Thyroxine glucuronide (BioDeep_00001872457)
代谢物信息卡片
化学式: C21H19I4NO10 (952.7188)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)OC3C(C(C(C(O3)C(=O)O)O)O)O)I)I)CC(C(=O)O)N
InChI: InChI=1S/C21H19I4NO10/c22-8-1-6(3-12(26)19(30)31)2-9(23)16(8)34-7-4-10(24)17(11(25)5-7)35-21-15(29)13(27)14(28)18(36-21)20(32)33/h1-2,4-5,12-15,18,21,27-29H,3,26H2,(H,30,31)(H,32,33)/t12-,13-,14-,15+,18-,21?/m0/s1
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Hidenori Nagao, Makoto Sasaki, Tetsuya Imazu, Kenjo Takahashi, Hironori Aoki, Kouichi Minato. Effects of triiodothyronine on turnover rate and metabolizing enzymes for thyroxine in thyroidectomized rats.
Life sciences.
2014 Oct; 116(2):74-82. doi:
10.1016/j.lfs.2014.09.016. [PMID: 25261596] - Maarten Buitendijk, Valerie Anne Galton. Is the kidney a major storage site for thyroxine as thyroxine glucuronide?.
Thyroid : official journal of the American Thyroid Association.
2012 Feb; 22(2):187-91. doi:
10.1089/thy.2011.0307. [PMID: 22175240] - Marguerite T Hays. Deconjugation of thyroxine glucuronide by the rat kidney.
Thyroid : official journal of the American Thyroid Association.
2009 Sep; 19(9):1001-4. doi:
10.1089/thy.2008.0375. [PMID: 19731980] - Lloyd Lecureux, Matthew Z Dieter, David M Nelson, Linda Watson, Harvey Wong, Brian Gemzik, Curtis D Klaassen, Lois D Lehman-McKeeman. Hepatobiliary disposition of thyroid hormone in Mrp2-deficient TR- rats: reduced biliary excretion of thyroxine glucuronide does not prevent xenobiotic-induced hypothyroidism.
Toxicological sciences : an official journal of the Society of Toxicology.
2009 Apr; 108(2):482-91. doi:
10.1093/toxsci/kfp026. [PMID: 19211616] - Jeffrey W Fisher, Jerry Campbell, Srinivasa Muralidhara, James V Bruckner, Duncan Ferguson, Moiz Mumtaz, Barry Harmon, Joan M Hedge, Kevin M Crofton, Hekap Kim, Tara L Almekinder. Effect of PCB 126 on hepatic metabolism of thyroxine and perturbations in the hypothalamic-pituitary-thyroid axis in the rat.
Toxicological sciences : an official journal of the Society of Toxicology.
2006 Mar; 90(1):87-95. doi:
10.1093/toxsci/kfj069. [PMID: 16339789] - M Rutgers, I G Pigmans, F Bonthuis, R Docter, T J Visser. Effects of propylthiouracil on the biliary clearance of thyroxine (T4) in rats: decreased excretion of 3,5,3'-triiodothyronine glucuronide and increased excretion of 3,3',5'-triiodothyronine glucuronide and T4 sulfate.
Endocrinology.
1989 Oct; 125(4):2175-86. doi:
10.1210/endo-125-4-2175. [PMID: 2791984]
