PYRAZINE (BioDeep_00001873598)

   

Volatile Flavor Compounds natural product


代谢物信息卡片


PYRAZINE

化学式: C4H4N2 (80.0374464)
中文名称: 吡嗪
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CN=CC=N1
InChI: InChI=1S/C4H4N2/c1-2-6-4-3-5-1/h1-4H

描述信息

A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.

同义名列表

2 个代谢物同义名

PYRAZINE; Pyrazine



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

21 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Baoshang Fu, Yiqian Wang, Xuhui Huang, Xiuping Dong, Dayong Zhou, Libo Qi, Lei Qin. The formation and conversion of characteristic aroma profiles and key harmful substances in different high-temperature processing of hairtail (Trichiurus Haumela). Food research international (Ottawa, Ont.). 2024 Jul; 187(?):114323. doi: 10.1016/j.foodres.2024.114323. [PMID: 38763630]
  • Xiuzhi Chen, Bin Zou, Zhen Yang. CircACTR2 attenuated the effects of tetramethylpyrazine on human kidney cell injury. Journal of bioenergetics and biomembranes. 2024 Jun; 56(3):273-284. doi: 10.1007/s10863-024-10001-6. [PMID: 38427129]
  • Congyan Liu, Wenting Su, Xi Jiang, Yanli Lv, Fei Kong, Qin Chen, Qun Zhang, Huangqin Zhang, Yuping Liu, Xiaoqi Li, Xinrong Xu, Yan Chen, Ding Qu. A Sustainable Retinal Drug Co-Delivery for Boosting Therapeutic Efficacy in wAMD: Unveiling Multifaceted Evidence and Synergistic Mechanisms. Advanced healthcare materials. 2024 Jun; 13(14):e2303659. doi: 10.1002/adhm.202303659. [PMID: 38386849]
  • Bowen Deng, Shengyuan Jiang, Gang Liu, Xiaoye Li, Yi Zhao, Xiao Fan, Jingpei Ren, Chengyun Ning, Lin Xu, Linhong Ji, Xiaohong Mu. Tetramethylpyrazine-loaded electroconductive hydrogels promote tissue repair after spinal cord injury by protecting the blood-spinal cord barrier and neurons. Journal of materials chemistry. B. 2024 May; 12(18):4409-4426. doi: 10.1039/d3tb02160b. [PMID: 38630533]
  • Buguo Wang, Yongjie Zhang, Ya Wei, Min Liao, Haiqun Cao, Quan Gao. Functional analysis of three odorant receptors in Plutella xylostella response to repellent activity of 2,3-dimethyl-6-(1-hydroxy)-pyrazine. Pesticide biochemistry and physiology. 2024 May; 201(?):105856. doi: 10.1016/j.pestbp.2024.105856. [PMID: 38685238]
  • Xiangyu Chen, Tong Yang, Yue Zhou, Zhigang Mei, Wenli Zhang. Astragaloside IV combined with ligustrazine ameliorates abnormal mitochondrial dynamics via Drp1 SUMO/deSUMOylation in cerebral ischemia-reperfusion injury. CNS neuroscience & therapeutics. 2024 04; 30(4):e14725. doi: 10.1111/cns.14725. [PMID: 38615367]
  • Zhongqiang Zhu, Jun Li, Zhiyong Song, Tonglu Li, Zongping Li, Xuezhong Gong. Tetramethylpyrazine attenuates renal tubular epithelial cell ferroptosis in contrast-induced nephropathy by inhibiting transferrin receptor and intracellular reactive oxygen species. Clinical science (London, England : 1979). 2024 03; 138(5):235-249. doi: 10.1042/cs20231184. [PMID: 38357976]
