N-Butyl-N-(4-hydroxybutyl)nitrosamine (BioDeep_00001874438)
代谢物信息卡片
N-butyl-N-(4-hydroxybutyl)nitrous amide
化学式: C8H18N2O2 (174.1368)
中文名称: N-丁基-N-(4-羟丁基)亚硝胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCN(CCCCO)N=O
InChI: InChI=1S/C8H18N2O2/c1-2-3-6-10(9-12)7-4-5-8-11/h11H,2-8H2,1H3
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:91275
- PubChem: 19665
- ChEMBL: CHEMBL164923
- MeSH: Butylhydroxybutylnitrosamine
- CAS: 3817-11-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Hesham Afify, Alia Ghoneum, Sameh Almousa, Ammar Yasser Abdulfattah, Bailey Warren, Kendall Langsten, Daniela Gonzalez, Randy Casals, Manish Bharadwaj, Steven Kridel, Neveen Said. Metabolomic credentialing of murine carcinogen-induced urothelial cancer.
Scientific reports.
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PloS one.
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Zhonghua yi xue za zhi.
2001 Oct; 81(20):1227-9. doi:
NULL. [PMID: 11825523] - Y Mori, A Koide, K Fuwa, H Wanibuchi, S Fukushima. Lack of change in the levels of liver and kidney cytochrome P-450 isozymes in p53+/- knockout mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
Mutagenesis.
2001 Sep; 16(5):377-83. doi:
10.1093/mutage/16.5.377. [PMID: 11507236] - A el-Marjou, A Delouvée, J P Thiery, F Radvanyi. Involvement of epidermal growth factor receptor in chemically induced mouse bladder tumour progression.
Carcinogenesis.
2000 Dec; 21(12):2211-8. doi:
10.1093/carcin/21.12.2211. [PMID: 11133810] - C Masuda, H Wanibuchi, K Sekine, Y Yano, S Otani, T Kishimoto, H Tsuda, S Fukushima. Chemopreventive effects of bovine lactoferrin on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced rat bladder carcinogenesis.
Japanese journal of cancer research : Gann.
2000 Jun; 91(6):582-8. doi:
10.1111/j.1349-7006.2000.tb00985.x. [PMID: 10874209] - E Kunze, H Schulz, M Adamek, H J Gabius. Long-term administration of galactoside-specific mistletoe lectin in an animal model: no protection against N-butyl-N-(4-hydroxybutyl)-nitrosamine-induced urinary bladder carcinogenesis in rats and no induction of a relevant local cellular immune response.
Journal of cancer research and clinical oncology.
2000 Mar; 126(3):125-38. doi:
10.1007/s004320050022. [PMID: 10741906] - Y Chone, T Kinouchi, T Yamada, Y Suzuki, K Kitaura, Z Jiao, T Minami, Y Bando, H Uehara, M Mochizuki, Y Ohnishi, K Izumi. Low susceptibility of Long-Evans Cinnamon rats to N-butyl-N-(4-hydroxybutyl)-nitrosamine-induced urinary bladder carcinogenesis and inhibitory effect of urinary copper.
Japanese journal of cancer research : Gann.
2000 Jan; 91(1):16-24. doi:
10.1111/j.1349-7006.2000.tb00855.x. [PMID: 10744040] - N Kimoto, M Hirose, M Kawabe, T Satoh, H Miyataka, T Shirai. Post-initiation effects of a super critical extract of propolis in a rat two-stage carcinogenesis model in female F344 rats.
Cancer letters.
1999 Dec; 147(1-2):221-7. doi:
10.1016/s0304-3835(99)00305-5. [PMID: 10660110] - M Hirose, S Fukushima, K Imaida, N Ito, T Shirai. Modifying effects of phytic acid and gamma-oryzanol on the promotion stage of rat carcinogenesis.
Anticancer research.
1999 Sep; 19(5A):3665-70. doi:
NULL. [PMID: 10625936] - E M Youssef, H Wanibuchi, S Mori, E I Salim, S Hayashi, S Fukushima. Elevation of urinary enzyme levels in rat bladder carcinogenesis.
Carcinogenesis.
1999 Jul; 20(7):1247-52. doi:
10.1093/carcin/20.7.1247. [PMID: 10383897] - S Kurashige, Y Akuzawa, F Endo. Effects of astragali radix extract on carcinogenesis, cytokine production, and cytotoxicity in mice treated with a carcinogen, N-butyl-N'-butanolnitrosoamine.
