Canditral (BioDeep_00001873681)
代谢物信息卡片
itraconazole
化学式: C35H38Cl2N8O4 (704.2392927999999)
中文名称: 伊曲康唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(C)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5COC(O5)(CN6C=NC=N6)C7=C(C=C(C=C7)Cl)Cl
InChI: InChI=1S/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3
描述信息
J - Antiinfectives for systemic use > J02 - Antimycotics for systemic use > J02A - Antimycotics for systemic use > J02AC - Triazole and tetrazole derivatives
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D065088 - Steroid Synthesis Inhibitors
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065692 - Cytochrome P-450 CYP3A Inhibitors
D004791 - Enzyme Inhibitors > D065088 - Steroid Synthesis Inhibitors > D058888 - 14-alpha Demethylase Inhibitors
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
2 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:94366
- PubChem: 3793
- ChEMBL: CHEMBL64391
- MeSH: Itraconazole
- CAS: 1217512-35-0
- CAS: 2049588-24-9
- CAS: 84604-65-9
- CAS: 84625-61-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Victor Carp Kofoed, Christopher Campion, Pil Uthaug Rasmussen, Signe Agnete Møller, Mathias Eskildsen, Jeppe Lund Nielsen, Anne Mette Madsen. Exposure to resistant fungi across working environments and time.
The Science of the total environment.
2024 May; 923(?):171189. doi:
10.1016/j.scitotenv.2024.171189. [PMID: 38447726] - Amal M Sindi, Waleed Y Rizg, Muhammad Khalid Khan, Hala M Alkhalidi, Waleed S Alharbi, Fahad Y Sabei, Eman Alfayez, Hanaa Alkharobi, Mohammed Korayem, Mohammed Majrashi, Majed Alharbi, Mohammed Alissa, Awaji Y Safhi, Abdulmajeed M Jali, Khaled M Hosny. Tailoring and optimization of a honey-based nanoemulgel loaded with an itraconazole-thyme oil nanoemulsion for oral candidiasis.
Drug delivery.
2023 Dec; 30(1):2173337. doi:
10.1080/10717544.2023.2173337. [PMID: 36708105] - Kevin Ehemann, Andrés Contreras, Adriana Marcela Celis-Ramírez. In vitro sensitivity of Malassezia furfur isolates from HIV-positive and negative patients to antifungal agents.
Biomedica : revista del Instituto Nacional de Salud.
2023 Aug; 43(Sp. 1):120-131. doi:
10.7705/biomedica.6871. [PMID: 37721914] - Brooke Rathie, Bart Theelen, Martin Laurence, Rebecca S Shapiro. Antimicrobial Susceptibility Testing for Three Malassezia Species.
Microbiology spectrum.
2023 08; 11(4):e0507622. doi:
10.1128/spectrum.05076-22. [PMID: 37310217] - Yumi Takimoto, Hiroshi Tsubamoto, Roze Isono-Taniguchi, Tomoko Ueda, Kazuko Sakata, Kohei Nakagawa, Sachiyo Narita, Y U Wakimoto, Hiroaki Shibahara, Shin Nishiumi. Itraconazole Modulates Phospholipid Levels in Tumor-associated Macrophages.
Anticancer research.
2023 May; 43(5):1981-1984. doi:
10.21873/anticanres.16358. [PMID: 37097657] - Stefanie Bressan Waller, Márcia Kutscher Ripoll, Luciéle Pereira de Melo, Patrícia Lindemann, Angelita Dos Reis Gomes, Otávia de Almeida Martins, Marlete Brum Cleff, João Roberto Braga de Mello, Renata Osório de Faria, Mário Carlos Araújo Meireles. Are polar extracts and essential oil from Origanum vulgare Linn. (oregano) an alternative against itraconazole-resistant dermatophytes from veterinary cases?.
Journal de mycologie medicale.
2023 Apr; 33(3):101391. doi:
10.1016/j.mycmed.2023.101391. [PMID: 37137171] - Lais Cavalcanti Dos Santos Velasco de Souza, Nathália Faria Reis, Lucas Martins Alcântara, Simone Rocha Leal da Silveira Souto, Bruno de Araújo Penna, Renan Caetano Souza Santos, Bruno Kaufmann Robbs, Francisco Paiva Machado, Helena Carla Castro, Ricardo Luiz Dantas Machado, Leandro Rocha, Andréa Regina de Souza Baptista. Ethyl acetate fractions of Myrciaria floribunda, Ocotea pulchella, and Ocotea notata exhibit promising in vitro activity against Sporothrix brasiliensis isolates with low susceptibility to itraconazole.
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology].
2023 Mar; 54(1):579-586. doi:
10.1007/s42770-023-00904-8. [PMID: 36701111] - Ji Qi, Weiwei Cheng, Zhe Gao, Yuanyuan Chen, Megan L Shipton, David Furkert, Alfred C Chin, Andrew M Riley, Dorothea Fiedler, Barry V L Potter, Chenglai Fu. Itraconazole inhibits endothelial cell migration by disrupting inositol pyrophosphate-dependent focal adhesion dynamics and cytoskeletal remodeling.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Feb; 161(?):114449. doi:
10.1016/j.biopha.2023.114449. [PMID: 36857911] - Vanessa Cunningham Gmyterco, Tomasz Jagielski, Gustavo Baldasso, Louise Helene Bacher, Márcio Garcia Ribeiro, Marconi Rodrigues de Farias. Cutaneous protothecosis in a dog successfully treated with oral itraconazole in pulse dosing.
Acta veterinaria Scandinavica.
2023 Feb; 65(1):7. doi:
10.1186/s13028-022-00662-x. [PMID: 36810141] - Yanming Wang, Zhang Chenghao, Zhaoli Wu, Xinran Cui, Jinmei Ren, Jingling Tang. In vivo and in vitro evaluation of pulmonary administration of itraconazole nanostructured lipid carriers for pulmonary aspergillosis.
