CHIR 99021 (BioDeep_00001875168)
代谢物信息卡片
6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile
化学式: C22H18Cl2N8 (464.10314079999995)
中文名称: CHIR-99021
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N
InChI: InChI=1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32)
描述信息
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C61074 - Serine/Threonine Kinase Inhibitor
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Dongjie Sun, Zhehao Huang, Jinying Xu, Yiqing Wang, Lin Chen, Yi Hou, Guangfan Chi. HaCaT‑conditioned medium supplemented with the small molecule inhibitors SB431542 and CHIR99021 and the growth factor PDGF‑AA prevents the dedifferentiation of dermal papilla cells in vitro.
Molecular medicine reports.
2021 05; 23(5):. doi:
10.3892/mmr.2021.11965. [PMID: 33760132] - Durairaj Ragu Varman, Lankupalle D Jayanthi, Sammanda Ramamoorthy. Glycogen synthase kinase-3ß supports serotonin transporter function and trafficking in a phosphorylation-dependent manner.
Journal of neurochemistry.
2021 02; 156(4):445-464. doi:
10.1111/jnc.15152. [PMID: 32797733] - Jihei Sara Lee, Min Kyoung Chae, Don O Kikkawa, Eun Jig Lee, Jin Sook Yoon. Glycogen Synthase Kinase-3β Mediates Proinflammatory Cytokine Secretion and Adipogenesis in Orbital Fibroblasts from Patients with Graves' Orbitopathy.
Investigative ophthalmology & visual science.
2020 07; 61(8):51. doi:
10.1167/iovs.61.8.51. [PMID: 32735324] - Yang Yang, Qin-Qin Wang, Oliver Bozinov, Ru-Xiang Xu, Yi-Lin Sun, Shan-Shan Wang. GSK‑3 inhibitor CHIR99021 enriches glioma stem‑like cells.
Oncology reports.
2020 05; 43(5):1479-1490. doi:
10.3892/or.2020.7525. [PMID: 32323804] - Jingqing Chen, Yuchen Yang, Shuai Li, Ying Yang, Zhaolai Dai, Fengchao Wang, Zhenlong Wu, Patrick Tso, Guoyao Wu. E2F1 Regulates Adipocyte Differentiation and Adipogenesis by Activating ICAT.
Cells.
2020 04; 9(4):. doi:
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Reproductive toxicology (Elmsford, N.Y.).
2020 01; 91(?):74-91. doi:
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Tissue engineering and regenerative medicine.
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Drug research.
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Scientific reports.
2017 08; 7(1):7605. doi:
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Stem cell research & therapy.
2017 03; 8(1):67. doi:
10.1186/s13287-017-0519-0. [PMID: 28302184] - Shigeharu G Yabe, Satsuki Fukuda, Fujie Takeda, Kiyoko Nashiro, Masayuki Shimoda, Hitoshi Okochi. Efficient generation of functional pancreatic β-cells from human induced pluripotent stem cells.
Journal of diabetes.
2017 Feb; 9(2):168-179. doi:
10.1111/1753-0407.12400. [PMID: 27038181] - Shoubao Wang, Lincai Ye, Minghui Li, Jinfen Liu, Chuan Jiang, Haifa Hong, Hongbin Zhu, Yanjun Sun. GSK-3β Inhibitor CHIR-99021 Promotes Proliferation Through Upregulating β-Catenin in Neonatal Atrial Human Cardiomyocytes.
Journal of cardiovascular pharmacology.
2016 Dec; 68(6):425-432. doi:
10.1097/fjc.0000000000000429. [PMID: 27575008] - Hui Zhao, Wei Meng, Yang Li, Wei Liu, Binsheng Fu, Yang Yang, Qi Zhang, Guihua Chen. The protective effects of CHIR99021 against oxidative injury in LO2 cells.
Die Pharmazie.
2016 11; 71(11):629-635. doi:
10.1691/ph.2016.6714. [PMID: 29441966] - Di Li, Linli Wang, Jundi Hou, Qun Shen, Qianyu Chen, Xiaoshan Wang, Juan Du, Xiujuan Cai, Yongli Shan, Tian Zhang, Tiancheng Zhou, Xi Shi, Yuhua Li, Hua Zhang, Guangjin Pan. Optimized Approaches for Generation of Integration-free iPSCs from Human Urine-Derived Cells with Small Molecules and Autologous Feeder.
