Hydroxymetronidazole (BioDeep_00001875267)

   


代谢物信息卡片


1-(2-Hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole

化学式: C6H9N3O4 (187.0593034)
中文名称: 羟基甲硝唑
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=C(N(C(=N1)CO)CCO)[N+](=O)[O-]
InChI: InChI=1S/C6H9N3O4/c10-2-1-8-5(4-11)7-3-6(8)9(12)13/h3,10-11H,1-2,4H2

描述信息

同义名列表

2 个代谢物同义名

1-(2-Hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole; Hydroxymetronidazole



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Nina Zemanová, Pavel Anzenbacher, Tomáš Hudcovic, Eva Anzenbacherová. Rapid Determination of Metronidazole and 2-Hydroxymetronidazole in Murine Blood Plasma. Journal of chromatographic science. 2022 Jan; 60(1):81-87. doi: 10.1093/chromsci/bmab049. [PMID: 33876238]
  • Stephani L Stancil, Leon van Haandel, Susan Abdel-Rahman, Robin E Pearce. Development of a UPLC-MS/MS method for quantitation of metronidazole and 2-hydroxy metronidazole in human plasma and its application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Aug; 1092(?):272-278. doi: 10.1016/j.jchromb.2018.06.024. [PMID: 29933220]
  • Colin S Thompson, Imelda M Traynor, Terence L Fodey, Steven R H Crooks. Improved screening method for the detection of a range of nitroimidazoles in various matrices by optical biosensor. Analytica chimica acta. 2009 Apr; 637(1-2):259-64. doi: 10.1016/j.aca.2008.09.040. [PMID: 19286038]
  • C M Da Silva, F L David, M N Muscará, S S Sousa, J G Ferraz, G De Nucci, N C Polimeno, J Pedrazzoli. Plasma hydroxy-metronidazole/metronidazole ratio can detect early changes in hepatic function in ethanol-induced liver injury. Alimentary pharmacology & therapeutics. 1999 Oct; 13(10):1335-41. doi: 10.1046/j.1365-2036.1999.00620.x. [PMID: 10540049]
  • M J Jessa, A F Goddard, D A Barrett, P N Shaw, R C Spiller. The effect of omeprazole on the pharmacokinetics of metronidazole and hydroxymetronidazole in human plasma, saliva and gastric juice. British journal of clinical pharmacology. 1997 Sep; 44(3):245-53. doi: 10.1046/j.1365-2125.1997.t01-1-00572.x. [PMID: 9296318]
  • M J Jessa, D A Barrett, P N Shaw, R C Spiller. Rapid and selective high-performance liquid chromatographic method for the determination of metronidazole and its active metabolite in human plasma, saliva and gastric juice. Journal of chromatography. B, Biomedical applications. 1996 Mar; 677(2):374-9. doi: 10.1016/0378-4347(95)00421-1. [PMID: 8704944]
  • M N Muscará, J Pedrazzoli, E L Miranda, J G Ferraz, E Hofstätter, G Leite, A F Magalhães, S Leonardi, G De Nucci. Plasma hydroxy-metronidazole/metronidazole ratio in patients with liver disease and in healthy volunteers. British journal of clinical pharmacology. 1995 Nov; 40(5):477-80. doi: 10.1111/j.1365-2125.1995.tb05792.x. [PMID: 8703652]
  • S Loft, C Egsmose, J Sonne, H E Poulsen, M Døssing, P B Andreasen. Metronidazole elimination is preserved in the elderly. Human & experimental toxicology. 1990 May; 9(3):155-9. doi: 10.1177/096032719000900306. [PMID: 2375881]
  • C M Passmore, J C McElnay, E A Rainey, P F D'Arcy. Metronidazole excretion in human milk and its effect on the suckling neonate. British journal of clinical pharmacology. 1988 Jul; 26(1):45-51. doi: 10.1111/j.1365-2125.1988.tb03362.x. [PMID: 3203060]
  • O Eradiri, F Jamali, A B Thomson. Steady-state pharmacokinetics of metronidazole in Crohn's disease. Biopharmaceutics & drug disposition. 1987 May; 8(3):249-59. doi: 10.1002/bdd.2510080306. [PMID: 3593902]
  • B Fredricsson, B Hagström, C E Nord, A Rane. Systemic concentrations of metronidazole and its main metabolites after intravenous oral and vaginal administration. Gynecologic and obstetric investigation. 1987; 24(3):200-7. doi: 10.1159/000298803. [PMID: 3692332]
  • R P Bolton, M A Culshaw. Faecal metronidazole concentrations during oral and intravenous therapy for antibiotic associated colitis due to Clostridium difficile. Gut. 1986 Oct; 27(10):1169-72. doi: 10.1136/gut.27.10.1169. [PMID: 3781329]
  • T Bergan. Antibacterial activity and pharmacokinetics of nitroimidazoles. A review. Scandinavian journal of infectious diseases. Supplementum. 1985; 46(?):64-71. doi: NULL. [PMID: 3865352]
  • R A Gibson, L Lattanzio, H McGee. Optimized liquid-chromatographic determination of metronidazole and its metabolites in plasma. Clinical chemistry. 1984 May; 30(5):784-7. doi: 10.1093/clinchem/30.5.784. [PMID: 6713641]
  • D R Guay, R C Meatherall, H Baxter, W R Jacyk, B Penner. Pharmacokinetics of metronidazole in patients undergoing continuous ambulatory peritoneal dialysis. Antimicrobial agents and chemotherapy. 1984 Mar; 25(3):306-10. doi: 10.1128/aac.25.3.306. [PMID: 6721462]
  • M U Schneider, J F Riemann, G Laudage. Serum concentrations of metronidazole and its main metabolite in patients with active Crohn's disease: correlation with disease activity and therapeutic efficacy?. Chemotherapy. 1984; 30(6):345-52. doi: 10.1159/000238292. [PMID: 6518833]
  • T Bergan, S Aase, O Leinebo, T Harbitz, A Olsen, I Liavag. Pharmacokinetics of metronidazole and its major metabolite after a high intravenous dose. Scandinavian journal of gastroenterology. Supplement. 1984; 91(?):113-23. doi: NULL. [PMID: 6588488]
  • B Salvesen, O Leinebo, T Bergan. Assay of metronidazole by HPLC compared with microbial method. Scandinavian journal of gastroenterology. Supplement. 1984; 91(?):31-43. doi: NULL. [PMID: 6377472]
  • E D Ralph. Comparative antimicrobial activity of metronidazole and the hydroxy metabolite against Gardnerella vaginalis. Scandinavian journal of infectious diseases. Supplementum. 1983; 40(?):115-20. doi: NULL. [PMID: 6607518]
  • C S Easmon, C A Ison, C M Kaye, R M Timewell, S G Dawson. Pharmacokinetics of metronidazole and its principal metabolites and their activity against Gardnerella vaginalis. The British journal of venereal diseases. 1982 Aug; 58(4):246-9. doi: 10.1136/sti.58.4.246. [PMID: 6980684]
  • B Lambert, A Lindblad, U Ringborg. Absence of genotoxic effects of metronidazole and two of its urinary metabolites on human lymphocytes in vitro. Mutation research. 1979 Jul; 67(3):281-7. doi: 10.1016/0165-1218(79)90022-3. [PMID: 481453]