N-ETHYL-N-(2-HYDROXYETHYL)NITROSAMINE (BioDeep_00001874158)
代谢物信息卡片
N-ETHYL-N-(2-HYDROXYETHYL)NITROSAMINE
化学式: C4H10N2O2 (118.074224)
中文名称: N-乙基-N-(2-羟乙基)亚硝胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCN(CCO)N=O
InChI: InChI=1S/C4H10N2O2/c1-2-6(5-8)3-4-7/h7H,2-4H2,1H3
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
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COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Min Wei, Al-Salmy Hamoud, Takashi Yamaguchi, Anna Kakehashi, Keiichirou Morimura, Kenichiro Doi, Masahiko Kushida, Mitsuaki Kitano, Hideki Wanibuchi, Shoji Fukushima. Potassium bromate enhances N-ethyl-N-hydroxyethylnitrosamine-induced kidney carcinogenesis only at high doses in Wistar rats: indication of the existence of an enhancement threshold.
Toxicologic pathology.
2009 Dec; 37(7):983-91. doi:
10.1177/0192623309351720. [PMID: 19833912] - Takashi Umemura, Yuji Kurokawa. Etiology of bromate-induced cancer and possible modes of action-studies in Japan.
Toxicology.
2006 Apr; 221(2-3):154-7. doi:
10.1016/j.tox.2006.01.007. [PMID: 16473452] - Nobuo Satake, Makoto Miyagawa, Junko Sakurai, Hiroaki Mitani, Toshiyuki Kobayashi, Hiroshi Tamura, Okio Hino. N-ethyl-N-hydroxyethylnitrosamine (EHEN)-induced renal and hepatocarcinogenesis in the tumor suppressor Tsc2 transgenic rat.
Cancer letters.
2002 Oct; 184(2):157-63. doi:
10.1016/s0304-3835(02)00209-4. [PMID: 12127687] - Yih Horng Shiao, Gayatri Ramakrishna, Lucy M Anderson, Alan O Perantoni, Jerry M Rice, Bhalchandra A Diwan. Down-regulation of von Hippel-Lindau protein in N-nitroso compound-induced rat non-clear cell renal tumors.
Cancer letters.
2002 May; 179(1):33-8. doi:
10.1016/s0304-3835(01)00863-1. [PMID: 11880179] - K Takashima, S Ozono, I Nakanou, M Ota, M Tanaka, M Tani, K Hirao, Y Hirao, S Kuwashima, Y Hiasa. Strain variation in renal carcinogenesis by N-ethyl-N-hydroxyethylnitrosamine in F1 (Wistar-Fischer) rats.
Cancer letters.
2001 Sep; 170(2):125-30. doi:
10.1016/s0304-3835(01)00608-5. [PMID: 11463489] - N Konishi, M Nakamura, E Ishida, Y Kawada, M Nishimine, H Nagai, M Emi. Specific genomic alterations in rat renal cell carcinomas induced by N-ethyl-N-hydroxyethylnitrosamine.
Toxicologic pathology.
2001 Mar; 29(2):232-6. doi:
10.1080/019262301317052503. [PMID: 11421490] - R Tokuzen, Y Iwahori, M Asamoto, M Iigo, F Hasegawa, T Satoh, M Ishidate, H Tsuda. Establishment and characterization of three new rat renal cell carcinoma cell lines from N-ethyl-N-hydroxyethylnitrosamine-induced basophilic cell tumors.
Pathology international.
2001 Feb; 51(2):65-71. doi:
10.1046/j.1440-1827.2001.01167.x. [PMID: 11169143] - T Fujioka, Y Suzuki, T Okamoto, N Mastushita, M Hasegawa, S Omori. Prevention of renal cell carcinoma by active vitamin D3.
World journal of surgery.