  • Guodong Qi, Shujun Li, Qiong Jiang, Zhijuan Yu, Zhenggang Peng, Qiurui Li, Wei Qi, Mingjun Guo. Network pharmacology analysis and experimental validation to explore the effect and mechanism of tetramethylpyrazine for spinal cord injury. Journal of chemical neuroanatomy. 2024 03; 136(?):102386. doi: 10.1016/j.jchemneu.2023.102386. [PMID: 38176475]
  • Buguo Wang, Yongjie Zhang, Chenyang Zhang, Min Liao, Haiqun Cao, Quan Gao. Identification and functional characterization of two antenna-specifc odorant-binding proteins in Plutella xylostella response to 2,3-dimethyl-6-(1-hydroxy)-pyrazine. International journal of biological macromolecules. 2024 Mar; 262(Pt 1):130031. doi: 10.1016/j.ijbiomac.2024.130031. [PMID: 38331072]
  • Aysha S Ansari, Remant K C, Luis C Morales, Mohammad Nasrullah, Daniel Nisakar Meenakshi Sundaram, Cezary Kucharski, Xiaoyan Jiang, Joseph Brandwein, Hasan Uludağ. Lipopolymer mediated siRNA delivery targeting aberrant oncogenes for effective therapy of myeloid leukemia in preclinical animal models. Journal of controlled release : official journal of the Controlled Release Society. 2024 Mar; 367(?):821-836. doi: 10.1016/j.jconrel.2024.02.018. [PMID: 38360178]
  • Claire McDonald, Craig Alderson, Matthew G Birkbeck, Laura Brown, Silvia Del Din, Grainne G Gorman, Kieren Hollingsworth, Clare Massarella, Rana Rehman, Lynn Rochester, Avan Ap Sayer, Huizhong Su, Helen Tuppen, Charlotte Warren, Miles D Witham. A study protocol to investigate if acipimox improves muscle function and sarcopenia: an open-label, uncontrolled, before-and-after experimental medicine feasibility study in community-dwelling older adults. BMJ open. 2024 Feb; 14(2):e076518. doi: 10.1136/bmjopen-2023-076518. [PMID: 38417968]
  • Zixuan Zhang, Lei Luo, Xueling Li, Yifei Zhong. The effects of Salvia miltiorrhiza and ligustrazine injection combined with ACEI/ARB on diabetic kidney disease: A systematic review and meta-analysis. Medicine. 2024 Feb; 103(8):e35853. doi: 10.1097/md.0000000000035853. [PMID: 38394516]
  • Bowen Deng, Shengyuan Jiang, Gang Liu, Xiaoye Li, Huizhong Bai, Luyao Huo, Jie Xu, Lin Xu, Xiaohong Mu. [Experimental study of tetramethylpyrazine-loaded electroconductive hydrogel on angiogenesis and neuroprotection after spinal cord injury]. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery. 2024 Feb; 38(2):189-197. doi: 10.7507/1002-1892.202311009. [PMID: 38385232]
  • Xiaoyi Hu, Ping Yuan, Jun Chen, Shang Wang, Hui Zhao, Yaqin Wei, Jiaqi Fu, Fadong Chen, Hongyun Ruan, Wei Zhang, Yanli Zhou, Qiqi Wang, Xiaoling Xu, Kefu Feng, Jianzhou Guo, Sugang Gong, Ruifeng Zhang, Qinhua Zhao, Lan Wang. Impact of different sequential triple oral combination therapies based selexipag on outcomes in pulmonary arterial hypertension. Clinical cardiology. 2024 Feb; 47(2):e24245. doi: 10.1002/clc.24245. [PMID: 38402556]
  • Fan Feng, Ding-Qiao Xu, Shi-Jun Yue, Yan-Yan Chen, Yu-Ping Tang. Neuroprotection by tetramethylpyrazine and its synthesized analogues for central nervous system diseases: a review. Molecular biology reports. 2024 Jan; 51(1):159. doi: 10.1007/s11033-023-09068-y. [PMID: 38252346]
