lorglumide (BioDeep_00001874603)
代谢物信息卡片
lorglumide
化学式: C22H32Cl2N2O4 (458.1739012)
中文名称: 氯戊米特钠盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCN(CCCCC)C(=O)C(CCC(=O)O)NC(=O)C1=CC(=C(C=C1)Cl)Cl
InChI: InChI=1S/C22H32Cl2N2O4/c1-3-5-7-13-26(14-8-6-4-2)22(30)19(11-12-20(27)28)25-21(29)16-9-10-17(23)18(24)15-16/h9-10,15,19H,3-8,11-14H2,1-2H3,(H,25,29)(H,27,28)
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists
C78276 - Agent Affecting Digestive System or Metabolism > C29701 - Anti-ulcer Agent
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mehmet Bülbül, Osman Sinen, İlknur Birsen, Vecihe Izgüt-Uysal. Peripheral apelin-13 administration inhibits gastrointestinal motor functions in rats: The role of cholecystokinin through CCK1 receptor-mediated pathway.
Neuropeptides.
2017 Jun; 63(?):91-97. doi:
10.1016/j.npep.2016.12.001. [PMID: 28012561] - Kok-Min Seow, Jyun-Lin Lee, Ming-Luen Doong, Seng-Wong Huang, Jiann-Loung Hwang, Wei-Ju Huang, Full-Young Chang, Low-Tone Ho, Chi-Chang Juan. Human chorionic gonadotropin regulates gastric emptying in ovariectomized rats.
The Journal of endocrinology.
2013 Mar; 216(3):307-14. doi:
10.1530/joe-12-0421. [PMID: 23197744] - Kuldeep Sharma, Anitha Police, Avinash Kumar, Gopal V Pawar, Sanjeev Giri, Sriram Rajagopal, Ramesh Mullangi. Development and validation of an LC-MS/MS-ESI method for the determination of lorglumide, a CCK-1 antagonist in mouse plasma: application to a pharmacokinetic study.
Biomedical chromatography : BMC.
2012 Jul; 26(7):833-8. doi:
10.1002/bmc.1737. [PMID: 22052726] - Yuko Yamada, Masashi Iwasaki, Hachiro Usui, Kousaku Ohinata, Ewa D Marczak, Andrzej W Lipkowski, Masaaki Yoshikawa. Rapakinin, an anti-hypertensive peptide derived from rapeseed protein, dilates mesenteric artery of spontaneously hypertensive rats via the prostaglandin IP receptor followed by CCK(1) receptor.
Peptides.
2010 May; 31(5):909-14. doi:
10.1016/j.peptides.2010.02.013. [PMID: 20188776] - Noemi Fantini, Claudia Cabras, Carla Lobina, Giancarlo Colombo, Gian Luigi Gessa, Antonella Riva, Fabio Donzelli, Paolo Morazzoni, Ezio Bombardelli, Mauro A M Carai. Reducing effect of a Phaseolus vulgaris dry extract on food intake, body weight, and glycemia in rats.
Journal of agricultural and food chemistry.
2009 Oct; 57(19):9316-23. doi:
10.1021/jf900711z. [PMID: 19731962] - Takenori Onaga, Aya Sugita, Rena Wakaiki, Ichiro Hara, Kanji Kagawa, Rikio Kirisawa, Hideaki Hayashi. Localization of CCK-1R in the omasum and role of CCK in the regulation of omasal contractions in sheep.
Domestic animal endocrinology.
2008 Aug; 35(2):231-44. doi:
10.1016/j.domaniend.2008.05.004. [PMID: 18638666] - Chiu-Lung Wu, Ming-Luen Doong, Paulus S Wang. Involvement of cholecystokinin receptor in the inhibition of gastrointestinal motility by oxytocin in ovariectomized rats.
European journal of pharmacology.
