Phorone (BioDeep_00001873891)
代谢物信息卡片
Phorone
化学式: C9H14O (138.1045)
中文名称: 2,6-二甲基-2,5-庚二烯-4-酮, 佛罗酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=CC(=O)C=C(C)C)C
InChI: InChI=1S/C9H14O/c1-7(2)5-9(10)6-8(3)4/h5-6H,1-4H3
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Ayodele Morakinyo, Bolanle Iranloye, Olufeyisipe Adegoke. Calcium antagonists modulate oxidative stress and acrosomal reaction in rat spermatozoa.
Archives of medical science : AMS.
2011 Aug; 7(4):613-8. doi:
10.5114/aoms.2011.24130. [PMID: 22291796] - Chieko Saito, John J Lemasters, Hartmut Jaeschke. c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity.
Toxicology and applied pharmacology.
2010 Jul; 246(1-2):8-17. doi:
10.1016/j.taap.2010.04.015. [PMID: 20423716] - Ji-Young Hong, Margitta Lebofsky, Anwar Farhood, Hartmut Jaeschke. Oxidant stress-induced liver injury in vivo: role of apoptosis, oncotic necrosis, and c-Jun NH2-terminal kinase activation.
American journal of physiology. Gastrointestinal and liver physiology.
2009 Mar; 296(3):G572-81. doi:
10.1152/ajpgi.90435.2008. [PMID: 19136381] - Hazem A H Kataya, Alaaeldin A Hamza. Red Cabbage (Brassica oleracea) Ameliorates Diabetic Nephropathy in Rats.
Evidence-based complementary and alternative medicine : eCAM.
2008 Sep; 5(3):281-7. doi:
10.1093/ecam/nem029. [PMID: 18830445] - Volker Mostert, Akihiro Nakayama, Lori M Austin, Ximena A Levander, Christopher D Ferris, Kristina E Hill, Raymond F Burk. Serum iron increases with acute induction of hepatic heme oxygenase-1 in mice.
Drug metabolism reviews.
2007; 39(2-3):619-26. doi:
10.1080/03602530701468342. [PMID: 17786642] - Yoshiji Ohta, Mutsumi Kongo-Nishimura, Takahiro Hayashi, Akira Kitagawa, Tatsuya Matsura, Kazuo Yamada. Saikokeishito Extract Exerts a Therapeutic Effect on alpha-Naphthylisothiocyanate-Induced Liver Injury in Rats through Attenuation of Enhanced Neutrophil Infiltration and Oxidative Stress in the Liver Tissue.
Journal of clinical biochemistry and nutrition.
2007 Jan; 40(1):31-41. doi:
10.3164/jcbn.40.31. [PMID: 18437211] - Tom S Chan, Nandita Shangari, John X Wilson, Helen Chan, Roger F Butterworth, Peter J O'Brien. The biosynthesis of ascorbate protects isolated rat hepatocytes from cumene hydroperoxide-mediated oxidative stress.
Free radical biology & medicine.
2005 Apr; 38(7):867-73. doi:
10.1016/j.freeradbiomed.2004.12.006. [PMID: 15749382] - Tamara R Knight, Marc W Fariss, Anwar Farhood, Hartmut Jaeschke. Role of lipid peroxidation as a mechanism of liver injury after acetaminophen overdose in mice.
Toxicological sciences : an official journal of the Society of Toxicology.
2003 Nov; 76(1):229-36. doi:
10.1093/toxsci/kfg220. [PMID: 12944590] - Satoshi Numazawa, Makie Ishikawa, Aya Yoshida, Sachiko Tanaka, Takemi Yoshida. Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress.
American journal of physiology. Cell physiology.
2003 Aug; 285(2):C334-42. doi:
10.1152/ajpcell.00043.2003. [PMID: 12700136] - D Haouzi, M Lekehal, M Tinel, N Vadrot, L Caussanel, P Lettéron, A Moreau, G Feldmann, D Fau, D Pessayre. Prolonged, but not acute, glutathione depletion promotes Fas-mediated mitochondrial permeability transition and apoptosis in mice.
Hepatology (Baltimore, Md.).
2001 May; 33(5):1181-8. doi:
10.1053/jhep.2001.24235. [PMID: 11343247] - A Gupta, A Gupta, M Datta, G S Shukla. Cerebral antioxidant status and free radical generation following glutathione depletion and subsequent recovery.