  • Marlou L Dirks, Tom S O Jameson, Rob C Andrews, Mandy V Dunlop, Doaa R Abdelrahman, Andrew J Murton, Benjamin T Wall, Francis B Stephens. The impact of forearm immobilization and acipimox administration on muscle amino acid metabolism and insulin sensitivity in healthy, young volunteers. American journal of physiology. Endocrinology and metabolism. 2024 Jan; ?(?):. doi: 10.1152/ajpendo.00345.2023. [PMID: 38231001]
  • Yan Ma, Qian Cui, Wenjing Zhu, Mei Wang, Li Zhai, Wenmin Hu, Dongdong Liu, Min Liu, Yongchun Li, Meng Li, Wei Han. A Novel Tetramethylpyrazine Chalcone Hybrid- HCTMPPK, as a Potential Anti-Lung Cancer Agent by Downregulating MELK. Drug design, development and therapy. 2024; 18(?):1531-1546. doi: 10.2147/dddt.s449139. [PMID: 38737331]
  • Meng-Qi Shu, Yao-Yao Dai, Li-Juan Song, Dong Ma, Ke-Xin Liu, Zhu-Yue Miao, Ru-Heng Wei, Jin-Zhu Yin, Cun-Gen Ma, Jian-Jun Huang. [Tetramethylpyrazine regulates angiogenesis of endothelial cells in cerebral ischemic stroke injury via SIRT1/VEGFA signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2024 Jan; 49(1):162-174. doi: 10.19540/j.cnki.cjcmm.20231116.303. [PMID: 38403349]
  • Lin Wu, Weiyi Huang, Xiaoxiao Liu, Baochun Yang. Investigation of the clinical effects of acipimox in patients with vulnerable carotid atherosclerosis. Vascular. 2023 Dec; 31(6):1201-1208. doi: 10.1177/17085381221112551. [PMID: 35857037]
  • Jixin Zhang, Dongzhou Xia, Tiehan Li, Yuming Wei, Wanzhen Feng, Zhichao Xiong, Junlan Huang, Wei-Wei Deng, Jingming Ning. Effects of different over-fired drying methods on the aroma of Lu'an Guapian tea. Food research international (Ottawa, Ont.). 2023 Nov; 173(Pt 1):113224. doi: 10.1016/j.foodres.2023.113224. [PMID: 37803542]
  • Jing Wang, Haijun Bi, Mengru Li, Hui Wang, Manman Xue, Jieyao Yu, Chi-Tang Ho, Liang Zhang, Qinglin Zhuo, Jiadao Jiang, Xiaochun Wan, Xiaoting Zhai. Contribution of theanine to the temperature-induced changes in aroma profile of Wuyi rock tea. Food research international (Ottawa, Ont.). 2023 07; 169(?):112860. doi: 10.1016/j.foodres.2023.112860. [PMID: 37254434]
  • Gan Li, Kim Sia Sng, Bing Shu, Yong-Jun Wang, Min Yao, Xue-Jun Cui. Effects of tetramethylpyrazine treatment in a rat model of spinal cord injury: A systematic review and meta-analysis. European journal of pharmacology. 2023 Apr; 945(?):175524. doi: 10.1016/j.ejphar.2023.175524. [PMID: 36803629]
  • Simin Min, Weiting Tao, Yuchen Miao, Yan Li, Tianyu Wu, Xiaoyu He, Yijing Zhang, Bangye Liu, Zixin Meng, Ke Han, Saisai Liu, Li Li, Jie Chen, Shidi Zhao, Junjie Zhang, Xiaonan Zhang. Dual Delivery of Tetramethylpyrazine and miR-194-5p Using Soft Mesoporous Organosilica Nanoparticles for Acute Lung Injury Therapy. International journal of nanomedicine. 2023; 18(?):6469-6486. doi: 10.2147/ijn.s420802. [PMID: 38026537]
  • Mangesh Tiwaskar, Raja Dhar, Deepak Talwar, Abdul Ansari, Mahesh Lakhe, Sagar Panchal, Sagar Bhagat, Saiprasad Patil, Hanmant Barkate. Real-world Experience with Favipiravir for Treatment of COVID-19 among Indian Healthcare Professionals. The Journal of the Association of Physicians of India. 2022 Dec; 69(12):11-12. doi: NULL. [PMID: 35057588]
