2-Aminopyrimidine (BioDeep_00001874211)

   


代谢物信息卡片


2-Aminopyrimidine

化学式: C4H5N3 (95.04834500000001)
中文名称: 2-氨基嘧啶
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CN=C(N=C1)N
InChI: InChI=1S/C4H5N3/c5-4-6-2-1-3-7-4/h1-3H,(H2,5,6,7)

描述信息

同义名列表

1 个代谢物同义名

2-Aminopyrimidine



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yue Hu, Lingyu Li, Yu Tian, Yingjie Xiao, Jiawei Tang, Shuoyu Zeng, Zhongmei Zou, Hai Shang. Design, synthesis and evaluation of novel UDCA-aminopyrimidine hybrids as ATX inhibitors for the treatment of hepatic and pulmonary fibrosis. European journal of medicinal chemistry. 2024 Jan; 264(?):116029. doi: 10.1016/j.ejmech.2023.116029. [PMID: 38091892]
  • Lili Dong, Shengqiang Shen, Xi Jiang, Yaxin Liu, Jingjing Li, Wei Chen, Yizhen Wang, Jiakun Shi, Jiaxin Liu, Shujie Ma, Lihui Zhang, Jingao Dong, Qing Yang. Discovery of Azo-Aminopyrimidines as Novel and Potent Chitinase OfChi-h Inhibitors via Structure-Based Virtual Screening and Rational Lead Optimization. Journal of agricultural and food chemistry. 2022 Sep; 70(38):12203-12210. doi: 10.1021/acs.jafc.2c03997. [PMID: 36121180]
  • Chunhui Liu, Zining Cui, Xiaojing Yan, Zhiqiu Qi, Mingshan Ji, Xinghai Li. Synthesis, Fungicidal Activity and Mode of Action of 4-Phenyl-6-trifluoromethyl-2-aminopyrimidines against Botrytis cinerea. Molecules (Basel, Switzerland). 2016 Jun; 21(7):. doi: 10.3390/molecules21070828. [PMID: 27347910]
  • Seigo Sanoh, Kazuyoshi Nozaki, Hidetsugu Murai, Shigeyuki Terashita, Toshio Teramura, Shigeru Ohta. Prediction of human metabolism of FK3453 by aldehyde oxidase using chimeric mice transplanted with human or rat hepatocytes. Drug metabolism and disposition: the biological fate of chemicals. 2012 Jan; 40(1):76-82. doi: 10.1124/dmd.111.041954. [PMID: 21984595]
  • Eliška Procházková, Petr Jansa, Martin Dračínský, Antonín Holý, Helena Mertlíková-Kaiserová. Determination of the antioxidative activity of substituted 5-aminopyrimidines. Free radical research. 2012 Jan; 46(1):61-7. doi: 10.3109/10715762.2011.638292. [PMID: 22059896]
  • Stefanie Cornelius, Sandra Witz, Hardy Rolletschek, Torsten Möhlmann. Pyrimidine degradation influences germination seedling growth and production of Arabidopsis seeds. Journal of experimental botany. 2011 Nov; 62(15):5623-32. doi: 10.1093/jxb/err251. [PMID: 21865177]
  • J Thanusu, V Kanagarajan, S Nagini, M Gopalakrishnan. Evaluation of 3-(4'-(4″-fluorophenyl)-6'-phenylpyrimidin-2'-yl)-2-phenylthiazolidin-4-one for in vivo modulation of biomarkers of chemoprevention in the 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Journal of enzyme inhibition and medicinal chemistry. 2011 Jun; 26(3):422-9. doi: 10.3109/14756366.2010.525507. [PMID: 21028942]
  • Takafumi Akabane, Kohichiro Tanaka, Megumi Irie, Shigeyuki Terashita, Toshio Teramura. Case report of extensive metabolism by aldehyde oxidase in humans: pharmacokinetics and metabolite profile of FK3453 in rats, dogs, and humans. Xenobiotica; the fate of foreign compounds in biological systems. 2011 May; 41(5):372-84. doi: 10.3109/00498254.2010.549970. [PMID: 21385103]