2008 Feb; 580(3):407-15. doi:
10.1016/j.ejphar.2007.11.024. [PMID: 18078924] - K Nawrot-Porabka, J Jaworek, A Leja-Szpak, J Szklarczyk, M Kot, M Mitis-Musioł, S J Konturek, W W Pawlik. Involvement of vagal nerves in the pancreatostimulatory effects of luminal melatonin, or its precursor L-tryptophan. Study in the rats.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2007 Dec; 58 Suppl 6(?):81-95. doi:
. [PMID: 18212402] - Katarzyna Nawrot-Porabka, Jolanta Jaworek, Anna Leja-Szpak, Joanna Szklarczyk, Magdalena Macko, Michalina Kot, Małgorzata Mitis-Musioł, Stanisław J Konturek, Wiesław W Pawlik. The effect of luminal ghrelin on pancreatic enzyme secretion in the rat.
Regulatory peptides.
2007 Oct; 143(1-3):56-63. doi:
10.1016/j.regpep.2007.03.001. [PMID: 17462749] - Chun-Min Lo, Liyun Ma, Dian Ming Zhang, Rachel Lee, Abby Qin, Min Liu, Stephen C Woods, Randall R Sakai, Helen E Raybould, Patrick Tso. Mechanism of the induction of brain c-Fos-positive neurons by lipid absorption.
American journal of physiology. Regulatory, integrative and comparative physiology.
2007 Jan; 292(1):R268-73. doi:
10.1152/ajpregu.00334.2006. [PMID: 16990492] - Cristina González-Puga, Ana García-Navarro, Germaine Escames, Josefa León, Manuel López-Cantarero, Eduardo Ros, Darío Acuña-Castroviejo. Selective CCK-A but not CCK-B receptor antagonists inhibit HT-29 cell proliferation: synergism with pharmacological levels of melatonin.
Journal of pineal research.
2005 Oct; 39(3):243-50. doi:
10.1111/j.1600-079x.2005.00239.x. [PMID: 16150104] - Karine Proulx, Daniela Cota, Tamara R Castañeda, Matthias H Tschöp, David A D'Alessio, Patrick Tso, Stephen C Woods, Randy J Seeley. Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity.
American journal of physiology. Regulatory, integrative and comparative physiology.
2005 Sep; 289(3):R729-37. doi:
10.1152/ajpregu.00029.2005. [PMID: 15879057] - Hsiao-Fung Pu, Wei-Ju Huang, Wen-Min Tseng, Shyi-Wu Wang, Yu-Wen Liu, Ming-Long Doong, Paulus S Wang. Effects of juice from Morinda citrifolia (Noni) on gastric emptying in male rats.
The Chinese journal of physiology.
2004 Dec; 47(4):169-74. doi:
NULL. [PMID: 15803749] - M Latorre, J M Bartolomé-Nebreda, M T García-López, R González-Muñiz, R Herranz, J Del Río, E Cenarruzabeitia. Pharmacological study of IQM-97,423, a potent and selective CCK1 receptor antagonist with protective effect in experimental acute pancreatitis.
Pharmacology.
2004 Oct; 72(2):68-76. doi:
10.1159/000079134. [PMID: 15331911] - Kazuko Satoh, Yoshio Kase, Mitsutoshi Yuzurihara, Kazushige Mizoguchi, Kouji Kurauchi, Atsushi Ishige. Effect of Dai-kenchu-to (Da-Jian-Zhong-Tang) on the delayed intestinal propulsion induced by chlorpromazine in mice.
Journal of ethnopharmacology.
2003 May; 86(1):37-44. doi:
10.1016/s0378-8741(03)00038-2. [PMID: 12686439] - Chiu-Lung Wu, Chen-Road Hung, Full-Young Chang, K-Y Francis Pau, Paulus S Wang. Pharmacological effects of oxytocin on gastric emptying and intestinal transit of a non-nutritive liquid meal in female rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2003 Apr; 367(4):406-13. doi:
10.1007/s00210-003-0690-y. [PMID: 12690433] - C L Wu, C R Hung, F Y Chang, K Y F Pau, P S Wang. Involvement of cholecystokinin receptor in the inhibition of gastrointestinal motility by estradiol in ovariectomized rats.
Scandinavian journal of gastroenterology.
2002 Oct; 37(10):1133-9. doi:
10.1080/003655202760373326. [PMID: 12408516] - B F Kania, J Matczuk, K Romanowicz, L Buéno, J Fioramonti, K Kania. CCK1 central receptor antagonist prevented the intestinal stress symptoms in sheep.
