2-Ethyl-5-carboxypentyl phthalate (BioDeep_00001874819)
代谢物信息卡片
Mono(5-carboxy-2-ethylpentyl) phthalate
化学式: C16H20O6 (308.125982)
中文名称: rac-单(2-乙基-5-羧基戊基)邻苯二甲酸酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(CCCC(=O)O)COC(=O)C1=CC=CC=C1C(=O)O
InChI: InChI=1S/C16H20O6/c1-2-11(6-5-9-14(17)18)10-22-16(21)13-8-4-3-7-12(13)15(19)20/h3-4,7-8,11H,2,5-6,9-10H2,1H3,(H,17,18)(H,19,20)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Qi Xu, Shuang Ding, Wen Qi, Xueting Zhang, Meng Zhang, Jiqiang Xing, Aipeng Ju, Liting Zhou, Lin Ye. JAK3/STAT5b/PPARγ Pathway Mediates the Association between Di(2-ethylhexyl) Phthalate Exposure and Lipid Metabolic Disorder in Chinese Adolescent Students.
Chemical research in toxicology.
2023 Apr; ?(?):. doi:
10.1021/acs.chemrestox.2c00365. [PMID: 37093692] - Shuang Ding, Wen Qi, Qi Xu, Tianyang Zhao, Xu Li, Jianli Yin, Ruxuan Zhang, Chuanyi Huo, Liting Zhou, Lin Ye. Relationships between di-(2-ethylhexyl) phthalate exposure and lipid metabolism in adolescents: Human data and experimental rat model analyses.
Environmental pollution (Barking, Essex : 1987).
2021 Oct; 286(?):117570. doi:
10.1016/j.envpol.2021.117570. [PMID: 34438493] - Luchen Yang, Zhenghuan Liu, Zhufeng Peng, Pan Song, Jing Zhou, Linchun Wang, Junhao Chen, Qiang Dong. Exposure to Di-2-ethylhexyl Phthalate and Benign Prostatic Hyperplasia, NHANES 2001-2008.
Frontiers in endocrinology.
2021; 12(?):804457. doi:
10.3389/fendo.2021.804457. [PMID: 35095770] - Mary V Díaz Santana, Susan E Hankinson, Carol Bigelow, Susan R Sturgeon, R Thomas Zoeller, Lesley Tinker, Jo Ann E Manson, Antonia M Calafat, Jaymie R Meliker, Katherine W Reeves. Urinary concentrations of phthalate biomarkers and weight change among postmenopausal women: a prospective cohort study.
Environmental health : a global access science source.
2019 03; 18(1):20. doi:
10.1186/s12940-019-0458-6. [PMID: 30866962] - Yuqing Zhang, Tianyu Dong, Weiyue Hu, Xu Wang, Bo Xu, Zhongning Lin, Tim Hofer, Pawel Stefanoff, Ying Chen, Xinru Wang, Yankai Xia. Association between exposure to a mixture of phenols, pesticides, and phthalates and obesity: Comparison of three statistical models.
Environment international.
2019 02; 123(?):325-336. doi:
10.1016/j.envint.2018.11.076. [PMID: 30557812] - Pei-Jing Yang, Ming-Feng Hou, Eing-Mei Tsai, Shih-Shin Liang, Chien-Chih Chiu, Fu Ou-Yang, Jung-Yu Kan, Chiung-Yu Peng, Tsu-Nai Wang. Breast cancer is associated with methylation and expression of the a disintegrin and metalloproteinase domain 33 (ADAM33) gene affected by endocrine‑disrupting chemicals.
Oncology reports.
2018 Nov; 40(5):2766-2777. doi:
10.3892/or.2018.6675. [PMID: 30226539] - Jin Hee Kim, Sung Hoon Kim, Young Sang Oh, Hyo Jin Ihm, Hee Dong Chae, Chung-Hoon Kim, Byung Moon Kang. In vitro effects of phthalate esters in human myometrial and leiomyoma cells and increased urinary level of phthalate metabolite in women with uterine leiomyoma.
Fertility and sterility.
2017 04; 107(4):1061-1069.e1. doi:
10.1016/j.fertnstert.2017.01.015. [PMID: 28292620] - Haotian Wu, Alexandra Olmsted, David E Cantonwine, Shahin Shahsavari, Tayyab Rahil, Cynthia Sites, J Richard Pilsner. Urinary phthalate and phthalate alternative metabolites and isoprostane among couples undergoing fertility treatment.
