Aurintricarboxylic acid (BioDeep_00001874227)

   


代谢物信息卡片


Aurintricarboxylic acid

化学式: C22H14O9 (422.06377940000004)
中文名称: 金黄三羧酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=C(C=C1C(=C2C=CC(=O)C(=C2)C(=O)O)C3=CC(=C(C=C3)O)C(=O)O)C(=O)O)O
InChI: InChI=1S/C22H14O9/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31/h1-9,23-24H,(H,26,27)(H,28,29)(H,30,31)

描述信息

Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC50s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively[1]. Aurintricarboxylic acid is a potent anti-influenza agent by directly inhibiting the neuraminidase[2]. Aurintricarboxylic acid is an inhibitor of topoisomerase II and apoptosis[3]. Aurintricarboxylic acid is a selective inhibitor of the TWEAK-Fn14 signaling pathway[4]. Aurintricarboxylic acid also acts as a cystathionine-lyase (CSE) inhibitor with an IC50 of 0.6 μM[5]. Aurintricarboxylic acid is a modifier of miRNAs that regulate miRNA function, with an IC50 of 0.47 μM[6].

同义名列表

1 个代谢物同义名

Aurintricarboxylic acid



数据库引用编号

6 个数据库交叉引用编号

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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

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INOH(0)

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Berta Canal, Allison W McClure, Joseph F Curran, Mary Wu, Rachel Ulferts, Florian Weissmann, Jingkun Zeng, Agustina P Bertolin, Jennifer C Milligan, Souradeep Basu, Lucy S Drury, Tom D Deegan, Ryo Fujisawa, Emma L Roberts, Clovis Basier, Karim Labib, Rupert Beale, Michael Howell, John F X Diffley. Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease. The Biochemical journal. 2021 07; 478(13):2445-2464. doi: 10.1042/bcj20210198. [PMID: 34198326]
  • Alon Ben David, Eran Diamant, Eyal Dor, Ada Barnea, Niva Natan, Lilach Levin, Shira Chapman, Lilach Cherry Mimran, Eyal Epstein, Ran Zichel, Amram Torgeman. Identification of SARS-CoV-2 Receptor Binding Inhibitors by In Vitro Screening of Drug Libraries. Molecules (Basel, Switzerland). 2021 May; 26(11):. doi: 10.3390/molecules26113213. [PMID: 34072087]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • J Riegger, M Huber-Lang, R E Brenner. Crucial role of the terminal complement complex in chondrocyte death and hypertrophy after cartilage trauma. Osteoarthritis and cartilage. 2020 05; 28(5):685-697. doi: 10.1016/j.joca.2020.01.004. [PMID: 31981738]
  • Youtian Hu, Lu Wang, Xu Han, Yueyang Zhou, Tonghui Zhang, Li Wang, Ting Hong, Wei Zhang, Xun-Xiang Guo, Jielin Sun, Yingxin Qi, Jing Yu, Hong Liu, Fang Wu. Discovery of a Bioactive Inhibitor with a New Scaffold for Cystathionine γ-Lyase. Journal of medicinal chemistry. 2019 02; 62(3):1677-1683. doi: 10.1021/acs.jmedchem.8b01720. [PMID: 30562026]
  • Ramanjit Kaur, Rajat Mudgal, Manju Narwal, Shailly Tomar. Development of an ELISA assay for screening inhibitors against divalent metal ion dependent alphavirus capping enzyme. Virus research. 2018 09; 256(?):209-218. doi: 10.1016/j.virusres.2018.06.013. [PMID: 29958924]
  • Sophronia Lewis, Robert Little, Florence Baudoin, Sukhpal Prehar, Ludwig Neyses, Elizabeth J Cartwright, Clare Austin. Acute inhibition of PMCA4, but not global ablation, reduces blood pressure and arterial contractility via a nNOS-dependent mechanism. Journal of cellular and molecular medicine. 2018 02; 22(2):861-872. doi: 10.1111/jcmm.13371. [PMID: 29193716]