Drug development and industrial pharmacy.
2023 Feb; 49(2):232-239. doi:
10.1080/03639045.2023.2200533. [PMID: 37039088] - Esin Sakallı Çetin, Hamdi Sozen, Ozgur Ilhan Celik, Ibrahim Hakkı Cigerci, Nigar Yılmaz. Mistletoe (Viscum album L.) extract attenuates ıtraconazole-ınduced acute oxidative stress and hepatocellular ınjury in rats.
Pakistan journal of pharmaceutical sciences.
2023 Jan; 36(1):9-16. doi:
". [PMID: 36967491] - Siyue Kan, Jingwen Tan, Qing Cai, Lulu An, Zhiqin Gao, Hong Yang, Siyu Liu, Risong Na, Lianjuan Yang. Synergistic activity of the combination of falcarindiol and itraconazole in vitro against dermatophytes.
Frontiers in cellular and infection microbiology.
2023; 13(?):1128000. doi:
10.3389/fcimb.2023.1128000. [PMID: 37207188] - Xianzhen Chen, Wenzhi Lei, Hui Meng, Yi Jiang, Sanli Zhang, Huyan Chen, Mingwei Du, Xiaochun Xue. Succinylation modification provides new insights for the treatment of immunocompromised individuals with drug-resistant Aspergillus fumigatus infection.
Frontiers in immunology.
2023; 14(?):1161642. doi:
10.3389/fimmu.2023.1161642. [PMID: 37138872] - Armando Guevara, Andréia Ferreira Nery, Márcia de Souza Carvalho Melhem, Lucas Bonfietti, Anderson Messias Rodrigues, Ferry Hagen, Jamile Ambrósio de Carvalho, Zoilo Pires de Camargo, Bruna Jacomel F de Souza Lima, Vânia Aparecida Vicente, Rosane Christine Hahn. Molecular epidemiology and clinical-laboratory aspects of chromoblastomycosis in Mato Grosso, Brazil.
Mycoses.
2022 Dec; 65(12):1146-1158. doi:
10.1111/myc.13505. [PMID: 35869803] - Paulo H F Carmo, Marliete C Costa, Victor A T Leocádio, Ludmila Gouveia-Eufrásio, Elúzia C P Emídio, Samantha P Pimentel, Tatiane A Paixão, Nalu T A Peres, Daniel A Santos. Exposure to itraconazole influences the susceptibility to antifungals, physiology, and virulence of Trichophyton interdigitale.
Medical mycology.
2022 Nov; 60(11):. doi:
10.1093/mmy/myac088. [PMID: 36367546] - Lakshmi Goswami, Lovely Gupta, Sayantan Paul, Maansi Vermani, Pooja Vijayaraghavan, Asish K Bhattacharya. Design and synthesis of eugenol/isoeugenol glycoconjugates and other analogues as antifungal agents against Aspergillus fumigatus.
RSC medicinal chemistry.
2022 Aug; 13(8):955-962. doi:
10.1039/d2md00138a. [PMID: 36092146] - Keisuke Umemura, Yoshiki Katada, Shunsaku Nakagawa, Mitsuhiro Sugimoto, Katsuyuki Matsumura, Atsushi Yonezawa, Miki Nagao, Akihiro Ohsumi, Hiroshi Date, Tomohiro Terada. Improved absorption of itraconazole tablet by co-administration with lemon beverages in a lung transplant recipient: A case report.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2022 Aug; 28(8):1203-1207. doi:
10.1016/j.jiac.2022.04.026. [PMID: 35534338] - Mohd Waseem, Jitendra K Thakur, Naidu Subbarao. Prediction of novel and potent inhibitors of lanosterol 14-α demethylase.
Journal of biomolecular structure & dynamics.
2022 Jul; ?(?):1-13. doi:
10.1080/07391102.2022.2096116. [PMID: 35815531] - Tao Ji, Xuejun Chen, Swamy Yeleswaram. Evaluation of drug-drug interaction potential for pemigatinib using physiologically based pharmacokinetic modeling.
CPT: pharmacometrics & systems pharmacology.
2022 07; 11(7):894-905. doi:
10.1002/psp4.12805. [PMID: 35506332] - Philip Sandoval, Bei-Ching Chuang, Lawrence Cohen, Tomoki Yoneyama, Sandeepraj Pusalkar, Robert W Yucha, Swapan K Chowdhury, Paresh P Chothe. Sinusoidal Uptake Determines the Hepatic Clearance of Pevonedistat (TAK-924) as Explained by Extended Clearance Model.
Drug metabolism and disposition: the biological fate of chemicals.
2022 Jul; 50(7):980-988. doi:
10.1124/dmd.122.000836. [PMID: 35545257] - Ashit Trivedi, Omar Mather, Silvia Vega, Shauna Hutton, Jennifer Hellawell, Edward Lee. A Phase 1, Open-Label Study to Evaluate the Effect of Food and Concomitant Itraconazole Administration on the Pharmacokinetics of AMG 986 in Healthy Subjects.
Clinical pharmacology in drug development.
2022 Jul; 11(7):849-856. doi:
10.1002/cpdd.1074. [PMID: 35247290] - Matthias Hoch, Felix Huth, Masahiko Sato, Tirtha Sengupta, Michelle Quinlan, Stephanie Dodd, Shruti Kapoor, Florence Hourcade-Potelleret. Pharmacokinetics of asciminib in the presence of CYP3A or P-gp inhibitors, CYP3A inducers, and acid-reducing agents.
Clinical and translational science.
2022 07; 15(7):1698-1712. doi:
10.1111/cts.13285. [PMID: 35616006] - Acharya Balkrishna, Sudeep Verma, Vallabh Prakash Mulay, Ashish Kumar Gupta, Swati Haldar, Anurag Varshney. Withania somnifera (L.) Dunal whole-plant extracts exhibited anti-sporotrichotic effects by destabilizing peripheral integrity of Sporothrix globosa yeast cells.