Polish journal of veterinary sciences.
2002; 5(1):35-42. doi:
NULL. [PMID: 11944584] - M A Froetschel, M J Azain, G L Edwards, C R Barb, H E Amos. Opioid and cholecystokinin antagonists alleviate gastric inhibition of food intake by premeal loads of casein in meal-fed rats.
The Journal of nutrition.
2001 Dec; 131(12):3270-6. doi:
10.1093/jn/131.12.3270. [PMID: 11739879] - M L Doong, C C Lu, M M Kau, S C Tsai, Y C Chiao, J J Chen, J Y Yeh, H Lin, S W Huang, T S Chen, F Y Chang, P S Wang. Inhibition of gastric emptying and intestinal transit by amphetamine through a mechanism involving an increased secretion of CCK in male rats.
British journal of pharmacology.
1998 Jul; 124(6):1123-30. doi:
10.1038/sj.bjp.0701937. [PMID: 9720782] - A J Hirsh, R Tsang, S Kammila, C I Cheeseman. Effect of cholecystokinin and related peptides on jejunal transepithelial hexose transport in the Sprague-Dawley rat.
The American journal of physiology.
1996 Nov; 271(5 Pt 1):G755-61. doi:
10.1152/ajpgi.1996.271.5.g755. [PMID: 8944688] - C Niederau, F Borchard, R Lüthen, M Niederau. Early development of experimental biliary pancreatitis and its amelioration by CCK-receptor blockade.
Hepato-gastroenterology.
1996 Nov; 43(12):1442-53. doi:
NULL. [PMID: 8975946] - K Okubo, K Miyasaka, M Matsumoto, A Funakoshi. Mechanisms of stimulatory effect of neuromedin C on pancreatic exocrine secretion in conscious rats.
Pancreas.
1994 Sep; 9(5):585-90. doi:
10.1097/00006676-199409000-00008. [PMID: 7809013] - M Blackmore, E Doherty, J E Manning, B H Hirst. Autocrine growth stimulation of human renal Wilms' tumour G401 cells by a gastrin-like peptide.
International journal of cancer.
1994 May; 57(3):385-91. doi:
10.1002/ijc.2910570316. [PMID: 8169000] - S Evrard, A Hoeltzel, M Aprahamian, C Bernard, D Mutter, J Marescaux, C Damgé. Implication of cholecystokinin in pancreatic adaptation after biliopancreatic bypass in the rat.
Digestion.
1994; 55(4):208-13. doi:
10.1159/000201149. [PMID: 7520400] - S Kosidło, G Rydzewska, A Gabryelewicz. The effect of a cholecystokinin receptor antagonist lorglumid on the proteinase-antiproteinase balance in taurocholate acute experimental pancreatitis (AEP) in rats.
Materia medica Polona. Polish journal of medicine and pharmacy.
1992 Oct; 24(4):223-6. doi:
. [PMID: 1308047] - S Tsuzuki, A Kondo, T Fushiki, E Sugimoto. Monitor peptide gene expression is increased by exogenous CCK in the rat pancreas and in a rat pancreatic acinar cell line (AR4-2J).
FEBS letters.
1992 Aug; 307(3):386-8. doi:
10.1016/0014-5793(92)80719-w. [PMID: 1379547] - P Watanapa, M Egan, P H Deprez, J Calam, C E Sarraf, M R Alison, R C Williamson. Role of cholecystokinin in pancreatic adaptation to massive enterectomy.
Gut.
1992 Jul; 33(7):959-64. doi:
10.1136/gut.33.7.959. [PMID: 1644338] - D P Yox, L Brenner, R C Ritter. CCK-receptor antagonists attenuate suppression of sham feeding by intestinal nutrients.
The American journal of physiology.
1992 Apr; 262(4 Pt 2):R554-61. doi:
10.1152/ajpregu.1992.262.4.r554. [PMID: 1373576] - K Shiratori, S Watanabe, T Takeuchi. Role of endogenous secretin and cholecystokinin in intraduodenal oleic acid-induced inhibition of gastric acid secretion in rats.