2000 Oct; 24(10):1205-10. doi:
10.1007/s002680010206. [PMID: 11071463] - F Furukawa, A Nishikawa, M Miyauchi, H Nakamura, H Y Son, M Yamagishi, M Hirose. Concurrent administration of fish meal and sodium nitrite does not promote renal carcinogenesis in rats after initiation with N-ethyl-N-hydroxyethylnitrosamine.
Cancer letters.
2000 Jun; 154(1):45-51. doi:
10.1016/s0304-3835(00)00357-8. [PMID: 10799738] - Y Hiasa, M Paul, I Hayashi, M Mochizuki, H Tsutsumi, S Kuwashima, Y Kitahori, N Konishi. Carcinogenic effects of N-ethyl-N-hydroxyethylnitrosamine and its metabolites in rats and mice.
Cancer letters.
1999 Oct; 145(1-2):143-9. doi:
10.1016/s0304-3835(99)00247-5. [PMID: 10530782] - M Hirose, S Fukushima, K Imaida, N Ito, T Shirai. Modifying effects of phytic acid and gamma-oryzanol on the promotion stage of rat carcinogenesis.
Anticancer research.
1999 Sep; 19(5A):3665-70. doi:
NULL. [PMID: 10625936] - N Yoshioka, Y Hiasa, M Cho, Y Kitahori, K Hirao, N Konishi, S Kuwashima. Effect of polyphenon-60 on the development of renal cell tumors in rats treated with N-ethyl-N hydroxyethylnitrosamine.
Cancer letters.
1999 Feb; 136(1):79-82. doi:
10.1016/s0304-3835(98)00313-9. [PMID: 10211943] - N Satake, S Urakami, Y Hirayama, K Izumi, O Hino. Biallelic mutations of the Tsc2 gene in chemically induced rat renal cell carcinoma.
International journal of cancer.
1998 Sep; 77(6):895-900. doi:
10.1002/(sici)1097-0215(19980911)77:6<895::aid-ijc16>3.0.co;2-0. [PMID: 9714060] - Y Nakagawa, Y Kitahori, M Cho, N Konishi, K Tsumatani, S Ozono, E Okajima, Y Hirao, Y Hiasa. Effect of hexachloro-1,3-butadiene on renal carcinogenesis in male rats pretreated with N-ethyl-N-hydroxyethylnitrosamine.
Toxicologic pathology.
1998 May; 26(3):361-6. doi:
10.1177/019262339802600309. [PMID: 9608641] - M Sato, Y Kitahori, Y Nakagawa, N Konishi, M Cho, Y Hiasa. Formation of 8-hydroxydeoxyguanosine in rat kidney DNA after administration of N-ethyl-N-hydroxyethylnitrosamine.
Cancer letters.
1998 Feb; 124(1):111-8. doi:
10.1016/s0304-3835(97)00465-5. [PMID: 9500199] - S Urakami, R Tokuzen, H Tsuda, M Igawa, O Hino. Somatic mutation of the tuberous sclerosis (Tsc2) tumor suppressor gene in chemically induced rat renal carcinoma cell.
The Journal of urology.
1997 Jul; 158(1):275-8. doi:
10.1097/00005392-199707000-00085. [PMID: 9186374] - K Tsumatani, Y Nakagawa, Y Kitahori, N Konishi, H Uemura, S Ozono, Y Hirao, E Okajima, K Hirao, Y Hiasa. Experimental model of renal tumors in polycystic kidneys: effects of long-term 2-amino-4,5-diphenylthiazole administration in rats treated with N-ethyl-N-hydroxyethylnitrosamine.
Toxicologic pathology.
1997 Jul; 25(4):363-71. doi:
10.1177/019262339702500404. [PMID: 9280119] - L Robbiano, E Mereto, A Migliazzi Morando, P Pastore, G Brambilla. An in vivo micronucleus assay for detecting the clastogenic effect in rat kidney cells.
Mutation research.
