PK11195 (BioDeep_00001874367)
代谢物信息卡片
1-(2-CHLOROPHENYL)-N-METHYL-N-(1-METHYLPROPYL)-3-ISOQUINOLINECARBOXAMIDE
化学式: C21H21ClN2O (352.1342)
中文名称: PK-11195
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(C)N(C)C(=O)C1=CC2=CC=CC=C2C(=N1)C3=CC=CC=C3Cl
InChI: InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3
描述信息
D000970 - Antineoplastic Agents
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:73290
- PubChem: 1345
- ChEMBL: CHEMBL481537
- ChEMBL: CHEMBL15313
- CAS: 205934-46-9
- CAS: 85532-75-8
- CAS: 85340-56-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Laurent Bitker, François Dhelft, Sophie Lancelot, Didier Le Bars, Nicolas Costes, Nazim Benzerdjeb, Maciej Orkisz, Jean-Christophe Richard. Non-invasive quantification of acute macrophagic lung inflammation with [11C](R)-PK11195 using a three-tissue compartment kinetic model in experimental acute respiratory distress syndrome.
European journal of nuclear medicine and molecular imaging.
2022 Jun; 49(7):2122-2136. doi:
10.1007/s00259-022-05713-z. [PMID: 35129652] - Julia J Schubert, Mattia Veronese, Tim D Fryer, Roido Manavaki, Manfred G Kitzbichler, Maria A Nettis, Valeria Mondelli, Carmine M Pariante, Edward T Bullmore, Federico E Turkheimer. A Modest Increase in 11C-PK11195-Positron Emission Tomography TSPO Binding in Depression Is Not Associated With Serum C-Reactive Protein or Body Mass Index.
Biological psychiatry. Cognitive neuroscience and neuroimaging.
2021 07; 6(7):716-724. doi:
10.1016/j.bpsc.2020.12.017. [PMID: 33515765] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tom Dixon, Arzu Uyar, Shelagh Ferguson-Miller, Alex Dickson. Membrane-Mediated Ligand Unbinding of the PK-11195 Ligand from TSPO.
Biophysical journal.
2021 01; 120(1):158-167. doi:
10.1016/j.bpj.2020.11.015. [PMID: 33221248] - Zhuo-Wei Gao, Yu-Yun Huang, Jia-Qi Zhang, Jing-Yu Rong, Guan-Ying Qiao, Nan Chen, Guo-Dong Yu, Min Luo, Xiao-Fen Liu. Paeoniflorin elicits the anti-proliferative effects on glioma cell via targeting translocator protein 18 KDa.
Journal of pharmacological sciences.
2021 Jan; 145(1):115-121. doi:
10.1016/j.jphs.2020.10.004. [PMID: 33357769] - Seolsong Kim, Nayoun Kim, Seokjae Park, Yoonjeong Jeon, Jaemeun Lee, Seung-Jun Yoo, Ji-Won Lee, Cheil Moon, Seong-Woon Yu, Eun-Kyoung Kim. Tanycytic TSPO inhibition induces lipophagy to regulate lipid metabolism and improve energy balance.
Autophagy.
2020 07; 16(7):1200-1220. doi:
10.1080/15548627.2019.1659616. [PMID: 31469345] - Hana Manceau, Sophie D Lefevre, Arienne Mirmiran, Claude Hattab, Hugo R Sugier, Caroline Schmitt, Katell Peoc'h, Hervé Puy, Mariano A Ostuni, Laurent Gouya, Jean-Jacques Lacapere. TSPO2 translocates 5-aminolevulinic acid into human erythroleukemia cells.
Biology of the cell.
2020 Apr; 112(4):113-126. doi:
10.1111/boc.201900098. [PMID: 31989647] - Peter Parbo, Lasse Stensvig Madsen, Rola Ismail, Henrik Zetterberg, Kaj Blennow, Simon F Eskildsen, Thomas Vorup-Jensen, David J Brooks. Low plasma neurofilament light levels associated with raised cortical microglial activation suggest inflammation acts to protect prodromal Alzheimer's disease.
Alzheimer's research & therapy.