Digestive diseases and sciences.
1992 Mar; 37(3):397-402. doi:
10.1007/bf01307734. [PMID: 1735364] - S A Watson, D L Morris, L G Durrant, J F Robertson, J D Hardcastle. Inhibition of gastrin-stimulated growth of gastrointestinal tumour cells by octreotide and the gastrin/cholecystokinin receptor antagonists, proglumide and lorglumide.
European journal of cancer (Oxford, England : 1990).
1992; 28A(8-9):1462-7. doi:
10.1016/0959-8049(92)90544-c. [PMID: 1355350] - P Watanapa, E F Efa, K Beardshall, J Calam, C E Sarraf, M R Alison, R C Williamson. Inhibitory effect of a cholecystokinin antagonist on the proliferative response of the pancreas to pancreatobiliary diversion.
Gut.
1991 Sep; 32(9):1049-54. doi:
10.1136/gut.32.9.1049. [PMID: 1916490] - M Papp, G Varga, G Folly. Increase in plasma corticosterone level does not participate in increase of amylase content induced by lorglumide in the newborn rat pancreas.
Pancreas.
1991 Jul; 6(4):493-4. doi:
10.1097/00006676-199107000-00021. [PMID: 1715089] - F Larsen, D Schlarman, C C Andrus, D L Kaminski. The effect of the CCK receptor antagonist CR 1409 on bile reflux pancreatitis in the opossum.
Pancreas.
1991 May; 6(3):291-7. doi:
10.1097/00006676-199105000-00006. [PMID: 1713673] - K Miyasaka, A Funakoshi, M Matsumoto, R Nakamura, S Sakamoto, H Sakai, K Kitani. Bile acids in human plasma interfere with cholecystokinin bioassay using dispersed pancreatic acini.
Digestive diseases and sciences.
1991 Mar; 36(3):310-6. doi:
10.1007/bf01318202. [PMID: 1995267] - A J de Jong, M V Singer, J B Jansen, W Niebel, L C Rovati, C B Lamers. Effect of the cholecystokinin-receptor antagonist lorglumide on pancreatic enzyme secretion stimulated by bombesin, food, and caerulein, giving similar plasma cholecystokinin concentrations in the dog.
Gut.
1991 Feb; 32(2):215-9. doi:
10.1136/gut.32.2.215. [PMID: 1864545] - M Papp, G Varga, G Folly. Effect of lorglumide (CR-1409) on pancreatic secretory and trophic response to caerulein in newborn rats.
Acta physiologica Hungarica.
1991; 78(1):61-7. doi:
NULL. [PMID: 1722380] - P Li, K Y Lee, T M Chang, W Y Chey. Hormonal mechanism of sodium oleate-stimulated pancreatic secretion in rats.
The American journal of physiology.
1990 Dec; 259(6 Pt 1):G960-5. doi:
10.1152/ajpgi.1990.259.6.g960. [PMID: 2260665] - J Esclassan, C Murat, S Aired, P Vincensini, E Hollande. Demonstration of a new resonance peak by proton NMR in rat pancreas stimulated with caerulein.
Pancreas.
1990 Sep; 5(5):580-8. doi:
10.1097/00006676-199009000-00014. [PMID: 2235969] - J B Jansen, A J de Jong, M V Singer, W Niebel, L C Rovati, C B Lamers. Role of cholecystokinin in bombesin- and meal-stimulated pancreatic polypeptide secretion in dogs.
Digestive diseases and sciences.
1990 Sep; 35(9):1073-7. doi:
10.1007/bf01537577. [PMID: 2390922] - K Shiratori, S Watanabe, T Takeuchi, K Shimizu, Y Moriyoshi. Role of secretin and cholecystokinin in oleic acid-stimulated pancreatic secretion in rats.
Gastroenterologia Japonica.
1990 Feb; 25(1):104-11. doi:
10.1007/bf02785336. [PMID: 1689684] - F J van de Brug, J B Jansen, I J Kuijpers, C B Lamers. Effects of lorglumide on gastrin- and peptone-stimulated gastric acid secretion in rats.
Life sciences.