1997 Apr; 390(1-2):51-7. doi:
10.1016/s0165-1218(96)00165-6. [PMID: 9150752] - Y Yamada, M Takashi, T Sakata, Y Nakano, Y Takagi, H Hibi, K Miyake. Strain and sex differences in kidney carcinogenesis in rats treated with N-ethyl-N-hydroxyethylnitrosamine and uracil.
Hinyokika kiyo. Acta urologica Japonica.
1995 Oct; 41(10):781-7. doi:
NULL. [PMID: 8533674] - N Konishi, M Kitamura, I Hayashi, H Matsuda, M Tao, H Naitoh, Y Kitahori, Y Hiasa. Effect of methimazole on rat renal carcinogenesis induced by N-ethyl-N-hydroxyethylnitrosamine.
Toxicologic pathology.
1995 Sep; 23(5):606-11. doi:
10.1177/019262339502300506. [PMID: 8578103] - M Yaono, R Hasegawa, Y Mizoguchi, M Futakuchi, T Nakamura, N Ito, T Shirai. Hepatocyte growth factor enhancement of preneoplastic hepatic foci development in rats treated with diethylnitrosamine and N-ethyl-N-hydroxyethylnitrosamine.
Japanese journal of cancer research : Gann.
1995 Aug; 86(8):718-23. doi:
10.1111/j.1349-7006.1995.tb02459.x. [PMID: 7559093] - M Takashi, T Sakata, Y Nakano, Y Takagi, Y Yamada, H Hibi, K Miyake, T Shirai. Initiation-stage enhancement by uracil of N-ethyl-N-hydroxyethylnitrosamine-induction of kidney carcinogenesis in rats.
Cancer letters.
1994 Dec; 87(2):151-7. doi:
10.1016/0304-3835(94)90216-x. [PMID: 7812934] - H Tsuda, K Matsumoto, T Iwase, Y Nishida, H Baba. Enhanced neoplastic lesion development with adenine-induced experimental multicystic nephropathy by adenine--a model system for the analysis of renal tumor generation in long-term hemodialysis patients.
Cancer letters.
1994 Aug; 83(1-2):105-10. doi:
10.1016/0304-3835(94)90305-0. [PMID: 8062202] - M Takashi, T Sakata, Y Nakano, Y Yamada, K Miyake, K Kato. Elevated concentrations of the beta-subunit of S100 protein in renal cell tumors in rats.
Urological research.
1994; 22(4):251-5. doi:
10.1007/bf00541902. [PMID: 7871639] - N Konishi, K Nishii, I Hayashi, S Nakaoka, K Matsumoto, T Yabuno, Y Kitahori, Y Hiasa. Inhibitory effect of potassium citrate on rat renal tumors induced by N-ethyl-N-hydroxyethylnitrosamine followed by potassium dibasic phosphate.
Japanese journal of cancer research : Gann.
1993 Feb; 84(2):128-34. doi:
10.1111/j.1349-7006.1993.tb02845.x. [PMID: 7681816] - S Okazaki, T Hoshiya, S Takahashi, M Futakuchi, K Saito, M Hirose. Modification of hepato- and renal carcinogenesis by catechol and its isomers in rats pretreated with N-ethyl-N-hydroxyethylnitrosamine.
Teratogenesis, carcinogenesis, and mutagenesis.
1993; 13(3):127-37. doi:
10.1002/tcm.1770130303. [PMID: 7692615] - K Matsumoto, H Tsuda, T Iwase, M Ito, Y Nishida, F Oyama, K Titani, T Ushijima, M Nagao, I Hirono. Absence of ras family point mutations at codons 12, 13 and 61 in N-ethyl-N-hydroxyethylnitrosamine- or N-nitrosomorpholine-induced renal cell tumors in rats.
Japanese journal of cancer research : Gann.
1992 Sep; 83(9):933-6. doi:
10.1111/j.1349-7006.1992.tb02003.x. [PMID: 1429202] - A Hagiwara, M Sano, E Asakawa, H Tanaka, R Hasegawa, N Ito. Enhancing effects of harman and norharman on induction of preneoplastic and neoplastic kidney lesions in rats initiated with N-ethyl-N-hydroxyethylnitrosamine.