Cancer investigation.
1999; 17(1):30-5. doi:
10.1080/07357909909011714. [PMID: 10999046] - W Li, H Wanibuchi, E I Salim, S Yamamoto, K Yoshida, G Endo, S Fukushima. Promotion of NCI-Black-Reiter male rat bladder carcinogenesis by dimethylarsinic acid an organic arsenic compound.
Cancer letters.
1998 Dec; 134(1):29-36. doi:
10.1016/s0304-3835(98)00237-7. [PMID: 10381127] - K Ozaki, T Sukata, S Yamamoto, S Uwagawa, T Seki, H Kawasaki, A Yoshitake, H Wanibuchi, A Koide, Y Mori, S Fukushima. High susceptibility of p53(+/-) knockout mice in N-butyl-N-(4-hydroxybutyl)nitrosamine urinary bladder carcinogenesis and lack of frequent mutation in residual allele.
Cancer research.
1998 Sep; 58(17):3806-11. doi:
NULL. [PMID: 9731488] - G B Pliss, N N Vlasov, M G Iogannsen, A G Frolov. [A model of rat's urinary bladder tumor induced by subcutaneous injection of N-butyl-N-(4-hydroxybutyl)-nitrosamine].
Voprosy onkologii.
1998; 44(4):432-5. doi:
NULL. [PMID: 9807207] - S Mori, T Murai, M Hosono, S Machino, S Makino, C Chou, S Fukushima. Lack of promotion of urinary bladder carcinogenesis by sodium bicarbonate and/or L-ascorbic acid in male ODS/Shi-od/od rats synthesizing alpha 2 mu-globulin but not L-ascorbic acid.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
1997 Aug; 35(8):783-7. doi:
10.1016/s0278-6915(97)00048-3. [PMID: 9350223] - T Murai, S Mori, M Hosono, A Takashima, S Machino, T Oohara, H Yamashita, S Makino, T Matsuda, H Wanibuchi, S Fukushima. Strain differences in sensitivity to the promoting effect of sodium L-ascorbate in a two-stage rat urinary bladder carcinogenesis model.
Japanese journal of cancer research : Gann.
1997 Mar; 88(3):245-53. doi:
10.1111/j.1349-7006.1997.tb00374.x. [PMID: 9140108] - M Kitamura, N Konishi, Y Kitahori, Y Fukushima, N Yoshioka, Y Hiasa. Promoting effect of monosodium aspartate, but not glycine, on renal pelvis and urinary bladder carcinogenesis in rat induced by N-butyl-N-(4-hydroxybutyl)nitrosamine.
Toxicologic pathology.
1996 Sep; 24(5):573-9. doi:
10.1177/019262339602400506. [PMID: 8923678] - J Kimura, S Takahashi, T Ogiso, Y Yoshida, K Akagi, R Hasegawa, M Kurata, M Hirose, T Shirai. Lack of chemoprevention effects of the monoterpene d-limonene in a rat multi-organ carcinogenesis model.
Japanese journal of cancer research : Gann.
1996 Jun; 87(6):589-94. doi:
10.1111/j.1349-7006.1996.tb00264.x. [PMID: 8766522] - B Wu, H Watanabe, S Nakagawa, K Sugimoto. [Effect of BBN on the small intestine transplanted to the urinary bladder of rat].
Hinyokika kiyo. Acta urologica Japonica.
1995 Sep; 41(9):665-8. doi:
NULL. [PMID: 7484529] - K Akagi, M Hirose, T Hoshiya, Y Mizoguchi, N Ito, T Shirai. Modulating effects of ellagic acid, vanillin and quercetin in a rat medium term multi-organ carcinogenesis model.
Cancer letters.
1995 Jul; 94(1):113-21. doi:
10.1016/0304-3835(95)03833-i. [PMID: 7621439] - M Kitano, S Mori, T Chen, T Murai, S Fukushima. Lack of promoting effects of alpha-linolenic, linoleic or palmitic acid on urinary bladder carcinogenesis in rats.
Japanese journal of cancer research : Gann.
1995 Jun; 86(6):530-4. doi:
10.1111/j.1349-7006.1995.tb02430.x. [PMID: 7622416] - H Hojo, A Kaneko, N Kayagaki, M Saki, Y Hashimoto. Subcellular localization and characterization of interleukin-1 alpha produced by rat bladder cancer cells.