PLoS neglected tropical diseases.
2022 06; 16(6):e0010484. doi:
10.1371/journal.pntd.0010484. [PMID: 35714107] - Bo Wang, Yuerong Wang, Luwen Zhang, Fanbo Lu, Min Zhang, Yuanhong Xu. Surveillance Study of Epidemiology, Antifungal Susceptibility and Risk Factors of Invasive Candidiasis in Critically ill Patients.
Clinical laboratory.
2022 Jun; 68(6):. doi:
10.7754/clin.lab.2021.211001. [PMID: 35704741] - Lu Chen, Lixian Li, Wanyi Chen. Use of Modeling and Simulation to Predict the Influence of Triazole Antifungal Agents on the Pharmacokinetics of Crizotinib.
Clinical pharmacology in drug development.
2022 06; 11(6):724-733. doi:
10.1002/cpdd.1049. [PMID: 34995400] - Lu Liu, Le Yang, Wei Li, Xiaoyan Chen. Simultaneous determination of almonertinib and its active metabolite HAS-719 in human plasma by LC-MS/MS: Evaluation of pharmacokinetic interactions.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2022 May; 1197(?):123231. doi:
10.1016/j.jchromb.2022.123231. [PMID: 35344780] - Victoria Marinucci, Elias B Chahine, Larry M Bush. Invasive Fungal Rhinosinusitis Caused by Curvularia in a Patient With Type 1 Diabetes Mellitus: A Case Report.
Journal of pharmacy practice.
2022 Apr; 35(2):311-316. doi:
10.1177/0897190020966196. [PMID: 33054542] - Prashant Gupta, Hardeep Singh Malhotra, Priyamvada Saxena, Riddhi Singh, Deeksha Shukla, Mohd Saqib Hasan, Veerendra Verma, Gopa Banerjee, Bipin Puri, Himanshu Dandu. Utility of itraconazole and terbinafine in mucormycosis: a proof-of-concept analysis.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research.
2022 04; 70(4):914-918. doi:
10.1136/jim-2021-002179. [PMID: 35078866] - Ritesh Agarwal, Valliappan Muthu, Inderpaul Singh Sehgal, Sahajal Dhooria, Kuruswamy Thurai Prasad, Mandeep Garg, Ashutosh Nath Aggarwal, Arunaloke Chakrabarti. A randomised trial of prednisolone versus prednisolone and itraconazole in acute-stage allergic bronchopulmonary aspergillosis complicating asthma.
The European respiratory journal.
2022 04; 59(4):. doi:
10.1183/13993003.01787-2021. [PMID: 34503983] - Lu Liu, Wei Li, Le Yang, Zi-Tao Guo, Hao Xue, Ning-Jie Xie, Xiao-Yan Chen. Itraconazole and rifampicin, as CYP3A modulators but not P-gp modulators, affect the pharmacokinetics of almonertinib and active metabolite HAS-719 in healthy volunteers.
Acta pharmacologica Sinica.
2022 Apr; 43(4):1082-1090. doi:
10.1038/s41401-021-00710-8. [PMID: 34267345] - Yunfei Li, Mimi Tang, Shusen Sun, Qin Hu, Sheng Deng. Successful treatment of Talaromyces marneffei infection in a kidney transplant recipient with voriconazole followed by itraconazole for the first time.
Journal de mycologie medicale.
2022 Mar; 32(1):101214. doi:
10.1016/j.mycmed.2021.101214. [PMID: 34763148] - Song Ren, Karthick Vishwanathan, Mireille Cantarini, Paul Frewer, Indira Hara, Graeme Scarfe, Wendy Burke, Stein Schalkwijk, Yan Li, David Han, Ronald Goldwater. Clinical evaluation of the potential drug-drug interactions of savolitinib: Interaction with rifampicin, itraconazole, famotidine or midazolam.
British journal of clinical pharmacology.
2022 02; 88(2):655-668. doi:
10.1111/bcp.14994. [PMID: 34322894] - Hagar Bessar, Abdalla Hassan Kandil, Noha Mohammed Nasr, Fathia Khattab. Itraconazole versus propranolol: therapeutic and pharmacologic effect on serum angiopoietin-2 in patients with infantile hemangioma.
The Journal of dermatological treatment.
2022 Feb; 33(1):105-110. doi:
10.1080/09546634.2019.1687822. [PMID: 31668109] - Chunlin Chen, Liming Zhang, Cristina Almansa, Maria Rosario, Michael Cwik, Suresh K Balani, Ruth Lock. Evaluation of the Pharmacokinetics of Felcisetrag (TAK-954), a 5-HT4 Receptor Agonist, in the Presence and Absence of Itraconazole, a Potent CYP3A4 Inhibitor.
Clinical pharmacology in drug development.
2022 02; 11(2):142-149. doi:
10.1002/cpdd.1046. [PMID: 34989180] - Supriyo Saha, Gyu Seong Yeom, Satish Balasaheb Nimse, Dilipkumar Pal. Combination Therapy of Ledipasvir and Itraconazole in the Treatment of COVID-19 Patients Coinfected with Black Fungus: An In Silico Statement.
BioMed research international.
2022; 2022(?):5904261. doi:
10.1155/2022/5904261. [PMID: 35463967] - Michael Desch, Glen Wunderlich, Markus Goettel, Sophia Goetz, Karl-Heinz Liesenfeld, Tom S Chan, Holger Rosenbrock, Regina Sennewald, Jasmin Link, Sascha Keller, Sven Wind. Effects of Cytochrome P450 3A4 Induction and Inhibition on the Pharmacokinetics of BI 425809, a Novel Glycine Transporter 1 Inhibitor.
European journal of drug metabolism and pharmacokinetics.