2020 01; 12(1):3. doi:
10.1186/s13195-019-0574-0. [PMID: 31898549] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Ye-Ha Jung, Hyeonjin Kim, So Yeon Jeon, Jeong Min Kwon, Won Joon Lee, Yong Chul Kim, Joon Hwan Jang, Soo-Hee Choi, Jun-Young Lee, Do-Hyung Kang. Brain Metabolites and Peripheral Biomarkers Associated with Neuroinflammation in Complex Regional Pain Syndrome Using [11C]-(R)-PK11195 Positron Emission Tomography and Magnetic Resonance Spectroscopy: A Pilot Study.
Pain medicine (Malden, Mass.).
2019 03; 20(3):504-514. doi:
10.1093/pm/pny111. [PMID: 29986072] - Zhi-Kun Qiu, Xu Liu, Dan Tang, Zhe Zhang, Qing-Hong Fan, Yun-Yun Pan, Ying-Yu Chen, Mei-Yan Huang, Tao Zhu, Yu-Lu Wang, Xiao-Fang Cheng, Ji-Sheng Chen. Cytoprotective effects of paeoniflorin are associated with translocator protein 18 kDa.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Nov; 107(?):19-23. doi:
10.1016/j.biopha.2018.07.112. [PMID: 30075369] - Barbara Costa, Chiara Cavallini, Eleonora Da Pozzo, Sabrina Taliani, Federico Da Settimo, Claudia Martini. The Anxiolytic Etifoxine Binds to TSPO Ro5-4864 Binding Site with Long Residence Time Showing a High Neurosteroidogenic Activity.
ACS chemical neuroscience.
2017 07; 8(7):1448-1454. doi:
10.1021/acschemneuro.7b00027. [PMID: 28362078] - J Yankam Njiwa, N Costes, C Bouillot, S Bouvard, S Fieux, G Becker, E Levigoureux, G Kocevar, C Stamile, J B Langlois, R Bolbos, C Bonnet, L Bezin, L Zimmer, A Hammers. Quantitative longitudinal imaging of activated microglia as a marker of inflammation in the pilocarpine rat model of epilepsy using [11C]-( R)-PK11195 PET and MRI.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2017 Apr; 37(4):1251-1263. doi:
10.1177/0271678x16653615. [PMID: 27381824] - Renee Sokias, Eryn L Werry, Sook W Chua, Tristan A Reekie, Lenka Munoz, Erick C N Wong, Lars M Ittner, Michael Kassiou. Determination and reduction of translocator protein (TSPO) ligand rs6971 discrimination.
MedChemComm.
2017 Jan; 8(1):202-210. doi:
10.1039/c6md00523c. [PMID: 30108706] - Zhi-Kun Qiu, Jia-Li He, Xu Liu, Guan-Hua Zhang, Jia Zeng, Hong Nie, Yong-Gang Shen, Ji-Sheng Chen. The antidepressant-like activity of AC-5216, a ligand for 18KDa translocator protein (TSPO), in an animal model of diabetes mellitus.
Scientific reports.
2016 11; 6(?):37345. doi:
10.1038/srep37345. [PMID: 27886206] - Barbara Costa, Eleonora Da Pozzo, Chiara Cavallini, Sabrina Taliani, Federico Da Settimo, Claudia Martini. Long Residence Time at the Neurosteroidogenic 18 kDa Translocator Protein Characterizes the Anxiolytic Ligand XBD173.
ACS chemical neuroscience.
2016 08; 7(8):1041-6. doi:
10.1021/acschemneuro.6b00149. [PMID: 27385308] - Andrea Parente, Paula Kopschina Feltes, David Vállez García, Jurgen W A Sijbesma, Cristina M Moriguchi Jeckel, Rudi A J O Dierckx, Erik F J de Vries, Janine Doorduin. Pharmacokinetic Analysis of 11C-PBR28 in the Rat Model of Herpes Encephalitis: Comparison with (R)-11C-PK11195.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2016 May; 57(5):785-91. doi:
10.2967/jnumed.115.165019. [PMID: 26823567] - Li-Ming Zhang, Zhi-Kun Qiu, Xiao-Fei Chen, Nan Zhao, Hong-Xia Chen, Rui- Xue, You-Zhi Zhang, Ri-Fang Yang, Yun-Feng Li. Involvement of allopregnanolone in the anti-PTSD-like effects of AC-5216.