Japanese journal of cancer research : Gann.
1992 Sep; 83(9):949-54. doi:
10.1111/j.1349-7006.1992.tb02006.x. [PMID: 1429205] - Y Hiasa, N Konishi, S Nakaoka, T Nakamura, K Nishii, M Ohshima. Promoting effects of potassium dibasic phosphate on early-stage renal carcinogenesis in unilaterally nephrectomized rats treated with N-ethyl-N-hydroxyethylnitrosamine.
Japanese journal of cancer research : Gann.
1992 Jul; 83(7):688-94. doi:
10.1111/j.1349-7006.1992.tb01967.x. [PMID: 1517146] - Y Hiasa, N Konishi, S Nakaoka, M Nakamura, S Nishii, Y Kitahori, M Ohshima. Possible application to medium-term organ bioassays for renal carcinogenesis modifiers in rats treated with N-ethyl-N-hydroxyethylnitrosamine and unilateral nephrectomy.
Japanese journal of cancer research : Gann.
1991 Dec; 82(12):1385-90. doi:
10.1111/j.1349-7006.1991.tb01810.x. [PMID: 1778762] - M Hirose, K Ozaki, K Takaba, S Fukushima, T Shirai, N Ito. Modifying effects of the naturally occurring antioxidants gamma-oryzanol, phytic acid, tannic acid and n-tritriacontane-16, 18-dione in a rat wide-spectrum organ carcinogenesis model.
Carcinogenesis.
1991 Oct; 12(10):1917-21. doi:
10.1093/carcin/12.10.1917. [PMID: 1657429] - D R Dietrich, J A Swenberg. The presence of alpha 2u-globulin is necessary for d-limonene promotion of male rat kidney tumors.
Cancer research.
1991 Jul; 51(13):3512-21. doi:
NULL. [PMID: 1711412] - B G Short, W H Steinhagen, J A Swenberg. Promoting effects of unleaded gasoline and 2,2,4-trimethylpentane on the development of atypical cell foci and renal tubular cell tumors in rats exposed to N-ethyl-N-hydroxyethylnitrosamine.
Cancer research.
1989 Nov; 49(22):6369-78. doi:
NULL. [PMID: 2804983] - Y Kurokawa, N Takamura, Y Matushima, T Imazawa, Y Hayashi. Promoting effect of peroxisome proliferators in two-stage rat renal tumorigenesis.
Cancer letters.
1988 Dec; 43(1-2):145-9. doi:
10.1016/0304-3835(88)90227-3. [PMID: 3203323] - T Inoue, K Imaida, E Suzuki, M Okada, S Fukushima. Combined effects of L-ascorbic acid, citric acid or their sodium salts on tumor induction by N-butyl-N-(4-hydroxybutyl)nitrosamine or N-ethyl-N-(4-hydroxybutyl)nitrosamine in the rat urinary bladder.
Cancer letters.
1988 Jun; 40(3):265-73. doi:
10.1016/0304-3835(88)90085-7. [PMID: 3383181] - Y Kurata, H Tsuda, T Sakata, T Yamashita, N Ito. Reciprocal modifying effects of isomeric forms of aminophenol on induction of neoplastic lesions in rat liver and kidney initiated by N-ethyl-N-hydroxyethylnitrosamine.
Carcinogenesis.
1987 Sep; 8(9):1281-5. doi:
10.1093/carcin/8.9.1281. [PMID: 3621466] - H Tsuda, M A Moore, M Asamoto, T Inoue, S Fukushima, N Ito, K Satoh, Z Amelizad, F Oesch. Immunohistochemically demonstrated altered expression of cytochrome P-450 molecular forms and epoxide hydrolase in N-ethyl-N-hydroxyethylnitrosamine-induced rat kidney and liver lesions.