2022 Jan; 47(1):91-103. doi:
10.1007/s13318-021-00723-y. [PMID: 34716565] - Nabila A El-Sheridy, Riham M El-Moslemany, Alyaa A Ramadan, Maged W Helmy, Labiba K El-Khordagui. Itraconazole for Topical Treatment of Skin Carcinogenesis: Efficacy Enhancement by Lipid Nanocapsule Formulations.
Journal of biomedical nanotechnology.
2022 Jan; 18(1):97-111. doi:
10.1166/jbn.2022.3217. [PMID: 35180903] - Yuya Matsuda, Shunsaku Nakagawa, Ikuko Yano, Satohiro Masuda, Satoshi Imai, Atsushi Yonezawa, Takashi Yamamoto, Mitsuhiro Sugimoto, Masahiro Tsuda, Tetsunori Tsuzuki, Tomohiro Omura, Takayuki Nakagawa, Toyofumi Fengshi Chen-Yoshikawa, Miki Nagao, Hiroshi Date, Kazuo Matsubara. Effect of Itraconazole and Its Metabolite Hydroxyitraconazole on the Blood Concentrations of Cyclosporine and Tacrolimus in Lung Transplant Recipients.
Biological & pharmaceutical bulletin.
2022; 45(4):397-402. doi:
10.1248/bpb.b21-00738. [PMID: 35370263] - Akiko Watanabe, Tomoko Ishizuka, Makiko Yamada, Yoshiyuki Igawa, Takako Shimizu, Hitoshi Ishizuka. Physiologically based pharmacokinetic modelling to predict the clinical effect of CYP3A inhibitors/inducers on esaxerenone pharmacokinetics in healthy subjects and subjects with hepatic impairment.
European journal of clinical pharmacology.
2022 Jan; 78(1):65-73. doi:
10.1007/s00228-021-03194-x. [PMID: 34415382] - Armando Guevara, Nathan Pereira Siqueira, Andreia Ferreira Nery, Leticia Rossetto da Silva Cavalcante, Ferry Hagen, Rosane Christine Hahn. Chromoblastomycosis in Latin America and the Caribbean: Epidemiology over the past 50 years.
Medical mycology.
2021 Dec; 60(1):. doi:
10.1093/mmy/myab062. [PMID: 34637525] - Ananta Khurana, Aastha Agarwal, Ashutosh Singh, Kabir Sardana, Manik Ghadlinge, Diksha Agrawal, Sanjeet Panesar, Khushboo Sethia, Anuradha Chowdhary. Predicting a therapeutic cut-off serum level of itraconazole in recalcitrant tinea corporis and cruris-A prospective trial.
Mycoses.
2021 Dec; 64(12):1480-1488. doi:
10.1111/myc.13367. [PMID: 34532888] - Nabila A El-Sheridy, Riham M El-Moslemany, Alyaa A Ramadan, Maged W Helmy, Labiba K El-Khordagui. Enhancing the in vitro and in vivo activity of itraconazole against breast cancer using miltefosine-modified lipid nanocapsules.
Drug delivery.
2021 Dec; 28(1):906-919. doi:
10.1080/10717544.2021.1917728. [PMID: 33960245] - Ana Rita Sokolonski, Maísa Santos Fonseca, Bruna Aparecida Souza Machado, Kathleen Ramos Deegan, Roberto Paulo Correia Araújo, Marcelo Andrés Umsza-Guez, Roberto Meyer, Ricardo W Portela. Activity of antifungal drugs and Brazilian red and green propolis extracted with different methodologies against oral isolates of Candida spp.
BMC complementary medicine and therapies.
2021 Nov; 21(1):286. doi:
10.1186/s12906-021-03445-5. [PMID: 34814913] - Pannaporn Thongsuk, Rongpong Plongla, Arsa Thammahong, Jaruwan Tiewsurin, Navaporn Worasilchai, Ariya Chindamporn, Chusana Suankratay. Vascular pythiosis caused by Pythium aphanidermatum: the first case report in Asia.
European journal of medical research.
2021 Nov; 26(1):132. doi:
10.1186/s40001-021-00603-w. [PMID: 34775999] - Sarit Cohen-Rabbie, Li Zhou, Karthick Vishwanathan, Martin Wild, Sherrie Xu, Tomoko Freshwater, Lokesh Jain, Stein Schalkwijk, Helen Tomkinson, Diansong Zhou. Physiologically Based Pharmacokinetic Modeling for Selumetinib to Evaluate Drug-Drug Interactions and Pediatric Dose Regimens.
Journal of clinical pharmacology.
2021 11; 61(11):1493-1504. doi:
10.1002/jcph.1935. [PMID: 34196005] - Makoto Kataoka, Keiko Minami, Toshihide Takagi, Gregory E Amidon, Shinji Yamashita. In Vitro-In Vivo Correlation in Cocrystal Dissolution: Consideration of Drug Release Profiles Based on Coformer Dissolution and Absorption Behavior.
Molecular pharmaceutics.
2021 11; 18(11):4122-4130. doi:
10.1021/acs.molpharmaceut.1c00537. [PMID: 34618448] - Katharine E Stott, Thuy Le, Thu Nguyen, Sarah Whalley, Jennifer Unsworth, Vo Trieu Ly, Ruwanthi Kolamunnage-Dona, William Hope. Population Pharmacokinetics and Pharmacodynamics of Itraconazole for Disseminated Infection Caused by Talaromyces marneffei.
Antimicrobial agents and chemotherapy.
2021 10; 65(11):e0063621. doi:
10.1128/aac.00636-21. [PMID: 34370587] - Neeraj Kumar, Shishu Goindi. Development and Optimization of Itraconazole-Loaded Solid Lipid Nanoparticles for Topical Administration Using High Shear Homogenization Process by Design of Experiments: In Vitro, Ex Vivo and In Vivo Evaluation.
AAPS PharmSciTech.