Environmental research.
2017 Feb; 153(?):1-7. doi:
10.1016/j.envres.2016.11.003. [PMID: 27875712] - Ulla Nordström Joensen, Niels Jørgensen, Michael Meldgaard, Hanne Frederiksen, Anna-Maria Andersson, Torkil Menné, Jeanne Duus Johansen, Berit Christina Carlsen, Steen Stender, Pal Bela Szecsi, Niels Erik Skakkebæk, Ewa Rajpert-De Meyts, Jacob P Thyssen. Associations of filaggrin gene loss-of-function variants with urinary phthalate metabolites and testicular function in young Danish Men.
Environmental health perspectives.
2014 Apr; 122(4):345-50. doi:
10.1289/ehp.1306720. [PMID: 24380925] - Joe M Braun, Kristen W Smith, Paige L Williams, Antonia M Calafat, Katharine Berry, Shelley Ehrlich, Russ Hauser. Variability of urinary phthalate metabolite and bisphenol A concentrations before and during pregnancy.
Environmental health perspectives.
2012 May; 120(5):739-45. doi:
10.1289/ehp.1104139. [PMID: 22262702] - Claire Philippat, Marion Mortamais, Cécile Chevrier, Claire Petit, Antonia M Calafat, Xiaoyun Ye, Manori J Silva, Christian Brambilla, Isabelle Pin, Marie-Aline Charles, Sylvaine Cordier, Rémy Slama. Exposure to phthalates and phenols during pregnancy and offspring size at birth.
Environmental health perspectives.
2012 Mar; 120(3):464-70. doi:
10.1289/ehp.1103634. [PMID: 21900077] - Robin M Whyatt, Xinhua Liu, Virginia A Rauh, Antonia M Calafat, Allan C Just, Lori Hoepner, Diurka Diaz, James Quinn, Jennifer Adibi, Frederica P Perera, Pam Factor-Litvak. Maternal prenatal urinary phthalate metabolite concentrations and child mental, psychomotor, and behavioral development at 3 years of age.
Environmental health perspectives.
2012 Feb; 120(2):290-5. doi:
10.1289/ehp.1103705. [PMID: 21893441] - Thomas Göen, Lorenz Dobler, Jan Koschorreck, Johannes Müller, Gerhard Andreas Wiesmüller, Hans Drexler, Marike Kolossa-Gehring. Trends of the internal phthalate exposure of young adults in Germany--follow-up of a retrospective human biomonitoring study.
International journal of hygiene and environmental health.
2011 Dec; 215(1):36-45. doi:
10.1016/j.ijheh.2011.07.011. [PMID: 21889907] - John D Meeker, Kelly K Ferguson. Relationship between urinary phthalate and bisphenol A concentrations and serum thyroid measures in U.S. adults and adolescents from the National Health and Nutrition Examination Survey (NHANES) 2007-2008.
Environmental health perspectives.
2011 Oct; 119(10):1396-402. doi:
10.1289/ehp.1103582. [PMID: 21749963] - Sheela Sathyanarayana, Joe M Braun, Kimberly Yolton, Stacey Liddy, Bruce P Lanphear. Case report: high prenatal bisphenol a exposure and infant neonatal neurobehavior.
Environmental health perspectives.
2011 Aug; 119(8):1170-5. doi:
10.1289/ehp.1003064. [PMID: 21524981] - Katherine Svensson, Raúl U Hernández-Ramírez, Ana Burguete-García, Mariano E Cebrián, Antonia M Calafat, Larry L Needham, Luz Claudio, Lizbeth López-Carrillo. Phthalate exposure associated with self-reported diabetes among Mexican women.
Environmental research.
2011 Aug; 111(6):792-6. doi:
10.1016/j.envres.2011.05.015. [PMID: 21696718] - Lidia Casas, Mariana F Fernández, Sabrina Llop, Mònica Guxens, Ferran Ballester, Nicolás Olea, Mikel Basterrechea Irurzun, Loreto Santa Marina Rodríguez, Isolina Riaño, Adonina Tardón, Martine Vrijheid, Antonia M Calafat, Jordi Sunyer. Urinary concentrations of phthalates and phenols in a population of Spanish pregnant women and children.
Environment international.