Molecular and cellular biochemistry.
2000 Jun; 209(1-2):55-61. doi:
10.1023/a:1007000430394. [PMID: 10942201] - R Agarwal, G S Shukla. Potential role of cerebral glutathione in the maintenance of blood-brain barrier integrity in rat.
Neurochemical research.
1999 Dec; 24(12):1507-14. doi:
10.1023/a:1021191729865. [PMID: 10591399] - J M Yuann, K J Liu, J W Hamilton, K E Wetterhahn. In vivo effects of ascorbate and glutathione on the uptake of chromium, formation of chromium(V), chromium-DNA binding and 8-hydroxy-2'-deoxyguanosine in liver and kidney of osteogenic disorder shionogi rats following treatment with chromium(VI).
Carcinogenesis.
1999 Jul; 20(7):1267-75. doi:
10.1093/carcin/20.7.1267. [PMID: 10383900] - H Hentze, G Künstle, C Volbracht, W Ertel, A Wendel. CD95-Mediated murine hepatic apoptosis requires an intact glutathione status.
Hepatology (Baltimore, Md.).
1999 Jul; 30(1):177-85. doi:
10.1002/hep.510300111. [PMID: 10385654] - M P Chamberlain, E A Lock, B A Gaskell, C J Reed. The role of glutathione S-transferase- and cytochrome P450-dependent metabolism in the olfactory toxicity of methyl iodide in the rat.
Archives of toxicology.
1998 Jun; 72(7):420-8. doi:
10.1007/s002040050522. [PMID: 9708881] - G Mehmetçik, N Alptekin, G Toker, M Uysal. Mitochondrial lipid peroxides and antioxidant enzymes in the liver following phorone-induced glutathione depletion.
Research communications in molecular pathology and pharmacology.
1997 Jun; 96(3):353-6. doi:
". [PMID: 9261894] - H Autrup, E C Jørgensen, O Jensen. Aflatoxin B1 induced lacI mutation in liver and kidney of transgenic mice C57BL/6N: effect of phorone.
Mutagenesis.
1996 Jan; 11(1):69-73. doi:
10.1093/mutage/11.1.69. [PMID: 8671718] - J A Timbrell, C J Waterfield. Changes in taurine as an indicator of hepatic dysfunction and biochemical perturbations. Studies in vivo and in vitro.
Advances in experimental medicine and biology.
1996; 403(?):125-34. doi:
10.1007/978-1-4899-0182-8_15. [PMID: 8915350] - R F Burk, K E Hill. Reduced glutathione release into rat plasma by extrahepatic tissues.
The American journal of physiology.
1995 Sep; 269(3 Pt 1):G396-9. doi:
10.1152/ajpgi.1995.269.3.g396. [PMID: 7573450] - R F Burk, K E Hill, J A Awad, J D Morrow, P R Lyons. Liver and kidney necrosis in selenium-deficient rats depleted of glutathione.
Laboratory investigation; a journal of technical methods and pathology.
1995 Jun; 72(6):723-30. doi:
NULL. [PMID: 7783430] - M Paolini, R Mesirca, L Pozzetti, A Sapone, G Cantelli-Forti. Induction of CYP2B1 mediated pentoxyresorufin O-dealkylase activity in different species, sex and tissue by prototype 2B1-inducers.
Chemico-biological interactions.
1995 Mar; 95(1-2):127-39. doi:
10.1016/0009-2797(94)03352-8. [PMID: 7697745] - M T Ebron-McCoy, H P Nichols, J E Andrews, R J Kavlock. Profile of procarbazine-induced embryotoxicity in an embryo hepatocyte co-culture system and after in utero glutathione depletion.
Teratogenesis, carcinogenesis, and mutagenesis.
1995; 15(1):33-42. doi:
10.1002/tcm.1770150105. [PMID: 7604390] - J A Awad, R F Burk, L J Roberts. Effect of selenium deficiency and glutathione-modulating agents on diquat toxicity and lipid peroxidation in rats.
The Journal of pharmacology and experimental therapeutics.
1994 Sep; 270(3):858-64. doi:
NULL. [PMID: 7932197] - M Fujita, M Sano, K Yoshino, I Tomita. Effects of aldehyde dehydrogenase and glutathione on the degradation of (E)-4-hydroxy-2-nonenal and N-hexanal in rat liver.
