Azetidine (BioDeep_00001874546)
代谢物信息卡片
Azetidine
化学式: C3H7N (57.0578462)
中文名称: 氮杂环丁烷
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CNC1
InChI: InChI=1S/C3H7N/c1-2-4-3-1/h4H,1-3H2
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Deepa R Parmar, Jigar Y Soni, Ramakrishna Guduru, Rahul H Rayani, Rakesh V Kusurkar, Anand G Vala, Sahista N Talukdar, Ibrahim H Eissa, Ahmed M Metwaly, Ahmed Khalil, Vishwanath Zunjar, Satyanarayana Battula. Discovery of new anticancer thiourea-azetidine hybrids: design, synthesis, in vitro antiproliferative, SAR, in silico molecular docking against VEGFR-2, ADMET, toxicity, and DFT studies.
Bioorganic chemistry.
2021 10; 115(?):105206. doi:
10.1016/j.bioorg.2021.105206. [PMID: 34339975] - Andrew R Hudson, Vincent J Santora, Robert E Petroski, Theresa A Almos, Gary Anderson, Richard Barido, Jillian Basinger, Chris L Bellows, Brett C Bookser, Nicola J Broadbent, Clifford Cabebe, Chih-Kun Chai, Mi Chen, Stephine Chow, De Michael Chung, Lindsay Heger, Anne M Danks, Graeme C Freestone, Dany Gitnick, Varsha Gupta, Christine Hoffmaster, Alan P Kaplan, Michael R Kennedy, Dong Lee, James Limberis, Kiev Ly, Chi Ching Mak, Brittany Masatsugu, Andrew C Morse, Jim Na, David Neul, John Nikpur, Joel Renick, Kristen Sebring, Samantha Sevidal, Ali Tabatabaei, Jenny Wen, Shouzhen Xia, Yingzhuo Yan, Zachary W Yoder, Douglas Zook, Marco Peters, J Guy Breitenbucher. Azetidine-based selective glycine transporter-1 (GlyT1) inhibitors with memory enhancing properties.
Bioorganic & medicinal chemistry letters.
2020 07; 30(14):127214. doi:
10.1016/j.bmcl.2020.127214. [PMID: 32527538] - Ronald Scott Obach, Erik A LaChapelle, Michael A Brodney, Michelle Vanase-Frawley, Gregory W Kauffman, Aarti Sawant-Basak. Strategies toward optimization of the metabolism of a series of serotonin-4 partial agonists: investigation of azetidines as piperidine isosteres.
Xenobiotica; the fate of foreign compounds in biological systems.
2016 Dec; 46(12):1112-1121. doi:
10.3109/00498254.2016.1152522. [PMID: 26947511] - Herve Aloysius, Vincent W Tong, Jocelyn Yabut, Scott A Bradley, Jackie Shang, Yan Zou, Richard A Tschirret-Guth. Metabolic activation and major protein target of a 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonist.
Chemical research in toxicology.
2012 Jul; 25(7):1412-22. doi:
10.1021/tx300017s. [PMID: 22765480] - Monika Bhadauria. Propolis prevents hepatorenal injury induced by chronic exposure to carbon tetrachloride.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):235358. doi:
10.1155/2012/235358. [PMID: 21837248] - Timo Mühlhaus, Julia Weiss, Dorothea Hemme, Frederik Sommer, Michael Schroda. Quantitative shotgun proteomics using a uniform ¹⁵N-labeled standard to monitor proteome dynamics in time course experiments reveals new insights into the heat stress response of Chlamydomonas reinhardtii.
Molecular & cellular proteomics : MCP.
2011 Sep; 10(9):M110.004739. doi:
10.1074/mcp.m110.004739. [PMID: 21610104] - Yanmei Dong, Jing Li, Chao Wu, David Oupický. Bisethylnorspermine lipopolyamine as potential delivery vector for combination drug/gene anticancer therapies.
Pharmaceutical research.
2010 Sep; 27(9):1927-38. doi:
10.1007/s11095-010-0197-4. [PMID: 20577786] - Mark R Faust, Georg Höfner, Jörg Pabel, Klaus T Wanner. Azetidine derivatives as novel gamma-aminobutyric acid uptake inhibitors: synthesis, biological evaluation, and structure-activity relationship.
European journal of medicinal chemistry.
2010 Jun; 45(6):2453-66. doi:
10.1016/j.ejmech.2010.02.029. [PMID: 20219271] - Sarah T Pruett, Anatoliy Bushnev, Kerri Hagedorn, Madhura Adiga, Christopher A Haynes, M Cameron Sullards, Dennis C Liotta, Alfred H Merrill. Biodiversity of sphingoid bases ('sphingosines') and related amino alcohols.
Journal of lipid research.
2008 Aug; 49(8):1621-39. doi:
10.1194/jlr.r800012-jlr200. [PMID: 18499644] - M Reza Anari, Mellissa D Creighton, Jason S Ngui, Richard A Tschirret-Guth, Yohannes Teffera, George A Doss, Wei Tang, Nathan X Yu, Suzanne L Ciccotto, Donald F Hobra, John B Coleman, Stella H Vincent, David C Evans. Species differences in metabolism and pharmacokinetics of a sphingosine-1-phosphate receptor agonist in rats and dogs: formation of a unique glutathione adduct in the rat.
Drug metabolism and disposition: the biological fate of chemicals.
2006 Aug; 34(8):1367-75. doi:
10.1124/dmd.105.009027. [PMID: 16698892] - Tsung-Luo Jinn, Chi-Chou Chiu, Wei-Wen Song, Yih-Ming Chen, Chu-Yung Lin. Azetidine-induced accumulation of class I small heat shock proteins in the soluble fraction provides thermotolerance in soybean seedlings.
Plant & cell physiology.
2004 Dec; 45(12):1759-67. doi:
10.1093/pcp/pch193. [PMID: 15557296] - Mariko Kitajima, Noriyuki Kogure, Kentaro Yamaguchi, Hiromitsu Takayama, Norio Aimi. Structure reinvestigation of gelsemoxonine, a constituent of Gelsemium elegans, reveals a novel, azetidine-containing indole alkaloid.
Organic letters.
2003 Jun; 5(12):2075-8. doi:
10.1021/ol0344725. [PMID: 12790532] - Se-Ho Chang, Ione Barbosa-Tessmann, Chin Chen, Michael S Kilberg, Anupam Agarwal. Glucose deprivation induces heme oxygenase-1 gene expression by a pathway independent of the unfolded protein response.
The Journal of biological chemistry.
2002 Jan; 277(3):1933-40. doi:
10.1074/jbc.m108921200. [PMID: 11707454] - C R Hunt, A J Parsian, P C Goswami, C A Kozak. Characterization and expression of the mouse Hsc70 gene.
Biochimica et biophysica acta.
1999 Mar; 1444(3):315-25. doi:
10.1016/s0167-4781(98)00285-1. [PMID: 10095055] - M Thermann, W Lorenz, A Schmal, F Schingale, P Dormann, H Hamelmann. Alterations in the circulatory system of anaesthesized dogs following administration of histamine and histamine H1- and H2-Receptor antagonists in relation to plasma histamine levels.
Agents and actions.
1975 Dec; 5(5):450-4. doi:
10.1007/bf01972666. [PMID: 3955]