2021 Oct; 22(7):248. doi:
10.1208/s12249-021-02118-3. [PMID: 34647162] - Steven Zhang, Shu Jin, Celina Griffin, Zhongling Feng, Jianchang Lin, Karthik Venkatakrishnan, Neeraj Gupta. Effects of Itraconazole and Rifampin on the Pharmacokinetics of Mobocertinib (TAK-788), an Oral Epidermal Growth Factor Receptor Inhibitor, in Healthy Volunteers.
Clinical pharmacology in drug development.
2021 09; 10(9):1044-1053. doi:
10.1002/cpdd.967. [PMID: 34145979] - Chunling Tian, Jie Huang, Mengqiu Xia, Liu Liu, Wenxuan Cao, Jingbao Chen, Xiaoqin Chu. Physicochemical evaluation and pharmacodynamics of itraconazole-loaded liquid crystal precursor for vaginal delivery.
Drug development and industrial pharmacy.
2021 Aug; 47(8):1223-1234. doi:
10.1080/03639045.2021.1988096. [PMID: 34779328] - Simon Kallee, Christina Scharf, Ines Schroeder, Michael Paal, Michael Vogeser, Michael Irlbeck, Johannes Zander, Michael Zoller, Jette Jung, Nikolaus Kneidinger, Christian Schneider, Sebastian Michel, Uwe Liebchen. Comparing posaconazole and itraconazole for antifungal prophylaxis in critically ill lung transplant recipients: Efficacy and plasma concentrations.
Transplant infectious disease : an official journal of the Transplantation Society.
2021 Aug; 23(4):e13675. doi:
10.1111/tid.13675. [PMID: 34166573] - Rucha S Sane, Kit Wun Kathy Cheung, Eunpi Cho, Bianca M Liederer, Justin Hanover, Vikram Malhi, Emile Plise, Susan Wong, Luna Musib. Evaluation of Ipatasertib Interactions with Itraconazole and Coproporphyrin I and III in a Single Drug Interaction Study in Healthy Subjects.
The Journal of pharmacology and experimental therapeutics.
2021 08; 378(2):87-95. doi:
10.1124/jpet.121.000620. [PMID: 34049965] - Aurélio de Oliveira Bento, Alexandre Soares de Sena Costa, Soraia Lopes Lima, Manoella do Monte Alves, Analy Salles de Azevedo Melo, Anderson Messias Rodrigues, Walicyranison Plinio da Silva-Rocha, Eveline Pipolo Milan, Guilherme Maranhão Chaves. The spread of cat-transmitted sporotrichosis due to Sporothrix brasiliensis in Brazil towards the Northeast region.
PLoS neglected tropical diseases.
2021 08; 15(8):e0009693. doi:
10.1371/journal.pntd.0009693. [PMID: 34460830] - Adriana M Rauseo, Patrick Mazi, Phoebe Lewis, Bruce Burnett, Stuart Mudge, Andrej Spec. Bioavailability of Single-Dose SUBA-Itraconazole Compared to Conventional Itraconazole under Fasted and Fed Conditions.
Antimicrobial agents and chemotherapy.
2021 07; 65(8):e0013421. doi:
10.1128/aac.00134-21. [PMID: 34031053] - Song Mu, Chester Lin, Anna Skrzypczyk-Ostaszewicz, Iurie Bulat, Marina Maglakelidze, Viera Skarbova, Claudia Andreu-Vieyra, Srikumar Sahasranaman. The pharmacokinetics of pamiparib in the presence of a strong CYP3A inhibitor (itraconazole) and strong CYP3A inducer (rifampin) in patients with solid tumors: an open-label, parallel-group phase 1 study.
Cancer chemotherapy and pharmacology.
2021 07; 88(1):81-88. doi:
10.1007/s00280-021-04253-x. [PMID: 33772633] - Jianfu Heng, Qi Tang, Xue Chen, Jingjing Bao, Jun Deng, Yong Chen, Jiao Zhao, Songlin Zhu, Xiaobao Liu, Feng Yang, Yun Jiang, Nong Yang, Kunyan Li. Evaluation of the pharmacokinetic effects of itraconazole on alflutinib (AST2818): an open-label, single-center, single-sequence, two-period randomized study in healthy volunteers.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2021 Jul; 162(?):105815. doi:
10.1016/j.ejps.2021.105815. [PMID: 33771716] - Ellen Van Damme, Sandra De Meyer, Denisa Bojkova, Sandra Ciesek, Jindrich Cinatl, Steven De Jonghe, Dirk Jochmans, Pieter Leyssen, Christophe Buyck, Johan Neyts, Marnix Van Loock. In vitro activity of itraconazole against SARS-CoV-2.
Journal of medical virology.
2021 Jul; 93(7):4454-4460. doi:
10.1002/jmv.26917. [PMID: 33666253] - Zunaira Afzal, Sajid Asghar. Fabrication and characterization of itraconazole loaded anisotropic solid lipid-mannitol microstructures for enhanced antifungal activity.
Pakistan journal of pharmaceutical sciences.
2021 Jul; 34(4(Supplementary)):1607-1614. doi:
". [PMID: 34799338] - Sho Shimazaki, Junko Kuroda, Kenju Shimomura, Shingen Misaka. Urinary Excretion of Nadolol as a Possible In Vivo Probe for Drug Interactions Involving P-Glycoprotein.
Journal of clinical pharmacology.
2021 06; 61(6):799-805. doi:
10.1002/jcph.1812. [PMID: 33387374] - Sebastian Schloer, Linda Brunotte, Angeles Mecate-Zambrano, Shuyu Zheng, Jing Tang, Stephan Ludwig, Ursula Rescher. Drug synergy of combinatory treatment with remdesivir and the repurposed drugs fluoxetine and itraconazole effectively impairs SARS-CoV-2 infection in vitro.
British journal of pharmacology.