Biochemistry and molecular biology international.
1994 Mar; 32(3):429-34. doi:
. [PMID: 8032311] - W G Bottje, W G Graupner, B Enkvetchakul, K G Allen. Prostacyclin elevation following glutathione depletion in vivo. Possible threshold dependency in liver and lung.
Biochemical pharmacology.
1993 Sep; 46(6):1019-27. doi:
10.1016/0006-2952(93)90666-k. [PMID: 8216344] - M Okuda, H C Lee, B Chance, C Kumar. Glutathione and ischemia-reperfusion injury in the perfused rat liver.
Free radical biology & medicine.
1992; 12(4):271-9. doi:
10.1016/0891-5849(92)90114-v. [PMID: 1577330] - J W Bauman, J Liu, Y P Liu, C D Klaassen. Increase in metallothionein produced by chemicals that induce oxidative stress.
Toxicology and applied pharmacology.
1991 Sep; 110(2):347-54. doi:
10.1016/s0041-008x(05)80017-1. [PMID: 1891778] - L J Dahm, R A Roth. Protection against alpha-naphthylisothiocyanate-induced liver injury by decreased hepatic non-protein sulfhydryl content.
Biochemical pharmacology.
1991 Aug; 42(6):1181-8. doi:
10.1016/0006-2952(91)90252-z. [PMID: 1679629] - H Nederbragt. Effect of the glutathione-depleting agents diethylmaleate, phorone and buthionine sulfoximine on biliary copper excretion in rats.
Biochemical pharmacology.
1989 Oct; 38(20):3399-406. doi:
10.1016/0006-2952(89)90107-x. [PMID: 2818632] - P L Goering. Acute exposure to formaldehyde induces hepatic metallothionein synthesis in mice.
Toxicology and applied pharmacology.
1989 Apr; 98(2):325-37. doi:
10.1016/0041-008x(89)90237-8. [PMID: 2711395] - Z Gregus, C White, S Howell, C D Klaassen. Effect of glutathione depletion on sulfate activation and sulfate ester formation in rats.
Biochemical pharmacology.
1988 Nov; 37(22):4307-12. doi:
10.1016/0006-2952(88)90611-9. [PMID: 3196355] - J P Buchet, R Lauwerys. Study of factors influencing the in vivo methylation of inorganic arsenic in rats.
Toxicology and applied pharmacology.
1987 Oct; 91(1):65-74. doi:
10.1016/0041-008x(87)90194-3. [PMID: 3672518] - O Strubelt, M Younes, R Pentz. Enhancement by glutathione depletion of ethanol-induced acute hepatotoxicity in vitro and in vivo.
Toxicology.
1987 Aug; 45(2):213-23. doi:
10.1016/0300-483x(87)90107-7. [PMID: 3603586] - K P Wilhelm, M Younes, D Sellin, C P Siegers. Halothane hepatotoxicity in glutathione depleted rats.
Journal of applied toxicology : JAT.
1987 Apr; 7(2):105-10. doi:
10.1002/jat.2550070206. [PMID: 3624765] - M Younes, G Craig, N H Stacey. Cell-mediated cytotoxicity by natural killer and killer cells, lipid peroxidation and glutathione.
Experientia.
1986 Dec; 42(11-12):1257-9. doi:
10.1007/bf01946412. [PMID: 3780952] - L G Costa, S D Murphy. Effect of diethylmaleate and other glutathione depletors on protein synthesis.
Biochemical pharmacology.
1986 Oct; 35(19):3383-8. doi:
10.1016/0006-2952(86)90439-9. [PMID: 3768026] - R G Schnellmann, L J Mandel. Multiple effects of presumed glutathione depletors on rabbit proximal tubules.
Kidney international.
1986 Apr; 29(4):858-62. doi:
10.1038/ki.1986.77. [PMID: 3712969] - M Younes, S C Sharma, C P Siegers. Glutathione depletion by phorone organ specificity and effect on hepatic microsomal mixed-function oxidase system.
Drug and chemical toxicology.
1986; 9(1):67-73. doi:
10.3109/01480548609042831. [PMID: 3743463] - C P Siegers, W Horn, M Younes. Effect of phorone-induced glutathione depletion on the metabolism and hepatotoxicity of carbon tetrachloride and vinylidene chloride in rats.