  • Sathishkumar Kurusamy, Dolores López-Maderuelo, Robert Little, David Cadagan, Aaron M Savage, Jude C Ihugba, Rhiannon R Baggott, Farjana B Rowther, Sara Martínez-Martínez, Pablo Gómez-Del Arco, Clare Murcott, Weiguang Wang, J Francisco Nistal, Delvac Oceandy, Ludwig Neyses, Robert N Wilkinson, Elizabeth J Cartwright, Juan Miguel Redondo, Angel Luis Armesilla. Selective inhibition of plasma membrane calcium ATPase 4 improves angiogenesis and vascular reperfusion. Journal of molecular and cellular cardiology. 2017 08; 109(?):38-47. doi: 10.1016/j.yjmcc.2017.07.001. [PMID: 28684310]
  • Tamer M A Mohamed, Riham Abou-Leisa, Nicholas Stafford, Arfa Maqsood, Min Zi, Sukhpal Prehar, Florence Baudoin-Stanley, Xin Wang, Ludwig Neyses, Elizabeth J Cartwright, Delvac Oceandy. The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy. Nature communications. 2016 Mar; 7(?):11074. doi: 10.1038/ncomms11074. [PMID: 27020607]
  • Moonhee Lee, Matthew Wathier, Jennifer A Love, Edith McGeer, Patrick L McGeer. Inhibition of aberrant complement activation by a dimer of acetylsalicylic acid. Neurobiology of aging. 2015 Oct; 36(10):2748-56. doi: 10.1016/j.neurobiolaging.2015.06.018. [PMID: 26248865]
  • Timo Wille, Horst Thiermann, Franz Worek. In vitro kinetics of nerve agent degradation by fresh frozen plasma (FFP). Archives of toxicology. 2014 Feb; 88(2):301-7. doi: 10.1007/s00204-013-1130-5. [PMID: 24057572]
  • Moonhee Lee, Sujaatha Narayanan, Edith G McGeer, Patrick L McGeer. Aurin tricarboxylic acid protects against red blood cell hemolysis in patients with paroxysmal nocturnal hemoglobinemia. PloS one. 2014; 9(1):e87316. doi: 10.1371/journal.pone.0087316. [PMID: 24489894]
  • Tamer M A Mohamed, Riham Abou-Leisa, Florence Baudoin, Nicholas Stafford, Ludwig Neyses, Elizabeth J Cartwright, Delvac Oceandy. Development and characterization of a novel fluorescent indicator protein PMCA4-GCaMP2 in cardiomyocytes. Journal of molecular and cellular cardiology. 2013 Oct; 63(?):57-68. doi: 10.1016/j.yjmcc.2013.07.007. [PMID: 23880607]
  • Tsung-Yih Lee, Wen-Shin Chen, Yung-An Huang, Ting-Wei Liu, Eric Hwang, Ching-Ping Tseng. Application of aurintricarboxylic acid for the adherence of mouse P19 neurons and primary hippocampal neurons to noncoated surface in serum-free culture. Biotechnology progress. 2012 Nov; 28(6):1566-74. doi: 10.1002/btpr.1638. [PMID: 23011767]
  • Munmun Bardhan, Tapas Misra, Tapan Ganguly. Quantization of bovine serum albumin by fluorescence enhancement effects and corresponding binding of macrocyclic host-protein assembly. Journal of photochemistry and photobiology. B, Biology. 2012 Jan; 106(?):113-9. doi: 10.1016/j.jphotobiol.2011.10.014. [PMID: 22115956]
  • Yerim Kwon, Si-In Yu, Hyoungseok Lee, Joung Han Yim, Jian-Kang Zhu, Byeong-Ha Lee. Arabidopsis serine decarboxylase mutants implicate the roles of ethanolamine in plant growth and development. International journal of molecular sciences. 2012; 13(3):3176-3188. doi: 10.3390/ijms13033176. [PMID: 22489147]
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  • Munmun Bardhan, Joydeep Chowdhury, Tapan Ganguly. Investigations on the interactions of aurintricarboxylic acid with bovine serum albumin: Steady state/time resolved spectroscopic and docking studies. Journal of photochemistry and photobiology. B, Biology. 2011 Jan; 102(1):11-9. doi: 10.1016/j.jphotobiol.2010.08.011. [PMID: 20863713]
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  • Anwar M Hashem, Anathea S Flaman, Aaron Farnsworth, Earl G Brown, Gary Van Domselaar, Runtao He, Xuguang Li. Aurintricarboxylic acid is a potent inhibitor of influenza A and B virus neuraminidases. PloS one. 2009 Dec; 4(12):e8350. doi: 10.1371/journal.pone.0008350. [PMID: 20020057]