  • Jun Ohwada, Hirosato Ebiike, Hatsuo Kawada, Masao Tsukazaki, Mitsuaki Nakamura, Takuya Miyazaki, Kenji Morikami, Kiyoshi Yoshinari, Miyuki Yoshida, Osamu Kondoh, Shino Kuramoto, Kotaro Ogawa, Yuko Aoki, Nobuo Shimma. Discovery and biological activity of a novel class I PI3K inhibitor, CH5132799. Bioorganic & medicinal chemistry letters. 2011 Mar; 21(6):1767-72. doi: 10.1016/j.bmcl.2011.01.065. [PMID: 21316229]
  • John B Tyburski, Andrew D Patterson, Kristopher W Krausz, Josef Slavík, Albert J Fornace, Frank J Gonzalez, Jeffrey R Idle. Radiation metabolomics. 2. Dose- and time-dependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice. Radiation research. 2009 Jul; 172(1):42-57. doi: 10.1667/rr1703.1. [PMID: 19580506]
  • Rita Zrenner, Heike Riegler, Cathleen R Marquard, Peter R Lange, Claudia Geserick, Caren E Bartosz, Celine T Chen, Robert D Slocum. A functional analysis of the pyrimidine catabolic pathway in Arabidopsis. The New phytologist. 2009; 183(1):117-132. doi: 10.1111/j.1469-8137.2009.02843.x. [PMID: 19413687]
  • Stuart L Emanuel, Terry V Hughes, Mary Adams, Catherine A Rugg, Angel Fuentes-Pesquera, Peter J Connolly, Niranjan Pandey, Sandra Moreno-Mazza, Jeannene Butler, Virna Borowski, Steven A Middleton, Robert H Gruninger, Jennifer R Story, Cheryl Napier, Beth Hollister, Lee M Greenberger. Cellular and in vivo activity of JNJ-28871063, a nonquinazoline pan-ErbB kinase inhibitor that crosses the blood-brain barrier and displays efficacy against intracranial tumors. Molecular pharmacology. 2008 Feb; 73(2):338-48. doi: 10.1124/mol.107.041236. [PMID: 17975007]
  • Ye-Xiang Xie, Shao-Feng Pi, Jian Wang, Du-Lin Yin, Jin-Heng Li. 2-aminopyrimidine-4,6-diol as an efficient ligand for solvent-free copper-catalyzed N-arylations of imidazoles with aryl and heteroaryl halides. The Journal of organic chemistry. 2006 Oct; 71(21):8324-7. doi: 10.1021/jo061572q. [PMID: 17025338]
  • Thomas Pfeifer, Jochen Tuerk, Regine Fuchs. Structural characterization of sulfadiazine metabolites using H/D exchange combined with various MS/MS experiments. Journal of the American Society for Mass Spectrometry. 2005 Oct; 16(10):1687-94. doi: 10.1016/j.jasms.2005.06.008. [PMID: 16099168]
  • Marina V Kovina, Aart De Kok, Irina A Sevostyanova, Ludmila S Khailova, Natalya V Belkina, German A Kochetov. The molecular origin of the thiamine diphosphate-induced spectral bands of ThDP-dependent enzymes. Proteins. 2004 Aug; 56(2):338-45. doi: 10.1002/prot.20115. [PMID: 15211516]
  • A Beaudry, J DeFoe, S Zinnen, A Burgin, L Beigelman. In vitro selection of a novel nuclease-resistant RNA phosphodiesterase. Chemistry & biology. 2000 May; 7(5):323-34. doi: 10.1016/s1074-5521(00)00110-1. [PMID: 10801472]
  • M J Kujau, A Siebert, S Wölfl. Design of leader sequences that improve the efficiency of the enzymatic synthesis of 2'-amino-pyrimidine RNA for in vitro selection. Journal of biochemical and biophysical methods. 1997 Dec; 35(3):141-51. doi: 10.1016/s0165-022x(97)00039-0. [PMID: 9470093]