2021 06; 178(11):2339-2350. doi:
10.1111/bph.15418. [PMID: 33825201] - Laurens Liesenborghs, Isabel Spriet, Dirk Jochmans, Ann Belmans, Iwein Gyselinck, Laure-Anne Teuwen, Sebastiaan Ter Horst, Erwin Dreesen, Tatjana Geukens, Matthias M Engelen, Ewout Landeloos, Vincent Geldhof, Helga Ceunen, Barbara Debaveye, Bert Vandenberk, Lorenz Van der Linden, Sofie Jacobs, Lana Langendries, Robbert Boudewijns, Thuc Nguyen Dan Do, Winston Chiu, Xinyu Wang, Xin Zhang, Birgit Weynand, Thomas Vanassche, Timothy Devos, Geert Meyfroidt, Wim Janssens, Robin Vos, Pieter Vermeersch, Joost Wauters, Geert Verbeke, Paul De Munter, Suzanne J F Kaptein, Joana Rocha-Pereira, Leen Delang, Eric Van Wijngaerden, Johan Neyts, Peter Verhamme. Itraconazole for COVID-19: preclinical studies and a proof-of-concept randomized clinical trial.
EBioMedicine.
2021 Apr; 66(?):103288. doi:
10.1016/j.ebiom.2021.103288. [PMID: 33752127] - Yumi Imoto, Takafumi Naito, Yukari Miyadera, Takaaki Ono, Junichi Kawakami. Associations between plasma hydroxylated metabolite of itraconazole and serum creatinine in patients with a hematopoietic or immune-related disorder.
European journal of clinical pharmacology.
2021 Mar; 77(3):369-379. doi:
10.1007/s00228-020-03010-y. [PMID: 33033881] - Hansraj Choudhary, Shreya Singh, Rachna Singh, Ritesh Agarwal, Harsimran Kaur, Anup Ghosh, Arunaloke Chakrabarti, Shivaprakash M Rudramurthy. Rapid and Simple Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC) Method for Simultaneous Quantifications of Triazole Antifungals in Human Serum.
Mycopathologia.
2021 Mar; 186(1):27-39. doi:
10.1007/s11046-020-00514-0. [PMID: 33389486] - Allison Gaudy, Christian Atsriku, Ying Ye, Kimberly MacGorman, Liangang Liu, Yongjun Xue, Sekhar Surapaneni, Maria Palmisano. Evaluation of iberdomide and cytochrome p450 drug-drug interaction potential in vitro and in a phase 1 study in healthy subjects.
European journal of clinical pharmacology.
2021 Feb; 77(2):223-231. doi:
10.1007/s00228-020-03004-w. [PMID: 32965548] - Ying Xu, Qian Wang, Xiaozhen Li, Yingyan Chen, Gang Xu. Itraconazole attenuates the stemness of nasopharyngeal carcinoma cells via triggering ferroptosis.
Environmental toxicology.
2021 Feb; 36(2):257-266. doi:
10.1002/tox.23031. [PMID: 32951314] - Taksaon Angsutararux, Piriyaporn Chongtrakool, Sanya Sukpanichnant, Kornpawee Wongwaipijarn, Walaiporn Wangchinda. Disseminated histoplasmosis in a kidney transplant patient.
Transplant infectious disease : an official journal of the Transplantation Society.
2021 Feb; 23(1):e13405. doi:
10.1111/tid.13405. [PMID: 32654347] - Jianhua Zhang, Lidia Lopez Jimenez, Eveline Snelders, Alfons J M Debets, Anton G Rietveld, Bas J Zwaan, Paul E Verweij, Sijmen E Schoustra. Dynamics of Aspergillus fumigatus in Azole Fungicide-Containing Plant Waste in the Netherlands (2016-2017).
Applied and environmental microbiology.
2021 01; 87(2):. doi:
10.1128/aem.02295-20. [PMID: 33127811] - Hui-Jun Wang, Chun-Yan Zhou, Yan-Ding Su, Kai-Feng Gou, Xiao-Nan Geng, Xiang-Jun Qiu. The Pharmacokinetic Effect of Itraconazole and Voriconazole on Ripretinib in Beagle Dogs by UPLC-MS/MS Technique.
Drug design, development and therapy.
2021; 15(?):4865-4873. doi:
10.2147/dddt.s337864. [PMID: 34876808] - Joanne Abbotsford, David A Foley, Zoy Goff, Asha C Bowen, Christopher C Blyth, Daniel K Yeoh. Clinical experience with SUBA-itraconazole at a tertiary paediatric hospital.
The Journal of antimicrobial chemotherapy.
2021 01; 76(1):249-252. doi:
10.1093/jac/dkaa382. [PMID: 32929460] - Weijiang Zhang, Michael Mathisen, Grant R Goodman, Harper Forbes, Yuyao Song, Enric Bertran, Lev Demidov, Sang Joon Shin. Effect of Itraconazole, a Potent CYP3A4 Inhibitor, on the Steady-State Pharmacokinetics of Vemurafenib in Patients With BRAFV600 Mutation-Positive Malignancies.
Clinical pharmacology in drug development.
2021 01; 10(1):39-45. doi:
10.1002/cpdd.822. [PMID: 32602215] - Yueyue Liu, Qian Zhang, Chao Lu, Wei Hu. Multiple Administrations of Itraconazole Increase Plasma Exposure to Pyrotinib in Chinese Healthy Adults.
Drug design, development and therapy.
2021; 15(?):2485-2493. doi:
10.2147/dddt.s312310. [PMID: 34140765] - Shan-Shan Zhang, Sajid Asghar, Jun-Xiu Ye, Ling Lin, Qi-Neng Ping, Zhi-Peng Chen, Feng Shao, Yan-Yu Xiao. A combination of receptor mediated transcytosis and photothermal effect promotes BBB permeability and the treatment of meningitis using itraconazole.
