2,6-Diaminopyrimidin-4-ol (BioDeep_00001874222)

   


代谢物信息卡片


2,4-Diamino-6-hydroxypyrimidine

  化学式: C4H6N4O (126.0542)
中文名称: 2,4-二氨基-6-羟基嘧啶, 2,6-二氨基嘧啶-4-醇
  谱图信息: 最多检出来源 () %

分子结构信息

SMILES: C1=C(N=C(NC1=O)N)N
InChI: InChI=1S/C4H6N4O/c5-2-1-3(9)8-4(6)7-2/h1H,(H5,5,6,7,8,9)


描述信息

D004791 - Enzyme Inhibitors

同义名列表

54 个代谢物同义名

2,4-Diamino-6-hydroxypyrimidine; 2,6-Diaminopyrimidin-4-ol; Tox21_500419; UNII-EDH7CNS75I; 2 pound not6-Diaminopyrimidin-4-ol; 2-Aminoisocytosine; 2,4-DAHP; 2,4-diamino-1H-pyrimidin-6-one; 2,4-diamino-6-hydroxy-pyrimidine; 2,4-Diamino-6-hydroxypyrimidiine; 2,4-DIAMINO-6-HYDROXYPYRIMIDINE [MI]; 2,4-Diamino-6-hydroxypyrimidine,98%; 2,4-Diamino-6-pyrimidinol; 2,4-Diamino-6-pyrimidinone; 2,4-Diamino-6-pyrimidone; 2,4-Diamino-6-pyrimidone 100 microg/mL in Acetonitrile:Methanol; 2,4-DIAMINO-6(1H)-PYRIMIDINONE; 2,4-diamino-6(1H)-pyrimidone; 2,4-diaminohypoxanthine; 2,4-diaminohypoxanthine sulfate; 2,6-diamino-1,4-dihydropyrimidin-4-one; 2,6-Diamino-1H-pyrimidin-4-one; 2,6-diamino-3,4-dihydropyrimidin-4-one; 2,6-Diamino-3H-pyrimidin-4-one; 2,6-Diamino-4-hydroxypyrimidine; 2,6-diamino-4-oxopyrimidine; 2,6-Diamino-4-pyrimidinol; 2,6-Diamino-4-pyrimidinone; 2,6-Diamino-4(1H)-pyrimidinone; 2,6-Diamino-4(1H)-pyrimidinone;2,6-Diaminopyrimidin-4-one;6-Aminoisocytosine; 2,6-Diamino-4(3H)-pyrimidinone; 2,6-diamino-pyrimidin-4-ol; 2,6-Diaminopyrimidin-4-one; 2,6-Diaminopyrimidin-4(1H)-one; 2,6-diaminopyrimidin-4(3H)-one; 2,6-diaminopyrimidine-4-one; 4-Pyrimidinol, 2,6-diamino-; 4-Pyrimidinol, 2,6-diamino- (9CI); 4(1H)-Pyrimidinone, 2,6-diamino-; 4(1H)-Pyrimidinone, 2,6-diamino-, monohydrate; 4(1H)-Pyrimidinone,6-diamino-; 4(3H)-pyrimidinone, 2,6-diamino-; 4(3H)-Pyrimidinone, 2,6-diamino- (9CI); 6-Aminoisocytosine; 6-Hydroxy-2,4-pyrimidinediamine; AI3-52085; CAS-56-06-4; DAHP; 2,4-Diamino-6-hydroxypyrimidine; DHAP-2,4; EDH7CNS75I; Lopac0_000419; pyrimidine, 2,4-diamino-6-hydroxy-; Tox21_113576; Tox21_113576_1



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome()

BioCyc()

PlantCyc()