2011 Jul; 37(5):858-66. doi:
10.1016/j.envint.2011.02.012. [PMID: 21440302] - Michelle Romero-Franco, Raúl U Hernández-Ramírez, Antonia M Calafat, Mariano E Cebrián, Larry L Needham, Susan Teitelbaum, Mary S Wolff, Lizbeth López-Carrillo. Personal care product use and urinary levels of phthalate metabolites in Mexican women.
Environment international.
2011 Jul; 37(5):867-71. doi:
10.1016/j.envint.2011.02.014. [PMID: 21429583] - Justin A Colacino, Amr S Soliman, Antonia M Calafat, Muna S Nahar, Adrienne Van Zomeren-Dohm, Ahmed Hablas, Ibrahim A Seifeldin, Laura S Rozek, Dana C Dolinoy. Exposure to phthalates among premenstrual girls from rural and urban Gharbiah, Egypt: a pilot exposure assessment study.
Environmental health : a global access science source.
2011 May; 10(?):40. doi:
10.1186/1476-069x-10-40. [PMID: 21575223] - Malene Boas, Hanne Frederiksen, Ulla Feldt-Rasmussen, Niels E Skakkebæk, Laszlo Hegedüs, Linda Hilsted, Anders Juul, Katharina M Main. Childhood exposure to phthalates: associations with thyroid function, insulin-like growth factor I, and growth.
Environmental health perspectives.
2010 Oct; 118(10):1458-64. doi:
10.1289/ehp.0901331. [PMID: 20621847] - Hanne Frederiksen, Niels Jørgensen, Anna-Maria Andersson. Correlations between phthalate metabolites in urine, serum, and seminal plasma from young Danish men determined by isotope dilution liquid chromatography tandem mass spectrometry.
Journal of analytical toxicology.
2010 Sep; 34(7):400-10. doi:
10.1093/jat/34.7.400. [PMID: 20822678] - Justin A Colacino, T Robert Harris, Arnold Schecter. Dietary intake is associated with phthalate body burden in a nationally representative sample.
Environmental health perspectives.
2010 Jul; 118(7):998-1003. doi:
10.1289/ehp.0901712. [PMID: 20392686] - Mary S Wolff, Susan L Teitelbaum, Susan M Pinney, Gayle Windham, Laura Liao, Frank Biro, Lawrence H Kushi, Chris Erdmann, Robert A Hiatt, Michael E Rybak, Antonia M Calafat. Investigation of relationships between urinary biomarkers of phytoestrogens, phthalates, and phenols and pubertal stages in girls.
Environmental health perspectives.
2010 Jul; 118(7):1039-46. doi:
10.1289/ehp.0901690. [PMID: 20308033] - Jennifer Weuve, Russ Hauser, Antonia M Calafat, Stacey A Missmer, Lauren A Wise. Association of exposure to phthalates with endometriosis and uterine leiomyomata: findings from NHANES, 1999-2004.
Environmental health perspectives.
2010 Jun; 118(6):825-32. doi:
10.1289/ehp.0901543. [PMID: 20185384] - Lizbeth López-Carrillo, Raúl U Hernández-Ramírez, Antonia M Calafat, Luisa Torres-Sánchez, Marcia Galván-Portillo, Larry L Needham, Rubén Ruiz-Ramos, Mariano E Cebrián. Exposure to phthalates and breast cancer risk in northern Mexico.
Environmental health perspectives.
2010 Apr; 118(4):539-44. doi:
10.1289/ehp.0901091. [PMID: 20368132] - Jennifer J Adibi, Robin M Whyatt, Russ Hauser, Hari K Bhat, Barbara J Davis, Antonia M Calafat, Lori A Hoepner, Frederica P Perera, Deliang Tang, Paige L Williams. Transcriptional biomarkers of steroidogenesis and trophoblast differentiation in the placenta in relation to prenatal phthalate exposure.
Environmental health perspectives.
2010 Feb; 118(2):291-6. doi:
10.1289/ehp.0900788. [PMID: 20123604] - John D Meeker, Howard Hu, David E Cantonwine, Hector Lamadrid-Figueroa, Antonia M Calafat, Adrienne S Ettinger, Mauricio Hernandez-Avila, Rita Loch-Caruso, Martha María Téllez-Rojo. Urinary phthalate metabolites in relation to preterm birth in Mexico city.
Environmental health perspectives.