Nanoscale.
2020 Dec; 12(46):23709-23720. doi:
10.1039/d0nr04035e. [PMID: 33231242] - Matthew R Durk, Nicholas S Jones, Jia Liu, Karthik Nagapudi, Chen Mao, Emile G Plise, Susan Wong, Jacob Z Chen, Yuan Chen, Leslie W Chinn, Po-Chang Chiang. Understanding the Effect of Hydroxypropyl-β-Cyclodextrin on Fenebrutinib Absorption in an Itraconazole-Fenebrutinib Drug-Drug Interaction Study.
Clinical pharmacology and therapeutics.
2020 12; 108(6):1224-1232. doi:
10.1002/cpt.1943. [PMID: 32535897] - David E Gerber, William C Putnam, Farjana J Fattah, Kemp H Kernstine, Rolf A Brekken, Ivan Pedrosa, Rachael Skelton, Jessica M Saltarski, Robert E Lenkinski, Richard D Leff, Chul Ahn, Chyndhri Padmanabhan, Vaidehi Chembukar, Sahba Kasiri, Raja Reddy Kallem, Indhumathy Subramaniyan, Qing Yuan, Quyen N Do, Yin Xi, Scott I Reznik, Lorraine Pelosof, Brandon Faubert, Ralph J DeBerardinis, James Kim. Concentration-dependent Early Antivascular and Antitumor Effects of Itraconazole in Non-Small Cell Lung Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2020 11; 26(22):6017-6027. doi:
10.1158/1078-0432.ccr-20-1916. [PMID: 32847935] - Michael G M Derks, Christoph Wandel, Annie Young, Stuart K Bolt, Christoph Meyenberg. Open-Label Assessment of the Effects of Itraconazole and Rifampicin on Balovaptan Pharmacokinetics in Healthy Volunteers.
Advances in therapy.
2020 11; 37(11):4720-4729. doi:
10.1007/s12325-020-01491-y. [PMID: 32935287] - Jia Li, Kevin Rockich, Brad Yuska, Gongfu Zhou, Noam Epstein, Naresh Punwani, Xuejun Chen, Swamy Yeleswaram. An Open-Label Study to Assess the Effect of Itraconazole and Rifampin on Parsaclisib Pharmacokinetics When Administered Orally in Healthy Participants.
Journal of clinical pharmacology.
2020 11; 60(11):1519-1526. doi:
10.1002/jcph.1653. [PMID: 32515832] - Chandra Prakash, Bin Fan, Alice Ke, Kha Le, Hua Yang. Physiologically based pharmacokinetic modeling and simulation to predict drug-drug interactions of ivosidenib with CYP3A perpetrators in patients with acute myeloid leukemia.
Cancer chemotherapy and pharmacology.
2020 11; 86(5):619-632. doi:
10.1007/s00280-020-04148-3. [PMID: 32978634] - Felix Bongomin, Tomaz Garcez, David W Denning. Impact of high baseline Aspergillus-specific IgG levels on weight and quality-of-life outcomes of patients with chronic pulmonary aspergillosis.
Medical mycology.
2020 Oct; 58(7):1000-1004. doi:
10.1093/mmy/myaa026. [PMID: 32343313] - Kaoru Kobayashi, Yoshikazu Abe, Asuka Kawai, Takao Furihata, Takuro Endo, Hiroo Takeda. Pharmacokinetic Drug Interactions of an Orally Available TRH Analog (Rovatirelin) With a CYP3A4/5 and P-Glycoprotein Inhibitor (Itraconazole).
Journal of clinical pharmacology.
2020 10; 60(10):1314-1323. doi:
10.1002/jcph.1628. [PMID: 32459872] - Felix Jaminion, Darren Bentley, Ken Wang, Christoph Wandel, Michael Derks, Cheikh Diack. PKPD and cardiac single cell modeling of a DDI study with a CYP3A4 substrate and itraconazole to quantify the effects on QT interval duration.
Journal of pharmacokinetics and pharmacodynamics.
2020 10; 47(5):447-459. doi:
10.1007/s10928-020-09696-y. [PMID: 32572738] - Yoshiaki Kirigaya, Masanari Shiramoto, Tomoko Ishizuka, Hinako Uchimaru, Shin Irie, Manabu Kato, Takako Shimizu, Takafumi Nakatsu, Yasuhiro Nishikawa, Hitoshi Ishizuka. Effects of itraconazole and rifampicin on the single-dose pharmacokinetics of the nonsteroidal mineralocorticoid receptor blocker esaxerenone in healthy Japanese subjects.
British journal of clinical pharmacology.
2020 10; 86(10):2070-2079. doi:
10.1111/bcp.14302. [PMID: 32250463] - Jonathan Q Tran, Peijin Zhang, Atalanta Ghosh, Liangang Liu, Mary Syto, Xiaomin Wang, Maria Palmisano. Single-Dose Pharmacokinetics of Ozanimod and its Major Active Metabolites Alone and in Combination with Gemfibrozil, Itraconazole, or Rifampin in Healthy Subjects: A Randomized, Parallel-Group, Open-Label Study.
Advances in therapy.
2020 10; 37(10):4381-4395. doi:
10.1007/s12325-020-01473-0. [PMID: 32857315] - Thanat Ounsinman, Piriyaporn Chongtrakool, Nasikarn Angkasekwinai. Continuous ambulatory peritoneal dialysis-associated Histoplasma capsulatum peritonitis: a case report and literature review.
BMC infectious diseases.
2020 Sep; 20(1):717. doi:
10.1186/s12879-020-05441-5. [PMID: 32993529] - Shiva Shahmohamadnejad, Seyed Fazel Nabavi, Solomon Habtemariam, Kasturi Sarkar, Parames C Sil, Razieh Dowran, Seyed Mohammad Nabavi. May we target double-membrane vesicles and oxysterol-binding protein to combat SARS-CoV-2 infection?.