Journal of psychopharmacology (Oxford, England).
2016 05; 30(5):474-81. doi:
10.1177/0269881115625115. [PMID: 26783231] - Zhuo-Wei Gao, Jing-Bin Huang, Qing Lin, Qiang Qin, Yao-Jun Liang, Lu Zhou, Min Luo. The effects of PK11195 on meningioma was associated with allopregnanolone biosynthesis, which was mediated by translocator protein 18 KDa.
Cancer biomarkers : section A of Disease markers.
2016; 16(1):65-9. doi:
10.3233/cbm-150541. [PMID: 26835706] - Xiaoming Liu, Hongjun Liu, Shuangshuang Xu, Zongxiang Tang, Weiliang Xia, Zhuqiang Cheng, Weiyan Li, Yi Jin. Spinal translocator protein alleviates chronic neuropathic pain behavior and modulates spinal astrocyte-neuronal function in rats with L5 spinal nerve ligation model.
Pain.
2016 Jan; 157(1):103-116. doi:
10.1097/j.pain.0000000000000339. [PMID: 26307860] - Federico E Turkheimer, Gaia Rizzo, Peter S Bloomfield, Oliver Howes, Paolo Zanotti-Fregonara, Alessandra Bertoldo, Mattia Veronese. The methodology of TSPO imaging with positron emission tomography.
Biochemical Society transactions.
2015 Aug; 43(4):586-92. doi:
10.1042/bst20150058. [PMID: 26551697] - Kentaro Hatano, Katsuhiko Sekimata, Takashi Yamada, Junichiro Abe, Kengo Ito, Mikako Ogawa, Yasuhiro Magata, Jun Toyohara, Kiichi Ishiwata, Giovanni Biggio, Mariangela Serra, Valentino Laquintana, Nunzio Denora, Andrea Latrofa, Giuseppe Trapani, Gaetano Liso, Hiromi Suzuki, Makoto Sawada, Masahiko Nomura, Hiroshi Toyama. Radiosynthesis and in vivo evaluation of two imidazopyridineacetamides, [(11)C]CB184 and [ (11)C]CB190, as a PET tracer for 18 kDa translocator protein: direct comparison with [ (11)C](R)-PK11195.
Annals of nuclear medicine.
2015 May; 29(4):325-35. doi:
10.1007/s12149-015-0948-8. [PMID: 25616581] - Samuel D Banister, Corinne Beinat, Shane M Wilkinson, Bin Shen, Cecilia Bartoli, Silvia Selleri, Eleonora Da Pozzo, Claudia Martini, Frederick T Chin, Michael Kassiou. Ether analogues of DPA-714 with subnanomolar affinity for the translocator protein (TSPO).
European journal of medicinal chemistry.
2015 Mar; 93(?):392-400. doi:
10.1016/j.ejmech.2015.02.004. [PMID: 25725375] - Caterina Vicidomini, Mariarosaria Panico, Adelaide Greco, Sara Gargiulo, Anna Rita Daniela Coda, Antonella Zannetti, Matteo Gramanzini, Giovanni N Roviello, Mario Quarantelli, Bruno Alfano, Bertrand Tavitian, Frederic Dollé, Marco Salvatore, Arturo Brunetti, Sabina Pappatà. In vivo imaging and characterization of [(18)F]DPA-714, a potential new TSPO ligand, in mouse brain and peripheral tissues using small-animal PET.
Nuclear medicine and biology.
2015 Mar; 42(3):309-16. doi:
10.1016/j.nucmedbio.2014.11.009. [PMID: 25537727] - Bartholomeus C M Benno Haarman, Rixt F Riemersma-Van der Lek, Jan Cees de Groot, Henricus G Eric Ruhé, Hans C Klein, Tjitske E Zandstra, Huibert Burger, Robert A Schoevers, Erik F J de Vries, Hemmo A Drexhage, Willem A Nolen, Janine Doorduin. Neuroinflammation in bipolar disorder - A [(11)C]-(R)-PK11195 positron emission tomography study.