  • Mohamad-Hadi Karbasi, Babak Jahanparast, Mojtaba Shamsipur, Jalal Hassan. Simultaneous trace multielement determination by ICP-OES after solid phase extraction with modified octadecyl silica gel. Journal of hazardous materials. 2009 Oct; 170(1):151-5. doi: 10.1016/j.jhazmat.2009.04.119. [PMID: 19487077]
  • Sini Junttila, Kean-Jin Lim, Stephen Rudd. Optimization and comparison of different methods for RNA isolation for cDNA library construction from the reindeer lichen Cladonia rangiferina. BMC research notes. 2009 Oct; 2(?):204. doi: 10.1186/1756-0500-2-204. [PMID: 19804636]
  • Huan-Xin Jiang, Ning Tang, Jin-Gui Zheng, Li-Song Chen. Antagonistic actions of boron against inhibitory effects of aluminum toxicity on growth, CO2 assimilation, ribulose-1,5-bisphosphate carboxylase/oxygenase, and photosynthetic electron transport probed by the JIP-test, of Citrus grandis seedlings. BMC plant biology. 2009 Aug; 9(?):102. doi: 10.1186/1471-2229-9-102. [PMID: 19646270]
  • Kenji Hayata, Takayuki Nakayama, Tadashi Matsushita, Katsuichi Sakano. A new binding assay of von Willebrand factor and glycoprotein Ib using solid-phase biotinylated platelets. Journal of pharmacological sciences. 2008 Oct; 108(2):217-21. doi: 10.1254/jphs.08147sc. [PMID: 18845909]
  • Laura Piccagli, Enrica Fabbri, Monica Borgatti, Valentino Bezzerri, Irene Mancini, Elena Nicolis, Maria C Dechecchi, Ilaria Lampronti, Giulio Cabrini, Roberto Gambari. Docking of molecules identified in bioactive medicinal plants extracts into the p50 NF-kappaB transcription factor: correlation with inhibition of NF-kappaB/DNA interactions and inhibitory effects on IL-8 gene expression. BMC structural biology. 2008 Sep; 8(?):38. doi: 10.1186/1472-6807-8-38. [PMID: 18768082]
  • Hyun Kyung Kim, Ji-Eun Kim, Hyun Cho Wi, Sang Woo Lee, Ji Yeon Kim, Hee Jung Kang, Young Tae Kim. Aurintricarboxylic acid inhibits endothelial activation, complement activation, and von Willebrand factor secretion in vitro and attenuates hyperacute rejection in an ex vivo model of pig-to-human pulmonary xenotransplantation. Xenotransplantation. 2008 Jul; 15(4):246-56. doi: 10.1111/j.1399-3089.2008.00481.x. [PMID: 18957047]
  • Hyun Kyung Kim, Ji-Eun Kim, Junho Chung, Young Tae Kim, Seong-Ho Kang, Kyou-Sup Han, Han-Ik Cho. Lipopolysaccharide down-regulates the thrombomodulin expression of peripheral blood monocytes: effect of serum on thrombomodulin expression in the THP-1 monocytic cell line. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 2007 Mar; 18(2):157-64. doi: 10.1097/mbc.0b013e32801481cb. [PMID: 17287633]
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  • Miriam Galbusera, Simona Buelli, Sara Gastoldi, Daniela Macconi, Stefania Angioletti, Cristian Testa, Giuseppe Remuzzi, Marina Morigi. Activation of porcine endothelium in response to xenogeneic serum causes thrombosis independently of platelet activation. Xenotransplantation. 2005 Mar; 12(2):110-20. doi: 10.1111/j.1399-3089.2005.00203.x. [PMID: 15693841]
  • Roberta Foresti, Martha Hoque, Diego Monti, Colin J Green, Roberto Motterlini. Differential activation of heme oxygenase-1 by chalcones and rosolic acid in endothelial cells. The Journal of pharmacology and experimental therapeutics. 2005 Feb; 312(2):686-93. doi: 10.1124/jpet.104.074153. [PMID: 15537827]
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  • Hyeongjin Cho, Dong Yoon Lee, Suja Shrestha, Yi Sup Shim, Ki Chul Kim, Mee-Kyung Kim, Keun-Hyeung Lee, Jonghwa Won, Jae-Seung Kang. Aurintricarboxylic acid translocates across the plasma membrane, inhibits protein tyrosine phosphatase and prevents apoptosis in PC12 cells. Molecules and cells. 2004 Aug; 18(1):46-52. doi: NULL. [PMID: 15359123]
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