  • Ting Zhu, Bin-Yu Fang, Xiang-Bao Meng, Shu-Xia Zhang, Hong Wang, Ge Gao, Fei Liu, Yu Wu, Jin Hu, Gui-Bo Sun, Xiao-Bo Sun. Folium Ginkgo extract and tetramethylpyrazine sodium chloride injection (Xingxiong injection) protects against focal cerebral ischaemia/reperfusion injury via activating the Akt/Nrf2 pathway and inhibiting NLRP3 inflammasome activation. Pharmaceutical biology. 2022 Dec; 60(1):195-205. doi: 10.1080/13880209.2021.2014895. [PMID: 35060427]
  • Heng Wang, Jing Bi, Yuan Zhang, Miaomiao Pan, Qinglong Guo, Genhui Xiao, Yumeng Cui, Song Hu, Chi Kin Chan, Ying Yuan, Takushi Kaneko, Guoliang Zhang, Shawn Chen. Human Kinase IGF1R/IR Inhibitor Linsitinib Controls the In Vitro and Intracellular Growth of Mycobacterium tuberculosis. ACS infectious diseases. 2022 10; 8(10):2019-2027. doi: 10.1021/acsinfecdis.2c00278. [PMID: 36048501]
  • Zongyang Li, Xiangbao Meng, Guoxu Ma, Wenlan Liu, Weiping Li, Qian Cai, Sicen Wang, Guodong Huang, Yuan Zhang. Increasing brain glucose metabolism by ligustrazine piperazine ameliorates cognitive deficits through PPARγ-dependent enhancement of mitophagy in APP/PS1 mice. Alzheimer's research & therapy. 2022 10; 14(1):150. doi: 10.1186/s13195-022-01092-7. [PMID: 36217155]
  • Xin Shen, Gaofu Li, Libin Wang, Huijin Yu, Lei Zhou, Huifang Deng, Ningning Wang, Chengcai Lai, Wei Zhou, Yue Gao. Quantification of Acipimox in Plasma and Tissues by LC-MS/MS: Application to Pharmacokinetic Comparison between Normoxia and Hypoxia. Molecules (Basel, Switzerland). 2022 Sep; 27(19):. doi: 10.3390/molecules27196413. [PMID: 36234950]
  • Jia-Chun Cai, Qing-Qing Li, Jun-Wei Liu, Xue-Fen Zheng, Nan Wang, Chun-Yuan Li, Ya-Hong Xiong. [Metabolites of endophytic fungus Nigrospora sphaerica S5 from Myoporum bontioides]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Sep; 47(17):4658-4664. doi: 10.19540/j.cnki.cjcmm.20220418.203. [PMID: 36164872]
  • Zixin Li, Luchen Shan, Pei Yu. Preventive effect of tetramethylpyrazine on nitroglycerin-tolerance in rats by improving oxidative stress and ribosome homeostasis. Biochemical and biophysical research communications. 2022 08; 618(?):141-147. doi: 10.1016/j.bbrc.2022.06.013. [PMID: 35724458]
  • Mengyu Zhang, Soichiro Tajima, Kimitaka Suetsugu, Takeshi Hirota, Yuichi Tsuchiya, Takuji Yamauchi, Goichi Yoshimoto, Toshihiro Miyamoto, Nobuaki Egashira, Koichi Akashi, Ichiro Ieiri. Development and Validation of an LC-MS/MS Method to Quantify Gilteritinib and Its Clinical Application in Patients With FLT3 Mutation-Positive Acute Myelogenous Leukemia. Therapeutic drug monitoring. 2022 Aug; 44(4):592-596. doi: 10.1097/ftd.0000000000000971. [PMID: 35149666]
  • Buyun Chen, Diansong Zhou, Hua Wei, Marmor Yotvat, Li Zhou, Jean Cheung, Nicole Sarvaria, Richard Lai, Shringi Sharma, Karthick Vishwanathan, Joseph Ware. Acalabrutinib CYP3A-mediated drug-drug interactions: Clinical evaluations and physiologically based pharmacokinetic modelling to inform dose adjustment strategy. British journal of clinical pharmacology. 2022 Aug; 88(8):3716-3729. doi: 10.1111/bcp.15278. [PMID: 35165925]
