4-Nitroimidazole (BioDeep_00001874547)
代谢物信息卡片
4-Nitroimidazole
化学式: C3H3N3O2 (113.0225258)
中文名称: 4-硝基咪唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=C(NC=N1)[N+](=O)[O-]
InChI: InChI=1S/C3H3N3O2/c7-6(8)3-1-4-2-5-3/h1-2H,(H,4,5)
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- R Cañete, A L Noda, M Rodríguez, K Brito, E Herrera, P-E Kofoed, J Ursing. 5-Nitroimidazole refractory giardiasis is common in Matanzas, Cuba and effectively treated by secnidazole plus high-dose mebendazole or quinacrine: a prospective observational cohort study.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
2020 Aug; 26(8):1092.e1-1092.e6. doi:
10.1016/j.cmi.2019.12.017. [PMID: 31901492] - Tomasz Tuzimski, Tomasz Rejczak. A QuEChERS-Based Sample Preparation Method for the Analysis of 5-Nitroimidazoles in Bovine Milk by HPLC-DAD.
Journal of AOAC International.
2017 Nov; 100(6):1671-1680. doi:
10.5740/jaoacint.17-0213. [PMID: 28707620] - Maykel Hernández-Mesa, Carmen Cruces-Blanco, Ana M García-Campaña. Capillary electrophoresis-tandem mass spectrometry combined with molecularly imprinted solid phase extraction as useful tool for the monitoring of 5-nitroimidazoles and their metabolites in urine samples.
Talanta.
2017 Jan; 163(?):111-120. doi:
10.1016/j.talanta.2016.10.092. [PMID: 27886759] - Maykel Hernández-Mesa, Diego Airado-Rodríguez, Ana M García-Campaña, Carmen Cruces-Blanco. Development of an ultrasensitive stacking technique for 5-nitroimidazole determination in untreated biological fluids by micellar electrokinetic chromatography.
Electrophoresis.
2015 Oct; 36(20):2538-41. doi:
10.1002/elps.201500193. [PMID: 26174089] - Maykel Hernández-Mesa, Giovanni D'Orazio, Anna Rocco, Ana M García-Campaña, Carmen Cruces Blanco, Salvatore Fanali. Capillary electrochromatography-mass spectrometry for the determination of 5-nitroimidazole antibiotics in urine samples.
Electrophoresis.
2015 Oct; 36(20):2606-15. doi:
10.1002/elps.201500126. [PMID: 26200811] - Suresh B Lakshminarayana, Helena I M Boshoff, Joseph Cherian, Sindhu Ravindran, Anne Goh, Jan Jiricek, Mahesh Nanjundappa, Amit Nayyar, Meera Gurumurthy, Ramandeep Singh, Thomas Dick, Francesca Blasco, Clifton E Barry, Paul C Ho, Ujjini H Manjunatha. Pharmacokinetics-pharmacodynamics analysis of bicyclic 4-nitroimidazole analogs in a murine model of tuberculosis.
PloS one.
2014; 9(8):e105222. doi:
10.1371/journal.pone.0105222. [PMID: 25141257] - Soledad Fernández, Sylvia Dematteis, Javier Giglio, Hugo Cerecetto, Ana Rey. Synthesis, in vitro and in vivo characterization of two novel 68Ga-labelled 5-nitroimidazole derivatives as potential agents for imaging hypoxia.
Nuclear medicine and biology.
2013 Feb; 40(2):273-9. doi:
10.1016/j.nucmedbio.2012.11.003. [PMID: 23218939] - Ruina Gao, Dafang Zhong, Ke Liu, Yu Xia, Rongwei Shi, Hua Li, Xiaoyan Chen. Simultaneous determination of morinidazole, its N-oxide, sulfate, and diastereoisomeric N(+)-glucuronides in human plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Nov; 908(?):52-8. doi:
10.1016/j.jchromb.2012.09.017. [PMID: 23122401] - Javier Giglio, Soledad Fernández, Hans-Jürgen Pietzsch, Sylvia Dematteis, María Moreno, José P Pacheco, Hugo Cerecetto, Ana Rey. Synthesis, in vitro and in vivo characterization of novel 99mTc-'4+1'-labeled 5-nitroimidazole derivatives as potential agents for imaging hypoxia.
Nuclear medicine and biology.
2012 Jul; 39(5):679-86. doi:
10.1016/j.nucmedbio.2011.12.012. [PMID: 22534030] - Soledad Fernández, Javier Giglio, Ana M Rey, Hugo Cerecetto. Influence of ligand denticity on the properties of novel ⁹⁹mTc(I)-carbonyl complexes. Application to the development of radiopharmaceuticals for imaging hypoxic tissue.
Bioorganic & medicinal chemistry.
2012 Jul; 20(13):4040-8. doi:
10.1016/j.bmc.2012.05.010. [PMID: 22658538] - Amanda Piccoli Frasson, Odelta dos Santos, Mariana Duarte, Danielle da Silva Trentin, Raquel Brandt Giordani, Alexandre Gomes da Silva, Márcia Vanusa da Silva, Tiana Tasca, Alexandre José Macedo. First report of anti-Trichomonas vaginalis activity of the medicinal plant Polygala decumbens from the Brazilian semi-arid region, Caatinga.