Brain, behavior, and immunity.
2014 Aug; 40(?):219-25. doi:
10.1016/j.bbi.2014.03.016. [PMID: 24703991] - Sabrina Castellano, Sabrina Taliani, Monica Viviano, Ciro Milite, Eleonora Da Pozzo, Barbara Costa, Elisabetta Barresi, Agostino Bruno, Sandro Cosconati, Luciana Marinelli, Giovanni Greco, Ettore Novellino, Gianluca Sbardella, Federico Da Settimo, Claudia Martini. Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors.
Journal of medicinal chemistry.
2014 Mar; 57(6):2413-28. doi:
10.1021/jm401721h. [PMID: 24580635] - Claire R Hatty, Anton P Le Brun, Vanessa Lake, Luke A Clifton, Guo Jun Liu, Michael James, Richard B Banati. Investigating the interactions of the 18kDa translocator protein and its ligand PK11195 in planar lipid bilayers.
Biochimica et biophysica acta.
2014 Mar; 1838(3):1019-30. doi:
10.1016/j.bbamem.2013.12.013. [PMID: 24374318] - Tao Chen, Elizabeth M Laurenzana, Denise M Coslo, Fengming Chen, Curtis J Omiecinski. Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor.
The Biochemical journal.
2014 Feb; 458(1):95-107. doi:
10.1042/bj20130685. [PMID: 24224465] - Beatriz Caballero, Leo Veenman, Julia Bode, Svetlana Leschiner, Moshe Gavish. Concentration-dependent bimodal effect of specific 18 kDa translocator protein (TSPO) ligands on cell death processes induced by ammonium chloride: potential implications for neuropathological effects due to hyperammonemia.
CNS & neurological disorders drug targets.
2014; 13(4):574-92. doi:
10.2174/18715273113126660194. [PMID: 24168369] - Maqsood Yaqub, Bart N M van Berckel, Alie Schuitemaker, Rainer Hinz, Federico E Turkheimer, Giampaolo Tomasi, Adriaan A Lammertsma, Ronald Boellaard. Optimization of supervised cluster analysis for extracting reference tissue input curves in (R)-[(11)C]PK11195 brain PET studies.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2012 Aug; 32(8):1600-8. doi:
10.1038/jcbfm.2012.59. [PMID: 22588187] - L Veenman, M Gavish. The role of 18 kDa mitochondrial translocator protein (TSPO) in programmed cell death, and effects of steroids on TSPO expression.
Current molecular medicine.
2012 May; 12(4):398-412. doi:
10.2174/1566524011207040398. [PMID: 22348610] - Lucy J Garvey, Nicola Pavese, Anil Ramlackhansingh, Emma Thomson, Joanna M Allsop, Marios Politis, Ranjababu Kulasegaram, Janice Main, David J Brooks, Simon D Taylor-Robinson, Alan Winston. Acute HCV/HIV coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation.
PloS one.
2012; 7(7):e38980. doi:
10.1371/journal.pone.0038980. [PMID: 22808022] - Katsushi Kumata, Joji Yui, Akiko Hatori, Masayuki Fujinaga, Kazuhiko Yanamoto, Tomoteru Yamasaki, Kazunori Kawamura, Hidekatsu Wakizaka, Nobuki Nengaki, Yuichiro Yoshida, Masanao Ogawa, Toshimitsu Fukumura, Ming-Rong Zhang. Synthesis and evaluation of novel carbon-11 labeled oxopurine analogues for positron emission tomography imaging of translocator protein (18 kDa) in peripheral organs.
Journal of medicinal chemistry.
2011 Sep; 54(17):6040-9. doi:
10.1021/jm200516a. [PMID: 21790126] - C A Frye, J J Paris. Progesterone turnover to its 5α-reduced metabolites in the ventral tegmental area of the midbrain is essential for initiating social and affective behavior and progesterone metabolism in female rats.
Journal of endocrinological investigation.