代谢反应

个相关的代谢反应过程信息。

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • D C Bulmer, C A Botha, A Wheeldon, K Grey, C A Mein, K Lee, C H Knowles, W J Winchester, Q Aziz. Evidence of a role for GTP cyclohydrolase-1 in visceral pain. Neurogastroenterology and motility. 2015 May; 27(5):656-62. doi: 10.1111/nmo.12538. [PMID: 25783971]
  • Marty Hinz, Alvin Stein, Thomas Uncini. Validity of urinary monoamine assay sales under the 'spot baseline urinary neurotransmitter testing marketing model'. International journal of nephrology and renovascular disease. 2011; 4(?):101-13. doi: 10.2147/ijnrd.s22783. [PMID: 21912487]
  • Asli F Ceylan-Isik, Kelly K Guo, Edward C Carlson, Jamie R Privratsky, Song-Jie Liao, Lu Cai, Alex F Chen, Jun Ren. Metallothionein abrogates GTP cyclohydrolase I inhibition-induced cardiac contractile and morphological defects: role of mitochondrial biogenesis. Hypertension (Dallas, Tex. : 1979). 2009 Jun; 53(6):1023-31. doi: 10.1161/hypertensionaha.108.123422. [PMID: 19398661]
  • Naobumi Hamadate, Katsuhiko Noguchi, Mayuko Sakanashi, Toshihiro Matsuzaki, Junko Nakasone, Matao Sakanashi. Effect of decreased levels of intrinsic tetrahydrobiopterin on endothelial function in anesthetized rats. Journal of pharmacological sciences. 2008 May; 107(1):49-56. doi: 10.1254/jphs.fp0071967. [PMID: 18446004]
  • Shujiang Tu, Junyong Zhang, Runhong Jia, Bo Jiang, Yan Zhang, Hong Jiang. An efficient route for the synthesis of a new class of pyrido[2,3-d]pyrimidine derivatives. Organic & biomolecular chemistry. 2007 May; 5(9):1450-3. doi: 10.1039/b617201f. [PMID: 17464415]
  • Kwok-Keung Lam, Yen-Mei Lee, George Hsiao, Shu-Ying Chen, Mao-Hsiung Yen. Estrogen therapy replenishes vascular tetrahydrobiopterin and reduces oxidative stress in ovariectomized rats. Menopause (New York, N.Y.). 2006 Mar; 13(2):294-302. doi: 10.1097/01.gme.0000182806.99137.5e. [PMID: 16645543]
  • Sung Tae Kim, Ji Hyun Choi, Jin Woo Chang, Seong Who Kim, Onyou Hwang. Immobilization stress causes increases in tetrahydrobiopterin, dopamine, and neuromelanin and oxidative damage in the nigrostriatal system. Journal of neurochemistry. 2005 Oct; 95(1):89-98. doi: 10.1111/j.1471-4159.2005.03342.x. [PMID: 16181415]
  • S Yamashiro, K Noguchi, Y Kuniyoshi, K Koja, M Sakanashi. Role of tetrahydrobiopterin on ischemia-reperfusion injury in isolated perfused rat hearts. The Journal of cardiovascular surgery. 2003 Feb; 44(1):37-49. doi: ". [PMID: 12627070]
  • Zsolt Bagi, Akos Koller. Lack of nitric oxide mediation of flow-dependent arteriolar dilation in type I diabetes is restored by sepiapterin. Journal of vascular research. 2003 Jan; 40(1):47-57. doi: 10.1159/000068938. [PMID: 12644725]
  • Junko Tanaka, Kunio Koshimura, Yoshio Murakami, Yuzuru Kato. Possible involvement of tetrahydrobiopterin in the trophic effect of insulin-like growth factor-1 on rat pheochromocytoma-12 (PC12) cells. Neuroscience letters. 2002 Aug; 328(2):201-3. doi: 10.1016/s0304-3940(02)00497-4. [PMID: 12133588]
  • Yongming Yao, Hongyun Li, Ning Dong, Yan Yu, Lianrong Lu, Zhiguo Shi, Zhiyong Sheng. [The protective effects and its underlying mechanism of 2,4-diamino-6-hydroxy-pyrimidine on postburn Staphylococcus aureus sepsis in rats]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. 2002 Apr; 18(2):84-7. doi: NULL. [PMID: 12515652]
  • J Tanaka, K Koshimura, M Sohmiya, Y Murakami, Y Kato. Involvement of tetrahydrobiopterin in trophic effect of erythropoietin on PC12 cells. Biochemical and biophysical research communications. 2001 Nov; 289(2):358-62. doi: 10.1006/bbrc.2001.6002. [PMID: 11716480]
  • A J Bune, M P Brand, S J Heales, J K Shergill, R Cammack, H T Cook. Inhibition of tetrahydrobiopterin synthesis reduces in vivo nitric oxide production in experimental endotoxic shock. Biochemical and biophysical research communications. 1996 Mar; 220(1):13-9. doi: 10.1006/bbrc.1996.0348. [PMID: 8602831]
  • A J Bune, H T Cook. Inhibition of tetrahydrobiopterin synthesis reduces nitric oxide production by isolated glomeruli in immune complex glomerulonephritis. Experimental nephrology. 1996 Jan; 4(1):43-7. doi: NULL. [PMID: 8788599]
  • B Amoah-Apraku, S S Tang, J R Ingelfinger, N J Guzman. Guanosine triphosphate cyclohydrolase I regulates nitric oxide synthesis in renal proximal tubules. Journal of the American Society of Nephrology : JASN. 1995 Feb; 5(8):1630-3. doi: 10.1681/asn.v581630. [PMID: 7756597]
  • H Mühl, J Pfeilschifter. Tetrahydrobiopterin is a limiting factor of nitric oxide generation in interleukin 1 beta-stimulated rat glomerular mesangial cells. Kidney international. 1994 Nov; 46(5):1302-6. doi: 10.1038/ki.1994.398. [PMID: 7531790]
  • S Suzuki, Y Watanabe, S Tsubokura, H Kagamiyama, O Hayaishi. Decrease in tetrahydrobiopterin content and neurotransmitter amine biosynthesis in rat brain by an inhibitor of guanosine triphosphate cyclohydrolase. Brain research. 1988 Apr; 446(1):1-10. doi: 10.1016/0006-8993(88)91290-5. [PMID: 2453255]