Parasitology research.
2012 Jun; 110(6):2581-7. doi:
10.1007/s00436-011-2787-4. [PMID: 22205352] - Ruina Gao, Liang Li, Cen Xie, Xingxing Diao, Dafang Zhong, Xiaoyan Chen. Metabolism and pharmacokinetics of morinidazole in humans: identification of diastereoisomeric morpholine N+-glucuronides catalyzed by UDP glucuronosyltransferase 1A9.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Mar; 40(3):556-67. doi:
10.1124/dmd.111.042689. [PMID: 22184458] - Javier Giglio, Soledad Fernández, Ana Rey, Hugo Cerecetto. Synthesis and biological characterisation of novel dithiocarbamate containing 5-nitroimidazole (99m)Tc-complexes as potential agents for targeting hypoxia.
Bioorganic & medicinal chemistry letters.
2011 Jan; 21(1):394-7. doi:
10.1016/j.bmcl.2010.10.130. [PMID: 21087863] - J L Gookin, S H Stauffer, D Dybas, D H Cannon. Documentation of in vivo and in vitro aerobic resistance of feline Tritrichomonas foetus isolates to ronidazole.
Journal of veterinary internal medicine.
2010 Jul; 24(4):1003-7. doi:
10.1111/j.1939-1676.2010.0534.x. [PMID: 20492492] - Dorota Olender, Justyna Zwawiak, Victor Lukianchuk, Roman Lesyk, Aleksandra Kropacz, Andrzej Fojutowski, Lucjusz Zaprutko. Synthesis of some N-substituted nitroimidazole derivatives as potential antioxidant and antifungal agents.
European journal of medicinal chemistry.
2009 Feb; 44(2):645-52. doi:
10.1016/j.ejmech.2008.05.016. [PMID: 18590938] - Annamaria Buschini, Lisa Ferrarini, Susanna Franzoni, Serena Galati, Mirca Lazzaretti, Francesca Mussi, Cristina Northfleet de Albuquerque, Tânia Maria Araújo Domingues Zucchi, Paola Poli. Genotoxicity revaluation of three commercial nitroheterocyclic drugs: nifurtimox, benznidazole, and metronidazole.
Journal of parasitology research.
2009; 2009(?):463575. doi:
10.1155/2009/463575. [PMID: 20981287] - Hatice Ertabaklar, Bijen Kivçak, Tuba Mert, Seray Ozensoy Töz. In vitro activity of Arbutus unedo leaf extracts against Trichomonas vaginalis trophozoites.
Turkiye parazitolojii dergisi.
2009; 33(4):263-5. doi:
". [PMID: 20101573] - O Kurt, N Girginkardeşler, I C Balcioğlu, A Ozbilgin, U Z Ok. A comparison of metronidazole and single-dose ornidazole for the treatment of dientamoebiasis.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
2008 Jun; 14(6):601-4. doi:
10.1111/j.1469-0691.2008.02002.x. [PMID: 18397330] - A A Escobedo, G Alvarez, M E González, P Almirall, R Cañete, S Cimerman, A Ruiz, R Pérez. The treatment of giardiasis in children: single-dose tinidazole compared with 3 days of nitazoxanide.
Annals of tropical medicine and parasitology.
2008 Apr; 102(3):199-207. doi:
10.1179/136485908x267894. [PMID: 18348774] - Roberto Cañete, Angel A Escobedo, Maria Elena González, Pedro Almirall, Nereyda Cantelar. A randomized, controlled, open-label trial of a single day of mebendazole versus a single dose of tinidazole in the treatment of giardiasis in children.
Current medical research and opinion.
2006 Nov; 22(11):2131-6. doi:
10.1185/030079906x132497. [PMID: 17076973] - M Ozyazici, E Gökçe, S Y Hizarcioglu, M S Taner, K Köseoglu, G Ertan. Dissolution and vaginal absorption characteristics of metronidazole and ornidazole.
Die Pharmazie.
2006 Oct; 61(10):855-61. doi:
NULL. [PMID: 17069425] - Daniel D Rossouw, Mattheus G Lötter, Hanlie du Raan, Susara E Jansen, Alexander Höhn, Ben V Burger. Radiosynthesis and evaluation of two novel 123I-labeled 2-methyl-4-nitroimidazole derivatives as potential infection imaging agents.
Nuclear medicine and biology.
2005 May; 32(4):385-94. doi:
10.1016/j.nucmedbio.2005.02.001. [PMID: 15878508] - J K Grover, V Vats, M Srinivas, S N Das, P Jha, D K Gupta, D K Mitra. Effect of metronidazole on spermatogenesis and FSH, LH and testosterone levels of pre-pubertal rats.
Indian journal of experimental biology.
2001 Nov; 39(11):1160-2. doi:
NULL. [PMID: 11906111] - F Dubini, L Riviera, M M Scaltrito, M G Bellotti. Susceptibility of Helicobacter pylori and pharmacokinetic properties in mice of new 5-nitroimidazole derivatives devoid of mutagenic activity in the Ames test.
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