Didesethylflurazepam (BioDeep_00001875252)

   

Chemicals and Drugs


代谢物信息卡片


Didesethylflurazepam

化学式: C17H15ClFN3O (331.0887622)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(=O)N(C2=C(C=C(C=C2)Cl)C(=N1)C3=CC=CC=C3F)CCN
InChI: InChI=1S/C17H15ClFN3O/c18-11-5-6-15-13(9-11)17(12-3-1-2-4-14(12)19)21-10-16(23)22(15)8-7-20/h1-6,9H,7-8,10,20H2

描述信息

A primary amino compound resulting from the dealkylation of both ethyl groups of the anti-insomnia drug flurazepam. It is the major metabolite of flurazepam.

同义名列表

1 个代谢物同义名

Didesethylflurazepam



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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Plant Reactome(0)

INOH(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Yu-Dong Jeong, Min Kyung Kim, Sung Ill Suh, Moon Kyo In, Jin Young Kim, Ki-Jung Paeng. Rapid determination of benzodiazepines, zolpidem and their metabolites in urine using direct injection liquid chromatography-tandem mass spectrometry. Forensic science international. 2015 Dec; 257(?):84-92. doi: 10.1016/j.forsciint.2015.07.043. [PMID: 26282513]
  • Susanne Vogt, Jürgen Kempf, Jürgen Buttler, Volker Auwärter, Wolfgang Weinmann. Desalkylflurazepam found in patients' samples after high-dose midazolam treatment. Drug testing and analysis. 2013 Sep; 5(9-10):745-7. doi: 10.1002/dta.1484. [PMID: 23713025]
  • Franz E Dussy, Cornelia Hamberg, Thomas A Briellmann. Quantification of benzodiazepines in whole blood and serum. International journal of legal medicine. 2006 Nov; 120(6):323-30. doi: 10.1007/s00414-005-0042-1. [PMID: 16220317]
  • D Song, S Zhang, K Kohlhof. Gas chromatographic-mass spectrometric method for the determination of flurazepam and its major metabolites in mouse and rat plasma. Journal of chromatography. B, Biomedical applications. 1994 Aug; 658(1):142-8. doi: 10.1016/0378-4347(94)00210-x. [PMID: 7952115]
  • E Ellinwood, M Linnoila, G Marsh. Plasma concentrations of flurazepam and midazolam in chronic insomniacs during 14-day use and their relationship to therapeutic effects and next-day performance and mood. Journal of clinical psychopharmacology. 1990 Aug; 10(4 Suppl):68S-75S. doi: NULL. [PMID: 2229465]
  • N Barzaghi, L Leone, M Monteleone, G Tomasini, E Perucca. Pharmacokinetics of flutoprazepam, a novel benzodiazepine drug, in normal subjects. European journal of drug metabolism and pharmacokinetics. 1989 Oct; 14(4):293-8. doi: 10.1007/bf03190114. [PMID: 2633923]
  • Z Salama, B Schraufstetter, H Jaeger. Determination of flurazepam and its major metabolites N-1-hydroxyethyl- and N-1-desalkylflurazepam in plasma by capillary gas chromatography. Arzneimittel-Forschung. 1988 Mar; 38(3):400-3. doi: NULL. [PMID: 3382464]
  • H R Ochs, D J Greenblatt, E S Burstein, W Eichelkraut, N Hahn. Pharmacokinetics and CSF entry of flurazepam in dogs. Pharmacology. 1988; 36(3):166-71. doi: 10.1159/000138380. [PMID: 3368503]
  • C C Chiueh, M Ohata, L A Jonas, D J Greenblatt, S I Rapoport. Brain uptake of flurazepam and of N1-desalkyl flurazepam after administration of flurazepam to the cat. Drug metabolism and disposition: the biological fate of chemicals. 1985 Jan; 13(1):1-4. doi: NULL. [PMID: 2858364]
  • M M Mitler, W F Seidel, J van den Hoed, D J Greenblatt, W C Dement. Comparative hypnotic effects of flurazepam, triazolam, and placebo: a long-term simultaneous nighttime and daytime study. Journal of clinical psychopharmacology. 1984 Feb; 4(1):2-13. doi: . [PMID: 6141188]
  • R Jochemsen, D D Breimer. Assay of flunitrazepam, temazepam and desalkylflurazepam in plasma by capillary gas chromatography with electron-capture detection. Journal of chromatography. 1982 Jan; 227(1):199-206. doi: 10.1016/s0378-4347(00)80372-2. [PMID: 6120178]