  • Roma Patel, Nishant Parmar, Nirali Rathwa, Sayantani Pramanik Palit, Yansui Li, Adolfo Garcia-Ocaña, Rasheedunnisa Begum. A novel therapeutic combination of sitagliptin and melatonin regenerates pancreatic β-cells in mouse and human islets. Biochimica et biophysica acta. Molecular cell research. 2022 08; 1869(8):119263. doi: 10.1016/j.bbamcr.2022.119263. [PMID: 35364117]
  • Jatinder Dhaliwal, Navneet Dhaliwal, Ansab Akhtar, Anurag Kuhad, Kanwaljit Chopra. Tetramethylpyrazine Attenuates Cognitive Impairment Via Suppressing Oxidative Stress, Neuroinflammation, and Apoptosis in Type 2 Diabetic Rats. Neurochemical research. 2022 Aug; 47(8):2431-2444. doi: 10.1007/s11064-022-03640-x. [PMID: 35665448]
  • Ting Wang, Mei Jing, Ting Zhang, Zaijun Zhang, Yewei Sun, Yuqiang Wang. Tetramethylpyrazine nitrone TBN extends the lifespan of C. elegans by activating the Nrf2/SKN-1 signaling pathway. Biochemical and biophysical research communications. 2022 07; 614(?):107-113. doi: 10.1016/j.bbrc.2022.05.009. [PMID: 35576681]
  • Markus Fischer, Peter Müller, Holger A Scheidt, Meike Luck. Drug-Membrane Interactions: Effects of Virus-Specific RNA-Dependent RNA Polymerase Inhibitors Remdesivir and Favipiravir on the Structure of Lipid Bilayers. Biochemistry. 2022 Jul; 61(13):1392-1403. doi: 10.1021/acs.biochem.2c00042. [PMID: 35731976]
  • Zhenli Liu, Yongjun Wu, Lincheng Zhang, Shuoqiu Tong, Jing Jin, Xian Gong, Jie Zhong. rocF affects the production of tetramethylpyrazine in fermented soybeans with Bacillus subtilis BJ3-2. BMC biotechnology. 2022 07; 22(1):18. doi: 10.1186/s12896-022-00748-4. [PMID: 35787694]
  • Kimiyasu Shiraki, Noriaki Sato, Kaoru Sakai, Shirou Matsumoto, Richard H Kaszynski, Masaya Takemoto. Antiviral therapy for COVID-19: Derivation of optimal strategy based on past antiviral and favipiravir experiences. Pharmacology & therapeutics. 2022 07; 235(?):108121. doi: 10.1016/j.pharmthera.2022.108121. [PMID: 35121001]
  • Prajakta Kulkarni, Sriram Padmanabhan. A novel property of hexokinase inhibition by Favipiravir and proposed advantages over Molnupiravir and 2 Deoxy D glucose in treating COVID-19. Biotechnology letters. 2022 Jul; 44(7):831-843. doi: 10.1007/s10529-022-03259-6. [PMID: 35608787]
  • Mehdi Hassaniazad, Hossein Farshidi, Abdollah Gharibzadeh, Ali Bazram, Elham Khalili, Afsaneh Noormandi, Mohammad Fathalipour. Efficacy and safety of favipiravir plus interferon-beta versus lopinavir/ritonavir plus interferon-beta in moderately ill patients with COVID-19: A randomized clinical trial. Journal of medical virology. 2022 Jul; 94(7):3184-3191. doi: 10.1002/jmv.27724. [PMID: 35292989]
  • Won Sriwijitalai, Viroj Wiwanitkit. COVID-19 and favipiravir induce cutaneous adverse reactions: a difficulty in clinical dermatology practice. Clinical and experimental dermatology. 2022 Jul; 47(7):1382-1383. doi: 10.1111/ced.15202. [PMID: 35357031]