Stem cell reports.
2016 05; 6(5):717-728. doi:
10.1016/j.stemcr.2016.04.001. [PMID: 27132887] - Zhiying Ai, Jingjing Shao, Yongyan Wu, Mengying Yu, Juan Du, Xiaoyan Shi, Xinglong Shi, Yong Zhang, Zekun Guo. CHIR99021 enhances Klf4 Expression through β-Catenin Signaling and miR-7a Regulation in J1 Mouse Embryonic Stem Cells.
PloS one.
2016; 11(3):e0150936. doi:
10.1371/journal.pone.0150936. [PMID: 26938105] - Fabian Zanella, Farah Sheikh. Patient-Specific Induced Pluripotent Stem Cell Models: Generation and Characterization of Cardiac Cells.
Methods in molecular biology (Clifton, N.J.).
2016; 1353(?):147-62. doi:
10.1007/7651_2014_172. [PMID: 25520292] - Cathelijne W van den Berg, David A Elliott, Stefan R Braam, Christine L Mummery, Richard P Davis. Differentiation of Human Pluripotent Stem Cells to Cardiomyocytes Under Defined Conditions.
Methods in molecular biology (Clifton, N.J.).
2016; 1353(?):163-80. doi:
10.1007/7651_2014_178. [PMID: 25626427] - Lipeng Tian, Neha Prasad, Yoon-Young Jang. In Vitro Modeling of Alcohol-Induced Liver Injury Using Human-Induced Pluripotent Stem Cells.
Methods in molecular biology (Clifton, N.J.).
2016; 1353(?):271-83. doi:
10.1007/7651_2014_168. [PMID: 25520290] - Gopu Sriram, Jia Yong Tan, Intekhab Islam, Abdul Jalil Rufaihah, Tong Cao. Efficient differentiation of human embryonic stem cells to arterial and venous endothelial cells under feeder- and serum-free conditions.
Stem cell research & therapy.
2015 Dec; 6(?):261. doi:
10.1186/s13287-015-0260-5. [PMID: 26718617] - Vimal Kishor Singh, Neeraj Kumar, Manisha Kalsan, Abhishek Saini, Ramesh Chandra. Mechanism of Induction: Induced Pluripotent Stem Cells (iPSCs).
Journal of stem cells.
2015; 10(1):43-62. doi:
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In vitro cellular & developmental biology. Animal.
2015 Jan; 51(1):1-8. doi:
10.1007/s11626-014-9801-y. [PMID: 25124871] - Mehdi Pirouz, Ali Rahjouei, Farnaz Shamsi, Kolja Neil Eckermann, Gabriela Salinas-Riester, Claudia Pommerenke, Michael Kessel. Destabilization of pluripotency in the absence of Mad2l2.
Cell cycle (Georgetown, Tex.).
2015; 14(10):1596-610. doi:
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Stem cell reports.
2014 Sep; 3(3):516-29. doi:
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Stem cell reports.
2014 Jul; 3(1):5-14. doi:
10.1016/j.stemcr.2014.05.007. [PMID: 25068117] - Kosuke Kanke, Hideki Masaki, Taku Saito, Yuske Komiyama, Hironori Hojo, Hiromitsu Nakauchi, Alexander C Lichtler, Tsuyoshi Takato, Ung-Il Chung, Shinsuke Ohba. Stepwise differentiation of pluripotent stem cells into osteoblasts using four small molecules under serum-free and feeder-free conditions.
Stem cell reports.
2014 Jun; 2(6):751-60. doi:
10.1016/j.stemcr.2014.04.016. [PMID: 24936463] - Albert Q Lam, Benjamin S Freedman, Ryuji Morizane, Paul H Lerou, M Todd Valerius, Joseph V Bonventre. Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers.
Journal of the American Society of Nephrology : JASN.
2014 Jun; 25(6):1211-25. doi:
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Cell research.
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Human reproduction (Oxford, England).
2012 Aug; 27(8):2312-24. doi:
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PloS one.
2012; 7(4):e35892. doi:
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