Immunology letters.
1994 Dec; 43(3):215-20. doi:
10.1016/0165-2478(94)90226-7. [PMID: 7721336] - A Hagiwara, H Tanaka, S Tamano, K Imaida, S Takahashi, S Fukushima. Inhibiting effects of diethylmaleate or NH4Cl on NaHCO3, but not butylated hydroxyanisole, promotion of urinary bladder carcinogenesis in male F344 rats initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
The Journal of toxicological sciences.
1994 Nov; 19(4):189-95. doi:
10.2131/jts.19.4_189. [PMID: 7884829] - S Mori, M Hosono, S Machino, S Nakai, S Makino, H Nakao, Y Takeuchi, R Takeda, T Murai, S Fukushima. Induction of the renal pelvic and ureteral carcinomas by N-butyl-N-(4-hydroxybutyl)nitrosamine in SD/cShi rats with spontaneous hydronephrosis.
Toxicologic pathology.
1994 Jul; 22(4):373-80. doi:
10.1177/019262339402200403. [PMID: 7817126] - K Takaba, M Hirose, K Ogawa, K Hakoi, S Fukushima. Modification of N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated urinary bladder carcinogenesis in rats by phytic acid and its salts.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
1994 Jun; 32(6):499-503. doi:
10.1016/0278-6915(94)90105-8. [PMID: 8045454] - T Murai, S Mori, M Hosono, Y Takeuchi, T Ohhara, S Makino, Y Hayashi, R Takeda, S Fukushima. Influences of aging and sex on renal pelvic carcinogenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine in NON/Shi mice.
Cancer letters.
1994 Jan; 76(2-3):147-53. doi:
10.1016/0304-3835(94)90391-3. [PMID: 8149343] - M Takashi, T Sakata, Y Nakano, Y Yamada, K Miyake, K Kato. Elevated concentrations of the beta-subunit of S100 protein in renal cell tumors in rats.
Urological research.
1994; 22(4):251-5. doi:
10.1007/bf00541902. [PMID: 7871639] - T Murai, S Mori, M Hosono, Y Takeuchi, T Oohara, S Makino, R Takeda, S Fukushima. Effect of phenacetin pretreatment on renal pelvic carcinogenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine in NON/Shi mice of both sexes.
Teratogenesis, carcinogenesis, and mutagenesis.
1994; 14(4):193-201. doi:
10.1002/tcm.1770140406. [PMID: 7992231] - M Hirose, T Hoshiya, K Akagi, S Takahashi, Y Hara, N Ito. Effects of green tea catechins in a rat multi-organ carcinogenesis model.
Carcinogenesis.
1993 Aug; 14(8):1549-53. doi:
10.1093/carcin/14.8.1549. [PMID: 8353840] - M Shibata, S Tamano, T Shirai, M Kawabe, S Fukushima. Inorganic alkalizers and acidifiers under conditions of high urinary Na+ or K+ on cell proliferation and two-stage carcinogenesis in the rat bladder.
Japanese journal of cancer research : Gann.
1992 Aug; 83(8):821-9. doi:
10.1111/j.1349-7006.1992.tb01986.x. [PMID: 1399819] - K Kudo, J Suwa. [Inhibitory effect of vitamin E on rats with bladder tumors induced by N-butyl-N-(4-hydroxybutyl) nitrosamine].
Hinyokika kiyo. Acta urologica Japonica.
1992 Apr; 38(4):399-404. doi:
NULL. [PMID: 1529812] - S Hashimoto. [Study on the effects of the hypocholesteremic agents, cholestyramine and compactin on the induction of renal tumors in rats by N-ethyl-N-hydroxyethyl nitrosamine].
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology.
1992 Jan; 83(1):75-84. doi:
10.5980/jpnjurol1989.83.75. [PMID: 1564828] - J W Rak, M Debiec-Rychter, F R Miller, C Y Wang. Cell line specific abnormalities in expression of PNA, SBA and L-PHA binding sites by carcinogen induced rat urothelial carcinomas.
Neoplasma.
1992; 39(3):141-6. doi:
". [PMID: 1528317] - T Murai, S Mori, M Hosono, Y Takeuchi, T Ohara, S Makino, R Takeda, Y Hayashi, S Fukushima. Renal pelvic carcinoma which shows metastatic potential to distant organs, induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in NON/Shi mice.