Carcinogenesis.
1987 May; 8(5):711-7. doi:
10.1093/carcin/8.5.711. [PMID: 3581429] - H Tsuda, T Ogiso, R Hasegawa, K Imaida, T Masui, N Ito. Inhibition of neoplastic development in rat liver, kidney, oesophagus and forestomach by 4,4'-diaminodiphenylmethane administration.
Carcinogenesis.
1987 May; 8(5):719-22. doi:
10.1093/carcin/8.5.719. [PMID: 3581430] - T Shirai, H Tsuda, T Ogiso, M Hirose, N Ito. Organ specific modifying potential of ethinyl estradiol on carcinogenesis initiated with different carcinogens.
Carcinogenesis.
1987 Jan; 8(1):115-9. doi:
10.1093/carcin/8.1.115. [PMID: 3802386] - H Tsuda, H J Hacker, H Katayama, T Masui, N Ito, P Bannasch. Correlative histochemical studies on preneoplastic and neoplastic lesions in the kidney of rats treated with nitrosamines.
Virchows Archiv. B, Cell pathology including molecular pathology.
1986; 51(5):385-404. doi:
10.1007/bf02899047. [PMID: 2876545] - H Tsuda, M A Moore, M Asamoto, K Satoh, S Tsuchida, K Sato, A Ichihara, N Ito. Comparison of the various forms of glutathione S-transferase with glucose-6-phosphate dehydrogenase and gamma-glutamyltranspeptidase as markers of preneoplastic and neoplastic lesions in rat kidney induced by N-ethyl-N-hydroxyethylnitrosamine.
Japanese journal of cancer research : Gann.
1985 Oct; 76(10):919-29. doi:
NULL. [PMID: 2867080] - Y Kurokawa, S Aoki, T Imazawa, Y Hayashi, Y Matsushima, N Takamura. Dose-related enhancing effect of potassium bromate on renal tumorigenesis in rats initiated with N-ethyl-N-hydroxyethyl-nitrosamine.
Japanese journal of cancer research : Gann.
1985 Jul; 76(7):583-9. doi:
NULL. [PMID: 3928554] - Y Hiasa, Y Kitahori, N Konishi, T Shimoyama. Dose-related effect of trisodium nitrilotriacetate monohydrate on renal tumorigenesis initiated with N-ethyl-N-hydroxyethylnitrosamine in rats.
Carcinogenesis.
1985 Jun; 6(6):907-10. doi:
10.1093/carcin/6.6.907. [PMID: 4006078] - Y Hiasa, N Enoki, Y Kitahori, N Konishi, T Shimoyama. DL-Serine: promoting activity on renal tumorigenesis by N-ethyl-N-hydroxyethylnitrosamine in rats.
Journal of the National Cancer Institute.
1984 Jul; 73(1):297-9. doi:
. [PMID: 6429402] - Y Hiasa, J C Lin, N Konishi, Y Kitahori, N Enoki, T Shimoyama. Histopathological and biochemical analyses of transplantable renal adenocarcinoma in rats induced by N-ethyl-N-hydroxyethylnitrosamine.
Cancer research.
1984 Apr; 44(4):1664-70. doi:
NULL. [PMID: 6142766] - H Tsuda, T Sakata, T Masui, K Imaida, N Ito. Modifying effects of butylated hydroxyanisole, ethoxyquin and acetaminophen on induction of neoplastic lesions in rat liver and kidney initiated by N-ethyl-N-hydroxyethylnitrosamine.
Carcinogenesis.
1984 Apr; 5(4):525-31. doi:
10.1093/carcin/5.4.525. [PMID: 6142774] - Y Hiasa, Y Kitahori, N Konishi, N Enoki, T Shimoyama, A Miyashiro. Trisodium nitrilotriacetate monohydrate: promoting effects on the development of renal tubular cell tumors in rats treated with N-ethyl-N-hydroxyethylnitrosamine.