1990; 47(26):2459-64. doi:
10.1016/0024-3205(90)90491-9. [PMID: 2263169] - B R Douglas, R A Woutersen, J B Jansen, L C Rovati, C B Lamers. Comparison of the effect of lorglumide on pancreatic growth stimulated by camostate in rat and hamster.
Life sciences.
1990; 46(4):281-6. doi:
10.1016/0024-3205(90)90034-o. [PMID: 2304371] - F Shikado, K Miyasaka, A Funakoshi, K Kitani. Necessity of hyperglycemia for effects of endogenous cholecystokinin on insulin and pancreatic exocrine secretion in conscious rats.
The Japanese journal of physiology.
1990; 40(3):383-91. doi:
10.2170/jjphysiol.40.383. [PMID: 2273636] - R Nakamura, K Miyasaka, A Funakoshi, K Kitani. Interactions between bile and pancreatic juice diversions on cholecystokinin release and pancreas in conscious rats.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1989 Nov; 192(2):182-6. doi:
10.3181/00379727-192-42976. [PMID: 2813449] - D Menozzi, J D Gardner, R T Jensen, P N Maton. Properties of receptors for gastrin and CCK on gastric smooth muscle cells.
The American journal of physiology.
1989 Jul; 257(1 Pt 1):G73-9. doi:
10.1152/ajpgi.1989.257.1.g73. [PMID: 2473654] - B R Douglas, R A Woutersen, J B Jansen, A J de Jong, L C Rovati, C B Lamers. Modulation by CR-1409 (lorglumide), a cholecystokinin receptor antagonist, of trypsin inhibitor-enhanced growth of azaserine-induced putative preneoplastic lesions in rat pancreas.
Cancer research.
1989 May; 49(9):2438-41. doi:
NULL. [PMID: 2706631] - S Karlsson, B Ahrén. Effects of three different cholecystokinin receptor antagonists on basal and stimulated insulin and glucagon secretion in mice.
Acta physiologica Scandinavica.
1989 Mar; 135(3):271-8. doi:
10.1111/j.1748-1716.1989.tb08577.x. [PMID: 2648765] - B R Douglas, R A Woutersen, J B Jansen, A J de Jong, L C Rovati, C B Lamers. Influence of cholecystokinin antagonist on the effects of cholecystokinin and bombesin on azaserine-induced lesions in rat pancreas.
Gastroenterology.
1989 Feb; 96(2 Pt 1):462-9. doi:
10.1016/0016-5085(89)91572-2. [PMID: 2910761] - J B Jansen, A J de Jong, C B Lamers. The cholecystokinin receptor antagonist CR1409 increases plasma cholecystokinin in rats.
Regulatory peptides.
1989 Feb; 24(2):209-13. doi:
10.1016/0167-0115(89)90239-5. [PMID: 2922496] - K Shiratori, K Shimizu, S Watanabe, T Takeuchi, Y Moriyoshi. Effect of CCK antagonists CR 1409 and CR 1505 on rat pancreatic exocrine secretion in vivo.
Pancreas.
1989; 4(6):744-50. doi:
10.1097/00006676-198912000-00014. [PMID: 2813333] - P Thor, J Laskiewicz, P Konturek, S J Konturek. Cholecystokinin in the regulation of intestinal motility and pancreatic secretion in dogs.
The American journal of physiology.
1988 Oct; 255(4 Pt 1):G498-504. doi:
10.1152/ajpgi.1988.255.4.g498. [PMID: 3177646] - K Miyasaka, R Nakamura, A Funakoshi, K Kitani. Inhibitory effect of CR-1409, a competitive inhibitor of cholecystokinin, on pancreatic exocrine secretion in the conscious rat.
The Tohoku journal of experimental medicine.
1988 Jun; 155(2):165-72. doi:
10.1620/tjem.155.165. [PMID: 3212779] - C Niederau, R A Liddle, J A Williams, J H Grendell. Pancreatic growth: interaction of exogenous cholecystokinin, a protease inhibitor, and a cholecystokinin receptor antagonist in mice.
Gut.
1987; 28 Suppl(?):63-9. doi:
10.1136/gut.28.suppl.63. [PMID: 2446964]