Japanese journal of cancer research : Gann.
1991 Dec; 82(12):1371-7. doi:
10.1111/j.1349-7006.1991.tb01808.x. [PMID: 1778760] - T Masui, A M Mann, T L Macatee, E M Garland, T Okamura, R A Smith, S M Cohen. Direct DNA sequencing of the rat neu oncogene transmembrane domain reveals no mutation in urinary bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl)nitrosamine, N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide or N-methyl-N-nitrosourea.
Carcinogenesis.
1991 Oct; 12(10):1975-8. doi:
10.1093/carcin/12.10.1975. [PMID: 1682063] - S Mori, T Murai, Y Takeuchi, M Hosono, T Ohhara, S Makino, Y Hayashi, M A Shibata, Y Kurata, A Hagiwara. No promotion of urinary bladder carcinogenesis by sodium L-ascorbate in male ODS/Shi-od/od rats lacking L-ascorbic acid-synthesizing ability.
Carcinogenesis.
1991 Oct; 12(10):1869-73. doi:
10.1093/carcin/12.10.1869. [PMID: 1934267] - M Okumura, T Shirai, M Asamoto, T Ogiso, S Fukushima. Lack of synergism in rat urinary tract carcinogenesis between prior uracil treatment and N-butyl-N-(4-hydroxybutyl)-nitrosamine administration.
Cancer letters.
1991 Jun; 58(1-2):81-5. doi:
10.1016/0304-3835(91)90027-f. [PMID: 2049787] - Y Homma, Y Kondo, T Kakizoe, Y Aso, S Nagase. Lack of bladder carcinogenicity of dietary sodium saccharin in analbuminaemic rats, which are highly susceptible to N-nitroso-n-butyl-(4-hydroxybutyl)amine.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
1991 Jun; 29(6):373-6. doi:
10.1016/0278-6915(91)90076-j. [PMID: 1874464] - S M Cohen, L B Ellwein, T Okamura, T Masui, S L Johansson, R A Smith, J M Wehner, M Khachab, C I Chappel, G P Schoenig. Comparative bladder tumor promoting activity of sodium saccharin, sodium ascorbate, related acids, and calcium salts in rats.
Cancer research.
1991 Apr; 51(7):1766-77. doi:
NULL. [PMID: 2004360] - P H Bach. A molecular basis for target-cell toxicity and upper urothelial carcinoma in analgesic abusers and patients with Balkan endemic nephropathy.
IARC scientific publications.
1991; ?(115):215-27. doi:
NULL. [PMID: 1820336] - M A Shibata, M Kagawa, M Kawabe, A Hagiwara, S Fukushima. Comparative promoting activities of phosphate salts on rat two-stage bladder carcinogenesis under conditions of equivalent urinary Na+ or K+ levels.
Teratogenesis, carcinogenesis, and mutagenesis.
1991; 11(6):305-16. doi:
10.1002/tcm.1770110604. [PMID: 1687839] - H Momose, K Uchida, H Kakinuma, Y Yura, R Oyasu. Involvement of urine in epithelial-stromal interactions in urinary bladder carcinogenesis.
Cancer letters.
1990 Sep; 53(2-3):91-6. doi:
10.1016/0304-3835(90)90199-8. [PMID: 2208083] - S Mori, T Murai, Y Takeuchi, M Toyama, S Makino, T Konishi, Y Hayashi, Y Kurata, S Fukushima. Dose response of N-butyl-N-(4-hydroxybutyl)nitrosamine on urinary bladder carcinogenesis in mutant ODS rats lacking L-ascorbic acid synthesizing ability.
Cancer letters.
1990 Feb; 49(2):139-45. doi:
10.1016/0304-3835(90)90150-v. [PMID: 2306707] - K Uchida, J Seidenfeld, A Rademaker, R Oyasu. Inhibitory action of alpha-difluoromethylornithine on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced rat urinary bladder carcinogenesis.
Cancer research.
1989 Oct; 49(19):5249-53. doi:
NULL. [PMID: 2504487] - B A Lina, R A Woutersen. Effects of urinary potassium and sodium ion concentrations and pH on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in rats.
Carcinogenesis.
1989 Sep; 10(9):1733-6. doi:
10.1093/carcin/10.9.1733. [PMID: 2548752]