Journal of the National Cancer Institute.
1984 Feb; 72(2):483-9. doi:
NULL. [PMID: 6582331] - T Shirai, M Ohshima, A Masuda, S Tamano, N Ito. Promotion of 2-(ethylnitrosamino)ethanol-induced renal carcinogenesis in rats by nephrotoxic compounds: positive responses with folic acid, basic lead acetate, and N-(3,5-dichlorophenyl)succinimide but not with 2,3-dibromo-1-propanol phosphate.
Journal of the National Cancer Institute.
1984 Feb; 72(2):477-82. doi:
. [PMID: 6582330] - H Tsuda, S Fukushima, K Imaida, T Sakata, N Ito. Modification of carcinogenesis by antioxidants and other compounds.
Acta pharmacologica et toxicologica.
1984; 55 Suppl 2(?):125-43. doi:
10.1111/j.1600-0773.1984.tb02486.x. [PMID: 6148834] - Y Kurokawa, M Takahashi, T Kokubo, Y Ohno, Y Hayashi. Enhancement by potassium bromate of renal tumorigenesis initiated by N-ethyl-N-hydroxyethylnitrosamine in F-344 rats.
Gan.
1983 Oct; 74(5):607-10. doi:
NULL. [PMID: 6642133] - Y Hiasa, M Ohshima, Y Kitahori, T Fujita, T Yuasa, A Miyashiro. Basic lead acetate: promoting effect on the development of renal tubular cell tumors in rats treated with N-ethyl-N-hydroxyethylnitrosamine.
Journal of the National Cancer Institute.
1983 Apr; 70(4):761-5. doi:
NULL. [PMID: 6572762] - H Tsuda, T Sakata, S Tamano, M Okumura, N Ito. Sequential observations on the appearance of neoplastic lesions in the liver and kidney after treatment with N-ethyl-N-hydroxyethylnitrosamine followed by partial hepatectomy and unilateral nephrectomy.
Carcinogenesis.
1983; 4(5):523-8. doi:
10.1093/carcin/4.5.523. [PMID: 6850982] - N Ito, S Fukushima, H Tsuda, T Shirai, M Tatematsu, K Imaida. Modification of chemical carcinogenesis by antioxidants.
Princess Takamatsu symposia.
1983; 14(?):381-9. doi:
NULL. [PMID: 6680729] - Y Hiasa, M Ohshima, Y Kitahori, N Konishi, T Fujita, T Yuasa. beta-Cyclodextrin: promoting effect on the development of renal tubular cell tumors in rats treated with N-ethyl-N-hydroxyethylnitrosamine.
Journal of the National Cancer Institute.
1982 Oct; 69(4):963-7. doi:
NULL. [PMID: 6956770] - M Hirose, T Shirai, H Tsuda, S Fukushima, T Ogiso, N Ito. Effect of phenobarbital, polychlorinated biphenyl and sodium saccharin on hepatic and renal carcinogenesis in unilaterally nephrectomized rats given N-ethyl-N-hydroxyethylnitrosamine orally.
Carcinogenesis.
1981; 2(12):1299-302. doi:
10.1093/carcin/2.12.1299. [PMID: 6799217] - S Fukushima, M Hirose, A Hagiwara, R Hasegawa, N Ito. Inhibitory effect of 4,4'-diaminodiphenylmethane on liver, kidney and bladder carcinogenesis in rats ingesting N-ethyl-N-hydroxyethylnitrosamine or N-butyl-N-(4-hydroxybutyl) nitros-amine.
Carcinogenesis.
1981; 2(10):1033-7. doi:
10.1093/carcin/2.10.1033. [PMID: 7296757] - Y Hiasa, M Ohshima, C Iwata, T Tanikake. Histopathological studies on renal tubular cell tumors in rats treated with N-ethyl-N-hydroxyethylnitrosamine.
Gan.
1979 Dec; 70(6):817-20. doi:
NULL. [PMID: 231537]