2011 Jul; 34(7):e188-99. doi:
10.3275/7334. [PMID: 21060252] - Victor W Pike, Sabrina Taliani, Talakad G Lohith, David R J Owen, Isabella Pugliesi, Eleonora Da Pozzo, Jinsoo Hong, Sami S Zoghbi, Roger N Gunn, Christine A Parker, Eugenii A Rabiner, Masahiro Fujita, Robert B Innis, Claudia Martini, Federico Da Settimo. Evaluation of novel N1-methyl-2-phenylindol-3-ylglyoxylamides as a new chemotype of 18 kDa translocator protein-selective ligand suitable for the development of positron emission tomography radioligands.
Journal of medicinal chemistry.
2011 Jan; 54(1):366-73. doi:
10.1021/jm101230g. [PMID: 21133364] - Frederic Lamare, Rainer Hinz, Oliver Gaemperli, Francesca Pugliese, Justin C Mason, Terence Spinks, Paolo G Camici, Ornella E Rimoldi. Detection and quantification of large-vessel inflammation with 11C-(R)-PK11195 PET/CT.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2011 Jan; 52(1):33-9. doi:
10.2967/jnumed.110.079038. [PMID: 21149475] - Mariano A Ostuni, Leeyah Issop, Gabriel Péranzi, Francine Walker, Magali Fasseu, Carole Elbim, Vassilios Papadopoulos, Jean-Jacques Lacapere. Overexpression of translocator protein in inflammatory bowel disease: potential diagnostic and treatment value.
Inflammatory bowel diseases.
2010 Sep; 16(9):1476-87. doi:
10.1002/ibd.21250. [PMID: 20222126] - Joji Yui, Jun Maeda, Katsushi Kumata, Kazunori Kawamura, Kazuhiko Yanamoto, Akiko Hatori, Tomoteru Yamasaki, Nobuki Nengaki, Makoto Higuchi, Ming-Rong Zhang. 18F-FEAC and 18F-FEDAC: PET of the monkey brain and imaging of translocator protein (18 kDa) in the infarcted rat brain.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2010 Aug; 51(8):1301-9. doi:
10.2967/jnumed.109.072223. [PMID: 20660373] - Pauliina Luoto, Iina Laitinen, Sami Suilamo, Kjell Någren, Anne Roivainen. Human dosimetry of carbon-11 labeled N-butan-2-yl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide extrapolated from whole-body distribution kinetics and radiometabolism in rats.
Molecular imaging and biology.
2010 Aug; 12(4):435-42. doi:
10.1007/s11307-009-0293-1. [PMID: 19941083] - William C Kreisl, Masahiro Fujita, Yota Fujimura, Nobuyo Kimura, Kimberly J Jenko, Pavitra Kannan, Jinsoo Hong, Cheryl L Morse, Sami S Zoghbi, Robert L Gladding, Steven Jacobson, Unsong Oh, Victor W Pike, Robert B Innis. Comparison of [(11)C]-(R)-PK 11195 and [(11)C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarker.
NeuroImage.
2010 Feb; 49(4):2924-32. doi:
10.1016/j.neuroimage.2009.11.056. [PMID: 19948230] - Kevin N Boyd, Sandeep Kumar, Todd K O'Buckley, Patrizia Porcu, A Leslie Morrow. Ethanol induction of steroidogenesis in rat adrenal and brain is dependent upon pituitary ACTH release and de novo adrenal StAR synthesis.
Journal of neurochemistry.
2010 Feb; 112(3):784-96. doi:
10.1111/j.1471-4159.2009.06509.x. [PMID: 20021565] - M Sakai, V Ferraz-de-Paula, M L Pinheiro, A Ribeiro, W M Quinteiro-Filho, M B Rone, D B Martinez-Arguelles, M L Z Dagli, V Papadopoulos, J Palermo-Neto. Translocator protein (18 kDa) mediates the pro-growth effects of diazepam on Ehrlich tumor cells in vivo.
European journal of pharmacology.