  • Dang The Hung, Suhaib Ghula, Jeza Muhamad Abdul Aziz, Abdelrahman M Makram, Gehad Mohamed Tawfik, Ali Ahmed-Fouad Abozaid, Rohan Andrew Pancharatnam, Amr Mohamed Ibrahim, Muhammad Besher Shabouk, Morgan Turnage, Saloni Nakhare, Zahra Karmally, Basel Kouz, Tran Nhat Le, Suleiman Alhijazeen, Nguyen Quoc Phuong, Alaa Mohamed Ads, Ali Hussein Abdelaal, Nguyen Hai Nam, Tatsuo Iiyama, Kyoshi Kita, Kenji Hirayama, Nguyen Tien Huy. The efficacy and adverse effects of favipiravir on patients with COVID-19: A systematic review and meta-analysis of published clinical trials and observational studies. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2022 Jul; 120(?):217-227. doi: 10.1016/j.ijid.2022.04.035. [PMID: 35470021]
  • Rezzan Gülhan, Emel Eryüksel, Medine Gülçebi İdriz Oğlu, Yekta Çulpan, Aylin Toplu, Derya Kocakaya, Elif Tigen, Buket Ertürk Şengel, Uluhan Sili, Şehnaz Olgun Yıldızeli, Mehmet Baran Balcan, Abdullah Elçi, Cenk Bulut, Atila Karaalp, Hasan Raci Yananlı, Abdullah Emre Güner, Mustafa Hatipoğlu, Sait Karakurt, Volkan Korten, Neville Ratnaraj, Philip Patsalos, Pınar Ay, Filiz Onat. Pharmacokinetic characterization of favipiravir in patients with COVID-19. British journal of clinical pharmacology. 2022 07; 88(7):3516-3522. doi: 10.1111/bcp.15227. [PMID: 35014080]
  • Yafang Zhang, Linfeng He, Cheng Ma, Cheng Wang, Honglin Zhou, Chaocheng Guo, Lihong Gong, Yan Wan, Cheng Peng, Yunxia Li. Research progress on the pharmacy of tetramethylpyrazine and its pharmacological activity in cardiovascular and cerebrovascular diseases. The Journal of pharmacy and pharmacology. 2022 Jun; 74(6):843-860. doi: 10.1093/jpp/rgac015. [PMID: 35385110]
  • Mengru Li, Chi-Tang Ho, Jing Wang, Yuemeng Hu, Xiaoting Zhai, Liang Zhang, Xiaochun Wan, Xiaogen Yang. Formation of Volatile Heterocyclic Compounds and Open-Chain Amides of Theanine in Model Systems with Glucose, Tea Leaves, and Tea Extract under Tea-Roasting Conditions. Journal of agricultural and food chemistry. 2022 Jun; 70(22):6737-6746. doi: 10.1021/acs.jafc.2c02039. [PMID: 35621700]
  • Adel Ehab Ibrahim, Yasmine Ahmed Sharaf, Sami El Deeb, Rania Adel Sayed. Analytical Performance and Greenness Evaluation of Five Multi-Level Design Models Utilized for Impurity Profiling of Favipiravir, a Promising COVID-19 Antiviral Drug. Molecules (Basel, Switzerland). 2022 Jun; 27(12):. doi: 10.3390/molecules27123658. [PMID: 35744781]
  • Jonathan J Pinney, Sara K Blick-Nitko, Andrea M Baran, Derick R Peterson, Hannah E Whitehead, Raquel Izumi, Veerendra Munugalavadla, Karl R Van DerMeid, Paul M Barr, Clive S Zent, Michael R Elliott, Charles C Chu. The highly selective Bruton tyrosine kinase inhibitor acalabrutinib leaves macrophage phagocytosis intact. Haematologica. 2022 06; 107(6):1460-1465. doi: 10.3324/haematol.2021.279560. [PMID: 35172559]