Journal of applied toxicology : JAT.
1985 Dec; 5(6):352-6. doi:
10.1002/jat.2550050603. [PMID: 4078216] - M Younes, S Cornelius, C P Siegers. Fe2+-supported in vivo lipid peroxidation induced by compounds undergoing redox cycling.
Chemico-biological interactions.
1985 Jun; 54(1):97-103. doi:
10.1016/s0009-2797(85)80155-1. [PMID: 4017107] - A Müller, H Gabriel, H Sies. A novel biologically active selenoorganic compound--IV. Protective glutathione-dependent effect of PZ 51 (ebselen) against ADP-Fe induced lipid peroxidation in isolated hepatocytes.
Biochemical pharmacology.
1985 Apr; 34(8):1185-9. doi:
10.1016/0006-2952(85)90493-9. [PMID: 3994741] - T Masukawa, T Nishimura, H Iwata. Tissue-specific induction of intestinal glutathione S-transferases by alpha beta-unsaturated carbonyl compounds.
Experientia.
1984 Nov; 40(11):1272-3. doi:
10.1007/bf01946670. [PMID: 6500015] - R Barsacchi, G Pelosi, P Camici, L Bonaldo, M Maiorino, F Ursini. Glutathione depletion increases chemiluminescence emission and lipid peroxidation in the heart.
Biochimica et biophysica acta.
1984 Jul; 804(3):356-60. doi:
10.1016/0167-4889(84)90139-3. [PMID: 6743695] - R E Dudley, C D Klaassen. Changes in hepatic glutathione concentration modify cadmium-induced hepatotoxicity.
Toxicology and applied pharmacology.
1984 Mar; 72(3):530-8. doi:
10.1016/0041-008x(84)90130-3. [PMID: 6710502] - M Younes, M Albrecht, C P Siegers. The role of iron in the NADPH-dependent lipid peroxidation due to glutathione depletion by phorone.
Pharmacological research communications.
1984 Feb; 16(2):153-60. doi:
10.1016/s0031-6989(84)80090-9. [PMID: 6504967] - K E Hill, R F Burk. Toxicity studies in isolated hepatocytes from selenium-deficient rats and vitamin E-deficient rats.
Toxicology and applied pharmacology.
1984 Jan; 72(1):32-9. doi:
10.1016/0041-008x(84)90246-1. [PMID: 6710482] - M Younes, C P Siegers. Formation of ethane in vitro by rat liver homogenates following glutathione depletion in vivo.
Toxicology letters.
1983 Feb; 15(2-3):213-8. doi:
10.1016/0378-4274(83)90218-7. [PMID: 6829044] - W G Levine. Glutathione and hepatic mixed-function oxidase activity.
Drug metabolism reviews.
1983; 14(5):909-30. doi:
10.3109/03602538308991416. [PMID: 6418502] - C P Siegers, W Hübscher, M Younes. Glutathione-S-transferase and GSH-peroxidase activities during the state of GSH-depletion leading to lipid peroxidation in rat liver.
Research communications in chemical pathology and pharmacology.
1982 Aug; 37(2):163-9. doi:
". [PMID: 7134625] - R Reiter, A Wendel. Chemically-induced glutathione depletion and lipid peroxidation.
Chemico-biological interactions.
1982 Jul; 40(3):365-74. doi:
10.1016/0009-2797(82)90159-4. [PMID: 6805968] - M Younes, C P Siegers. Mechanistic aspects of enhanced lipid peroxidation following glutathione depletion in vivo.
Chemico-biological interactions.
1981 Mar; 34(3):257-66. doi:
10.1016/0009-2797(81)90098-3. [PMID: 7460086] - J L Plummer, B R Smith, H Sies, J R Bend. Chemical depletion of glutathione in vivo.
Methods in enzymology.
1981; 77(?):50-9. doi:
10.1016/s0076-6879(81)77010-1. [PMID: 7035795] - R van Doorn, C M Leijdekkers, P T Henderson. Synergistic effects of phorone on the hepatotoxicity of bromobenzene and paracetamol in mice.
Toxicology.
1978 Nov; 11(3):225-33. doi:
10.1016/s0300-483x(78)91389-6. [PMID: 569914]