Cell biology international.
2020 09; 44(9):1770-1772. doi:
10.1002/cbin.11400. [PMID: 32449802] - Oleg O Glebov. Understanding SARS-CoV-2 endocytosis for COVID-19 drug repurposing.
The FEBS journal.
2020 09; 287(17):3664-3671. doi:
10.1111/febs.15369. [PMID: 32428379] - Arunima Ray, Kaustuv Mukherjee, Sharmila Thukral, Arpita Sarkar, Deepak Shankar Ray. An Unusual Case of a Dematiaceous Fungus with an Exclusive Cerebral Involvement After ABO-Incompatible Renal Transplantation.
The American journal of case reports.
2020 Aug; 21(?):e925473. doi:
10.12659/ajcr.925473. [PMID: 32859888] - Saili Xie, Lei Ye, Xuemei Ye, Guanyang Lin, Ren-Ai Xu. Inhibitory effects of voriconazole, itraconazole and fluconazole on the pharmacokinetic profiles of ivosidenib in rats by UHPLC-MS/MS.
Journal of pharmaceutical and biomedical analysis.
2020 Aug; 187(?):113353. doi:
10.1016/j.jpba.2020.113353. [PMID: 32417565] - Keigo Nakayama, Hidetaka Kamimura, Hiroshi Suemizu, Nao Yoneda, Megumi Nishiwaki, Kazuhiko Iwamoto, Mari Mizunaga, Tamotsu Negoro, Soichiro Ito, Hiroshi Yamazaki, Yukihiro Nomura. Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data.
Drug metabolism and pharmacokinetics.
2020 Aug; 35(4):389-396. doi:
10.1016/j.dmpk.2020.05.004. [PMID: 32690433] - Deng Linqiang, Chen Yiguo, Xu Heping, Chen Dongke, Hu Longhua, Gui Xiaomei, Zou Xia. Subcutaneous phaeohyphomycosis caused by Hongkongmyces snookiorum in a kidney transplant patient: a case report.
BMC infectious diseases.
2020 Aug; 20(1):562. doi:
10.1186/s12879-020-05295-x. [PMID: 32738901] - Parminder Kaur, Pankaj Kumar, Shivani Randev, Vishal Guglani. Allergic bronchopulmonary aspergillosis without asthma or cystic fibrosis.
Paediatrics and international child health.
2020 08; 40(3):199-201. doi:
10.1080/20469047.2020.1744872. [PMID: 32238049] - Monica E D'Arcy, Ruth M Pfeiffer, Donna R Rivera, Gregory P Hess, Elizabeth K Cahoon, Sarah T Arron, Isaac Brownell, Edward W Cowen, Ajay K Israni, Matthew A Triplette, Elizabeth L Yanik, Eric A Engels. Voriconazole and the Risk of Keratinocyte Carcinomas Among Lung Transplant Recipients in the United States.
JAMA dermatology.
2020 07; 156(7):772-779. doi:
10.1001/jamadermatol.2020.1141. [PMID: 32401271] - Gregory Scott, Cara L Field, Mark G Papich, Craig A Harms. Plasma concentrations of itraconazole following a single oral dose in juvenile California sea lions (Zalophus californianus).
Journal of veterinary pharmacology and therapeutics.
2020 Jul; 43(4):377-380. doi:
10.1111/jvp.12865. [PMID: 32286696] - Maria M Posada, Bridget L Morse, P Kellie Turner, Palaniappan Kulanthaivel, Stephen D Hall, Gemma L Dickinson. Predicting Clinical Effects of CYP3A4 Modulators on Abemaciclib and Active Metabolites Exposure Using Physiologically Based Pharmacokinetic Modeling.
Journal of clinical pharmacology.
2020 07; 60(7):915-930. doi:
10.1002/jcph.1584. [PMID: 32080863] - Tian Cai, Youming Liao, Zhenhua Chen, Yingchang Zhu, Xincai Qiu. The Influence of Different Triazole Antifungal Agents on the Pharmacokinetics of Cyclophosphamide.
The Annals of pharmacotherapy.
2020 07; 54(7):676-683. doi:
10.1177/1060028019896894. [PMID: 31893943] - Mazhar Hussein Amirali, Jacques Liebenberg, Sheylyn Pillay, Johan Nel. Sporotrichosis in renal transplant patients: two case reports and a review of the literature.
Journal of medical case reports.
2020 Jun; 14(1):79. doi:
10.1186/s13256-020-02385-x. [PMID: 32586384] - Surbhi Gupta, Colin Andrew Hinkamp, Matthew Lo. Urine antigen-negative disseminated histoplasmosis mimicking post-transplant lymphoproliferative disorder.
BMJ case reports.
2020 Jun; 13(6):. doi:
10.1136/bcr-2019-233976. [PMID: 32532906] - A Samaddar, A Sharma, T Shrimali. Pulmonary infection due to Acrophialophora fusispora in a patient with underlying mixed connective tissue disease and chronic pulmonary aspergillosis: A case report and review of literature.
Journal de mycologie medicale.
2020 Jun; 30(2):100932. doi:
10.1016/j.mycmed.2020.100932. [PMID: 32008965] - J A Braue, R W Larue, A S Boyd, J-D Fine. Phaeohyphomycosis caused by Rhytidhysteron rufulum.
Clinical and experimental dermatology.
2020 Jun; 45(4):524-526. doi:
10.1111/ced.14123. [PMID: 31696561] - Katharina R Beck, Lucija Telisman, Chris J van Koppen, George R Thompson, Alex Odermatt. Molecular mechanisms of posaconazole- and itraconazole-induced pseudohyperaldosteronism and assessment of other systemically used azole antifungals.
The Journal of steroid biochemistry and molecular biology.
2020 05; 199(?):105605. doi:
10.1016/j.jsbmb.2020.105605. [PMID: 31982514]