (BioDeep_00001875455)
代谢物信息卡片
3-(1-Propyl-3-piperidinyl)phenol
化学式: C14H21NO (219.1623)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCN1CCCC(C1)C2=CC(=CC=C2)O
InChI: InChI=1S/C14H21NO/c1-2-8-15-9-4-6-13(11-15)12-5-3-7-14(16)10-12/h3,5,7,10,13,16H,2,4,6,8-9,11H2,1H3
描述信息
D002491 - Central Nervous System Agents > D018726 - Anti-Dyskinesia Agents > D000978 - Antiparkinson Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018491 - Dopamine Agonists
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1 个代谢物同义名
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代谢反应
0 个相关的代谢反应过程信息。
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Judith Varady, Xihan Wu, Xueliang Fang, Ji Min, Zengjian Hu, Beth Levant, Shaomeng Wang. Molecular modeling of the three-dimensional structure of dopamine 3 (D3) subtype receptor: discovery of novel and potent D3 ligands through a hybrid pharmacophore- and structure-based database searching approach.
Journal of medicinal chemistry.
2003 Oct; 46(21):4377-92. doi:
10.1021/jm030085p. [PMID: 14521403] - Jianjing Cao, Santosh S Kulkarni, Stephen M Husbands, Wayne D Bowen, Wanda Williams, Theresa Kopajtic, Jonathan L Katz, Clifford George, Amy Hauck Newman. Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents.
Journal of medicinal chemistry.
2003 Jun; 46(13):2589-98. doi:
10.1021/jm030008u. [PMID: 12801223] - K K Borowicz, Z Kleinrok, S J Czuczwar. Influence of 3-PPP, a sigma receptor ligand, on the anticonvulsive action of conventional antiepileptic drugs.
Pharmacological research.
1999 Dec; 40(6):509-16. doi:
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Brain research.
1995 Jan; 670(1):14-28. doi:
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1992 Aug; 346(2):152-7. doi:
10.1007/bf00165296. [PMID: 1360151] - J Lundström, J E Lindgren, S Ahlenius, V Hillegaart. Relationship between brain levels of 3-(3-hydroxyphenyl)-N-n-propylpiperidine HCl enantiomers and effects on locomotor activity in rats.
The Journal of pharmacology and experimental therapeutics.
1992 Jul; 262(1):41-7. doi:
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Cancer research.
1991 Dec; 51(24):6558-62. doi:
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Life sciences.
1991; 48(4):311-20. doi:
10.1016/0024-3205(91)90551-l. [PMID: 1671291] - T S Rao, J A Cler, S J Mick, V M Dilworth, P C Contreras, S Iyengar, P L Wood. Neurochemical characterization of dopaminergic effects of opipramol, a potent sigma receptor ligand, in vivo.
Neuropharmacology.
1990 Dec; 29(12):1191-7. doi:
10.1016/0028-3908(90)90044-r. [PMID: 1963476] - I A Paul, G Kuypers, M Youdim, P Skolnick. Polyamines non-competitively inhibit [3H]3-PPP binding to sigma receptors.
European journal of pharmacology.
1990 Aug; 184(1):203-4. doi:
10.1016/0014-2999(90)90685-y. [PMID: 1976528] - M Carlsson, E Eriksson. The enhanced responsiveness of hypophyseal DA receptors in female rats induced by repeated reserpine treatment is not due to decreased oestrogen secretion.
Pharmacology & toxicology.
1989 Sep; 65(3):236-8. doi:
10.1111/j.1600-0773.1989.tb01163.x. [PMID: 2813297] - B R de Costa, W D Bowen, S B Hellewell, J M Walker, A Thurkauf, A E Jacobson, K C Rice. Synthesis and evaluation of optically pure [3H]-(+)-pentazocine, a highly potent and selective radioligand for sigma receptors.
FEBS letters.
1989 Jul; 251(1-2):53-8. doi:
10.1016/0014-5793(89)81427-9. [PMID: 2568952] - M Carlsson, E Eriksson. The intrinsic activity of (-)-3-PPP (preclamol) on pituitary DA receptors in female rats is enhanced following chronic DA depletion.
Life sciences.
1988; 42(5):585-8. doi:
10.1016/0024-3205(88)90100-2. [PMID: 3339950] - S O Thorberg, S Berg, J Lundström, B Pettersson, A Wijkström, D Sanchez, P Lindberg, J L Nilsson. Carbamate ester derivatives as potential prodrugs of the presynaptic dopamine autoreceptor agonist (-)-3-(3-hydroxyphenyl)-N-propylpiperidine.
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1987 Nov; 30(11):2008-12. doi:
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European journal of pharmacology.
1987 Oct; 142(1):39-43. doi:
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Neuropharmacology.
1986 Aug; 25(8):951-4. doi:
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1985; 64(3-4):187-98. doi:
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Life sciences.
1984 Jan; 34(3):239-46. doi:
10.1016/0024-3205(84)90595-2. [PMID: 6694521] - S Ahlenius, V Hillegaart, O Magnusson, J Lundström. Behavioral and biochemical effects of subchronic treatment with (-)3-(3-hydroxyphenyl)-N-n-propylpiperidine in the rat: dopamine receptor sensitivity and tolerance.
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1984; 60(2):103-13. doi:
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European journal of pharmacology.
1983 Jun; 90(4):423-5. doi:
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