2010 Jan; 626(2-3):131-8. doi:
10.1016/j.ejphar.2009.09.036. [PMID: 19782064] - Ajay Kumar, Otto Muzik, Diane Chugani, Pulak Chakraborty, Harry T Chugani. PET-derived biodistribution and dosimetry of the benzodiazepine receptor-binding radioligand (11)C-(R)-PK11195 in children and adults.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2010 Jan; 51(1):139-44. doi:
10.2967/jnumed.109.066472. [PMID: 20008990] - R Nagler, D Savulescu, Ella Krayzler, S Leschiner, L Veenman, M Gavish. Cigarette Smoke Decreases Salivary 18 kDa Translocator Protein Binding Affinity – in Association with Oxidative Stress.
Current medicinal chemistry.
2010; 17(23):2539-46. doi:
10.2174/092986710791556050. [PMID: 20491643] - A L Bartels, A T M Willemsen, J Doorduin, E F J de Vries, R A Dierckx, K L Leenders. [11C]-PK11195 PET: quantification of neuroinflammation and a monitor of anti-inflammatory treatment in Parkinson's disease?.
Parkinsonism & related disorders.
2010 Jan; 16(1):57-9. doi:
10.1016/j.parkreldis.2009.05.005. [PMID: 19487152] - Yasuomi Ouchi, Shunsuke Yagi, Masamichi Yokokura, Masanobu Sakamoto. Neuroinflammation in the living brain of Parkinson's disease.
Parkinsonism & related disorders.
2009 Dec; 15 Suppl 3(?):S200-4. doi:
10.1016/s1353-8020(09)70814-4. [PMID: 20082990] - M A Kropholler, R Boellaard, E H Elzinga, C J van der Laken, K Maruyama, R W Kloet, A E Voskuyl, B A C Dijkmans, A A Lammertsma. Quantification of (R)-[11C]PK11195 binding in rheumatoid arthritis.
European journal of nuclear medicine and molecular imaging.
2009 Apr; 36(4):624-31. doi:
10.1007/s00259-008-0987-7. [PMID: 19043704] - Anne Roivainen, Kjell Någren, Jussi Hirvonen, Vesa Oikonen, Pauliina Virsu, Tuula Tolvanen, Juha O Rinne. Whole-body distribution and metabolism of [N-methyl-11C](R)-1-(2-chlorophenyl)-N-(1-methylpropyl)-3-isoquinolinecarboxamide in humans; an imaging agent for in vivo assessment of peripheral benzodiazepine receptor activity with positron emission tomography.
European journal of nuclear medicine and molecular imaging.
2009 Apr; 36(4):671-82. doi:
10.1007/s00259-008-1000-1. [PMID: 19050880] - Federico Da Settimo, Francesca Simorini, Sabrina Taliani, Concettina La Motta, Anna Maria Marini, Silvia Salerno, Marusca Bellandi, Ettore Novellino, Giovanni Greco, Barbara Cosimelli, Eleonora Da Pozzo, Barbara Costa, Nicola Simola, Micaela Morelli, Claudia Martini. Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis.
Journal of medicinal chemistry.
2008 Sep; 51(18):5798-806. doi:
10.1021/jm8003224. [PMID: 18729350] - Weiping Yu, Eric Wang, Ronald J Voll, Andrew H Miller, Mark M Goodman. Synthesis, fluorine-18 radiolabeling, and in vitro characterization of 1-iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivatives as potential PET radioligands for imaging peripheral benzodiazepine receptor.
Bioorganic & medicinal chemistry.
2008 Jun; 16(11):6145-55. doi:
10.1016/j.bmc.2008.04.046. [PMID: 18472268] - Vincenzo Micale, Giovanni Scapagnini, Claudia Colombrita, Carmen Mazzola, Daniel L Alkon, Filippo Drago. Behavioral effects of dietary cholesterol in rats tested in experimental models of mild stress and cognition tasks.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2008 Jun; 18(6):462-71. doi:
10.1016/j.euroneuro.2007.11.006. [PMID: 18222653] - Chao Ji, Yun Yue, Sen-Yang Lang, Nan Yang, Yan-Yong Liu, Qin-Sheng Ge, Ping-Ping Zuo. Effects of long-term low-dose hormone replacement therapy on the binding capacity of platelet peripheral-type benzodiazepine receptor in postmenopausal women.
Psychoneuroendocrinology.
