SCH 58261 (BioDeep_00001875186)

   


代谢物信息卡片


2-(Furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine

化学式: C18H15N7O (345.133802)
中文名称: 2-(2-呋喃基)-7-(2-苯基乙基)-7H-吡唑并[4,3-e][1,2,4]噻唑并[1,5-c]嘧啶-5-胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C=C1)CCN2C3=C(C=N2)C4=NC(=NN4C(=N3)N)C5=CC=CO5
InChI: InChI=1S/C18H15N7O/c19-18-22-16-13(11-20-24(16)9-8-12-5-2-1-3-6-12)17-21-15(23-25(17)18)14-7-4-10-26-14/h1-7,10-11H,8-9H2,(H2,19,22)

描述信息

D018377 - Neurotransmitter Agents > D058905 - Purinergic Agents > D058914 - Purinergic Antagonists
D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
D020011 - Protective Agents
SCH 58261 is a potent, selective and competitive antagonist of adenosine A2A receptor with an IC50 of 15 nM, and displays 323-, 53- and 100-fold more selective for A2A receptor than A1, A2B, and A3 receptors, respectively[1][2][3].

同义名列表

2 个代谢物同义名

2-(Furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine; SCH 58261



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Zhichao Zhong, Xingrui He, Jiamin Ge, Junlong Zhu, Chuansheng Yao, Hong Cai, Xiang-Yang Ye, Tian Xie, Renren Bai. Discovery of small-molecule compounds and natural products against Parkinson's disease: Pathological mechanism and structural modification. European journal of medicinal chemistry. 2022 Jul; 237(?):114378. doi: 10.1016/j.ejmech.2022.114378. [PMID: 35462165]
  • Samantha L Cooper, Edward S Wragg, Patrizia Pannucci, Mark Soave, Stephen J Hill, Jeanette Woolard. Regionally selective cardiovascular responses to adenosine A2A and A2B receptor activation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2022 04; 36(4):e22214. doi: 10.1096/fj.202101945r. [PMID: 35230706]
  • Yuri Park, Min-Ho Park, Jin-Ju Byeon, Seok-Ho Shin, Byeong Ill Lee, Jang-Mi Choi, Nahye Kim, Seo-Jin Park, Min-Jae Park, Jeong-Hyeon Lim, Young G Shin. Assessment of Pharmacokinetics and Metabolism Profiles of SCH 58261 in Rats Using Liquid Chromatography-Mass Spectrometric Method. Molecules (Basel, Switzerland). 2020 May; 25(9):. doi: 10.3390/molecules25092209. [PMID: 32397307]
  • Xiao-Yu Bai, Xue-Qiong Zhang, Yong-He Zhang, Song Wu, Ling-Hua Hao, Rui Liu, Zhong-Lin Huang, Wei-Ku Zhang, Zong-Miao Sun, Guan-Hua Du. WS0701: a novel sedative-hypnotic agent acting on the adenosine system. Behavioural pharmacology. 2014 Oct; 25(7):648-60. doi: 10.1097/fbp.0000000000000075. [PMID: 25171078]
  • Salvatore Giunta, Violetta Andriolo, Alessandro Castorina. Dual blockade of the A1 and A2A adenosine receptor prevents amyloid beta toxicity in neuroblastoma cells exposed to aluminum chloride. The international journal of biochemistry & cell biology. 2014 Sep; 54(?):122-36. doi: 10.1016/j.biocel.2014.07.009. [PMID: 25058312]
  • Eszter Kozma, P Suresh Jayasekara, Lucia Squarcialupi, Silvia Paoletta, Stefano Moro, Stephanie Federico, Giampiero Spalluto, Kenneth A Jacobson. Fluorescent ligands for adenosine receptors. Bioorganic & medicinal chemistry letters. 2013 Jan; 23(1):26-36. doi: 10.1016/j.bmcl.2012.10.112. [PMID: 23200243]
  • Jing Sun, Min Li, Rui-xia Kang, Jian-gong Shi, Jian-jun Zhang. [Protective effect of new adenosine analog B2 against serum deprivation-induced PC12 cell injury]. Yao xue xue bao = Acta pharmaceutica Sinica. 2011 Oct; 46(10):1199-203. doi: NULL. [PMID: 22242450]
  • Ming-Guo Feng, L Gabriel Navar. Afferent arteriolar vasodilator effect of adenosine predominantly involves adenosine A2B receptor activation. American journal of physiology. Renal physiology. 2010 Aug; 299(2):F310-5. doi: 10.1152/ajprenal.00149.2010. [PMID: 20462966]
  • Unmesh Shah, Craig D Boyle, Samuel Chackalamannil, Bernard R Neustadt, Neil Lindo, William J Greenlee, Carolyn Foster, Leyla Arik, Ying Zhai, Kwokei Ng, Shiyong Wang, Angela Monopoli, Jean E Lachowicz. Biaryl and heteroaryl derivatives of SCH 58261 as potent and selective adenosine A2A receptor antagonists. Bioorganic & medicinal chemistry letters. 2008 Jul; 18(14):4199-203. doi: 10.1016/j.bmcl.2008.05.074. [PMID: 18562199]
  • Kenneth A Jacobson, Zhan-Guo Gao. Adenosine receptors as therapeutic targets. Nature reviews. Drug discovery. 2006 Mar; 5(3):247-64. doi: 10.1038/nrd1983. [PMID: 16518376]
  • J E Coelho, N Rebola, I Fragata, J A Ribeiro, A de Mendonça, R A Cunha. Hypoxia-induced desensitization and internalization of adenosine A1 receptors in the rat hippocampus. Neuroscience. 2006; 138(4):1195-203. doi: 10.1016/j.neuroscience.2005.12.012. [PMID: 16442739]
  • Tiago M Alfaro, Emanuel Vigia, Catarina R Oliveira, Rodrigo A Cunha. Effect of free radicals on adenosine A(2A) and dopamine D2 receptors in the striatum of young adult and aged rats. Neurochemistry international. 2004 Oct; 45(5):733-8. doi: 10.1016/j.neuint.2004.02.003. [PMID: 15234116]
  • James Fossetta, James Jackson, Gregory Deno, Xuedong Fan, Xixuan Karen Du, Loretta Bober, Anne Soudé-Bermejo, Odette de Bouteiller, Christophe Caux, Charles Lunn, Daniel Lundell, R Kyle Palmer. Pharmacological analysis of calcium responses mediated by the human A3 adenosine receptor in monocyte-derived dendritic cells and recombinant cells. Molecular pharmacology. 2003 Feb; 63(2):342-50. doi: 10.1124/mol.63.2.342. [PMID: 12527805]
  • J W Fisher, J Brookins. Adenosine A(2A) and A(2B) receptor activation of erythropoietin production. American journal of physiology. Renal physiology. 2001 Nov; 281(5):F826-32. doi: 10.1152/ajprenal.2001.281.5.f826. [PMID: 11592940]
  • K Varani, B Cacciari, P G Baraldi, S Dionisotti, E Ongini, P A Borea. Binding affinity of adenosine receptor agonists and antagonists at human cloned A3 adenosine receptors. Life sciences. 1998; 63(5):PL 81-7. doi: 10.1016/s0024-3205(98)00289-6. [PMID: 9714428]
  • A M van Rhee, S M Siddiqi, N Melman, D Shi, W L Padgett, J W Daly, K A Jacobson. Tetrahydrobenzothiophenone derivatives as a novel class of adenosine receptor antagonists. Journal of medicinal chemistry. 1996 Jan; 39(2):398-406. doi: 10.1021/jm9504823. [PMID: 8558508]