  • Michelle L Green, Radojka M Savic, Margaret Tonda, Karin Jorga, Carla B Washington. Model-informed drug development of voxelotor in sickle cell disease: Exposure-response analysis to support dosing and confirm mechanism of action. CPT: pharmacometrics & systems pharmacology. 2022 Jun; 11(6):698-710. doi: 10.1002/psp4.12780. [PMID: 35447017]
  • Mona E El Sharkasy, Manar M Tolba, Fathalla Belal, Mohamed Walash, Rasha Aboshabana. Quantitative analysis of favipiravir and hydroxychloroquine as FDA-approved drugs for treatment of COVID-19 using synchronous spectrofluorimetry: application to pharmaceutical formulations and biological fluids. Luminescence : the journal of biological and chemical luminescence. 2022 Jun; 37(6):953-964. doi: 10.1002/bio.4240. [PMID: 35343627]
  • Inas A Abdallah, Sherin F Hammad, Alaa Bedair, Mohamed A Abdelaziz, Neil D Danielson, Ahmed H Elshafeey, Fotouh R Mansour. A gadolinium-based magnetic ionic liquid for supramolecular dispersive liquid-liquid microextraction followed by HPLC/UV for the determination of favipiravir in human plasma. Biomedical chromatography : BMC. 2022 Jun; 36(6):e5365. doi: 10.1002/bmc.5365. [PMID: 35274347]
  • Jianguo Lin, Qingqing Wang, Simin Zhou, Siyu Xu, Kuiwu Yao. Tetramethylpyrazine: A review on its mechanisms and functions. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):113005. doi: 10.1016/j.biopha.2022.113005. [PMID: 35483189]
  • Divya Kumar Vemuri, Rambabu Gundla, Naresh Konduru, Ravindra Mallavarapu, Naresh Kumar Katari. Favipiravir (SARS-CoV-2) degradation impurities: Identification and route of degradation mechanism in the finished solid dosage form using LC/LC-MS method. Biomedical chromatography : BMC. 2022 Jun; 36(6):e5363. doi: 10.1002/bmc.5363. [PMID: 35292997]
  • Radojka M Savic, Michelle L Green, Karin Jorga, Michael Zager, Carla B Washington. Model-informed drug development of voxelotor in sickle cell disease: Population pharmacokinetics in whole blood and plasma. CPT: pharmacometrics & systems pharmacology. 2022 Jun; 11(6):687-697. doi: 10.1002/psp4.12731. [PMID: 35447014]
  • Yan Xu, Raquel Izumi, Helen Nguyen, Anna Kwan, Howard Kuo, Jeannine Madere, J Greg Slatter, Terry Podoll, Karthick Vishwanathan, Thomas Marbury, William Smith, Richard A Preston, Shringi Sharma, Joseph A Ware. Evaluation of the Pharmacokinetics and Safety of a Single Dose of Acalabrutinib in Subjects With Hepatic Impairment. Journal of clinical pharmacology. 2022 06; 62(6):812-822. doi: 10.1002/jcph.2013. [PMID: 34897701]
  • Rundong Jiang, Jiaqi Xu, Yuezhong Zhang, Jiachen Liu, Yutong Wang, Mingliang Chen, Xiang Chen, Mingzhu Yin. Ligustrazine alleviates psoriasis-like inflammation through inhibiting TRAF6/c-JUN/NFκB signaling pathway in keratinocyte. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):113010. doi: 10.1016/j.biopha.2022.113010. [PMID: 35468584]
  • Henrietta Papp, Zsófia Lanszki, György M Keserű, Ferenc Jakab. Favipiravir for the treatment of COVID-19 in elderly patients-what do we know after 2 years of COVID-19?. GeroScience. 2022 Jun; 44(3):1263-1268. doi: 10.1007/s11357-022-00582-8. [PMID: 35543795]
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