2008 Jun; 33(5):670-5. doi:
10.1016/j.psyneuen.2008.02.007. [PMID: 18378096] - Katsuhiko Sekimata, Kentaro Hatano, Mikako Ogawa, Junichiro Abe, Yasuhiro Magata, Giovanni Biggio, Mariangela Serra, Valentino Laquintana, Nunzio Denora, Andrea Latrofa, Giuseppe Trapani, Gaetano Liso, Kengo Ito. Radiosynthesis and in vivo evaluation of N-[11C]methylated imidazopyridineacetamides as PET tracers for peripheral benzodiazepine receptors.
Nuclear medicine and biology.
2008 Apr; 35(3):327-34. doi:
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Synapse (New York, N.Y.).
2008 Apr; 62(4):253-8. doi:
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Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2007 Dec; 48(12):2072-9. doi:
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Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2007 Dec; 27(12):1965-74. doi:
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Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2007 Sep; 27(9):1603-15. doi:
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Neuropharmacology.
2007 Aug; 53(2):318-29. doi:
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NeuroImage.
2007 May; 35(4):1473-9. doi:
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Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2007 Jan; 48(1):158-67. doi:
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Nuclear medicine and biology.
2006 Nov; 33(8):971-5. doi:
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Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2006 Nov; 26(11):1431-41. doi:
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Nuclear medicine and biology.
2006 Aug; 33(6):797-800. doi:
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Journal of neurovirology.
2006 Aug; 12(4):262-71. doi:
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Bioorganic & medicinal chemistry.
2006 Jun; 14(12):4055-66. doi:
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Bioorganic & medicinal chemistry.
2006 Jun; 14(11):3938-46. doi:
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Journal of medicinal chemistry.
2006 May; 49(9):2735-42. doi:
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Biochemical pharmacology.
2006 Feb; 71(4):472-8. doi:
10.1016/j.bcp.2005.10.046. [PMID: 16376309] - Marc Verleye, Yvette Akwa, Philippe Liere, Nathalie Ladurelle, Antoine Pianos, Bernard Eychenne, Michael Schumacher, Jean-Marie Gillardin. The anxiolytic etifoxine activates the peripheral benzodiazepine receptor and increases the neurosteroid levels in rat brain.
Pharmacology, biochemistry, and behavior.
2005 Dec; 82(4):712-20. doi:
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Blood.
2005 Nov; 106(10):3584-93. doi:
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The Journal of pharmacology and experimental therapeutics.
2005 Nov; 315(2):658-67. doi:
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Neurobiology of disease.
2005 Nov; 20(2):550-61. doi:
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Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2005 Jul; 25(7):842-51. doi:
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Bioorganic & medicinal chemistry letters.
2005 Feb; 15(3):733-6. doi:
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Journal of medicinal chemistry.
2005 Jan; 48(1):292-305. doi:
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Journal of medicinal chemistry.
2004 Apr; 47(9):2228-35. doi:
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Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2004 Feb; 137(2):197-206. doi:
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European journal of pharmacology.
2003 Oct; 478(2-3):97-104. doi:
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Bioconjugate chemistry.
2003 Jul; 14(4):830-9. doi:
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The European respiratory journal.
2003 Apr; 21(4):567-73. doi:
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Nuclear medicine and biology.
2003 Feb; 30(2):199-206. doi:
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Photochemistry and photobiology.
2002 Jul; 76(1):91-7. doi:
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Photochemistry and photobiology.
2002 Jun; 75(6):652-61. doi:
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Bioorganic & medicinal chemistry.
2001 Oct; 9(10):2661-71. doi:
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Biochemistry.
2001 Aug; 40(34):10213-22. doi:
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British journal of pharmacology.
2001 Aug; 133(8):1355-61. doi:
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Cancer chemotherapy and pharmacology.
2001 Aug; 48(2):169-76. doi:
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Pharmacology.
2001 Jul; 63(1):42-9. doi:
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Biochemical and biophysical research communications.
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Immunopharmacology and immunotoxicology.
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Life sciences.
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2000 Sep; 109(2):105-11. doi:
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Neuropharmacology.
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European journal of nuclear medicine.
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Psychopharmacology.
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