2009 Oct; 117(10):1587-92. doi:
10.1289/ehp.0800522. [PMID: 20019910] - Tamar Berman, Drorit Hochner-Celnikier, Antonia M Calafat, Larry L Needham, Yona Amitai, Uri Wormser, Elihu Richter. Phthalate exposure among pregnant women in Jerusalem, Israel: results of a pilot study.
Environment international.
2009 Feb; 35(2):353-7. doi:
10.1016/j.envint.2008.08.010. [PMID: 18824263] - Sonia Hernández-Díaz, Allen A Mitchell, Katherine E Kelley, Antonia M Calafat, Russ Hauser. Medications as a potential source of exposure to phthalates in the U.S. population.
Environmental health perspectives.
2009 Feb; 117(2):185-9. doi:
10.1289/ehp.11766. [PMID: 19270786] - Erin P Hines, Antonia M Calafat, Manori J Silva, Pauline Mendola, Suzanne E Fenton. Concentrations of phthalate metabolites in milk, urine, saliva, and Serum of lactating North Carolina women.
Environmental health perspectives.
2009 Jan; 117(1):86-92. doi:
10.1289/ehp.11610. [PMID: 19165392] - Mary S Wolff, Stephanie M Engel, Gertrud S Berkowitz, Xiaoyun Ye, Manori J Silva, Chenbo Zhu, James Wetmur, Antonia M Calafat. Prenatal phenol and phthalate exposures and birth outcomes.
Environmental health perspectives.
2008 Aug; 116(8):1092-7. doi:
10.1289/ehp.11007. [PMID: 18709157] - Jennifer J Adibi, Robin M Whyatt, Paige L Williams, Antonia M Calafat, David Camann, Robert Herrick, Heather Nelson, Hari K Bhat, Frederica P Perera, Manori J Silva, Russ Hauser. Characterization of phthalate exposure among pregnant women assessed by repeat air and urine samples.
Environmental health perspectives.
2008 Apr; 116(4):467-73. doi:
10.1289/ehp.10749. [PMID: 18414628] - Hermann Fromme, Gabriele Bolte, Holger M Koch, Jürgen Angerer, Sigrun Boehmer, Hans Drexler, Richard Mayer, Bernhard Liebl. Occurrence and daily variation of phthalate metabolites in the urine of an adult population.
International journal of hygiene and environmental health.
2007 Jan; 210(1):21-33. doi:
10.1016/j.ijheh.2006.09.005. [PMID: 17182278] - Mary S Wolff, Susan L Teitelbaum, Gayle Windham, Susan M Pinney, Julie A Britton, Carol Chelimo, James Godbold, Frank Biro, Lawrence H Kushi, Christine M Pfeiffer, Antonia M Calafat. Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girls.
Environmental health perspectives.
2007 Jan; 115(1):116-21. doi:
10.1289/ehp.9488. [PMID: 17366830] - Antonia M Calafat, Richard H McKee. Integrating biomonitoring exposure data into the risk assessment process: phthalates [diethyl phthalate and di(2-ethylhexyl) phthalate] as a case study.
Environmental health perspectives.
2006 Nov; 114(11):1783-9. doi:
10.1289/ehp.9059. [PMID: 17107868] - Manori J Silva, John A Reidy, James L Preau, Larry L Needham, Antonia M Calafat. Oxidative metabolites of diisononyl phthalate as biomarkers for human exposure assessment.
Environmental health perspectives.
2006 Aug; 114(8):1158-61. doi:
10.1289/ehp.8865. [PMID: 16882519] - Manori J Silva, Ella Samandar, James L Preau, Larry L Needham, Antonia M Calafat. Urinary oxidative metabolites of di(2-ethylhexyl) phthalate in humans.
Toxicology.
2006 Feb; 219(1-3):22-32. doi:
10.1016/j.tox.2005.10.018. [PMID: 16332407] - M J Silva, J A Reidy, J L Preau, E Samandar, L L Needham, A M Calafat. Measurement of eight urinary metabolites of di(2-ethylhexyl) phthalate as biomarkers for human exposure assessment.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2006 Jan; 11(1):1-13. doi:
10.1080/13547500500382868. [PMID: 16484133] - P W Albro, J T Corbett, J Schroeder, J K Reddy. Beta-oxidation of 2-ethyl-5-carboxypentyl phthalate in rodent liver.
Biochimica et biophysica acta.
1987 Feb; 923(2):196-205. doi:
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